Clinical trials: Smoking Addiction
Smoking Cessation
The Effects of Cigarette Addiction on Lower Extremity Movement Speed and Coordination
This observational study will aim to investigate the effects of cigarette addiction on lower extremity motor coordination and movement speed in young adults.
- Trial name
- NCT07075068
- Testing
- Behavioral and Functional Performance Assessment Battery
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Saglik Bilimleri Universitesi
Cigarette Addiction
The Effects of Electronic Cigarette and Traditional Cigarette
The aim of the study is to investigate and compare the effects of traditional cigarette and e-cigarette consumption habits on sleep quality, fatigue, mental health and quality of life.
- Trial name
- NCT07131891
- Testing
- Fatigue Severity Scale, Depression, Anxiety and Stress Scale-21, Jenkins Sleep Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Atılım University
Nicotine Dependence
Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction
The purpose of this study is to investigate the effect of gemfibrozil on nicotine reinforcement and cue-elicited craving. Other objectives of this study include screening for the ability of gemfibrozil to aid smoking abstinence…
- Trial name
- NCT01876810
- Testing
- Gemfibrozil
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Use Disorder
Effects of Novel E-cigarette Constituents on Adults TCORS 3.0
This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.
- Trial name
- NCT05932745
- Testing
- E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Yale University
Cancer of Head and Neck, Breast Cancer
Brain Stimulation For Cancer Smokers
Smoking cessation and relapse prevention represent and important opportunity to improve cancer survival rates, reduce the risk of cancer treatment complication, and improve the quality of life of patients with and survivors of…
- Conditions
- Cancer of Head and Neck, Breast Cancer, Prostate Cancer, Nicotine Dependence
- Trial name
- NCT03419741
- Testing
- Transcranial Magnetic Stimulation Clinical Research System
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Tobacco Smoking
The Effects of Sedatives on Tobacco Use Disorder Version 2
Double-blind, placebo-controlled, randomized mechanistic clinical trial to test an intravenous dose of either ketamine, midazolam, dexmedetomidine, or a placebo (saline) on cigarette smoking behavior, craving, and neural effects.
- Trial name
- SED-TUD2 (NCT05505630)
- Testing
- Ketamine, Midazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Tobacco Addiction, Smoking Related Diseases
A Photoaging Mobile App Promoting Poster Campaign for Preventing Smoking in Secondary Schools
The purpose of this study is to determine whether photoaging mobile app promoting poster campaigns are effective to reduce smoking prevalence among adolescents in Germany. This is measured via questionnaire.
- Conditions
- Tobacco Addiction, Smoking Related Diseases, Adolescent Smoking
- Trial name
- Smokerface (NCT02544360)
- Testing
- Photoaging mobile app promoting poster campaign.
- Where
- Germany
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Nicotine Addiction, Panic Attack
Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine
The purpose of the current study is to evaluate the efficacy of d-cycloserine in augmenting treatment of smoking cessation for individuals with panic attacks.
- Trial name
- DCS/PSRT (NCT01944423)
- Testing
- d-cycloserine, Nicotine replacement therapy, Panic and Smoking Reduction Treatment
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Smoking Cessation, Cancer, Treatment-Related
Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment
Smoking cessation has been shown to improve the effectiveness and reduce the morbidity of tobacco-related cancer treatments. We will identify effective smoking cessation strategies for patients who are receiving treatment for…
- Trial name
- TTOP (NCT04634071)
- Testing
- Varenicline, Bupropion, Long-acting nicotine replacement therapy
- Where
- 3 sites in United States
- Volunteers
- 126 people
- Sponsor
- Joseph Valentino, MD
Smoking Cessation Intervention, Pain
Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain
The goal of this pilot study is to assess whether 4-weeks of verified smoking abstinence following financial incentive treatment for smoking cessation improves physiological markers of chronic pain risk in adult Native American…
- Conditions
- Smoking Cessation Intervention, Pain, Smoking (Tobacco) Addiction
- Trial name
- OK-SNAPIV (NCT07080788)
- Testing
- Smoking Cessation
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Substance Use Disorder (SUD), Alcohol Use Disorder (AUD)
Metabolome and Gut Microbiome Changes During Smoking Cessation in Long-term Drug Therapy in a Therapeutic Community
Theoretical Framework: Cigarette smoking is the leading preventable cause of death worldwide, with nicotine dependence notably common among individuals with Substance Use Disorders (SUD).
- Conditions
- Substance Use Disorder (SUD), Alcohol Use Disorder (AUD), Nicotine Addiction, Healthy Adult Participants
- Trial name
- NCT06803706
- Testing
- 6-weeks CBT smoking cessation programme, Long-term drug therapy within a therapeutic community
- Where
- 3 sites in Austria
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Sigmund Freud PrivatUniversitat
Smoking, Cigarette, Craving
QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt
Cigarette smoking constitutes the greatest preventable cause of mortality and morbidity in the US. The most critical period for long term success of smoking cessation appears to be in the first 7 days after the quit date.
- Conditions
- Smoking, Cigarette, Craving, Addiction, Nicotine
- Trial name
- NCT03576768
- Testing
- Real cTBS, Real iTBS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical University of South Carolina
Smoking Cessation, Tobacco Use Cessation
Safety and Effectiveness of NicVAX in Treating Nicotine Dependent Individuals
Nicotine is highly addictive and many individuals are unable to quit smoking even with treatment. The purpose of this study is to determine the effectiveness of various doses of NicVAX in treating nicotine dependent individuals.
- Trial name
- NCT00218413
- Testing
- NicVAX
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Nabi Biopharmaceuticals
Cigar Smoking, Tobacco Use
Cigar Legislation and Regulation in Tobacco for the Young (Project CLARITY)
This clinical trial will recruit young adults who currently use cigarillos and examine the smoking behavior and perceptions of different flavored cigarillos, product ingredients/additives impacting these perceptions, and…
- Trial name
- CLARITY (NCT07162935)
- Testing
- Cigarillo brand 1, Cigarillo brand 2, Cigarillo brand 3
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Nicotine Addiction, E-Cig Use
Quit Smoking Study for People Who Use E-Cigarettes
The overarching aim of this proposed randomized controlled trial (RCT) is to test nicotine replacement therapy (NRT) with text message support for two smoking cessation approaches among young adult dual users of combustible…
- Conditions
- Nicotine Addiction, E-Cig Use, Quitting Smoking
- Trial name
- NCT04946825
- Testing
- Nicotine replacement therapy patch, Nicotine replacement therapy lozenge, Quit electronic cigarettes
- Where
- United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Smoking, Smoking Behaviors
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products.
- Conditions
- Smoking, Smoking Behaviors, Nicotine Dependence
- Trial name
- NCT06077240
- Testing
- E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Yale University
Nicotine Dependence
Study on Smoking Cessation and Cost Outcomes in the Duke Smoking Cessation Program
The purpose of this study is to conduct an observational assessment of natural outcomes within the Duke Smoking Cessation Program (DSCP), "Quit at Duke." This assessment will include information regarding abstinence rates…
- Trial name
- NCT02845687
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Duke University
Nicotine Dependence
The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence
The advent of electronic cigarette (e-cigarette) technologies represents one of the most significant developments in the last several decades, and provides a novel and promising strategy for substantially reducing the morbidity…
- Trial name
- Ecig1 (NCT02590393)
- Testing
- E-cigarettes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Addiction Nicotine
The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction
This clinical trial evaluates the VapeAway system, a novel, multi-modal intervention designed to address the multifaceted nature of vaping addiction.
- Trial name
- CONQUER (NCT07322432)
- Testing
- VapeAway filter system
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- VapeAway
Tobacco Dependence, Smoking Cessation
Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence
The addition of tDCS as an adjunct to pharmacotherapy is a novel approach but one that is grounded in a growing evidence-base.The primary objective of this research is to provide preliminary evidence of the effectiveness of tDCS…
- Conditions
- Tobacco Dependence, Smoking Cessation, Tobacco Smoking, Tobacco Use Disorder
- Trial name
- NCT03841292
- Testing
- Varenicline, Active tDCS
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Centre for Addiction and Mental Health