Clinical trials: Smoking Tobacco
COVID-19
Prospective Natural History Study of Smoking, Immune Cell Profiles, Epigenetics and COVID-19
Background: Early evidence in the COVID-19 pandemic suggests that smokers are at a higher risk of having severe effects or dying from the disease. Smoking causes changes in immune cells.
- Trial name
- NCT04403386
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Patient Participation
Role of MSCT of Chest in Differentiation Between COPD Patients According to Their Smoking Status
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality all over the world. Smoking is considered as an important risk factor, but other risk factors are present.
- Trial name
- NCT05475977
- Testing
- MSCT chest
- Volunteers
- 90 people
- Sponsor
- Somaia Ahmad AbdAllah Ahmad
Smoking, Prevention
Celecoxib as a Chemopreventive Agent in Current and Former Smokers
The purpose of this study is: To examine the effect of celecoxib treatment on Ki-67 expression, a marker of cell proliferation, in the bronchial epithelium of current and former smokers.
- Trial name
- NCT00981201
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Dental Caries
The Effect of Aerosol Formed From Tobacco Heating Systems on the Microbiome of Supragingival Dental Biofilm
Dental caries is a multifactorial disease primarily caused by supragingival dental biofilm. Its progression is influenced by many environmental factors, which include smoking.
- Trial name
- NCT06314100
- Testing
- Tobacco heating systems, cigarette smoking, non smoking
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Smoking Addiction
Evaluation of the Effectiveness of Routine Nurse Education in Prescribing Nicotine Replacement Therapy for Hospitalized Smokers in a University Hospital
The goal of this study is to determine whether training nurses to prescribe nicotine replacement therapy (NRT) can increase the proportion of smoking cessation at one month after hospital discharge among active smokers (daily or…
- Trial name
- NICOTINURSE (NCT06789536)
- Testing
- training nurses to prescribe nicotine substitutes, to adapt doses and to transmit to the outpatient physician and/or nurse nurse to facilitate the continuation of treatment
- Where
- 4 sites in France
- Volunteers
- 442 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Smoking
Web and Mobile Smoking Cessation
This study seeks to develop and then perform a controlled efficacy Randomized Controlled Trial assessing tobacco abstinence of a best-practices Web-based PC-delivered smoking cessation intervention (QuitOnline) compared to a…
- Trial name
- MobileQuit (NCT01952236)
- Testing
- Web+Mobile, Web Only
- Where
- United States
- Volunteers
- 1,266 people
- Sponsor
- Oregon Research Institute
Smoking Cessation
Evaluation of a Tailored Smoking Cessation Treatment Algorithm Based on Initial Treatment Response and Genotype
Nicotine replacement therapy (NRT) is a well-tolerated and efficacious smoking cessation treatment, and yet many smokers fail to quit using NRT.
- Trial name
- ConNic3 (NCT00894166)
- Testing
- Nicotine Patches, Nicotine patches, then bupropion & nicotine patches (Pre-Quit), Nicotine patches, then varenicline (Pre-Quit)
- Where
- United States
- Volunteers
- 606 people
- Sponsor
- Duke University
Chronic Disease
Activity ,Smoking Cessation, Healthy Eating and Alcohol Intervention Program:(ACCELERATION)
The ACCELERATION (ACtivity, smoking Cessation, healthy Eating and aLcohol Education, inteRvention, and motivATION) Program is a collaborative project in cancer and chronic disease prevention that has been designed by and will be…
- Trial name
- NCT02264366
- Testing
- Motivational Communication for Health Behavior management
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- University Health Network, Toronto
Smoking Cessation
A Study To Evaluate The Efficacy And Safety Of Varenicline Compared To Placebo For Smoking Cessation Through Reduction
This study will determine whether varenicline is safe and helps people to quit smoking through reduction when they are not willing/able to make an abrupt quit attempt.
- Trial name
- NCT01370356
- Testing
- Varenicline Tartrate
- Where
- 65 sites in United States, Australia and 8 more
- Volunteers
- 1,510 people
- Sponsor
- Pfizer
Nicotine Dependence
Approach Bias Retraining to Augment Smoking Cessation
Tobacco use is the most preventable cause of disease, disability, and death in the United States. Standard smoking cessation care (cognitive behavioral therapy and nicotine replacement therapy), is effective in approximately 20%…
- Trial name
- NCT03325777
- Testing
- Approach Bias Retraining
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Jasper A. Smits
Cigarette Smoking, Schizophrenia
Knowledge and Perception of Smoking Risks/Consequences
This proposed 2-year questionnaire study examines views and attitudes regarding health risks of cigarette smoking, smoking patterns and motivators for cessation in smokers who suffer from schizophrenia compared to a sample of…
- Trial name
- SmokCess (NCT00686101)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Smoking Addiction
Addictive Threshold of Nicotine
To determine the nicotine threshold dose(s) for discrimination, subjective-rewarding effects, -and reinforcement in smokers with different levels of dependence.
- Trial name
- NCT06096714
- Testing
- Nicotine, Saline
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Yale University
Pulmonary Disease, Chronic Obstructive
Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
This is a multicenter, prospective, randomized, double-blind, placebo-controlled trial that will enroll 1028 patients with at least moderately severe COPD over a three year period and follow them at regular intervals for one…
- Trial name
- NCT02587351
- Testing
- Metoprolol succinate
- Where
- 27 sites in United States
- Volunteers
- 532 people
- Sponsor
- University of Minnesota
Macular Degeneration
Complement Factor H Haplotypes and Smoking in Age-related Macular Degeneration
Risk factors for Age-related Macular Degeneration (AMD) involves genetic variations in the alternative pathway of complement inhibitor factor H. The complement system is part of the innate and adaptive immune system.
- Trial name
- CFH&AMD (NCT01115231)
- Where
- 2 sites in United States
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Nicotine Dependence
Bupropion Treatment for Youth Smoking Cessation
The purpose of this study is to 1) evaluate the safety and efficacy of two doses of bupropion SR (150mg/day and 300mg/day) when compared to placebo, as an aid to smoking cessation in adolescents and 2) to examine which factors…
- Trial name
- NCT00344695
- Testing
- bupropion SR
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Smoking
Stop Smoking Therapy for Ontario Patients
Approximately 2 million Ontarians are current smokers. While smoking rates have declined over the past 25 years, these rates have remained constant since 2002.
- Trial name
- STOP (NCT00352781)
- Testing
- nicotine replacement therapy, behavioural intervention
- Where
- Canada
- Volunteers
- 1,767 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Smoking
Developing Smokers for Smoker (S4S): A Collective Intelligence Tailoring System
This study will advance computer tailoring by adapting machine learning collective intelligence algorithms that have been used outside healthcare by companies like Amazon and Google to enhance the personal relevance of the health…
- Trial name
- S4S (NCT02265354)
- Testing
- Collective-Intelligence computer tailored health communication, Rule-based computer tailored health communication
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Smoking
Safety and Efficacity of NFL101 as Tobacco Therapy
This Phase I study is to investigate the safety of two dose levels of NFL-101 in smokers.
- Trial name
- CESTO (NCT02521701)
- Testing
- NFL101
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Cigarette Smoking, Veterans
Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment
Veterans with substance use disorders smoke at extraordinarily high rates and have high rates of smoking-related death and disease.
- Trial name
- Co-STOP (NCT07809854)
- Testing
- Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- VA Office of Research and Development
Tobacco Smoking, Psychiatric Disorders
The Effect of Electronic Cigarette Use on Smoking Behaviors Among Smokers Receiving Outpatient Psychiatric Treatment
This study aims to establish the feasibility and acceptability of a project designed to investigate the impact of electronic cigarette use on combustible cigarette smoking and smoking-related factors among smokers with…
- Trial name
- NCT04014322
- Testing
- E-cigarette
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Fordham University