Clinical trials: Sodium Depletion
Hyponatremia
Subclassification of the Syndrome of Inappropriate ADH Secretion
The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH.
- Trial name
- NCT01341665
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wuerzburg
Hyponatremia
Influence of Serum Sodium Levels on Bone Metabolism and Turnover in Hospitalized Patients
In this study, the possible role of serum sodium concentration and its changes on bone markers in hospitalized, hyponatremic patients is determined.
- Trial name
- BONA (NCT04227301)
- Testing
- blood sampling
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- University Hospital, Basel, Switzerland
Hyponatremia
Beer for Endurance Exercise Recovery
Athletes who are participating in the Keys100 Ultramarathon event in Key West, FL are eligible, based on inclusion criteria, to participate in this research study that is seeking to determine whether supplementation of beer…
- Trial name
- BEER (NCT03032445)
- Testing
- Alcoholic Beer, Non alcoholic beer
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Heart Failure, Hyponatremia
The Effect of Fluid Restriction in Congestive Heart Failure Complicated With Hyponatremia
The purpose of this study is to determine the effect of fluid restriction and the neurohormonal mechanisms in the development of hyponatremia in patients with congestive heart failure and hyponatremia.
- Trial name
- Decongest (NCT01748331)
- Testing
- Fluid restriction
- Where
- 2 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Finn Gustafsson
Hyponatremia
Saline Infusion Test in Hyponatremia
Observational study of biochemical volume biomarker levels in response to a standardized intravenous isotonic saline infusion in patients with hyponatremia.
- Trial name
- SITH (NCT06498856)
- Testing
- Isotonic saline infusion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Hyponatremia
Establishment of an Algorithm for a Clinical Classfication of Hypoosmolar Hyponatremia
The prospective clinical diagnosis of hyponatremia is often very difficult- but requirement for an appropriate and riskless treatment of hyponatremia.
- Trial name
- CONA (NCT00541944)
- Where
- Germany
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Wuerzburg
Non-hypovolemic Non-acute Hyponatremia
Efficacy and Safety Study of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia
This drug has been developed to treat Hyponatremia. The primary purpose of this study is to verify the efficacy and safety of seven-day repeated oral administration of tolvaptan at 15, 30, and 60 mg or placebo in patients with…
- Trial name
- NCT01507727
- Testing
- Tolvaptan
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Inappropriate ADH Syndrome
Effects of Empagliflozin an SGLT2-Inhibitor on Healthy Volunteers With Induced Hypotonic Hyponatremia - the DIVE Study
Empagliflozin (Jardiance)® is a sodium glucose co-transporter 2 (SGLT2)-Inhibitor, which is a new treatment option developed for patients with diabetes mellitus type 2.
- Trial name
- DIVE (NCT02729766)
- Testing
- Induced hypotonic hyponatremia - SIAD model, Empagliflozin 25mg Tbl
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hyponatremia
Study of Efficacy & Safety for 3 Infusion Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia
The study is designed to assess the efficacy and safety of multiple infusions of conivaptan in subjects with euvolemic or hypervolemic hyponatremia
- Trial name
- NCT00478192
- Testing
- Conivaptan
- Where
- 26 sites in United States, India
- Volunteers
- 50 people
- Sponsor
- Cumberland Pharmaceuticals
Hyponatremia, Pituitary Surgery
Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery
The investigators are conducting this study to investigate new preventive measures for patients with low sodium levels (hyponatremia), which can occur after surgery on the pituitary gland.
- Trial name
- TREASURE-PIT (NCT07273630)
- Testing
- Fluid restriction, Dietary protein supplementation, Standard post-operative care
- Where
- Switzerland
- Volunteers
- 282 people
- Sponsor
- University Hospital, Basel, Switzerland
Supratentorial Brain Tumor
Spectrum of Serum Sodium Disturbances in Patients With Non-sellar/Suprasellar Supratentorial Tumors
This study was designed to quantify the incidence of hyponatremia in patients of supratentorial/supra-sellar lesions and observe their effect on neurological morbidity and mortality.
- Trial name
- NCT03570203
- Testing
- Serum Sodium
- Volunteers
- 173 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Hyponatremia, Inappropriate ADH Syndrome
A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional Hyponatremia
The primary objective of this study is to assess the efficacy of satavaptan versus placebo in participants with dilutional hyponatremia due to SIADH.
- Trial name
- AQUARIST1 (NCT00728091)
- Testing
- Satavaptan
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sanofi
Hyponatremia, Covid19
HYPONATREMIA IN COVID-19 PATIENTS
SYSTEMIC INFLAMMATION HAS BEEN ASSOCIATED WITH SEVERE COVID-19. HYPONATREMIA CAN RESULT FROM INFLAMMATION DUE TO NON-OSMOTIC STIMULI FOR VASOPRESSIN PRODUCTION.
- Conditions
- Hyponatremia, Covid19, Corona Virus Infection
- Trial name
- NCT04493268
- Where
- Argentina
- Volunteers
- 250 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
Carcinoma
Impact of Peri-Operative Hyponatremia on Postoperative Outcomes in Major HPB Surgeries for Cancers
The present study is being designed to study the impact and predictive nature of perioperative hyponatremia on post operative outcomes in patients undergoing Major HPB surgeries for cancers.
- Trial name
- NCT06475911
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hyponatremia
Tolvaptan for In-hospital Hyponatremia
Hyponatremia is a common electrolyte disorder encountered in hospitalized patients. A preliminary, observational, feasibility analysis finalized to assess retrospectively the incidence of hyponatremia (Serum sodium < 135 mEq/L)…
- Trial name
- INSERT (NCT01386372)
- Testing
- Tolvaptan, Standard therapy
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Hyponatremia
Characterization of Neuropsychologic and Physical Performance in Geriatric Patients With Hyponatremia.
Our purpose is to investigate the improvement of the cognitive, neuropsychologic and physical capabilities using a standardized multidimensional geriatric assessment (MGA) consisting of a battery of validated assays after…
- Trial name
- NCT02242604
- Testing
- Multidimensional Geriatric Assessment (MGA)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Volker Burst
Hyponatremia
Use of Isotonic Solutions Versus Hypotonic Solutions for Preventing Hospital Acquired Hyponatremia
The purpose of this study is to determine if isotonic solutions reduce the risk of hospital acquired hyponatremia compared with hypotonic solutions.
- Trial name
- NCT01909336
- Testing
- 0.3% Saline in 3.3% dextrose, 0.45% Saline in 5% dextrose, 0.9% Saline in 5% dextrose
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Instituto Tecnologico y de Estudios Superiores de Monterey
Hyponatremia
Factors Associated With Hyponatremia Induced by High-dose Cyclophosphamide
Prospoctive cohort of high-dose cyclophosphamide exposed patients. With active estandardize screening of hyponatremia development in the follow up period.
- Trial name
- NCT02399358
- Where
- Argentina
- Volunteers
- 200 people
- Sponsor
- Diego Hernan Giunta, MD
Traumatic Brain Injury
Prevalence, Severity, Risk Factors, and Prognostic Value of Hyponatremia in Patients With Traumatic Brain Injury
Hyponatremia (HN) is the most common electrolytic disorder in the traumatic brain injury (TBI) population, found in 17 to 51% of patients according to the series.
- Trial name
- WATERWAR (NCT05301049)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Montpellier
Brain Injury, Hyponatremia
Pharmacokinetics and Clinical Response of Tolvaptan in Neurocritical Care Patients
To assess the pharmacokinetic profile of tolvaptan in critically ill acute brain injury patients and to secondarily evaluate the clinical response and safety of tolvaptan in acute brain injured patients
- Trial name
- NCT02215148
- Testing
- Tolvaptan
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of North Carolina, Chapel Hill