Clinical trials: Sodium Excess
Blood Pressure, Salt; Excess
Sodium Glucose Cotransporter-2 Inhibitors and Salt-sensitivity in Type 2 Diabetes
The goal of this interventional study is to test whether sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce the effects of high dietary sodium intake in patients with type 2 diabetes.
- Conditions
- Blood Pressure, Salt; Excess, Diabete Type 2
- Trial name
- SALT (NCT06007157)
- Testing
- Hypersodic/Hyposodic diet
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Hyponatraemia, Hypernatraemia
Do Changes in Plasma Osmolality Influence Ventilation?
Primary hypothesis: osmolality changes influence the sensitivity of the respiratory center to carbon dioxide, hyponatraemia causing hyperventilation, and hypernatraemia depressing ventilation.
- Trial name
- OSM (NCT01008644)
- Testing
- Water, Saline 3%
- Where
- Sweden
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vibeke Moen
Sodium Excess, Cardiovascular Risk Factor
A Short, Animated Storytelling Video to Increase Knowledge About Sodium Intake as a Cardiovascular Risk Factor
This study will evaluate the effect of a short, animated storytelling intervention video on sodium intake as a major risk factor for cardiovascular disease on immediate and medium-term retention of knowledge about the risks of…
- Conditions
- Sodium Excess, Cardiovascular Risk Factor, Education Entertainment Intervention, Short, Animated Storytelling
- Trial name
- NCT05735457
- Testing
- A short, animated storytelling video on dietary sodium
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Leukemia, Myelodysplastic Syndromes
Azacitidine Plus Phenylbutyrate in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome
RATIONALE: Azacitidine plus phenylbutyrate may help leukemia cells develop into normal white blood cells. PURPOSE: Phase I trial to study the effectiveness of combining azacitidine and phenylbutyrate in treating patients who have…
- Conditions
- Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
- Trial name
- NCT00004871
- Testing
- azacitidine, sodium phenylbutyrate
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Head Trauma
Early Induced Hypernatremia for the Prevention and Management of Brain Edema
The purpose of this study is to estimate the effect of an early induced hypernatremia protocol (150-155 milliequivalent/L) versus normonatremia plus mannitol (135 - 145 milliequivalent/L) in terms of neurologic outcome in…
- Trial name
- EHIBE (NCT02798601)
- Testing
- Hypernatremia
- Sponsor
- Hospital Pablo Tobón Uribe
Sodium Excess
Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics
High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who…
- Trial name
- NCT04233957
- Testing
- High Sodium
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Delaware
HYPERNATREMIA
Evaluation of the Cerebral Oxygenation With Near Infrared Spectrophotometry (NIRS) at the Hypernatremic Dehydration in Newborn
The aim of the study is to evaluate cerebral oxygenation with Near infrared spectrophotometry (NIRS) at the hypernatremic dehydration in newborns.
- Trial name
- NCT01299428
- Testing
- INVOS 5100
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Hyponatremia, Hypernatremia
Frequency and Origin of Dysnatremias in the Emergency Department
Hypo- and hypernatremia are the most frequent electrolyte disorders found in hospitalized patients. The increasing use of diuretics and other medications influencing the water and sodium homeostasis potentially lead to a rise in…
- Trial name
- NCT01326429
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Leukemia, Myelodysplastic Syndromes
Phenylbutyrate and Tretinoin in Treating Patients With Hematologic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Tretinoin may help hematologic cancer cells develop into normal white blood cells.
- Conditions
- Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
- Trial name
- NCT00006239
- Testing
- sodium phenylbutyrate, tretinoin
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
ICU-acquired Hypernatremia
Balance Study on ICU-acquired Hypernatremia and Sodium Handling (BIAS)
The goal of this study is to find differences between patients who do and do not develop ICU-acquired hypernatremia (IAH). Therefore extended sodium and fluid balances will be performed.
- Trial name
- BIAS (NCT03093766)
- Where
- Netherlands
- Volunteers
- 155 people
- Sponsor
- Frisius Medisch Centrum
Extremely Low Birth Weight Infants, Hypernatremia
Use of Sterile Water Feeds for Treatment of Hypernatremia in Extremely Low Birth Weight Infants
The improved survival rate of extremely low birth weight(ELBW)infants has resulted in new fluid and electrolyte problems that have not been encountered previously,in particular electrolyte imbalance.
- Trial name
- NCT01219179
- Testing
- Sterile water feedings
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Case Western Reserve University
Hypertension, Sodium Excess
Effects of Salt on Serum Osmolarity and Hemodynamics Parameters
Diets containing excessive salt (>12 g/day) have negative effects on kidney and cardiovascular system. Considering this known fact, the investigators aimed to study if the amount of the water taken with excessive salt had any…
- Conditions
- Hypertension, Sodium Excess, Oxidative Stress, Inflammation
- Trial name
- NCT03314727
- Testing
- High salt (NaCl) intake
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Koç University
Metabolic Diseases
Metabolic Disorders in Ultramarathon Runners During and After the Reunion Island Madmen's Diagonal
Acute consequences of ultramarathon running are still unknown as very little research has been done on the matter. The investigators will assess the consequences on the metabolism of runners in the ultramarathon Madmen's Diagonal…
- Trial name
- METARUN (NCT02275429)
- Testing
- Blood test
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Hypernatremia
Rapid Rehydration for Severe Hypernatremia
The goal of this study is to show the feasibility of rapid identification, consenting, randomization, treatment, and follow-up of patients with severe hypernatremia (Na ≥ 155 mEq/L).
- Trial name
- RaRe Treat (NCT07783191)
- Testing
- Intravenous Dextrose 5% solution
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Columbia University
Hypernatremia, Critically Ill
Continuous Venovenous Hemofiltration Versus Conventional Treatment for Acute Severe Hypernatremia
The patients with severe hypernatremia who received conventional treatment are often undertreated. Continuous venovenous hemofiltration (CVVH) can effectively remove solute or water from circulation system.
- Trial name
- NCT02449382
- Testing
- continuous venovenous hemofiltration, Control group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Air Force Military Medical University, China
Hypokalemia, Hyponatremia
Intravenous Fluids in Hospitalised Children
The main objective of the trial is to evaluate the risk of hypokalemia following administration of a isotonic solution compared to a hypotonic solution in acutely ill hospitalised children, who need intravenous fluid therapy.
- Conditions
- Hypokalemia, Hyponatremia, Hypernatremia, Dehydration
- Trial name
- NCT02926989
- Testing
- Plasmalyte Glucos 50 mg/mL, 0.45% saline in 5% dextrose
- Where
- Finland
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Oulu
The Patients Suffered With Sellar Diseases, The Fluid and Electrolyte Imbalance Happened After Surgery
Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy
The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions.
- Trial name
- NCT01406041
- Testing
- Chemical and physical detection
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Southern Medical University, China
Hypernatremia, Critical Illness
Safety and Efficacy of Hydrochlorothiazide in the Treatment of Hypernatremia in Critically Ill Patients
HYDRA is a randomized clinical trial designed to evaluate safety and efficiency of hydrochlorothiazide in critical patients with hypernatremia
- Trial name
- HYDRA (NCT03658850)
- Testing
- Hydrochlorothiazide 50Mg
- Where
- Brazil
- Volunteers
- 184 people
- Sponsor
- University of Sao Paulo
Newborn Complication, Hyponatremia of Newborn
Comparison of the Isotonic and Hypotonic Intravenous Maintenance Fluids In Term Newborns: Neofluid Study
Considering the physiological changes in fluid and electrolyte balance and providing proper support are one of the important aspects of neonatal intensive care.
- Conditions
- Newborn Complication, Hyponatremia of Newborn, Hypernatremia of Newborn, Fluid Therapy
- Trial name
- NEOFLUID (NCT04781361)
- Testing
- Intravenous isotonic fluid - NaCl 131-154 mmol/L in 5% dextrose, Intravenous Hypotonic fluid- Sodium Chloride < 130 mmol/L
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Dokuz Eylul University
Fluid Retention, Sodium Retention
The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress
The primary purpose of the proposed study is to evaluate the effects of a topical sodium bicarbonate lotion (PR Lotion, AMP Human, Park City, UT) on measures of hydration status and fluid balance in humans when exposed to the…
- Conditions
- Fluid Retention, Sodium Retention, Heat Stress, Dehydration (Physiology)
- Trial name
- AMP2 (NCT05092854)
- Testing
- PR Lotion - AMP Human Performance, AminoVital - Rapid Recovery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Connecticut