Clinical trials: Smoking Cigarette
Nicotine Use Disorder
Pharmacokinetics and Acute Effects of Multiple Dose of Nicotine: Electronic Cigarette and Cigarette
The purposes of this study are 1) to determine the pharmacokinetics of nicotine after multiple dose administration by electronic cigarette and 2) to compare the acute effects of multiple dose of nicotine administrated by…
- Trial name
- NCT02511704
- Testing
- Nicotine
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Nicotine Dependence, Electronic Cigarette Use
E-cigarette Nicotine Study
This is a pilot randomized controlled trial (RCT) with the overarching aim of testing the influence of reducing electronic nicotine delivery system (ENDS) use or nicotine on addiction and combustible cigarette (CC) smoking among…
- Conditions
- Nicotine Dependence, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- NCT04709471
- Testing
- Nicotine, Juul e-cigarette, Reduction
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Smoking Cessation
Cigarette Reduction Using the Quitbit Digital Lighter and Mobile Application for Smoking Cessation: a Randomized Controlled Trial
The study is designed to evaluate the efficacy of a cigarette reduction intervention using a novel device called the Quitbit, a digital lighter paired with a smartphone mobile application, to enhance self-regulatory techniques…
- Trial name
- NCT02515500
- Testing
- Gradual Cessation, Gradual Cessation w/ Quitbit
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Dependence
Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes
Project 1, Study 1 will evaluate the relationship between nicotine yield of very low nicotine content cigarettes and cigarettes smoked per day, nicotine exposure, discomfort/dysfunction, other health-related behaviors…
- Trial name
- P1S1 (NCT01681875)
- Testing
- very low nicotine content cigarettes
- Where
- 9 sites in United States
- Volunteers
- 839 people
- Sponsor
- Wake Forest University Health Sciences
Smoking, Smoking Habit
PRogetto Salute Parma
This project from the University Hospital of Parma (AOUPR) aims to verify the feasibility of a prevention program in our district, relying on advanced technological resources and highly experienced team in lung cancer early…
- Conditions
- Smoking, Smoking Habit, Smoking, Tobacco, Smoking, Cigarette
- Trial name
- PSP (NCT04282694)
- Testing
- Low-dose computed tomography (LDCT)
- Where
- Italy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Parma
Cigarette Smoking
Mechanisms of the Nicotine Metabolism Effect on Tobacco Dependence
The purpose of the study is to learn more about tobacco dependence and nicotine metabolism in African-Americans and whites, by studying to see if how fast a person metabolizes nicotine (how the body breaks down nicotine into…
- Trial name
- NMR (NCT01627392)
- Testing
- Smoking abstinence
- Where
- United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking, Smoking Cessation
Couples Dynamics and Smoking Cessation
This study is about investigating smoking and attempts to quit smoking in couples. Participation will help determine better treatment efforts for couples who want to quit smoking.
- Conditions
- Smoking, Smoking Cessation, Cessation, Smoking, Smoking Behaviors
- Trial name
- SCOR (NCT03885336)
- Testing
- No Interventions
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- University of Southern California
Nicotine Use Disorder, Tobacco Use Disorder
Evaluation of the Addictive Potential of E-Cigarettes
This study will examine the subject matter from a neurobiological and a neuropsychological vantage point to ascertain whether the e-cigarette is potentially as addictive as the traditional tobacco cigarette.
- Trial name
- EVAPE (NCT04772014)
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Cigarette Smoking Behavior
Effects of Contingency Management and Nicotine Replacement Therapy on Youth Smoking
Cigarette smoking is an important public health concern, and it is most often initiated in adolescence. Despite substantial research on smoking cessation in adults, however, relatively little effort has focused on therapeutic…
- Trial name
- NCT01359709
- Testing
- Nicotine polacrilex
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Schizophrenia, Cigarette Smoking
Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia - Efficacy and Predictors
This is a 8-week double-blind placebo controlled parallel group study of the efficacy of varenicline (Chantix) for smoking cessation in schizophrenic patients, and its effect on cognitive function in patients with…
- Trial name
- NCT00802919
- Testing
- Varenicline
- Where
- 4 sites in United States, China and 1 more
- Volunteers
- 93 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Cigarette Smoking-Related Carcinoma
mHealth Mood Management Tool (Actify) to Improve Population-Level Smoking Cessation
This phase I trial investigates a new smartphone application (called Actify) for improving population-level smoking cessation and mood management.
- Trial name
- NCT04525222
- Testing
- Health Promotion and Education, Smoking Cessation Intervention (Actify app), Smoking Cessation Intervention (Current Standard Care app)
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Panic Disorder
Evaluating the Relationship Between Tobacco Use, Anxiety Sensitivity, and Panic in Adolescents
This study will determine whether there is a relationship between tobacco use and a heightened response to panic-producing events among adolescents. This study is fundamental research. It was not a Clinical Trial.
- Trial name
- NCT00535964
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Dual Use of Cigarettes and E-cigarettes
DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy
This randomized clinical trial evaluates the effectiveness of augmented-dose combination nicotine replacement therapy (NRT) versus standard-dose NRT and no-NRT control for cessation of dual combustible cigarette (CC) and…
- Trial name
- NCT07754578
- Testing
- Text- and web-based support, Nicotine Replacement Therapy (NRT, nicotine patch), Nicotine replacement therapy lozenge
- Where
- United States
- Volunteers
- 321 people
- Sponsor
- Medical University of South Carolina
Secondhand Exposure to Electronic Cigarette
Bystanders' Exposure to Electronic Cigarette Aerosol in Confined Settings
Objective of this study is to investigate the bystanders' exposure to e-cigarette emissions in controlled conditions in confined settings. Design: a cross-sectional experimental study developed in two settings: a car and a room.
- Trial name
- NCT04140617
- Testing
- Exposure to aerosol of electronic cigarette
- Where
- Spain
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Institut Català d'Oncologia
Nicotine Dependence, Nicotine Vaping
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic.
- Trial name
- NCT05962229
- Testing
- (S)-Nicotine, (R)- nicotine, Racemic nicotine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking
Effect of Donepezil on Smoking
The objective of this proof-of-concept pilot study is to evaluate Donepezil HCL (Aricept) for side effects and effects on smoking behavior and performance on neurocognitive tasks in a population of dependent smokers.
- Trial name
- NCT01250977
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Tobacco Smoking
Cigarette Smoking Decision Study
The Family Smoking Prevention and Tobacco Control Act granted the FDA the authority to regulate and restrict tobacco advertising tactics that inaccurately convey reduced product risk, yet there is a dearth of up-to-date…
- Trial name
- NCT04595279
- Testing
- Smoking sessions
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cigarette Smoking, Nicotine Addiction
STOP Study: Effectiveness of Zyban in a Clinical Population
Despite the significant health, social and economic costs of cigarette smoking, 17% of Ontarians still currently smoke. Use of smoking cessation pharmacotherapy such as Zyban (bupropion HCl) has been shown to double quit rates…
- Conditions
- Cigarette Smoking, Nicotine Addiction, Smoking Cessation
- Trial name
- NCT01015170
- Testing
- bupropion HCl
- Where
- 24 sites in Canada
- Volunteers
- 454 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation
Applying mHealth to Tobacco-related Health Disparities
The purpose of this study is to better understand what happens when someone attempts to quit smoking.
- Trial name
- Time2Quit (NCT03404596)
- Testing
- Nicotine Patch, Counseling, Smartphone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Smoking (Tobacco) Addiction
Addiction and Behavior Related to Menthol Cigarette Substitutes
The goal of the proposed study is to examine the abuse liability and substitutability of plausible menthol cigarette alternatives currently on the market, including menthol filtered little cigars (mFLC), menthol roll-your-own…
- Trial name
- MENTHOL (NCT04844762)
- Testing
- Menthol cigarettes substitutes, Usual brand menthol cigarettes and substitutes, Menthol cigarettes substitutes and menthol cigarettes
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center