Clinical trials: Snake Envenomation
Envenomation, Snakebite, Envenomation
Clinical Profile and Antivenom Use in Hump-nosed Pit Viper Bites in Kerala, South India: A Review.
Several controversies exist in Hypnale bite management in Kerala. Even though leading bodies like WHO recommend against using antivenom for hypnale bites, many physicians still administer antivenom for snakebites even when the…
- Trial name
- NCT05954806
- Testing
- Antivenom Snakes
- Where
- India
- Volunteers
- 41 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Snake Bites
Safety and Effectiveness of PANAF-Premium TM Snake Venom Antiserum As Standard Treatment for Snakebites
Snakebite envenomation (SBE) is a major public health problem in many developing countries. Standard snake antivenom (SA) remains the primary treatment and has been shown to reduce mortality in observational studies conducted in…
- Trial name
- PMS (NCT06615960)
- Where
- Cameroon
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Premium Serums & Vaccines Pvt.Ltd.
Snake Bites
Routine Antibiotic vs. Directed Antibiotic Treatment in Snake Bite
Clinicians tend to overuse antibiotics in snake bite despite evidence from three previous clinical trials that failed to show a benefit. But, none of these trials was done in India.
- Trial name
- RADIANS (NCT02570347)
- Testing
- Co-amoxiclav, Tetanus toxoid
- Where
- India
- Volunteers
- 66 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Pit Viper Bite, Coagulopathy
Thrombelastography for Coagulopathy in Chinese Snakebites
This study aims to evaluate the coagulation disorders caused by pit viper bites in patients from Zhanjiang and surrounding areas.
- Conditions
- Pit Viper Bite, Coagulopathy, Thromboelastography (TEG), Venom-induced Consumptive Coagulopathy
- Trial name
- NCT06860503
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hansung University
Snake Bites
Non-inferiority Trial of Two Snake Antivenoms in CAR (PAVES)
Interventional, individually randomized, double (e.g. investigator and participant) blinded, parallel two-arm, non-inferiority trial to assess the efficacy of EchiTabPlus-ICP compared to FAV-Africa for the treatment of snakebite…
- Trial name
- PAVES (NCT02694952)
- Testing
- FAV-Africa, EchiTabPlus-ICP
- Sponsor
- Epicentre
Snakebite, Coagulopathy, Consumption
Waveform Analysis In Snakebite Victims With Hematotoxicity
In hematotoxic snakebites, due to the lack of a better alternative, 20 minute whole blood clotting test (20'WBCT) or Clotting time remains the standard test in developing countries even though its reliability and sensitivity has…
- Trial name
- WISH (NCT03859154)
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Snake Bites
Improving Safety of Antivenom in People Bitten by Snakes
A study to increase the safety of polyvalent antivenom involving 1000 patients in three centres: low dose adrenaline, promethazine, \& hydrocortisone (alone and in combination) to prevent acute adverse reactions to antivenom in…
- Trial name
- NCT00270777
- Testing
- adrenaline, promethazine, hydrocortisone
- Where
- Sri Lanka
- Volunteers
- 1,000 people
- Sponsor
- University of Kelaniya
Snake Bite
Multicenter Application Verification and Effect Evaluation of Artificial Intelligence-Based Snake Species Identification System in the Diagnosis and Treatment of Snakebites
This multicenter prospective observational study aims to develop and validate a deep learning-based artificial intelligence snake species identification system, and evaluate its clinical application efficacy in real-world…
- Trial name
- NCT07658885
- Testing
- SSRS system-assisted snake species identification
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Snake Envenomation
Retrospective Evaluation of CroFab - Efficacy in Severe Envenomation
Retrospective observational review of severe envenomation treatment with CroFab
- Trial name
- NCT00927381
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- BTG International Inc.
Snake Envenomation
The Efficacy of Crotaline Fab Antivenom for Copperhead Snake Envenomations
Most patients bitten by copperhead snakes do not currently receive antivenom. Some snakebite victims have long term problems with the function of the limb that was bitten.
- Trial name
- NCT00303303
- Testing
- Crotaline Polyvalent Immune Fab (ovine) (active initial and maintenance therapy)
- Where
- 4 sites in United States
- Volunteers
- 13 people
- Sponsor
- Wake Forest University Health Sciences
Snake Bite
Predictive Accuracy of the Snakebite Severity Score (SSS) in Identifying Syndrome-Specific Core Outcome Parameters Among Envenomated Patients Presenting to the Emergency Department
India reports ~58,000 snakebite deaths/year, over 50% of global mortality. Clinical outcomes of antivenom may vary due to regional venom differences, delayed access to care, ineffective use of existing polyvalent antivenom.
- Trial name
- SCOPE-Snake (NCT07079137)
- Testing
- History, examination, bite documentation, SSS scoring,Baseline labs as per institutional protocol
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
SNAKEBITE, THROMBOTIC MICROANGIOPATHY
Incidence of Snakebite Associated Thrombotic Microangiopathy & Role of Peripheral Blood Smear as a Predictor of Clinical Outcome
The aim of this study is to find the overall incidence of thrombotic microangiopathy in snakebite victims. As we know snakebite is a common in tropical regions.
- Conditions
- SNAKEBITE, THROMBOTIC MICROANGIOPATHY, SCHISTOCYTES
- Trial name
- NCT04845022
- Where
- India
- Volunteers
- 81 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Copperhead Snake Envenomation
Copperhead Envenomation Observational Study
The primary objective of the study is to evaluate the responsiveness and utility of several clinical outcome assessments in the setting of copperhead snakebite.
- Trial name
- NCT01651299
- Where
- 11 sites in United States
- Volunteers
- 20 people
- Sponsor
- BTG International Inc.
Necrotizing Skin Infections, Snakebite Envenomation
Predictive Modeling of Necrotizing Skin Infections in Snakebite Patients
This multicenter retrospective study aims to identify the risk factors associated with necrotizing skin infections following venomous snakebites and to develop a predictive model.
- Trial name
- NCT06622343
- Testing
- Antivenom Serum, Wound Debridement
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Snake Bite
Study to Evaluate the Efficacy of Two Treatment Schemes With Antivipmyn ® for the Treatment of Snake Bite Envenomation
The purpose of this study is to compare whether a same total dose given up front as a single dose is more effective and as safe as the same dose given as a fractioned dose.
- Trial name
- NCT00639951
- Testing
- A, Antivipmyn ®
- Where
- 5 sites in Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto Bioclon S.A. de C.V.
Snake Bite
Comparison of Two Dose Regimens of Snake Antivenom for the Treatment of Snake Bites Envenoming in Nepal
This study aims at comparing two doses of antivenom in the treatment of snake bite envenoming. It will take place in 3 centers in rural Nepal and will involve 250 snake bite victims presenting with one or more sign of neurotoxic…
- Trial name
- NCT01284855
- Testing
- Antivenom
- Where
- 3 sites in Nepal
- Volunteers
- 250 people
- Sponsor
- CTU
Pulmonary Embolism (PE), Snake Envenomation
Pulmonary Embolism Following Viper's Bites: A Case Report
Viper envenomation constitutes a medical emergency predominantly occurring in rural regions, where specific viper species are endemic, with their distribution influenced by climatic variations.
- Trial name
- NCT07009301
- Where
- Morocco
- Volunteers
- 1 people
- Sponsor
- Younes Oujidi
Rattlesnake Bite (Diagnosis)
Point-of-care Ultrasound in the Assessment of Snake Bite
Early identification of tissue injury from a rattlesnake bite is critical to prevent complications and reduce health care costs.
- Trial name
- NCT04188899
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Arizona
Snake Envenomation, Thrombi
Effects of Bothrops Spp. Snake Envenomation on Willebrand Factor Activity in Martinique and French Guiana
In 2017, the World Health Organization placed snakebites at the top of its list of neglected tropical diseases in an effort to facilitate funding for prevention programs, improve access to anti-venom, and stimulate new research…
- Conditions
- Snake Envenomation, Thrombi, Coagulopathy, Hemorrhage
- Trial name
- WBOTHROPS (NCT06304714)
- Testing
- Patients suffering from envenomation by Bothrops
- Where
- Martinique
- Volunteers
- 30 people
- Sponsor
- University Hospital Center of Martinique
Snakebite
Snakebite Prevention and First Aid Through Community Engagement
This study will be a community trial conducted in two Upazila (sub-district) of Bangladesh- Kalapara, Patuakhali district and Shibganj, Chapainawabganj district.
- Trial name
- SPACE (NCT05872373)
- Testing
- Snakebite prevention and first aid
- Where
- Bangladesh
- Volunteers
- 180,000 people, healthy volunteers welcome
- Sponsor
- Toxicology Society of Bangladesh