Clinical trials: Sodium-sensitivity
Asthma
Bioequivalency Study of Montelukast 10 mg Tablets Under Fed Conditions
The objective of this study was to prove the bioequivalence of Montelukast Tablet under fed conditions
- Trial name
- NCT01659918
- Testing
- Montelukast, Singulair
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Asthma
The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma
This study aims to assess the effect of inhaled corticosteroids (ICS) on airway smooth muscle (ASM) Na+, K+ pumps in patients with asthma.We wish to investigate differences in Na+, K+ pump content in healthy versus asthmatic…
- Trial name
- RECONSTRUCT (NCT03034005)
- Testing
- Budesonide
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Dentin Hypersensitivity
The Effect of Using Desensitizers Containing S-PRG In Treatment Of Dentin Hypersensitivity Over 6 Months: A Randomized Clinical Trial
The goal of this clinical trial is to compare the effect of desensitizer containing S-PRG have similar effect as sodium fluoride with functionalized tri-calcium phosphate containing desensitizer in relieving dentinal…
- Trial name
- S-PRG (NCT06276777)
- Testing
- Tooth varnish (PRG Barrier Coat from Shofu), Tooth varnish (Clinpro white varnish 3M)
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eman Omar Elfarouk
Cardiovascular Diseases, Heart Diseases
Sodium Sensitivity in African Americans
To compare the effects of two levels of dietary sodium on blood pressure in Black men and women, and to determine what factors predict the degree of response.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Vascular Diseases
- Trial name
- NCT00000536
- Testing
- sodium, dietary
- Sponsor
- University of Minnesota
Dentinal Hypersensitivity
Efficacy of Sensi-IP Toothpaste in the Treatment of Dentinal Hypersensitivity Compared to a Sodium Fluoride Toothpaste
The study is designed as a prospective, randomized, parallel arm, double blinded, pilot clinical trial.The primary objective is to evaluate the efficacy of Sensi-IP +NaF as compared to a NaF toothpaste in the reduction of dentin…
- Trial name
- NCT06166745
- Testing
- Sensi-IP toothpaste, Sodium Fluoride Toothpaste
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- IR Scientific Inc.
Abdominal Obesity, Metabolic Syndrome
Aldosterone, Microvascular Function and Salt-sensitivity
Currently, the incidence of obesity and obesity-related disorders is reaching epidemic proportions, which entails an increasing burden for health care systems.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Sodium-sensitivity, Insulin Resistance
- Trial name
- NCT02068781
- Testing
- Low-sodium diet, High-sodium diet
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Salt-sensitive Hypertension
Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet
The kidney plays a crucial role in maintaining salt balance by two opposing physiological mechanisms: the renal dopaminergic system which enhances salt excretion and the renin-angiotensin system (RAS) which causes salt retention.
- Trial name
- Salt (NCT01324245)
- Testing
- Fenoldopam
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Dentinal Hypersensitivity
Comparison of Clinical Efficacy of a Dentifrice Containing 5% Fluoro Calcium Phosphosilicate to a Dentifrice Containing Calcium Sodium Phosphosilicate on Dentinal Hypersensitivity
Aim of this study was to assess and compare the efficacy of a dentifrice containing 5% fluoro calcium phosphosilicate and dentifrice containing calcium sodium phosphosilicate on Dentinal Hypersensitivity (DH) compared to a…
- Trial name
- NCT03741309
- Testing
- 5% fluorocalcium phosphosilicate dentifrice, Calcium sodium phosphosilicate
- Where
- India
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Hypertension
The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure
The purpose of this study is to determine if the drug Celebrex changes the way the kidney gets rid of salt and maintains blood pressure.
- Trial name
- NCT00624559
- Testing
- celecoxib (Celebrex)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Hypertension
Nebivolol Versus Metoprolol: Sodium Sensitivity
Research objectives The objective of this randomized, placebo-controlled, 2 period crossover clinical trial is to determine the effects of nebivolol versus metoprolol on ambulatory blood pressure, the blood pressure response to…
- Trial name
- NCT00992056
- Testing
- nebivolol, Metoprolol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Miami
Asthma
A Study to Determine the Effect of Montelukast Sodium as an Episode Modifier in the Treatment of Infrequent Episodic Asthma in Children (0476-165)
A 53-week study to determine the effect of montelukast sodium when given to children (with infrequent episodic asthma) at the earliest symptoms of an acute episode of asthma.
- Trial name
- NCT00140881
- Testing
- MK0476; montelukast sodium
- Volunteers
- 220 people
- Sponsor
- Organon and Co
Salt Sensitivity of Blood Pressure
Central Sodium Sensing: Implications for Blood Pressure Regulation
The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans is poorly understood.
- Trial name
- NCT05480722
- Testing
- Hypertonic Saline with furosemide, Hypertonic Saline without furosemide
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Papillary Thyroid Cancer
A Study to Try to Bring Back Radioiodine Sensitivity in Patients With Advanced Thyroid Cancer.
Thyroid cancers that have spread beyond the neck are not curable. About 30,000 people worldwide die from thyroid cancer every year.
- Trial name
- NCT03469011
- Testing
- Imatinib Oral Tablet
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- AHS Cancer Control Alberta
Asthma
Investigation of Intravenous (IV) Administration of an Approved Drug (MK-0476, Montelukast Sodium) for Acute Asthma (MK-0476-288)
The purpose of this study is to evaluate improved results of treatment for patients entering an emergency department with asthma attacks when given an investigational IV administration of an approved drug (MK-0476, montelukast…
- Trial name
- NCT00092989
- Testing
- montelukast sodium
- Volunteers
- 650 people
- Sponsor
- Organon and Co
Salt Sensitivity of Blood Pressure, Hypertension
CARDIA-Salt Sensitivity of Blood Pressure (SSBP)
Salt sensitivity of blood pressure (SSBP) is defined as the change in blood pressure (BP) in relation to change in salt intake. An increase in BP from low- to high-salt diet is common and associated with an increased risk of…
- Trial name
- NCT04258332
- Testing
- High Salt Diet, Low Salt Diet
- Where
- 2 sites in United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Atopic Dermatitis
The Effect of Diluted Sodium Hypochlorite Solution and Moisturizers on Skin Barrier Function in Atopic Dermatitis
The goal is this study is to investigate the effects of dilute bleach on the skin of subjects with atopic dermatitis and those with healthy skin.
- Trial name
- AD (NCT02594969)
- Testing
- Bleach Bath and Moisturizers
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Blood Pressure, Salt; Excess
Sodium Glucose Cotransporter-2 Inhibitors and Salt-sensitivity in Type 2 Diabetes
The goal of this interventional study is to test whether sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce the effects of high dietary sodium intake in patients with type 2 diabetes.
- Conditions
- Blood Pressure, Salt; Excess, Diabete Type 2
- Trial name
- SALT (NCT06007157)
- Testing
- Hypersodic/Hyposodic diet
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Atopic Dermatitis (Eczema), Psoriasis
The Impact of Salt Intake on Sodium in the Skin and Inflammatory Skin Disease
The goal of this clinical trial is to demonstrate the feasibility of a trial that examines the impact of changes in dietary sodium intake on skin sodium levels, atopic dermatitis, and psoriasis.
- Trial name
- SIS-ISD (NCT07487831)
- Testing
- Sodium chloride tablets
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Seasonal Allergic Rhinitis
Effectiveness of Sodium Hyaluronate In Relieving Nasal Symptoms Of Children With Seasonal Allergic Rhinitis
Nasal irrigation (NI) is recommended as an add-on therapy in patients with allergic rhinitis (AR). The primary purpose of this study was to evaluate the clinical effectiveness of adding hyaluronic acid (HA) solution and normal…
- Trial name
- EHA (NCT04752956)
- Testing
- "Total nasal symptom score" (TNSS), Paediatric Rhinoconjunctivitis Quality of Life Questionnaire" (PRQLQ), Nasal cytology
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Blood Pressure
Analyzing Genetic Factors Involved in Blood Pressure Changes Due to Salt and Potassium Intake (The GenSalt Study)
High blood pressure is a serious health problem. In terms of diet recommendations, people with this condition are encouraged to eat a low sodium and high potassium diet.
- Trial name
- GenSalt (NCT00721721)
- Testing
- Low Sodium Diet, High Sodium Diet, Potassium Supplementation
- Where
- China
- Volunteers
- 1,906 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)