Clinical trials: Sodium Depletion
Dengue Fever, Children
New Tools for Predicting Capillary Leak Shock During Dengue Fever
Evaluate the prognostic value of different methods (Osmometry / clinical-biological score) compared to the occurrence of capillary leak shock during dengue fever.
- Conditions
- Dengue Fever, Children, Adults
- Trial name
- PrediDengue (NCT04422782)
- Testing
- For each routine sample, an additional tube will be collected to measure the osmotic pressure in the blood and urine
- Where
- France
- Volunteers
- 342 people
- Sponsor
- Centre Hospitalier de Cayenne
Liver Cirrhosis
To Study Effect of the Combination of Midodrine and Tolvaptan Versus Tolvaptan Alone in Patients With Severe Hyponatremia in Cirrhosis(TOLMINA Trial)
In this randomized controlled trial , The patients who satisfy the below inclusion and exclusion criteria will be included and they will be randomised, according to 2 groups ( in total 110patients in each group) to receive either…
- Trial name
- NCT05060523
- Testing
- Tolvaptan Tablets, Midodrine Oral Tablet
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Nocturia
Efficacy Study of VA106483 in Males With Nocturia.
To investigate the effect of VA106483 on nocturia related clinical outcomes compared to placebo.
- Trial name
- NCT01038843
- Testing
- VA106483
- Where
- 19 sites in United States
- Volunteers
- 152 people
- Sponsor
- Vantia Ltd
Inappropriate ADH Syndrome, Hyponatremia
Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion
To determine the long-term safety and tolerability of SR121463B in patients with syndrome of inappropriate antidiuretic secretion (SIADH).
- Trial name
- SIADH Safety (NCT00264914)
- Testing
- SR121463B
- Where
- 11 sites in United States, Australia and 9 more
- Volunteers
- 57 people
- Sponsor
- Sanofi
Heart Failure, Hyponatremia
Tolvaptan for Advanced or Refractory Heart Failure
This study will clarify the clinical usefulness of Tolvaptan therapy in patients with complicated acute decompensated heart failure and hyponatremia (low blood sodium).
- Trial name
- NCT02959411
- Testing
- Tolvaptan, Standard of care diuretic therapy
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University of Calgary
Non-hypervolemic Hyponatremia
Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial
To assess quantitatively the evolution over time of electrolyte-free water clearance and electrolyte mass balance in patients with non-hypervolemic hypotonic hyponatremia
- Trial name
- EvenT (NCT05692726)
- Testing
- Patients
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Syndrome of Inappropriate Antidiuresis (SIAD)
Effect of Protein Supplementation on Plasma Sodium Levels and Urinary Urea Excretion in Patients With SIAD
This study aims to investigate whether a 7-day dietary high protein supplementation of 90 grams per day increases plasma sodium levels in hyponatremic patients with chronic SIAD.
- Trial name
- TREASURE (NCT04987385)
- Testing
- Protein supplementation, Oral urea
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- University Hospital, Basel, Switzerland
Colorectal Cancer
C-Reactive Protein and Sodium in Predicting Anastomotic Leakage
Anastomotic leakage is serious morbidity that can develop in patients operated on for colorectal cancer and can reach potentially life-threatening dimensions.
- Trial name
- NCT04717648
- Testing
- Biochemical test
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Tepecik Training and Research Hospital
Hyponatremia, SIADH
The Clinical and Laboratory Characteristics of Recurrent Drug- Related Hyponatremia
The aim of this study is to identify factors associated with hyponatremia among patients hospitalized in the internal medicine ward. Consequtive patients hospitalized because of hyponatremia will be recruited.
- Trial name
- 0597-10-HMO (NCT01509170)
- Where
- 2 sites in Israel
- Volunteers
- 500 people
- Sponsor
- Hadassah Medical Organization
Heart Failure; With Decompensation, Heart Failure，Congestive
Dietary Sodium Intake in Acute Heart Failure
This study is design to assess two levels of dietary sodium intake in the treatment of patients with Acute Decompensated Heart Failure.
- Trial name
- SODIC (NCT03722069)
- Testing
- Low sodium diet, Normal sodium diet
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion
An Observational Study to Describe the Adherence to the SEOM Algorithm for the Treatment of Hyponatraemia in Spain
In 2014, the Spanish Sociedad Española de Oncología Médica (SEOM) algorithm for the treatment of hyponatraemia secondary to to syndrome of inappropriate antidiuretic hormone (SIADH) in oncology patients was developed.
- Trial name
- ALGA (NCT02548845)
- Where
- 4 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Otsuka Pharmaceutical Europe Ltd
Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion
An Observational Study on Real-world Use and Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due to SIADH
This is a retrospective chart review non-interventional study designed to collect real world data on the use and outcomes of tolvaptan for the treatment of patients with hyponatraemia secondary to syndrome of inappropriate…
- Trial name
- SAMPLE (NCT02545101)
- Where
- 7 sites in Germany, Spain
- Volunteers
- 100 people
- Sponsor
- Otsuka Pharmaceutical Europe Ltd
Diarrhoea
Introduction of Hypo-osmolar ORS for Routine Use
The World Health Organization has very recently recommended the routine use of a hypo-osmolar ORS in the management of diarrhoeal diseases.
- Trial name
- NCT00244777
- Testing
- Hypo-osmolar ORS
- Where
- Bangladesh
- Volunteers
- 75,000 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Coronary Artery Disease, Hyponatremia
Hyponatremia and Hypoalbuminemia is Morbimortality Predictors in Coronary Artery Bypass Graft Surgery
Coronary artery disease is a common medical disease in many populations. The pathogenesis of this disease is very complex. Surgery is one of the treatment choices. Assessing the risk factors will improve the surgical outcome.
- Conditions
- Coronary Artery Disease, Hyponatremia, Hypoalbuminemia
- Trial name
- NCT02765061
- Volunteers
- 1,157 people
- Sponsor
- Ankara University
Electrolyte Imbalance, Hyponatremia
V2 Receptor Effects on Fluid Regulation and Performance
This primary aim of this study was to critically assess whether or not sweat water content and sodium concentration were acutely regulated by dynamic changes in antidiuretic hormone (arginine vasopressin or AVP) acting on the…
- Conditions
- Electrolyte Imbalance, Hyponatremia, Hypernatremia
- Trial name
- NCT02084797
- Testing
- V2R (Vasopressin 2 receptor)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oakland University
Hyponatremia
Effects of Oral Salt Supplementation on Physical Performance During a Half-ironman
Background: Ultradistance athletes frequently consume salt supplements during competitions to compensate the loss of electrolytes by sweating.
- Trial name
- SALTED (NCT02103491)
- Testing
- Salt administration
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Camilo Jose Cela University
Cirrhosis, Hepatic Encephalopathy
Effect of Tolvaptan on Cognitive Function in Cirrhosis
Hypothesis: Tolvaptan will improve cognitive function, brain edema and health-related quality of life in cirrhotic patients with hyponatremia
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Hyponatremia
- Trial name
- NCT01556646
- Testing
- Tolvaptan
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Hyponatremia, Hypernatremia
Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery
The goal of this clinical trial is to determine if isotonic or hypotonic fluids are more effective in maintaining serum sodium levels in neonates undergoing maintenance fluid therapy post-surgery.
- Conditions
- Hyponatremia, Hypernatremia, Postoperative Care in Neonates, Edema
- Trial name
- NCT06484608
- Testing
- Isotonic Saline with Dextrose
- Where
- Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Hyponatremia
Study of Ascending Levels of Tolvaptan in Hyponatremia
The purpose of this study was to determine whether tolvaptan can safely and effectively return the body's balance of sodium and water toward normal and to characterize and quantify the potential clinical benefits of this…
- Trial name
- SALT2 (NCT00201994)
- Testing
- Tolvaptan
- Where
- Germany
- Volunteers
- 243 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Hyponatremia Symptomatic
Efficacy and Safety of Rapid Intermittent Compared With Slow Continuous Correction in Severe Hyponatremia Patients
This study will investigate efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patient with moderately severe or severe symptomatic severe hyponatremia
- Trial name
- NCT02887469
- Testing
- 3% hypertonic saline
- Where
- 3 sites in South Korea
- Volunteers
- 178 people
- Sponsor
- Seoul National University Hospital