Clinical trials: Sodium Depletion
Hyponatremia, Hospitalisation
Mortality and Neurologic Outcomes in Rapid vs. Slow Hyponatremia Correction
This study examines the impact of different rates of sodium correction on the outcomes of patients with severe hyponatremia (serum sodium ≤ 120 mEq/L).
- Conditions
- Hyponatremia, Hospitalisation, Mortality, SEVERE HYPONATREMIA
- Trial name
- RASC-HypoNa (NCT06675591)
- Testing
- Rapid sodium correction, Slow sodium correction
- Where
- Argentina
- Volunteers
- 2,037 people
- Sponsor
- Hospital Italiano de Buenos Aires
Thiazide Diuretics Induced Hyponatremia
Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and Development of Hyponatremia
The purpose of this study is to detect if there are any differences in the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without…
- Trial name
- NCT01346891
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Italiano de Buenos Aires
Nocturia Due to Nocturnal Polyuria
Specified Drug Use-results Survey (Long-term Use) on MINIRINMELT® OD Tablet (Nocturia)
To investigate the incidence and risk factors of desmopressin-induced hyponatremia during long-term treatment (1 year [52 weeks]) of MINIRINMELT orally disintegrating (OD) tablets 25μg/50μg (drug) for nocturia caused by nocturnal…
- Trial name
- NOC01 (NCT04329975)
- Testing
- Desmopressin
- Where
- Japan
- Volunteers
- 1,087 people
- Sponsor
- Ferring Pharmaceuticals
Hypertension
PHARES Study: Management of Resistant Hypertension
The purpose of this study is to assess the efficacy of two different treatment regimens for treating resistant hypertension previously uncontrolled with at least 3 antihypertensive treatments.
- Trial name
- NCT00224549
- Testing
- irbesartan, amlodipine and hydrochlorothiazide
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hyponatremia, Hypovolemia
Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia
Retrospective study that analyzes the changes in serum creatinine as a tool to correctly classify the volemic status volemic status (euvolemia vs hypovolemia) of the patients with hyponatremia.
- Conditions
- Hyponatremia, Hypovolemia, SIADH
- Trial name
- NCT04744987
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Hospital San Carlos, Madrid
Hyponatremia
Targeted Correction of Plasma Sodium Levels in Hospitalized Patients With Hyponatremia
Hyponatremia is the most common electrolyte disorder with a prevalence of up to 30% in hospitalized patients. While treatment of acute hyponatremia with severe clinical symptoms due to cerebral edema is undisputed and…
- Trial name
- HIT (NCT03557957)
- Testing
- Targeted correction of plasma sodium levels, Standard care
- Where
- 9 sites in Croatia, Germany and 3 more
- Volunteers
- 2,278 people
- Sponsor
- University Hospital, Basel, Switzerland
Cerebral Hyponatremia, SIADH
Fractional Urate Excretion in Nonedematous Hyponatremia
Hyponatremia, defined as a serum sodium < 135 mmol/l, in patients without edema has undergone significant changes where it is now evident that even mild hyponatremia should be treated because of its association with symptoms…
- Conditions
- Cerebral Hyponatremia, SIADH, Cerebral Salt-wasting Syndrome, Reset Hypothalamic Osmostat
- Trial name
- NCT01425125
- Testing
- Tolvaptan in euvolemic hyponatremia
- Where
- United States
- Sponsor
- NYU Langone Health
Hyponatremia, Inappropriate ADH Syndrome
Urea for Chronic Hyponatremia
This study is examining how a dietary supplement called urea can be used to treat low blood sodium level. Low blood sodium level is a common problem and some studies show that many patients with low blood sodium level suffer from…
- Trial name
- NCT04588207
- Testing
- Urea
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Helbert Rondon Berrios, MD, MS
Hyponatremia and Extracellular Fluid in Cirrhotic
Effect of Samsca on Control of Hyponatremia and Extracellular Fluid in Cirrhotic Patients With Ascites
This study is to evaluate the efficacy of a 2-week course of tolvaptan in improving serum sodium and the excretion of extracellular fluid in liver cirrhotic patients with ascites and hyponatremia
- Trial name
- ECF (NCT01552590)
- Testing
- Tolvaptan
- Where
- 3 sites in South Korea
- Volunteers
- 74 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Hyponatremia, Osmotic Demyelination Syndrome
Efficacy and Safety of Bolus Comparing With Continuous Drip of 3% NaCl in Patients With Severe Symptomatic Hyponatremia.
To compare between intermittent bolus and traditional continuous drip of 3%NaCl in patients with severe symptomatic hyponatremia in Rajavithi Hospital.
- Trial name
- NCT04561531
- Testing
- 3%NaCl
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Arterial Hypertension, Diabetes
Cicletanine in Hypertension With Diabetes: Added Magnesium Preserves Potassium and Sodium
Cicletanine, which has been approved and launched for hypertension in France and Germany, has promise beyond hypertension in critically-unmet needs such as diabetes.
- Conditions
- Arterial Hypertension, Diabetes, Hypokalemia, Hyponatremia
- Trial name
- CHAMP (NCT02709031)
- Testing
- Cicletanine + magnesium, Cicletanine
- Volunteers
- 24 people
- Sponsor
- Navitas Pharma
Hyponatremia, SIADH
Tolvaptan for Patients With Acute Neurological Injuries
Hyponatremia occurs frequently in patients with acute brain injury in the days to weeks following injury, and may contribute to adverse outcome.
- Trial name
- NCT02545114
- Testing
- Tolvaptan
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Polderman, Kees, H., MD, PhD
Hyponatremia
Study of IV YM087 to Assess Efficacy and Safety in Patients With Euvolemic or Hypervolemic Hyponatremia
This study will investigate the application of a vasopressin antagonist in the treatment of hyponatremia most likely caused by inappropriate AVP secretion.
- Trial name
- NCT00380575
- Testing
- YM087
- Where
- 47 sites in United States, Canada and 2 more
- Volunteers
- 84 people
- Sponsor
- Cumberland Pharmaceuticals
Hypokalemia, Hyponatremia
Intravenous Fluids in Hospitalised Children
The main objective of the trial is to evaluate the risk of hypokalemia following administration of a isotonic solution compared to a hypotonic solution in acutely ill hospitalised children, who need intravenous fluid therapy.
- Conditions
- Hypokalemia, Hyponatremia, Hypernatremia, Dehydration
- Trial name
- NCT02926989
- Testing
- Plasmalyte Glucos 50 mg/mL, 0.45% saline in 5% dextrose
- Where
- Finland
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Euvolemic Hyponatremia, Hypervolemic Hyponatremia
Hyponatremia Registry for Patients With Euvolemic and Hypervolemic Hyponatremia
The registry is a multi-center, prospective, observational study designed to collect data in patients with euvolemic and hypervolemic hyponatremia in the hospital setting in the USA and hyponatremia secondary to syndrome of…
- Trial name
- HN Registry (NCT01240668)
- Where
- 79 sites in United States, Germany and 1 more
- Volunteers
- 5,028 people
- Sponsor
- Otsuka America Pharmaceutical
Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage:
Subarachnoid hemorrhage (SAH) occurs after rupture of cerebral aneurysms. Treatment of SAH focuses on avoiding medical complications including cerebral vasospasm, which may result in limited circulation to the brain.
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Hyponatremia
- Trial name
- HS3 (NCT02432157)
- Testing
- HTS 3%, Standard fluid management
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Hyponatremia
Hyponatremia Due to Poly Ethylene Glycol (PEG)
Colonoscopy is a useful tool used in modern medicine and it is increasingly being employed for both diagnostic and therapeutic purposes.
- Trial name
- NCT03787888
- Where
- Pakistan
- Volunteers
- 151 people
- Sponsor
- Tazeen Rasheed
Hyponatremia
Influence of Triathlon on the Electrolyte Balance
Aim of the study is examining the incidence of the occurrence of hyponatremia during a Triathlon
- Trial name
- Ironman (NCT02263586)
- Testing
- Education in nutrition
- Where
- Germany
- Volunteers
- 1,089 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
Hyponatremia, Dilutional Hyponatremia
Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia
The purpose of this study is to determine if hospitalized patients with symptomatic hyponatremia treated with tolvaptan are in the hospital for less time than patients treated with fluid restriction.
- Conditions
- Hyponatremia, Dilutional Hyponatremia, Inappropriate ADH Syndrome
- Trial name
- SALACIA (NCT01227512)
- Testing
- tolvaptan, Fluid Restriction
- Where
- 56 sites in United States
- Volunteers
- 124 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Hyponatremia
International, Multicenter, Study of One-year, Open-label, Titrated Oral Tolvaptan Tablet Administration in Patients With Chronic Hyponatremia
This study will assess the safety of long-term tolvaptan use in patients previously enrolled in shorter-term Phase 3 studies and gather information on the natural history of hyponatremia in the context of tolvaptan therapy and…
- Trial name
- NCT02449044
- Testing
- Tolvaptan
- Volunteers
- 111 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.