Clinical trials: Smoking Dependence
Tobacco Use Disorder
Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women
This study will examine extended exposure to cigarettes varying in nicotine content among disadvantaged women. Disadvantaged women are at increased risk for smoking, nicotine dependence, and using high nicotine yield cigarettes…
- Trial name
- NCT02250534
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Cigarette Smoking
Tailored Tobacco Quitline for Rural Veterans
The proposed work is designed to help increase access to tobacco cessation services among rural veterans and to develop more effective treatment services that better address comorbid issues commonly experienced by rural smokers.
- Trial name
- NCT01592695
- Testing
- Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Vaping, Nicotine Dependence
Varenicline for Nicotine Vaping Cessation in Adolescents
The study will test the hypothesis that varenicline, when added to behavioral and texting support for vaping cessation, will improve vaping abstinence rates in adolescents dependent on vaped nicotine over placebo plus behavioral…
- Trial name
- ViVA (NCT05367492)
- Testing
- Double Blind Varenicline, QuitVaping, This Is Quitting
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Massachusetts General Hospital
Nicotine Dependence
Impact of Varenicline on Blood-Oxygen-Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Activation on Smokers
The purpose of this study is to evaluate the impact of varenicline treatment on cue induced craving to smoking using brain imaging.
- Trial name
- GRAND (NCT00934024)
- Testing
- varenicline
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Nicotine Dependence, Nicotine Withdrawal
Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence
The objective of this proposal is to elucidate effects of bupropion SR + varenicline on smoking-cessation related processes in early abstinence using a human laboratory model.
- Trial name
- ChanBan (NCT00749658)
- Testing
- Bupropion, Varenicline
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Nicotine Dependence, Nicotine Addiction
A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults
Almost one in ten young adults report current e-cigarette use, putting them at risk of developing nicotine addiction and long-term health effects of exposure to inhaled toxicants.
- Conditions
- Nicotine Dependence, Nicotine Addiction, Nicotine Use Disorder, Nicotine Vaping
- Trial name
- NCT05897242
- Testing
- Smartphone app, Text Message, Survey Administration
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Tobacco Dependence, Schizophrenia
Cigarette Smoking in Smokers With and Without Schizophrenia
Higher rates and severity of tobacco dependence in people with schizophrenia, as compared with the general population, contribute to the lower life expectancy seen in this population.
- Trial name
- NCT04001114
- Testing
- Sampling Research Cigarettes
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Tobacco Dependence
Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1
Schizophrenia is associated with high rates of cigarette smoking and associated morbidity and mortality. In this study, smokers with schizophrenia will complete a baseline session and then randomized to varenicline (VAR) or…
- Trial name
- NCT03507127
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brown University
Smoking, Nicotine Dependence
Helping Those With Mental Illness Quit Smoking
This study tests whether pre-cessation interventions known to be effective in the general population will increase acceptance of evidence-based treatment, engagement and compliance with that treatment and initial quitting…
- Conditions
- Smoking, Nicotine Dependence, Mental Disorders
- Trial name
- NCT01783912
- Testing
- Cognitive / Motivational Individual Sessions, Attention Control Individual Sessions, Nicotine Patch
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Wisconsin, Madison
Tobacco Use Disorder
Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women
Study 2 will evaluate the effects of extended exposure to cigarettes with varying levels of nicotine in pregnant smokers who have less than an Associate's degree. This study will be limited to two conditions: usual brand vs.
- Trial name
- NCT04033237
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Smoking, Tobacco Use Cessation
Group Therapy for Nicotine Dependence: Mindfulness and Smoking
The goal of this behavioral research study is to create and study a Mindfulness-Based Addiction Treatment (MBAT) for nicotine dependence.
- Trial name
- NCT00297479
- Testing
- MBAT Group Therapy, Nicotine, Group Therapy
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cancer, Smoking Cessation
VIDeOS for Smoking Cessation
The purpose of the current study is to pilot the efficacy, feasibility, and acceptability of an evidence-based smoking cessation intervention adapted for cancer patients and delivered via video.
- Trial name
- NCT06307496
- Testing
- Smoking cessation intervention, Informational intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Smoking Cessation
Varenicline for Treatment of E-cigarette Dependence
Varenicline is used to treat tobacco use dependence. It helps reduce cravings for tobacco use and decreases the pleasurable effects of cigarettes and other tobacco products.
- Trial name
- NCT05541497
- Testing
- Varenicline Tartrate
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Smoking
Varenicline for Light Smokers
The purpose of this study is to determine if varenicline is effective in treating tobacco dependence in adults who smoke 5-10 cigarettes per day.
- Trial name
- ChanLight (NCT01639560)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nicotine Dependence
Nicotine Withdrawal Symptoms and Smoking Relapse
Background: Smoking is thought to cause changes in the brain that lead to addiction and craving. Smokers who try to quit experience nicotine withdrawal symptoms that include irritability, anxiety, and difficulty concentrating.
- Trial name
- NCT01511614
- Testing
- Transcranial Direct Current Stimulation, Nicotine patch, Varenicline Pill
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation
Memory Reconsolidation Blockade as a Novel Intervention for Nicotine Dependence
Smoking is the leading cause of preventable morbidity and mortality in the US. While approximately 70% of smokers attempt to quit each year, only 5-15% maintain abstinence for 12 months, even with effective pharmacological and…
- Trial name
- SCP (NCT00916721)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Tobacco Dependence
Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study
Specific aims: 1. To obtain pilot data on 4-week continuous quit rates associated with 10 weeks of treatment with topiramate or placebo or topiramate plus nicotine patch for smoking cessation. 2.
- Trial name
- NCT00755716
- Testing
- Topiramate, Nicotine patch
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- UConn Health
Nicotine Dependence, Smoking Cessation
Nicotine Replacement for Smoking Cessation During Pregnancy
This is a clinical trial to determine if the nicotine inhaler in combination with counseling will help pregnant women quit smoking, and whether it is safe when compared to placebo (an inactive inhaler).
- Trial name
- NCT01656733
- Testing
- Nicotrol Inhaler
- Where
- 2 sites in United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- UConn Health
Nicotine Use Disorder, Nicotine Dependence
Baclofen Effects on Smoking Urge and Withdrawal
The purpose of this study is to determine whether baclofen is effective in reducing smoking urge, withdrawal, and reinforcement in moderate to heavy cigarette smokers.
- Conditions
- Nicotine Use Disorder, Nicotine Dependence, Smoking, Tobacco Use Disorder
- Trial name
- NCT00257894
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- VA Office of Research and Development
Tobacco Dependence
Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers
The overall goal of this project is to understand the likely health effects of cigarette smokers switching to a Standardized Research Electronic Cigarette (SREC) and to assess the role of nicotine delivery on switching and…
- Trial name
- NCT03625986
- Testing
- Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center