Clinical trials: Sodium Depletion
Transurethral Resection of Prostate Syndrome
Prophylaxis Versus Treatment for TURP Syndrome.
This study is designed to investigate the usage \& effects of prophylactic HS preloading, with two different concentrations, to combat the expected dilutional hyponatremia induced by irrigating fluid absorption and to prevent the…
- Trial name
- NCT03428451
- Testing
- NaCl 3% HS, NaCl 0.9% NS
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ahmed Mohamed ELbadawy
Hyponatremia, Hypernatremia
Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients
Background: Hypo- and hypernatremia are common in hospitalized patients. The differential diagnosis of dysnatremia is challenging.
- Trial name
- COMED (NCT01456533)
- Where
- 2 sites in Switzerland
- Volunteers
- 300 people
- Sponsor
- University Hospital, Basel, Switzerland
Adrenal Hyperplasia, Congenital, 21-hydroxylase Deficiency
Adrenocortical Functions in Women With Nonclassical 21-hydroxylase Deficiency.
The risk of adrenal insufficiency in patients with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency is not well documented.
- Trial name
- EVAF-21 (NCT01862380)
- Testing
- Functional explorations
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hyponatremia, Ascites
Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites
The purpose of the study is to investigate the efficacy and safety for the management of hyponatremia and ascites in patients with liver cirrhosis.
- Trial name
- TONIC (NCT01716611)
- Testing
- Tolvaptan
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Konkuk University Medical Center
Hyponatremia
Postoperative Hyponatremia - Are There Gender Differences?
The proposed study will focus on anesthesia and anesthesia-induced hypotension as a possible cause for postoperative fluid retention and hyponatremia, and investigate gender differences in this response.
- Trial name
- NCT00636857
- Testing
- Fluid administration, Perioperative fluid management based on Lean Body Mass
- Where
- 5 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Hypernatremia, Hyponatremia
Plasma Sodium and Sodium Administration in the ICU
Patients in the Intensive Care Unit often present with low levels of plasma sodium and are therefore often administered high amounts of sodium, both as an additive to intravenous glucose solutions and as a constituent of various…
- Conditions
- Hypernatremia, Hyponatremia, Critical Illness
- Trial name
- NCT06037928
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping
Newborn Complication, Hyponatremia of Newborn
Comparison of the Isotonic and Hypotonic Intravenous Maintenance Fluids In Term Newborns: Neofluid Study
Considering the physiological changes in fluid and electrolyte balance and providing proper support are one of the important aspects of neonatal intensive care.
- Conditions
- Newborn Complication, Hyponatremia of Newborn, Hypernatremia of Newborn, Fluid Therapy
- Trial name
- NEOFLUID (NCT04781361)
- Testing
- Intravenous isotonic fluid - NaCl 131-154 mmol/L in 5% dextrose, Intravenous Hypotonic fluid- Sodium Chloride < 130 mmol/L
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Dokuz Eylul University
CHRONIC HYPONATREMIA
Phase 2a Study for PK/PD of nC-001
CHRONIC EUVOLEMIC HYPONATREMIA
- Trial name
- NCT06798675
- Testing
- nC-001
- Volunteers
- 24 people
- Sponsor
- nephCentric
Heart Failure, Renal Failure
Hypertonic Saline Solution in Heart Failure
Patients with decompensated heart failure have high rates of mortality and morbidity despite recent improvements in diagnosis and treatment.
- Conditions
- Heart Failure, Renal Failure, Hyponatremia
- Trial name
- NCT00555685
- Testing
- NaCl 7,5% (Hypertonic Saline Solution), NaCl 0,9%
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo
Hepatic Encephalopathy
Post Transjugular Intrahepatic Portosystemic Shunt (Tips) Albumine Infusion to Prevent Hepatic Encephalopathy
The purpose of this study is to evaluate the efficacy of albumin infusion to prevent post tips hepatic encephalopathy'
- Trial name
- NCT01559519
- Testing
- Albumin
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Hyponatremia, Acute Decompensated Heart Failure
Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure (ADHF)
This study will evaluate the safety and effectiveness of Conivaptan, a vasopressin antagonist, in the treatment of hyponatremic subjects having symptomatic acute decompensated heart failure (ADHF).
- Trial name
- CONVERT-H (NCT00843986)
- Testing
- conivaptan
- Where
- 4 sites in India
- Volunteers
- 9 people
- Sponsor
- Cumberland Pharmaceuticals
SIAD - Syndrome of Inappropriate Antidiuresis, Hyponatremia
Water Load Test Value for Hyponatremia
Acute water load test has been using to diagnose renal ability to excrete water for decades. Latest recommendations for the diagnosis of hyponatremia do not recommend performing such a test.
- Trial name
- WATERLINE (NCT04256499)
- Testing
- Acute water load test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- European Georges Pompidou Hospital
Hyponatremia
Incidence of Hyponatremia in PEG-SD Compared to PEG-ELS
Objective: To compare the incidence of peri-colonoscopy hyponatremia associated with PEG 3350 + sports drink (PEG-SD) versus PEG 3350-electrolyte solution + sodium sulfate + sodium ascorbate and ascorbic acid (PEG-ELS).
- Trial name
- NCT01299779
- Testing
- PEG-SD, PEG-ELS
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Thomas Jefferson University
Hyponatremia
Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients
Conivaptan (Vaprisol) is FDA-Approved for the treatment of low serum sodium (hyponatremia), but there are few data in patients with neurologic disease.
- Trial name
- NCT00727090
- Testing
- Conivaptan
- Volunteers
- 6 people
- Sponsor
- Northwestern University
Hyponatremia
Variation in Natremia Using Two Different Maintenance Intravenous Fluids in Postsurgical Hospitalized Children
The primary objective of this study is to compare the blood sodium level after 12 hours following the initiation of therapy with either 0.3% NaCl/dextrose 5% or 0.45% NaCl/dextrose 5%, in postsurgical hospitalized children…
- Trial name
- surgical-Na (NCT01251770)
- Testing
- 0.45% NaCl/dextrose 5%, 0.3% NaCl/dextrose 5%
- Where
- Argentina
- Volunteers
- 78 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde
Decompensated Heart Failure, Hyponatremia
Regional Tolvaptan Registry
Low blood sodium is a common observation in patients presenting with heart failure and is associated with increased mortality, prolonged hospital stay, and repeat hospital visits.
- Trial name
- Tolvaptan (NCT02666651)
- Testing
- Tolvaptan, No intervention
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Cardiology Research UBC
Syndrome of Inappropriate Antidiuretic Hormone Secretion
A Multicenter Trial to Investigate the Efficacy and Safety of Tolvaptan in Patients With Hyponatremia in SIADH
The objective of this study is to investigate the efficacy and safety of tolvaptan based on the change in serum sodium concentration following administration of tolvaptan oral tablets at 7.5 to 60 mg/day for up to 30 days in…
- Trial name
- NCT03048747
- Testing
- Tolvaptan Oral Tablet
- Where
- 6 sites in Japan
- Volunteers
- 16 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Hyponatremia
A Trial of Tolvaptan in Children and Adolescent Subjects With Euvolemic and Hypervolemic Hyponatremia
The purpose of this trial is to demonstrate that tolvaptan effectively and safely increases and maintains serum sodium concentrations in children and adolescent subjects with euvolemic or hypervolemic hyponatremia.
- Trial name
- NCT02442674
- Testing
- Tolvaptan
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Bronchopulmonary Dysplasia, Hyponatremia on Diuretics
Management of Hyponatremia in Preterm Infants on Diuretics
Hydrochlorothiazide and spironolactone are diuretics that are commonly in preterm infants with bronchopulmonary dysplasia (BPD). Hyponatremia (low blood salt) is a common side effect.
- Trial name
- NCT00156572
- Testing
- Sodium supplementation, Fluid restriction
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hyponatremia, SIADH
Low-dose Tolvaptan for Inpatient Hyponatraemia.
This is a retrospective cohort study to assess the safety and efficacy of low first dose of Tolvaptan and low or standard second dose of Tolvaptan in patients with moderate to severe hyponatraemia associated with SIADH not…
- Trial name
- NCT06171100
- Testing
- Tolvaptan
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- King's College Hospital NHS Trust