Clinical trials: Sodium Depletion
Hyponatremia
Retrospective Analysis of ECG Changes and Arrhythmias in Patients With Profound Hyponatremia
The primary objective of this retrospective study is to determine the impact of hyponatremia on quantitative measurements and characteristics of the ECG.
- Trial name
- NCT07255833
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- University of Cologne
Acute Kidney Injury, Exercise-associated Hyponatremia
Non-steroidal Anti-inflammatory Affect on Kidneys in Endurance Distances
The specific aim of this study is to evaluate the safety of non-steroidal anti-inflammatory drugs (NSAIDs) and their impact on renal function and/or contribution to exercise-associated hyponatremia (EAH) during an ultramarathon…
- Conditions
- Acute Kidney Injury, Exercise-associated Hyponatremia, Perceived Exertion
- Trial name
- NAKED (NCT02272725)
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Stanford University
SIADH
Effects of the SGLT2-inhibitor Empagliflozin on Patients With SIADH - the SAND Study
Syndrome of inappropriate antidiuresis (SIADH) is characterized by an imbalance of antidiuretic vasopressin (AVP) secretion. The impaired AVP regulation leads to water retention and secondary natriuresis and is a common cause for…
- Trial name
- SAND (NCT02874807)
- Testing
- Empagliflozin
- Where
- Switzerland
- Volunteers
- 88 people
- Sponsor
- University Hospital, Basel, Switzerland
Hyponatremia With Excess Extracellular Fluid Volume, Cirrhosis, Liver
Albumin for Management of Hypervolemic Hyponatremia (AlbuCAT)
resolution of hyponatremia, defined as an increase in serum sodium of more than 5 mEq/L with a final value > 130 mEq/L, maintained for at least 48 consecutive hours during the 10-day treatment period
- Trial name
- AlbuCAT (NCT03941405)
- Testing
- Albumin treatment
- Where
- 3 sites in Spain
- Volunteers
- 52 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Hyponatremia Symptomatic, Osmotic Demyelination Syndrome
International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia
Electronic medical records dating back as far as available for each center to identify patients admitted to the hospital with a serum sodium ≤110 mmol/l.
- Conditions
- Hyponatremia Symptomatic, Osmotic Demyelination Syndrome, Cerebral Edema
- Trial name
- PRONATREOUS (NCT07576036)
- Testing
- Hypertonic 3% saline
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Rochester General Hospital
Hyponatremia, Hypernatremia
Frequency and Origin of Dysnatremias in the Emergency Department
Hypo- and hypernatremia are the most frequent electrolyte disorders found in hospitalized patients. The increasing use of diuretics and other medications influencing the water and sodium homeostasis potentially lead to a rise in…
- Trial name
- NCT01326429
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Asymptomatic Bacteriuria, Frailty
Asymptomatic Bacteriuria, Hyponatremia and Geri-atric Syndrome
The population is aging. Aged people are more prown to develop frailty. The causes of frailty are multifactorial and are being investigated in research settings.
- Conditions
- Asymptomatic Bacteriuria, Frailty, Geriatric Syndrome, SIADH
- Trial name
- NCT05055856
- Testing
- urine sample, Blood and urine sample
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Percutaneous Coronary Intervention
Radiocontrast Media Induced Hyponatremia
Osmolality of contrast media can be resulted in translocational hyponatremia after percutaneous coronary intervention.
- Trial name
- NCT01219270
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Healthy Volunteers
Adaptation of Thirst to a Single Administration of Tolvaptan (TOLVATHIRST)
Tolvaptan is a new drug that specifically antagonizes the V2-receptor of antidiuretic hormone (ADH) and leads to water diuresis: During acute administration of tolvaptan, the main fear is to induce a too fast increase in plasma…
- Trial name
- TOLVATHIRST (NCT03931369)
- Testing
- Tolvaptan 15 MG
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypervolemic Hyponatremia
International, Multicenter, Open-Label and Randomized Withdrawal Study of Oral Lixivaptan in Heart Failure Patients With Chronic Hyponatremia
To demonstrate that after 12 weeks of open-label lixivaptan treatment, serum sodium is maintained in hyponatremic patients continuing to receive lixivaptan compared to placebo during the 4 week double blind treatment period.
- Trial name
- NCT00876876
- Testing
- Lixivaptan
- Volunteers
- 300 people
- Sponsor
- CardioKine Inc.
Exercise-associated Hyponatremia
The Efficacy of Oral Versus Intravenous Hypertonic Saline Administration in Runners With Exercise-Associated Hyponatremia
The purpose of the study is to 1) evaluate incidence and primary cause of exercise-associated Hyponatremia (EAH) in race finishers participating in the Western States 100-mile Endurance Run, 2) determine if the ingestion of oral…
- Trial name
- NCT01110655
- Testing
- Intravenous hypertonic Saline, Oral hypertonic saline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western States Endurance Run Research Foundation
Hyponatremia
An Extension Follow-up Trial to Evaluate the Long-term Safety of Children and Adolescent Participants With Euvolemic or Hypervolemic Hyponatremia
The objective of this trial was to provide 6 months of safety follow-up for children and adolescents with dilutional (euvolemic or hypervolemic) hyponatremia who had previously participated in a tolvaptan hyponatremia trial and…
- Trial name
- NCT02020278
- Testing
- Tolvaptan
- Where
- 23 sites in United States, Belgium and 6 more
- Volunteers
- 3 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Dehydration in Children, Fluid Therapy
Boluses of Ringer's in Surgical Kids (BRiSK Study)
Traditional protocols for intravenous fluid administration in children who have undergone a major abdominal or thoracic operation are based on a landmark paper published in 1957 by Holliday and Segar.
- Trial name
- BRiSK (NCT05285371)
- Testing
- Urinalysis (UA), Complete Metabolic Panel (CMP), Glucose Stick Test (d-Stick)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Hyponatraemia, Hypernatraemia
Do Changes in Plasma Osmolality Influence Ventilation?
Primary hypothesis: osmolality changes influence the sensitivity of the respiratory center to carbon dioxide, hyponatraemia causing hyperventilation, and hypernatraemia depressing ventilation.
- Trial name
- OSM (NCT01008644)
- Testing
- Water, Saline 3%
- Where
- Sweden
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vibeke Moen
Hyponatremia
Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges
Hyponatremia is the most common electrolyte disorder of all and can be observed in more than 30% of all patients in hospitals. Osmotic homeostasis of body fluids is essential for survival of all living creatures.
- Trial name
- RESERVE (NCT06408077)
- Testing
- Water administration, NaCl-Administration
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Cologne
Hyponatremia
Hyponatremia and Myometrium Contractility. An Invitro Study
Hyponatremia during labour has been associated with prolonged labour, and increased incidence of instrumental delivery and emergency caesarean section.
- Trial name
- NCT01708811
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska University Hospital
Thiazide-induced Hyponatremia (TIH)
Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia
Thiazides and thiazide-like diuretics are one of the five major classes of antihypertensive drugs. This study is to investigate whether urinary PGE2 concentration at baseline (prior to thiazide initiation) is associated with the…
- Trial name
- PROPHECY (NCT05542056)
- Testing
- Data and biosample collection
- Where
- 3 sites in Spain, Switzerland
- Volunteers
- 232 people
- Sponsor
- University Hospital, Basel, Switzerland
Hyponatremia, Surgery
Fluid Tonicity and Hyponatraemia Post Surgery
Retrospective audit of adult patients who underwent major surgery in our institution, and biochemical outcomes including hyponatremia, in relation to the maintenance fluid tonicity administered peri-operatively.
- Conditions
- Hyponatremia, Surgery, Fluid and Electrolyte Imbalance
- Trial name
- NCT03840629
- Testing
- No study intervention.
- Volunteers
- 659 people
- Sponsor
- National University Hospital, Singapore
Hyponatremia of Multiple Myeloma
Pseudohyponatremia of Multiple Myeloma is True Hyponatremia
Hypothesis: the hyponatremia of multiple myeloma (m.m.)is true and not pseudohyponatremia by using the stewart approach to acid - base interpretation, would like to show that the positive charged m- proteins produced in…
- Trial name
- NCT01425606
- Testing
- blood test
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Hyponatremia
Characterisation of Neuropsychological and Motoric Performance in Patients With Hyponatremia
The aim of this epidemiological study is to characterize the neuropsychological and motoric performance in patients with hyponatremia.
- Trial name
- NCT01879774
- Testing
- Neuropsychological and motoric tests
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 189 people
- Sponsor
- University of Cologne