Clinical trials: Soft Tissue Cancer
Malignant Soft Tissue Sarcoma
Use of Propranolol Hydrochloride in the Treatment of Metastatic STS
Fifty patients with pathological proof of malignant soft tissue sarcoma will receive Anthracyclin based chemotherapy combined with propranolol 40 mg twice daily.
- Trial name
- NCT03108300
- Testing
- Propranolol Hydrochloride, Doxorubicin
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
HNSCC, Soft Tissue Cancer
Nano-Carbon Iron Suspension Injection Combined With Radiotherapy for Solid Tumors Phase II Clinical Trial
Study Primary Objective: To evaluate the efficacy of CNSI-Fe intra-tumoral injection combined with radiotherapy in patients with solid tumors. Study Secondary Objectives: 1.
- Trial name
- NCT07491783
- Testing
- Carbon Nanoparticle Iron Suspension for Injection
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sichuan Enray Pharmaceutical Sciences Company
Lymphangioleiomyomatosis
Pulmonary Rehabilitation in Lymphangioleiomyomatosis
Lymphangioleiomyomatosis (LAM) is a rare disease in which reduced exercise capacity is frequently present. The mechanisms applied are airflow obstruction, abnormal diffusion capacity and dynamic hyperinflation (DH).
- Trial name
- NCT02009241
- Testing
- Pulmonary Rehabilitation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Cancer, Pediatric Cancer
Study of Zanzalintinib in Children and Adolescents With Relapsed or Refractory Solid Tumors
The primary purpose of this study is to determine the pediatric maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D), and to evaluate the safety and tolerability of zanzalintinib.
- Trial name
- NCT07773454
- Testing
- Zanzalintinib
- Volunteers
- 18 people
- Sponsor
- Exelixis
Recurrent Adult Soft Tissue Sarcoma
Phase II Study of 5-Day Hypofractionated Preoperative Radiation Therapy for Soft Tissue Sarcomas: Expansion Cohort
This phase II trial studies the side effects of hypofractionated radiation therapy in treating patients with soft tissue sarcomas prior to surgery.
- Trial name
- NCT02701153
- Testing
- Conventional Surgery, Hypofractionated Radiation Therapy, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Sarcoma, Soft Tissue
Olaratumab Plus Trabectedin in Advanced Soft-tissue Sarcoma Patients Soft-tissue Sarcoma Patients
Phase I, multicentre clinical trial of olaratumab plus trabectedin in patients with advanced soft-tissue sarcoma. Olaratumab plus trabectedin could be synergistic and with a manageable toxicity profile in advanced STS.
- Trial name
- OLATRASTS (NCT03985722)
- Testing
- Olaratumab and Trabectedin
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Grupo Espanol de Investigacion en Sarcomas
Sarcoma, Bone Tumor
Dynamic Contrast Enhanced MRI(DCE-MRI)of Bone Tumors
The purpose of this study is to see whether fast imaging with MRI and the usual contrast material used for MRI, predicts which patients will do well with treatment.
- Trial name
- NCT00598741
- Testing
- DCE-MRI
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Osteosarcoma, Sarcoma
Cryoablation, Radiofrequency Ablation, or Microwave Ablation in Treating Patients With Metastatic Sarcoma Stable on Chemotherapy
This phase II trial studies how well cryoablation, radiofrequency ablation, or microwave ablation works in treating patients with metastatic sarcoma stable on chemotherapy. Cryoablation kills tumor cells by freezing them.
- Trial name
- NCT01986829
- Testing
- Microwave ablation, Cryoablation, Radiofrequency ablation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Washington University School of Medicine
Sarcoma
Phase II Study of Ridaforolimus (MK-8669) With Metastatic Bone or Soft-tissue Sarcoma Patients (MK-8669-030 AM1)
The study evaluates efficacy of Ridaforolimus when administered as maintenance therapy to patients with metastatic bone or soft-tissue sarcoma in Japan.
- Trial name
- NCT01010672
- Testing
- Ridaforolimus
- Volunteers
- 50 people
- Sponsor
- Merck Sharp & Dohme LLC
Leukemia, Lymphoma
Study of @neWorld: A Virtual Community for Children With Cancer
RATIONALE: Using an Internet Web site that enables children with cancer to interact online with classmates, participate in classroom activities, get easy-to-read medical information, and chat with family members, medical staff…
- Conditions
- Leukemia, Lymphoma, Psychosocial Effects of Cancer and Its Treatment, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00070421
- Testing
- complementary or alternative medicine procedure, management of therapy complications, psychosocial assessment and care
- Where
- United States
- Sponsor
- Leap of Faith Technologies
Sarcoma, Liposarcoma
Patient Reported Outcome Measures (PROMs) With Trabectedin
Patient reported outcome measures (PROMs) are central to understanding the impact of cancer treatments on patients. Treatment may control cancer growth, and even sometimes modestly improve the length of life, but at the expense…
- Conditions
- Sarcoma, Liposarcoma, Leiomyosarcoma
- Trial name
- NCT03959033
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Leeds
Sarcoma
MASCT-I Combined With Apatinib and/or Camrelizumab in the Treatment of Bone and Soft Tissue Sarcoma
This study will evaluate the safety and preliminary efficacy of Multi-Antigen Stimulated Cell Therapy-I Injection (MASCT-I) in combination with Apatinib and/or Camrelizumab in patients with advanced bone and soft-tissue sarcoma.
- Trial name
- NCT04074564
- Testing
- MASCT-I, Camrelizumab,Apatinib
- Where
- China
- Volunteers
- 60 people
- Sponsor
- HRYZ Biotech Co.
High-Grade Osteosarcoma
Treatment Patterns and Survival Outcomes in High-Grade Osteosarcoma: A Multicenter Retrospective Study
This is a multicenter, medical-record-based, retrospective observational study of approximately 400 patients with high-grade osteosarcoma treated at four sites in the Republic of Korea.
- Trial name
- NCT07878364
- Where
- 4 sites in South Korea
- Volunteers
- 400 people
- Sponsor
- MedPacto, Inc.
Sarcoma, Osteoid Sarcoma
Combination Immunotherapy Targeting Sarcomas
The aim of this clinical trial is to assess the feasibility, safety and efficacy of a combination low dose chemotherapy and immunotherapy in patients who have sarcoma that is relapsed or late staged.
- Conditions
- Sarcoma, Osteoid Sarcoma, Ewing Sarcoma
- Trial name
- NCT04433221
- Testing
- Multiple sarcoma-specific CAR-T cells and sarcoma vaccines
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Metastatic Esophageal, Gastric Cancer
Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors
This is an investigator-initiated industry-supported phase 1 clinical trial conducted in the phase 1 clinic at The University of Texas MD Anderson Cancer Center who will hold the Investigational New Drug (IND).
- Conditions
- Metastatic Esophageal, Gastric Cancer, Metastatic Head and Neck Carcinoma, Metastatic Hepatocellular Carcinoma
- Trial name
- NCT05075993
- Testing
- LVGN3616 + LVGN6051 + Nab-Paclitaxel, LVGN3616 + LVGN6051 + Bevacizumab + Cyclophosphamide, LVGN3616 + LVGN6051 + LVGN7409 + Nab-Paclitaxel
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- M.D. Anderson Cancer Center
Renal Cell Carcinoma, Gastrointestinal Stromal Tumor
Study to the Optimal Duration of Therapy With Oral Angiogenesis Inhibitors
The purpose of this study is to determine if and how often an unexpected fast increase of disease and complaints shows after stopping the anti-angiogenetic therapy
- Trial name
- NCT00777504
- Testing
- usage oral angiogenesis inhibitor, stop oral angiogenesis inhibitor
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Solid Tumor, Adult, Soft Tissue Sarcoma
Evaluation of AL3818 in Combination With Nivolumab in Solid Tumors
This study evaluates the safety and efficacy of AL3818 (anlotinib) hydrochloride in combination with Opdivo (nivilumab) for the treatment patients with of metastatic, advanced, or recurrent solid tumors.
- Conditions
- Solid Tumor, Adult, Soft Tissue Sarcoma, Non Small Cell Lung Cancer, Small Cell Lung Cancer
- Trial name
- NCT04165330
- Testing
- AL3818, Nivolumab Injection
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Sarcoma Oncology Research Center, LLC
Submucosal Tumor, Gastrointestinal Stromal Tumor (GIST)
CEH-EUS for Differentiating GISTs and Leiomyomas: A Multicenter Prospective Self-Controlled Study
The investigators conduct a prospective, multicenter diagnostic trial primarily aimed at evaluating the value of contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) in differentiating gastrointestinal stromal tumors…
- Conditions
- Submucosal Tumor, Gastrointestinal Stromal Tumor (GIST), Leiomyoma
- Trial name
- NCT07106411
- Testing
- Endoscopic Ultrasound, Contrast-Enhanced Harmonic Endoscopic Ultrasound (CEH-EUS)
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Huazhong University of Science and Technology
Soft Tissue Sarcoma
Circulating Tumor DNA in Soft Tissue Sarcoma
This research study will collect blood and tumor tissue samples from patients with soft tissue sarcoma to look at circulating tumor deoxyribonucleic acid (DNA).
- Trial name
- NCT03818412
- Testing
- Archival tumor tissue collection and blood draws
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Metastatic Soft Tissue Sarcoma, Unresectable Soft Tissue Sarcoma
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma
The goal of this clinical trial is to learn about the safety, tolerability and efficacy of ADCE-D01.
- Trial name
- ADCElerate1 (NCT06797999)
- Testing
- Antibody-drug conjugate (ADC)
- Where
- 9 sites in United States, Belgium and 3 more
- Volunteers
- 270 people
- Sponsor
- Adcendo ApS