Clinical trials: Sodium
Osteoarthritis
Efficacy and Safety of Diclofenac Sodium Gel in Hand Osteoarthritis
This study will test the efficacy and safety of topical diclofenac sodium gel in the treatment of hand osteoarthritis.
- Trial name
- NCT00171665
- Testing
- Diclofenac topical sodium gel 1%
- Where
- 69 sites in United States
- Volunteers
- 360 people
- Sponsor
- Novartis
Healthy, Hypertrophic Pyloric Stenosis
The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood
The loss of sodium during infancy causes long term changes in sodium intake. Human research shows that the loss of maternal sodium during pregnancy and neonatal after birth causes an increase sodium intake during childhood.
- Trial name
- NCT01159509
- Testing
- sodium taste tests
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Heart Attack, Enlarged Heart
Sodium Glucose Co-Transporter 2 (SGLT2) and STEMI
The purpose of the research is to determine whether a class of medication called SGLT2 inhibitor will improve the heart's function and reduce its enlargement after a heart attack.
- Trial name
- NCT05305911
- Testing
- SGLT-2 inhibitors
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Minneapolis Heart Institute Foundation
Osteoarthritis, Knee
Treatment and Duration Effect of Pentosan Polysulfate Sodium (PPS) in Participants With Knee Osteoarthritis Pain
The purpose of this study is to measure the duration of treatment effect with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with placebo in adult participants with knee osteoarthritis (OA) pain.
- Trial name
- NCT04814719
- Testing
- Pentosan Polysulphate Sodium
- Where
- 2 sites in United States, Australia
- Volunteers
- 133 people
- Sponsor
- Paradigm Biopharmaceuticals Ltd.
Dengue Shock Syndrome
Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS)
Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are among the leading causes of pediatric hospitalization in Asia.Mortality rates range from 1% at centres experienced in fluid resuscitation, to upto 44% in…
- Trial name
- NCT00966628
- Testing
- Hypertonic sodium lactate, Ringer's lactate
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Hypertension
Salt Study: Inhibited Breathing Pattern and Sodium Inhibitors in Sodium Sensitivity of Blood Pressure
The purpose of this study is to test the hypothesis that blood pressure sensitivity to high sodium intake in healthy humans is characterized by increased urinary excretion of two endogenous sodium pump inhibitors, marinobufagenin…
- Trial name
- NCT00800228
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Atherosclerotic Cardiovascular Disease, Atherosclerotic Cardiovascular Disease Risk Equivelents
Study in Primary Care Evaluating Inclisiran Delivery Implementation + Enhanced Support
The purpose of this study was to evaluate the implementation of inclisiran in a regional primary care setting in the UK Inclisiran, also known as KJX839, is a medication made to reduce the level of "bad" cholesterol…
- Conditions
- Atherosclerotic Cardiovascular Disease, Atherosclerotic Cardiovascular Disease Risk Equivelents, Elevated Low Density Lipoprotein Cholesterol
- Trial name
- SPIRIT (NCT04807400)
- Testing
- Inclisiran, Behavioural Support, Background lipid lowering therapy
- Where
- 17 sites in United Kingdom
- Volunteers
- 892 people
- Sponsor
- Novartis Pharmaceuticals
Systemic Inflammatory Response Syndrome, Oliguria
Bicarbonate and Lipocalin in Systemic Inflammatory Response Syndrome (SIRS) Study
The investigators will determine the feasibility, safety and efficacy of intravenous sodium bicarbonate in reducing progression to overt acute renal failure in patients with the systemic inflammatory response syndrome, and low…
- Conditions
- Systemic Inflammatory Response Syndrome, Oliguria, Renal Impairment
- Trial name
- BLISS (NCT00706771)
- Testing
- Sodium bicarbonate, Sodium chloride
- Where
- 2 sites in Australia
- Volunteers
- 70 people
- Sponsor
- Austin Health
Cardiovascular Risk Factor
DAPAgliflozin Sodium Water glucosE EffecTs in Patients at High Cardiovascular Risk
This study aims to elucidate the impact of SGLT2 inhibition on peripheral vascular function, renal function, fluid volume, neurohormonal activation and inflammatory/fibrotic pathways in patients with T2D at high cardiovascular…
- Trial name
- DAPA-SWEET (NCT04258371)
- Testing
- Dapagliflozin 10 MG
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Bowel Cleansing Process, Colonoscopy
A Multicenter Single-blind Comparison Between Standard and Individualized Approach in Bowel Preparation Before Colonoscopy
This study aims to compare a standard approach to bowel preparation for colonoscopy (using sodium picosulphate/magnesium citrate or 4lPEG) to an individualized approach where patients are assigned a specific regimen of either…
- Trial name
- NCT02024022
- Testing
- Standard approach, Individualized approach
- Where
- 3 sites in Romania
- Volunteers
- 185 people
- Sponsor
- Clinical Hospital Colentina
Age-Related Macular Degeneration
Macugen (Pegaptanib Sodium) Alone, Versus Macugen in Combination With PDT (Photodynamic Therapy) With Visudyne (Verteporfin) in Patients With Age-Related Macular Degeneration (AMD)
The purpose of the trial is to compare whether Macugen (pegaptanib sodium) in combination with PDT with Visudyne (verteporfin) is safe and effective in slowing down the leakage of fluid within the eye and thereby stabilizing or…
- Trial name
- NCT00134667
- Testing
- Photodynamic Therapy (PDT) with Visudyne (verteporfin), Macugen (pegaptanib sodium)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Eyetech Pharmaceuticals
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Hypertrophic, Familial
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
- Trial name
- NCT02862600
- Testing
- Perhexiline, Use of bioanalytical assay to monitor plasma levels of perhexiline
- Where
- 11 sites in United States
- Volunteers
- 35 people
- Sponsor
- Heart Metabolics Limited
Urinary Sodium Excretion, Salt Intakes
Sodium Sources and Sodium Intake in a Representative Sample of Spanish Children
Previous evidence shows that sodium intake in Spanish adult population is over the recommended limits and this high sodium intake is related with difficulties in body weight control and blood pressure control.
- Conditions
- Urinary Sodium Excretion, Salt Intakes, Body Weight
- Trial name
- NCT03465657
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Universidad Complutense de Madrid
Dry Eye Disease (DED)
Evaluation of Ophtholic Ultra for Ocular Surface Protection After Cataract Surgery
Study of the Effectiveness and Safety of Ophtholic Ultra in Preventing and Correcting Ocular Surface Disturbances After Uncomplicated Cataract Surgery This is a single-center, prospective, randomized, controlled, assessor-masked…
- Trial name
- NCT07868965
- Testing
- Ophtholic Ultra, Standard postoperative therapy without lubricating eye drops
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- Kazakh Eye Research Institute
Osteo Arthritis Shoulders
MONOVISC for Shoulder Joint Pain Relief Due to Osteoarthritis
Obtain real world, post market data to confirm the clinical improvement and safety in patients treated with a single injection of MONOVISC for the symptomatic relief of osteoarthritis in the shoulder joint.
- Trial name
- NCT04204265
- Testing
- Monovisc
- Where
- 4 sites in Czechia, Poland
- Volunteers
- 25 people
- Sponsor
- Anika Therapeutics, Inc.
Narcolepsy With Cataplexy
Exploratory Clinical Study to Evaluate Sodium Oxybate (Xyrem) on Potential Endocrine Changes
To monitor for endocrine changes in response to treatment of cataplexy with Xyrem, to focus on the hypothalamic pituitary axis and to confirm the safety of Xyrem on potential endocrine changes.
- Trial name
- NCT00345800
- Testing
- Sodium Oxybate (Xyrem)
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- UCB Pharma SA
Euvolemic Hyponatremia
A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of Oral Lixivaptan Capsules in Subjects With Euvolemic Hyponatremia
The purpose of this study is to evaluate the safety and tolerability of oral lixivaptan capsules in subjects with Euvolemic Hyponatremia.
- Trial name
- NCT00876798
- Testing
- Lixivaptan
- Where
- 90 sites in United States, Belgium and 6 more
- Volunteers
- 206 people
- Sponsor
- CardioKine Inc.
Respiratory Disorders, Asthma and Rhinitis
Bioequivalence of GW483100 10 Milligram (mg) Tablets in Healthy Subjects Under Fasting Conditions
This study is conducted to determine whether the test product (GW483100 10 mg containing montelukast sodium equivalent to 10 mg of montelukast) is bioequivalent to the reference montelukast sodium 10 mg tablets (innovator…
- Trial name
- NCT02658422
- Testing
- Test Montelukast, Reference Montelukast
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Heart Valve Diseases
Sodium Creatine Phosphate in Heart Valve Surgery
To explore the effect of intraoperative sodium creatine phosphate on myocardial protection in patients undergoing valve surgery
- Trial name
- NCT03186053
- Testing
- sodium creatine phosphate, saline
- Where
- 2 sites in China
- Volunteers
- 250 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Biliary Colic
Sedation for Patients Undergoing Endoscopic Retrograde Cholangiopancreatography
This study was performed to evaluate the role of BIS monitored sedation in reducing the dose of propofol and to know the effectiveness of pre-procedure administration of intravenous diclofenac sodium along with topical pharyngeal…
- Trial name
- NCT04860167
- Testing
- Propofol, Diclofenac Sodium and Lignocaine 10 % spray
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Institute of Liver and Biliary Sciences, India