Clinical trials: Sodium Retention
Hypernatremia
Efficacy and Safety of Rapid Intermittent Correction Compared With Slow Continuous Correction in Patients With Severe Hypernatremia
This study will evaluate the efficacy and safety of rapid intermittent correction and slow correction with an electrolyte-free solution in patients with severe hypernatremia (glucose-corrected serum sodium, ≥ 155 mmol/L).
- Trial name
- SALSAII (NCT04949139)
- Testing
- Dextrose 5% in water
- Where
- South Korea
- Volunteers
- 178 people
- Sponsor
- Seoul National University Hospital
Renal Failure, Anesthesia
Renal Function During Pediatric Anesthesia
It is known that volatile anesthesia, such as sevoflurane, retain water and that this appears more pronounced in children. However, the mechanisms for this effect is unknown and it is not clear if the commonly used anesthetic…
- Trial name
- NCT02571426
- Testing
- Sevoflurane, propofol
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Electrolyte Imbalance, Hyponatremia
V2 Receptor Effects on Fluid Regulation and Performance
This primary aim of this study was to critically assess whether or not sweat water content and sodium concentration were acutely regulated by dynamic changes in antidiuretic hormone (arginine vasopressin or AVP) acting on the…
- Conditions
- Electrolyte Imbalance, Hyponatremia, Hypernatremia
- Trial name
- NCT02084797
- Testing
- V2R (Vasopressin 2 receptor)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oakland University
Acromegaly
Physiopathology of Sodium Retention in Acromegaly
Acromegaly is a disease due to an excess of growth hormone that abnormally occurs in adulthood. It is due to a benign (non cancerous) tumor located in a particular part of the brain that secretes several hormones, the hypophysis.
- Trial name
- AcromEnaC (NCT00531908)
- Testing
- furosemide
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Diseases
Metabolic Disorders in Ultramarathon Runners During and After the Reunion Island Madmen's Diagonal
Acute consequences of ultramarathon running are still unknown as very little research has been done on the matter. The investigators will assess the consequences on the metabolism of runners in the ultramarathon Madmen's Diagonal…
- Trial name
- METARUN (NCT02275429)
- Testing
- Blood test
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Hyponatremia, Hypernatremia
Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients
Background: Hypo- and hypernatremia are common in hospitalized patients. The differential diagnosis of dysnatremia is challenging.
- Trial name
- COMED (NCT01456533)
- Where
- 2 sites in Switzerland
- Volunteers
- 300 people
- Sponsor
- University Hospital, Basel, Switzerland
Hypernatremia
Rapid Rehydration for Severe Hypernatremia
The goal of this study is to show the feasibility of rapid identification, consenting, randomization, treatment, and follow-up of patients with severe hypernatremia (Na ≥ 155 mEq/L).
- Trial name
- RaRe Treat (NCT07783191)
- Testing
- Intravenous Dextrose 5% solution
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Columbia University
Hypernatremia
ED Hypernatremia. Prognostic Factors and Epidemiology.
This study evaluate the 1-month mortality of patients who proceed a blood sample while in the ED with an hypernatremia (>145 mmol/l).
- Trial name
- NATSAU (NCT04265976)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Non-carious Cervical Lesions
Deproteinization as a Coadjuvant in Dentin Adhesion of Noncarious Cervical Lesions
This study will verify the effect of the application of a substance (10% sodium hypoclorite -NaOCL) in dentin on noncarious cervical lesions, with the aim of increasing the longevity of the restorations performed in this type of…
- Trial name
- NCT03086720
- Testing
- Sodium hypochlorite, Water
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Hypernatremia, Critically Ill
Continuous Venovenous Hemofiltration Versus Conventional Treatment for Acute Severe Hypernatremia
The patients with severe hypernatremia who received conventional treatment are often undertreated. Continuous venovenous hemofiltration (CVVH) can effectively remove solute or water from circulation system.
- Trial name
- NCT02449382
- Testing
- continuous venovenous hemofiltration, Control group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Air Force Military Medical University, China
Hyponatraemia, Hypernatraemia
Do Changes in Plasma Osmolality Influence Ventilation?
Primary hypothesis: osmolality changes influence the sensitivity of the respiratory center to carbon dioxide, hyponatraemia causing hyperventilation, and hypernatraemia depressing ventilation.
- Trial name
- OSM (NCT01008644)
- Testing
- Water, Saline 3%
- Where
- Sweden
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vibeke Moen
Hypernatremia
Prospective Data Analysis of the Development of Hypernatremia in Intensive Care Unit
Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay.
- Trial name
- HYPNIC (NCT03752450)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Nephrotic Syndrome, Edema
Amiloride in Nephrotic Syndrome
The AMILOR study compares treatment of edema in nephrotic syndrome with Amiloride vs. Furosemide.
- Conditions
- Nephrotic Syndrome, Edema, Sodium Retention
- Trial name
- AMILOR (NCT05079789)
- Testing
- Amiloride, Furosemide
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Hypernatremia, Critical Illness
Prospective Analysis Into Development of Hypernatremia in Critically Ill Patients
Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay.
- Trial name
- HYPNIC II (NCT05085223)
- Testing
- Daily urine collection for biochemical analysis, Subanalysis for comparison of 24hour urine collection versus spot-check measurements
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypertension, Sodium Excess
Effects of Salt on Serum Osmolarity and Hemodynamics Parameters
Diets containing excessive salt (>12 g/day) have negative effects on kidney and cardiovascular system. Considering this known fact, the investigators aimed to study if the amount of the water taken with excessive salt had any…
- Conditions
- Hypertension, Sodium Excess, Oxidative Stress, Inflammation
- Trial name
- NCT03314727
- Testing
- High salt (NaCl) intake
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Koç University
Hypernatremia, Hyponatremia
Plasma Sodium and Sodium Administration in the ICU
Patients in the Intensive Care Unit often present with low levels of plasma sodium and are therefore often administered high amounts of sodium, both as an additive to intravenous glucose solutions and as a constituent of various…
- Conditions
- Hypernatremia, Hyponatremia, Critical Illness
- Trial name
- NCT06037928
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping
Hypernatremia, Critical Illness
Safety and Efficacy of Hydrochlorothiazide in the Treatment of Hypernatremia in Critically Ill Patients
HYDRA is a randomized clinical trial designed to evaluate safety and efficiency of hydrochlorothiazide in critical patients with hypernatremia
- Trial name
- HYDRA (NCT03658850)
- Testing
- Hydrochlorothiazide 50Mg
- Where
- Brazil
- Volunteers
- 184 people
- Sponsor
- University of Sao Paulo