Clinical trials: Social Psychology
Pediatric Kidney Disease, Transplant;Failure,Kidney
Non-Invasive Monitoring of Pediatric Kidney Transplant Recipients and Immunosuppression Personalization: an Open-labeled Multicenter Randomized Controlled Study
Currently, the monitoring of children receiving a kidney transplantation includes surveillance biopsies to detect subclinical rejection and signs of toxicity of immunosuppressive drugs (tacrolimus).
- Trial name
- MONITOR (NCT06761482)
- Testing
- monitoring by dd-cfDNA, monitoring by T-Vis, monitoring by dd-cfDNA+ T-Vis
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Transplantation
Efficacy and Safety of AEB071 Versus Tacrolimus in Combination With Mycophenolate Acid Sodium, Basiliximab and Steroids in Preventing Acute Rejection After Kidney Transplantation
Efficacy and safety of AEB071 in combination with mycophenolate acid sodium, basiliximab and steroids in preventing acute rejection after kidney transplantation.
- Trial name
- NCT00492869
- Testing
- AEB071
- Where
- 41 sites in United States, Belgium and 5 more
- Volunteers
- 124 people
- Sponsor
- Novartis Pharmaceuticals
Social Psychology
Vasopressin and the Social Brain
It has long been established that interpersonal relationships can have a profound impact on health and well-being. Yet, the investigators are still learning about the complex biological processes that contribute to positive…
- Trial name
- NCT02394054
- Testing
- Intranasal vasopressin
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Lung Transplant Failure and Rejection, Primary Graft Dysfunction
CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation
Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD).
- Trial name
- NCT04558333
- Testing
- blood and exhaled breath specimens
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- University Hospital, Antwerp
Liver Transplant; Complications, Immunosuppression
Blood-Bile Ratio Tacrolimus After Liver Transplantation
Tacrolimus is the most widely used immunosuppressive drug in the prevention of rejection after solid organ transplantation. Pharmacokinetic studies in healthy volunteers and in transplanted patients have shown that this molecule…
- Conditions
- Liver Transplant; Complications, Immunosuppression, Transplant Failure, Transplant; Complication, Rejection
- Trial name
- BBRT (NCT03882164)
- Testing
- Blood-Bile Ratio of Tacrolimus
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lung Transplant Rejection
Histological Profiles of Lung Allograft Transbronchial Biopsies and Clinical Outcomes After Lung Transplantation
Lung transplantation is the only curative treatment for individuals with end-stage lung disease. Understanding the lung allograft's histological lesions, which is key for the patient management, remains difficult because of the…
- Trial name
- LANDSCAPE (NCT05655208)
- Volunteers
- 498 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Brain Damage Due to Hypoxia, Organ Donors
Endothelial Glycocalyx Damage in Brain Death Organ Donors
The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program.
- Conditions
- Brain Damage Due to Hypoxia, Organ Donors, Organ Transplant Failure or Rejection
- Trial name
- NCT05609123
- Testing
- Endothelial glycocalyx damage assessment
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Hradec Kralove
Kidney Transplant Rejection, Kidney Transplant Infection
Dynamic Changes of Torquetenovirus (TTV) Load in Chinese Renal Transplant Recipients
The goal of this observational study is to learn about dynamic changes of Torquetenovirus (TTV) load in Chinese renal transplant recipients.
- Conditions
- Kidney Transplant Rejection, Kidney Transplant Infection, Virus, Immunosuppression
- Trial name
- TTV (NCT05727709)
- Where
- 5 sites in China
- Volunteers
- 220 people
- Sponsor
- Tongji Hospital
Evidence of Liver Transplantation, Hyperglycemia
Study of Glycemic Control on Liver Transplantation Outcomes
Many but not all studies have shown improvement in morbidity and mortality with intensive glycemic management postoperatively. In this study, the investigators propose to determine whether improved glycemic control using…
- Conditions
- Evidence of Liver Transplantation, Hyperglycemia, Rejection
- Trial name
- NCT01211730
- Testing
- Insulin
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Northwestern University
Liver Transplant; Complications, Liver Transplant Rejection
Mortality, Morbidity and Risk Factors of Liver Retransplantation
This study aims to compare the short and long term outcomes of living donor and deceased donor liver retransplantation. Bearing that in mind, the investigators will retrospectively analyze the files of patients whom underwent a…
- Conditions
- Liver Transplant; Complications, Liver Transplant Rejection, Liver Transplant Failure, Liver Diseases
- Trial name
- NCT04789213
- Testing
- Liver Transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Memorial Bahçelievler Hospital
Kidney Transplant, Renal Transplant Failure
Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients
The purpose of this study is to assess a new test to detect antibodies which may form following kidney transplant. These antibodies can be difficult to detect as they do not cause any symptoms but can lead to kidney damage.
- Conditions
- Kidney Transplant, Renal Transplant Failure, Kidney Transplant Rejection, Frailty
- Trial name
- HLA-AB (NCT06025240)
- Testing
- cf-DNA, Immunological Events following renal transplant in older age, Determining Predictive Models for Post-transplant HLA-specific Antibody Formation
- Where
- United Kingdom
- Volunteers
- 282 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Antibody-mediated Rejection, Humoral Rejection
Efficacy and Safety of Eculizumab for Treatment of Antibody-mediated Rejection Following Renal Transplantation
This is an open-label analysis that will compare eculizumab versus Plasmapheresis (PP) and Immunoglobulin (IVIg) for the treatment of antibody-mediated rejection (AMR) in renal transplant recipients.
- Trial name
- NCT01895127
- Testing
- Eculizumab, Immunoglobulin, Plasmapheresis
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Disorder of Transplanted Kidney
Plasma Marine n-3 Polyunsaturated Fatty Acids and Patient and Graft Survival
This study will evaluate the association between n-3 polyunsaturated fatty acids and patient and graft survival. The association between other fatty acids and mortality and graft loss endpoints will also be evaluated.
- Trial name
- NCT02017990
- Where
- Norway
- Volunteers
- 2,002 people
- Sponsor
- Oslo University Hospital
Renal Transplant Rejection, Induction Therapy
Induction in Sensitized Kidney Transplant Recipients Without Pre-existing Donor-specific antiboDies
Induction therapy decreases the rate of acute allograft rejection in kidney transplant recipients (KTRs) and is strongly recommended.
- Trial name
- INSTEAD (NCT05385432)
- Testing
- Rabbit Anti thymocyte globulin (rATG), Basiliximab
- Where
- France
- Volunteers
- 244 people
- Sponsor
- University Hospital, Tours
Kidney Transplantation, Kidney Transplant Rejection
Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXR
The purpose of this study is to determine if the combination of once-daily tacrolimus extended-release (EnvarsusXR) and Azathioprine is non inferior with respect to the composite outcome of acute rejection, graft and patient…
- Trial name
- SIMPLE (NCT04773392)
- Testing
- Twice-daily Tacrolimus, Once-daily envarsus XR, Induction Immunosuppression with Basiliximab or Rabbit Anti Thymoglobulin (rATG)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Graft Dysfunction, Lung Transplantation
Prediction of Lung Transplant Outcome
Plain Language Summary of the PLUTO Study Prediction of Lung Transplant Outcomes (PLUTO) What is this study about? This study aims to improve how doctors predict the health of lung transplant recipients over time.
- Conditions
- Graft Dysfunction, Lung Transplantation, Chronic Lung Allograft Dysfunction (CLAD), Chronic Rejection of Lung Transplant
- Trial name
- PLUTO (NCT07356752)
- Testing
- Research Blood Sampling and Biocollection
- Where
- 9 sites in France
- Volunteers
- 4,200 people
- Sponsor
- Hopital Foch
Kidney Transplant; Complications, Immunosuppression
Efficacy of Single Dose Anti-thymocyte Globulin in the Modulation of T Lymphocytes in Kidney Transplantation
The use of polyclonal anti-T cell antibodies (ATG) has benefits in kidney transplantation, however, its use is associated mainly with hematological, infectious, and neoplastic complications.
- Trial name
- NCT04835948
- Testing
- single dose of Anti-thymocyte globulin
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Renal Transplant Failure and Rejection, Inflammation
The Effect of Biomarkers of Inflammation on Graft Function in Kidney Transplantation
The aim of the study was to investigate the relationship of inflammation markers with postoperative graft function and mortality in patients undergoing kidney transplantation.
- Trial name
- NCT05753488
- Testing
- graft function
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Metabolic Disease, Neurological and Mental Health Conditions
Singapore PREconception Study of Long-Term Maternal and Child Outcomes
We aim to test the following primary hypothesis that nutrition, lifestyle, and maternal emotional health prior to pregnancy and/or during the first trimester alter the expression of metabolic or neurodevelopmental endophenotypes…
- Conditions
- Metabolic Disease, Neurological and Mental Health Conditions, Genetics Predisposition, Skin Condition
- Trial name
- S-PRESTO (NCT03531658)
- Where
- Singapore
- Volunteers
- 1,054 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Type2 Diabetes Mellitus, Cardiovascular Diseases
Mil Familias Cohort Establishment: a Study to Understand Determinants of Diabetes and Its Complications Among US Latinos
The Mil Familias Cohort Establishment involves enrolling 1000 Latino families with at least one member in the family having type 2 diabetes, including children and youth, and measuring the 5 determinants of human health…
- Trial name
- NCT03830840
- Where
- United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute