Clinical trials: Smoking Cessation
Smoking, Bipolar Disorder
Varenicline in Bipolar Depressed Patients
Patients with bipolar disorder have one of the highest rates of nicotine dependence and one of the lowest quit rates. Varenicline has been shown in previous trials to be effective for smoking cessation, but has not been studied…
- Conditions
- Smoking, Bipolar Disorder, Depression
- Trial name
- Varenicline (NCT00813800)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mark Frye
Smoking
Youth Smoking Cessation: Therapy +/- "The Patch"
Reducing tobacco use by adolescents is a national health priority. In recent polls, most adolescent smokers reported having tried unsuccessfully to quit.
- Trial name
- NCT00631020
- Testing
- CBME, Optional NRT
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Smoking Cessation
A Study in Healthy Smokers to Investigate the Effect of Food on the Bioavailability of Cytisine in a New Formulation
This will be an open-label, randomised, 2-treatment period, single-dose crossover study to determine the comparative bioavailability and renal elimination following single-dose administration of 3.0 mg cytisine in healthy smokers…
- Trial name
- NCT03509948
- Testing
- cytisine
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Achieve Life Sciences
Smoking, Smoking Cessation
Evaluation of Treatments to Improve Smoking Cessation Medication Adherence
Many smokers fail to take their smoking cessation medication as recommended. This research is designed to identify treatments that improve the use of cessation medications and to determine whether an increase in medication use…
- Conditions
- Smoking, Smoking Cessation, Adherence, Nicotine Dependence
- Trial name
- Adherence (NCT01120704)
- Testing
- Short Term Combination Nicotine Replacement Therapy (patch + gum), Long Term Combination Nicotine Replacement Therapy (patch + gum), Intensive Maintenance Counseling
- Where
- United States
- Volunteers
- 544 people
- Sponsor
- University of Wisconsin, Madison
Smoking Cessation
Trial of Cytisine in Adult Smokers
This placebo-controlled Phase 2b trial is being conducted at sites within the United States (US) to evaluate the effectiveness cytisine dosage (1.5 mg, 3.0 mg) and administration schedule (commercial titration versus simplified 3…
- Trial name
- NCT03709823
- Testing
- Cytisine, Behavioral support
- Where
- 8 sites in United States
- Volunteers
- 254 people
- Sponsor
- Achieve Life Sciences
Smoking Cessation
Proof-Of-Concept Investigation With a Neurosteroid Analog (Ganaxolone) as a Smoking Cessation Candidate
The purpose of this research study is to evaluate whether the investigational drug ganaxolone can help smokers quit smoking. Ganaxolone is a drug that has been investigated (in other research studies) for the treatment of…
- Trial name
- Ganaxolone (NCT01857531)
- Testing
- Ganaxolone, Nicotine Patch
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- Jed E. Rose
Cigarette Smoking
A Smoking Cessation Study to Understand the Biological and Functional Changes After One Year of Smoking Cessation
The purpose of this study was to understand the biological and functional changes after one year of smoking cessation and to collect data on a broad range of biomarkers of exposure (BoExp) and biomarkers of effect (BoE).
- Trial name
- RIBESC (NCT02432729)
- Where
- 5 sites in United States, Germany and 3 more
- Volunteers
- 1,184 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Use Cessation, Cancer Prevention
Project Impact 2: A Culturally Tailored Smoking Cessation Intervention for Latino Smokers
The goal of this research study is to learn how 3 different kinds of counseling treatments may help individuals to quit smoking.
- Trial name
- NCT02596711
- Testing
- Nicotine Patch, Questionnaires, Carbon Monoxide (CO) Test
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Smoking
Behaviorally Enhanced Counseling on Nicotine Dependence (BEACON) Trial.
The major purpose of this exploratory developmental study will be to develop a patient-centered and feasible protocol for communicating genetic data as it relates to drug efficacy for smoking cessation inpatients receiving…
- Trial name
- NCT00991081
- Testing
- Counseling, Self-help guide, Pharmacotherapy
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Stanford University
Smoking Cessation, Nicotine Dependence
Varenicline and Motivational Advice for Smokers With Substance Use Disorders
The purpose of this study is to evaluate the effects of 12 weeks of varenicline as compared to nicotine replacement therapy for smoking cessation among outpatients in treatment for substance use disorders.
- Trial name
- VARSUD (NCT00756275)
- Testing
- Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Brown University
Tobacco Use Cessation
Improving Adherence to Smoking Cessation Medication Among PLWHA
Smoking rates among individuals living with HIV/AIDS range between 47% and 65%, a prevalence that is roughly three times the rate of the general population.
- Trial name
- HIV (NCT01898195)
- Testing
- Varenicline, Text Message, Adherence Behavioral Therapy
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- NYU Langone Health
Smoking Cessation, Pain
Project HOPES: Healthy Options for Pain and Ending Smoking. A Program for Cancer Survivors.
The proposed pilot study will develop and test feasibility, acceptability, and signal for efficacy of a smoking cessation and pain management intervention for 20 cancer survivors.
- Trial name
- NCT06029907
- Testing
- Smoking cessation and pain management intervention, Varenicline
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Smoking Cessation
Automated Mobile Contingency Management for Smoking Cessation: A Pilot RCT (SCC PREVAILgo)
The purpose of the proposed project is to pilot test an automated mobile phone-based contingency management (CM) approach to tobacco (smoking) cessation.
- Trial name
- NCT03739437
- Testing
- Mobile Contingency Management, Standard Care
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Smoking Cessation, Alcohol Drinking
Development and Pilot Testing of a Multimodal Web-based Program to Address Heavy Drinking During Smoking Cessation
The overall objective of this project is to develop and pilot-test a web-based smoking cessation program that specifically addresses heavy drinking (HD).
- Trial name
- NCT03068611
- Testing
- Standard Web-based Smoking Cessation, Alcohol-focused Web-Based Smoking Cessation
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Brown University
Cigarette Smoking
Mobile Health Technology for Personalized Tobacco Cessation Support Among Cancer Survivors in Laos
The parent project (1R21CA253600-01, R21 phase: 9/1/2020-8/31/2022, R33 phase: 9/1/2022-8/31/2025) aims to adapt and evaluate the efficacy of our theoretically and empirically based mobile health (mHealth) technology to help…
- Trial name
- SurvLaos (NCT05253573)
- Testing
- Nicotine patch, Self-help materials (to support smoking cessation), Smartphone-based automated treatment for smoking cessation
- Where
- 2 sites in Laos
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Smoking Cessation, Second Hand Tobacco Smoke
Smoke-free Home Intervention in Permanent Supportive Housing
The focus of this study is on expanding access to voluntary smoke-free homes to formerly homeless residents residing in permanent supportive housing and examining the impact of this intervention on reducing tobacco-caused…
- Trial name
- NCT04855357
- Testing
- Resident counselling, Staff Training
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking Cessation
"VIBRATIONS" - A Study In Smokers Who Are Willing And Motivated To Stop Smoking With The Aid Of Varenicline Which Will Be Prescribed According To Usual Clinical Practice In Germany
The aim of this study is to determine the success rates for stopping smoking with varenicline in Germany. The main measure of success will be continuous abstinence from smoking (not a single puff) in the last week of the standard…
- Trial name
- VIBRATIONS (NCT01104636)
- Testing
- Varenicline
- Volunteers
- 1,177 people
- Sponsor
- Pfizer
Smoking
Varenicline and Bupropion for Smoking Cessation
This study provides an opportunity to combine varenicline and bupropion SR and capitalize on the potential additive benefit. The investigators hypothesize that this will further increase long-term (≥ 6 months) smoking abstinence…
- Trial name
- CHANBAN (NCT00935818)
- Testing
- Varenicline, bupropion SR
- Where
- 3 sites in United States
- Volunteers
- 506 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Coronary Syndrome, Myocardial Infarction
Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial
Patients who continue to smoke after a heart attack have a 35% increased risk of a recurrent event or death compared with those who quit. Many patients attempt to stop smoking after a heart attack, but relapse rates approach 66%.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Smoking
- Trial name
- ZESCA (NCT00689611)
- Testing
- Bupropion HCl ER
- Where
- 38 sites in United States, Bangladesh and 5 more
- Volunteers
- 392 people
- Sponsor
- Mark Eisenberg
Smoking Cessation
A Pharmacokinetic and Pharmacodynamic Evaluation of Cytisine in Healthy Smokers
The primary objectives of this study are: To evaluate the pharmacokinetic (PK) parameters during repeat dosing of 1.5 mg or 3.0 mg cytisine when administered as the commercial 25-day schedule.
- Trial name
- NCT03303911
- Testing
- Cytisine
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Achieve Life Sciences