Clinical trials: Snakebite
Copperhead Snake Envenomation
Copperhead Envenomation Observational Study
The primary objective of the study is to evaluate the responsiveness and utility of several clinical outcome assessments in the setting of copperhead snakebite.
- Trial name
- NCT01651299
- Where
- 11 sites in United States
- Volunteers
- 20 people
- Sponsor
- BTG International Inc.
Snakebite, Epidemiology
Mapping Snakebite Risk in Kenya and Eswatini
The goal of this observational study is to learn about how snakebite risk varies in different environments in Kenya and understand how this information can be used to support decision makers.
- Trial name
- NCT06124872
- Testing
- Survey questionnaire, Key informant interview
- Where
- Kenya
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Snake Envenomation
The Efficacy of Crotaline Fab Antivenom for Copperhead Snake Envenomations
Most patients bitten by copperhead snakes do not currently receive antivenom. Some snakebite victims have long term problems with the function of the limb that was bitten.
- Trial name
- NCT00303303
- Testing
- Crotaline Polyvalent Immune Fab (ovine) (active initial and maintenance therapy)
- Where
- 4 sites in United States
- Volunteers
- 13 people
- Sponsor
- Wake Forest University Health Sciences
Snakebites, Envenoming
Broad-spectrum Rapid Antidote: Varespladib Oral for Snakebite
This is a multicenter, randomized, double-blind, placebo-controlled, phase 2 study designed to evaluate the safety, tolerability and efficacy of varespladib-methyl, concurrently with standard of care (SOC), in subjects bitten by…
- Conditions
- Snakebites, Envenoming, Envenoming, Snake, Envenomation, Snake
- Trial name
- BRAVO (NCT04996264)
- Testing
- Varespladib Methyl, Standard of care (SOC)
- Where
- 16 sites in United States, India
- Volunteers
- 95 people
- Sponsor
- Ophirex, Inc.
Snake Bites
Cryotherapy as a Coadjuvant in Crotaline Snakebite Management With Antivenom.
The study aimed to determine the effect of local cryotherapy as a coadjuvant in patients with snakebite treated with F(ab')2 therapy venom at the Hospital Juárez de Mexico.
- Trial name
- NCT04470791
- Testing
- F(ab)2 antivenom therapy (antivipmyn®)., Local cryotherapy.
- Volunteers
- 38 people
- Sponsor
- Hospital Juarez de Mexico
Snake Envenomation, Thrombi
Effects of Bothrops Spp. Snake Envenomation on Willebrand Factor Activity in Martinique and French Guiana
In 2017, the World Health Organization placed snakebites at the top of its list of neglected tropical diseases in an effort to facilitate funding for prevention programs, improve access to anti-venom, and stimulate new research…
- Conditions
- Snake Envenomation, Thrombi, Coagulopathy, Hemorrhage
- Trial name
- WBOTHROPS (NCT06304714)
- Testing
- Patients suffering from envenomation by Bothrops
- Where
- Martinique
- Volunteers
- 30 people
- Sponsor
- University Hospital Center of Martinique
Snakebite, Snake Envenomation
Mapping Snakebite Risk in Ghana and Rwanda
Snakebite causes approximately 138,000 deaths each year and non-fatal bites lead to considerable health burden, particularly in low-income tropical countries. Data on snakebite burden are lacking.
- Trial name
- NCT06808789
- Where
- Ghana
- Volunteers
- 32,000 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Snakebite, Coagulopathy, Consumption
Waveform Analysis In Snakebite Victims With Hematotoxicity
In hematotoxic snakebites, due to the lack of a better alternative, 20 minute whole blood clotting test (20'WBCT) or Clotting time remains the standard test in developing countries even though its reliability and sensitivity has…
- Trial name
- WISH (NCT03859154)
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Pit Viper Bite, Coagulopathy
Thrombelastography for Coagulopathy in Chinese Snakebites
This study aims to evaluate the coagulation disorders caused by pit viper bites in patients from Zhanjiang and surrounding areas.
- Conditions
- Pit Viper Bite, Coagulopathy, Thromboelastography (TEG), Venom-induced Consumptive Coagulopathy
- Trial name
- NCT06860503
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hansung University
Coral Snake Bite, Toxic Effect of Coral Snake Venom
Emergency Treatment of Coral Snake Envenomation With Antivenom
The purpose of this study is to see whether a new F(ab')2 antivenom will prevent injury and death from the bite of a coral snake. Funding Source - FDA OOPD.
- Trial name
- NCT01337245
- Testing
- Snake (Micrurus) North American immune F(ab')2 Equine
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of Arizona
Snake Bites
Safety and Effectiveness of PANAF-Premium TM Snake Venom Antiserum As Standard Treatment for Snakebites
Snakebite envenomation (SBE) is a major public health problem in many developing countries. Standard snake antivenom (SA) remains the primary treatment and has been shown to reduce mortality in observational studies conducted in…
- Trial name
- PMS (NCT06615960)
- Where
- Cameroon
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Premium Serums & Vaccines Pvt.Ltd.
Necrotizing Skin Infections, Snakebite Envenomation
Predictive Modeling of Necrotizing Skin Infections in Snakebite Patients
This multicenter retrospective study aims to identify the risk factors associated with necrotizing skin infections following venomous snakebites and to develop a predictive model.
- Trial name
- NCT06622343
- Testing
- Antivenom Serum, Wound Debridement
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Snake Bites, Snakebite
Analysis of the Efficacy of Pressure Pad vs Pressure Bandage Immobilisation for Snake Bite First Aid in Healthy Volunteers.
Snake bite affects thousands of Australians every year, but few die as a result due to high quality first aid and timely medical care.
- Conditions
- Snake Bites, Snakebite, Snake Envenomation, Snake Bite
- Trial name
- NCT07261982
- Testing
- Pressure bandage immobilisation first aid, Pressure pad first aid, Control - no first aid
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Townsville University Hospital
Snakebite
Trial of Oral Community SVMP INhibitors for Snakebite
Bites by venomous snakes can cause disability and can be life-threatening. We are doing research in adult patients to try and find medications that can be administered orally and can help to reduce disability and death due to…
- Trial name
- TOCSINS (NCT07500233)
- Testing
- 2,3-dimercapto-1-propanesulfonic acid, marimastat, Antivenom Snakes
- Volunteers
- 504 people
- Sponsor
- Liverpool School of Tropical Medicine
Snake Bite
Predictive Accuracy of the Snakebite Severity Score (SSS) in Identifying Syndrome-Specific Core Outcome Parameters Among Envenomated Patients Presenting to the Emergency Department
India reports ~58,000 snakebite deaths/year, over 50% of global mortality. Clinical outcomes of antivenom may vary due to regional venom differences, delayed access to care, ineffective use of existing polyvalent antivenom.
- Trial name
- SCOPE-Snake (NCT07079137)
- Testing
- History, examination, bite documentation, SSS scoring,Baseline labs as per institutional protocol
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Snake Bite
Comparison of Two Dose Regimens of Snake Antivenom for the Treatment of Snake Bites Envenoming in Nepal
This study aims at comparing two doses of antivenom in the treatment of snake bite envenoming. It will take place in 3 centers in rural Nepal and will involve 250 snake bite victims presenting with one or more sign of neurotoxic…
- Trial name
- NCT01284855
- Testing
- Antivenom
- Where
- 3 sites in Nepal
- Volunteers
- 250 people
- Sponsor
- CTU
Snake Bites
Improving Safety of Antivenom in People Bitten by Snakes
A study to increase the safety of polyvalent antivenom involving 1000 patients in three centres: low dose adrenaline, promethazine, \& hydrocortisone (alone and in combination) to prevent acute adverse reactions to antivenom in…
- Trial name
- NCT00270777
- Testing
- adrenaline, promethazine, hydrocortisone
- Where
- Sri Lanka
- Volunteers
- 1,000 people
- Sponsor
- University of Kelaniya
Snake Bites
Randomized, Double-Blind, Placebo-Controlled Study: CroFab® vs Placebo for Copperhead Snake Envenomation
This study will evaluate the recovery from copperhead snake bite in patients with mild or moderate venom effect. Potential subjects received CroFab antivenom or placebo.
- Trial name
- Copperhead (NCT01864200)
- Testing
- Crotalidae polyvalent immune fab (ovine)
- Where
- 18 sites in United States
- Volunteers
- 74 people
- Sponsor
- BTG International Inc.
Rattlesnake Bite (Diagnosis)
Point-of-care Ultrasound in the Assessment of Snake Bite
Early identification of tissue injury from a rattlesnake bite is critical to prevent complications and reduce health care costs.
- Trial name
- NCT04188899
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Arizona
Snake Bites, Antivenins
Evaluation of Anti-venoms Serum in Africa
There is little or no assessment under real-use conditions of the efficacy and the tolerance in the short, medium and long term of the antivenoms currently on the market and used in the treatment of snake bites.
- Conditions
- Snake Bites, Antivenins, Snake Venoms
- Trial name
- ESAA (NCT03326492)
- Testing
- Antivenom serum Inoserp Pan-Africa® injection
- Where
- 13 sites in Cameroon
- Volunteers
- 474 people
- Sponsor
- Institut Pasteur