Clinical trials: Smoking Dependence
Nicotine Dependence
Motivational Interviewing Compared to Psychoeducation for Smoking Precontemplators With SMI
The investigators primary hypothesis was that recipients of the Motivational Interviewing intervention would be significantly more likely than those assigned to the Psychoeducation intervention to demonstrate increased readiness…
- Trial name
- NCT01982617
- Testing
- Motivational Interviewing, Psychoeducation
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Massachusetts General Hospital
Smoking Cessation, Smoking, Tobacco
Helping Poor Smokers Quit
Using a 2x2 randomized factorial design, we will conduct a statewide field trial in Missouri to compare the relative and combined effects of these two strategies for augmenting an existing, evidence-based tobacco quitline…
- Conditions
- Smoking Cessation, Smoking, Tobacco, Smoking, Cigarette, Smoking, Pipe
- Trial name
- NCT03194958
- Testing
- Specialized Quitline, Basic Needs Navigator
- Where
- United States
- Volunteers
- 1,944 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Tobacco Use, Smoking Cessation
Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder
The purpose of the study is to examine whether an investigational medication called ketamine is able to improve treatment outcomes for tobacco use disorder when delivered in conjunction with brief motivational enhancement…
- Conditions
- Tobacco Use, Smoking Cessation, Nicotine Dependence
- Trial name
- NCT05796791
- Testing
- Ketamine Hydrochloride, Motivational enhancement therapy
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Dependence
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Adolescent Smokers
Background: Multiple social, psychological, and environmental factors contribute to adolescents' use of cigarettes. Environmental smoking cues have been shown to play an important role in the maintenance of nicotine addiction and…
- Trial name
- NCT01148355
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence, Tobacco Toxicity
Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
This is a crossover study that will examine use behaviors, chemical exposures, and biological effects of Standardized Research Electronic Cigarette (SREC) compared to usual brand e-cigarette use in natural or synthetic nicotine…
- Conditions
- Nicotine Dependence, Tobacco Toxicity, Cardiovascular Risk Factors
- Trial name
- SREC22 (NCT05658471)
- Testing
- Standardized Research E-Cigarette (SREC), Over the Counter E-Cigarette (EC), Biological Samples
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder
Effect of Progesterone on Smoking Behavior in Male and Female Smokers
Past research on nicotine addiction has shown that changes in estradiol and progesterone hormone levels during menstruation may cause women to respond differently than men to nicotine.
- Trial name
- NCT00271206
- Testing
- Progesterone, sugar pill
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Nicotine Dependence
Menstrual Cycle Effects on Smoking Cessation and Cue Reactivity
This is a brief smoking cessation trial in women, comparing transdermal nicotine patch (TNP) versus varenicline.
- Trial name
- NCT00664755
- Testing
- varenicline, transdermal nicotine patch
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Dependence
Varenicline for Adolescent Smoking Cessation
This is a placebo-controlled smoking cessation treatment study for adolescents ages 14-21. After assessment and inclusion into the study, participants will be randomized to receive a 12-week double blind course of varenicline or…
- Trial name
- NCT01509547
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Medical University of South Carolina
Smoking Dependence, Smoking
Provoked Craving Assessment
Evaluation of the ability of a nicotine mini lozenge to provide early relief of craving for a cigarette in smokers
- Trial name
- NCT01506908
- Testing
- oral nicotine
- Where
- United States
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tobacco Dependence, Veterans
Identifying Effective Treatment for Veterans Unwilling to Quit Smoking
This project will generate knowledge about the effectiveness of Enhanced Chronic Care, an intervention designed to enhance treatment use and smoking abstinence in Veterans who are initially unwilling to quit.
- Trial name
- NCT04061720
- Testing
- Enhanced Chronic Care, Standard Care
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- VA Office of Research and Development
Nicotine Dependence, Smoking
Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers
This research project addresses the hypothesis that a neurocognitive profile characterized by impairment of response inhibition and sustained attention may be a risk factor for smoking initiation and nicotine dependence among…
- Conditions
- Nicotine Dependence, Smoking, Tobacco Use Disorder, Nicotine Use Disorder
- Trial name
- NCT00429208
- Testing
- Nicotine
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Tobacco Smoking, Nicotine Dependence
Effects of Intensive Behavioral Training Program on Impulsivity and Inhibitory Control in Smokers
Dependence on tobacco derived nicotine is a major public health problem. Substance users who complete training in mindfulness subjectively report increased patience and improved motor control over their impulses.
- Conditions
- Tobacco Smoking, Nicotine Dependence, Impulsivity, Addiction
- Trial name
- IBTP (NCT01314378)
- Testing
- Mindfulness Training, Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Nicotine Addiction, Drug Addiction
Clinical Trial of Smoking Cessation Mobile Phone Program
The Sponsor is doing a research study to assess the effects of a smartphone program designed to help users smoke less and eventually quit. When participants join, their involvement in the core study will last 8 weeks.
- Conditions
- Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder
- Trial name
- NCT02656745
- Testing
- Mobile Smoking Cessation Solution
- Where
- United States
- Volunteers
- 416 people
- Sponsor
- Click Therapeutics, Inc.
Smoking, Tobacco
Proactive Population Health Strategy to Offer Tobacco Dependence Treatment to Smokers
Health care systems are key channels for delivering tobacco cessation treatment to the smokers in a population. A population-based approach could complement office-based care and offload busy clinicians.
- Trial name
- NCT03612895
- Testing
- Internal Care Coordination, External Community Referral, Usual Care
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Massachusetts General Hospital
Smoking Electronic Cigarettes (Vaping), With Moderate and High Dependence for Nicotine
EFFECT OF WIM HOF BREATHING EXERCISE ON VENTILATORY FUNCTIONS IN SMOKERS
Cigarette smoking is the most common form of tobacco use worldwide, but other tobacco products, such as e-cigarettes, cigars, cigarillos, roll-your-own, pipes, and various smokeless tobacco products are also damaging.
- Trial name
- NCT07153640
- Testing
- 1 ) Wim Hof Breathing Exercise, 2) Aerobic exercises
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- October 6 University
Schizophrenia, Tobacco Use Disorder
Effect of Bupropion on Smoking Behavior in Smokers With Schizophrenia
Many individuals with schizophrenia smoke cigarettes but little is known about the factors that control smoking in people with schizophrenia.
- Trial name
- NCT00218231
- Testing
- 300 mg/day bupropion-sr, 0 mg/day bupropion-sr
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, Smoking Cessation
Evaluation of Treatments to Improve Smoking Cessation Medication Adherence
Many smokers fail to take their smoking cessation medication as recommended. This research is designed to identify treatments that improve the use of cessation medications and to determine whether an increase in medication use…
- Conditions
- Smoking, Smoking Cessation, Adherence, Nicotine Dependence
- Trial name
- Adherence (NCT01120704)
- Testing
- Short Term Combination Nicotine Replacement Therapy (patch + gum), Long Term Combination Nicotine Replacement Therapy (patch + gum), Intensive Maintenance Counseling
- Where
- United States
- Volunteers
- 544 people
- Sponsor
- University of Wisconsin, Madison
Waterpipe Smoking
The Role of Contingency Management in Waterpipe Smoking Cessation
Tobacco use kills more than 500,000 people in the United States each year. Although the use of cigarettes has declined, the use of other tobacco products has remained steady.
- Trial name
- NCT02159092
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Washington State University
Smoking Cessation
A Pilot Text Messaging Intervention to Reduce Smoking in Office-based Buprenorphine and Inpatient Detoxification Patients
The primary purpose of this study is to understand the feasibility of a text messaging intervention developed by the National Cancer Institute, known as Smokefreetxt, to improve smoking cessation among opiate and/or alcohol…
- Trial name
- NCT02665208
- Testing
- Treatment As Usual (TAU), Nicotine Replacement Therapies, Text Message Intervention (TMI)
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Tobacco Use Disorder, Tobacco Smoking
Cannabidiol for Reducing Cigarette Use
The goal of this research is to evaluate the efficacy of cannabidiol (CBD) in reducing cigarette smoking. Although there are safe and effective treatments for smoking cessation, not everyone who attempts smoking cessation is…
- Conditions
- Tobacco Use Disorder, Tobacco Smoking, Tobacco Dependence
- Trial name
- NCT06218056
- Testing
- Cannabidiol (CBD) 800 mg
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles