Clinical trials: Soft-tissue Sarcomas
Soft Tissue Sarcoma (STS)
A Prospective, Multicenter, Open-label, Single-arm Phase II Clinical Study Evaluating the Efficacy and Safety of Spatially Fractionated Radiotherapy Combined With the PraG Strategy for the Treatment of Soft Tissue Sarcoma
The primary objective of this clinical trial is to evaluate the efficacy and safety of spatially fractionated radiotherapy combined with the PraG strategy in the treatment of soft tissue sarcoma (STS).
- Trial name
- NCT07342322
- Testing
- Spatially Fractionated Radiation Therapy Combined with Toripalimab and Human Granulocyte-Macrophage Colony-Stimulating Factor for Injection
- Where
- China
- Volunteers
- 25 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Breast Cancer, Ovarian Epithelial Cancer Recurrent
Mifepristone and Eribulin in Patients With Metastatic Triple Negative Breast Cancer or Other Specified Solid Tumors
This is a study to assess the safety of the combination of mifepristone and eribulin in patients with metastatic or locally advanced unresectable breast or other specified solid tumors, and determine preliminary efficacy of the…
- Conditions
- Breast Cancer, Ovarian Epithelial Cancer Recurrent, Sarcoma, Non-small Cell Lung Cancer
- Trial name
- NCT02014337
- Testing
- Mifepristone and Eribulin in combination
- Where
- 11 sites in United States
- Volunteers
- 37 people
- Sponsor
- Corcept Therapeutics
Soft Tissue Sarcoma
A Trial Comparing Two Medications as First Treatment in Elderly Patients With Metastatic or Advanced Soft Tissue Sarcoma
Patients with a locally advanced or metastatic (i.e., there are already metastases of the diagnosed tumor in the body outside the primary lesion) soft tissue sarcoma will be recruited for this study.
- Trial name
- EPAZ (NCT01861951)
- Testing
- Pazopanib, Doxorubicin
- Where
- 11 sites in Belgium, Germany
- Volunteers
- 120 people
- Sponsor
- Hannover Medical School
Ovarian Cancer, Carcinosarcoma
Pamiparib in Fusion Positive, Reversion Negative High Grade Serous Ovarian Cancer or Carcinosarcoma With BRCA1/2 Gene Mutations If Progression on Substrate Poly ADP Ribose Polymerase Inhibitbor (PARPI) or Chemotherapy
This study is a phase II, multi-centre, open label study in patients with advanced ovarian cancer. The treatment being tested is Pamiparib, with daily dosing.
- Trial name
- PRECISE (NCT03933761)
- Testing
- Pamiparib
- Sponsor
- Australia New Zealand Gynaecological Oncology Group
Cholangiocarcinoma, Chondrosarcoma
Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation
The purpose of this Phase I, multicenter study is to evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of AG-120 in advanced solid tumors, including glioma, that harbor an IDH1 mutation.
- Conditions
- Cholangiocarcinoma, Chondrosarcoma, Glioma, Other Advanced Solid Tumors
- Trial name
- NCT02073994
- Testing
- AG-120
- Where
- 12 sites in United States, France
- Volunteers
- 174 people
- Sponsor
- Institut de Recherches Internationales Servier
Sarcoma
Studying Biomarkers in Samples From Patients With Rhabdomyosarcoma
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01433237
- Testing
- RNA analysis, gene expression analysis, laboratory biomarker analysis
- Volunteers
- 40 people
- Sponsor
- Children's Oncology Group
High Grade Sarcoma, Sarcoma
Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT Trial
This phase II trial compares standard of care surgical resection to fluorescence-guided surgical resection using indocyanine green and fluorescence imaging for reducing unexpected positive margin rates in patients with sarcoma.
- Trial name
- NCT07650656
- Testing
- Electronic Health Record Review, Fluorescence Imaging, Fluorescence-Guided Surgery
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- City of Hope Medical Center
Leiomyosarcoma
Circulating " Cancer Cells / Macrophage " HYbrid Cells in Patients With Sarcoma, Part 2
Pilot, prospective, monocentric study aimed at evaluating the rate of patients with circulating "cancer cell/macrophage" hybrid cells in the peripheral blood and the evolution of this rate over time.
- Trial name
- SAMHY2 (NCT05427461)
- Testing
- Blood samples will be collected at different times.
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut Claudius Regaud
Leiomyosarcoma, Sarcoma
Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcoma
A phase 2 study assessing the efficacy of all-trans retinoic acid (ATRA) and Cemiplimab in patients with metastatic/locally advanced - unresectable leiomyosarcoma (LMS) who have progressed standard-of-care therapy.
- Trial name
- NCT06528769
- Testing
- all-trans retinoic acid, Cemiplimab, Computed Tomography
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Gabriel Tinoco
Breast Cancer, Ovarian Cancer
Study of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors.
This is a Phase 1, open-label, multicenter, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of PF-07224826, as a single agent or in…
- Conditions
- Breast Cancer, Ovarian Cancer, Liposarcoma, Non-small Cell Lung Cancer (NSCLC)
- Trial name
- NCT05905341
- Testing
- PF-07224826, Fulvestrant
- Sponsor
- Pfizer
Musculoskeletal Cancer, Sarcoma,Soft Tissue
Tranexamic Acid in Radical Resection and Endoprosthetic Reconstruction
This study intends to determine if any correlation exists between administration of TXA or not to musculoskeletal oncology patients undergoing endoprosthetic reconstruction and blood loss and blood transfusion rates.
- Trial name
- NCT04347122
- Testing
- Tranexamic Acid (TXA)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Kansas Medical Center
Synovial Sarcomas
Multi-center Study of TBI-1301 (INN: Mipetresgene Autoleucel; Mip-cel) in Patients With NY-ESO-1 Positive Synovial Sarcoma
The purpose of this study is to verify the safety and the efficacy of TBI-1301 for NY-ESO-1 expressing synovial sarcoma when administered following cyclophosphamide/fludarabine pre-treatment.
- Trial name
- NCT07174427
- Testing
- TBI-1301, Cyclophosphamide, Fludarabine
- Where
- 3 sites in Japan
- Volunteers
- 5 people
- Sponsor
- Takara Bio Inc.
Soft Tissue Sarcoma (STS)
A Phase Ib/II Study to Evaluate Safety and Efficacy of Bexmarilimab in Combination With Doxorubicin in Metastatic Soft-tissue Sarcoma.
This trial will Study a type of sarcoma defined metastatic soft-tissue sarcoma (STS). Participants will be treated with bexmarilimab, a CLEVER-1 antibody plus doxorubicin, a chemotherapy.
- Trial name
- BEXAR (NCT07460986)
- Testing
- bexmarilimab, Doxorubicin
- Where
- 11 sites in Spain
- Volunteers
- 278 people
- Sponsor
- MedSIR
Rare Peritoneal Surface Malignancies, Pseudomyxoma Peritonei
French National Registry of Rare Peritoneal Surface Malignancies
Despite advances in the management of and changes in clinical practice, little is known about the epidemiology, patterns of care and outcomes of rare peritoneal surface malignancies patients in France.
- Conditions
- Rare Peritoneal Surface Malignancies, Pseudomyxoma Peritonei, Peritoneal Mesothelioma, Desmoplastic Small Round Cell Tumor
- Trial name
- RENAPE (NCT02834169)
- Testing
- Non interventional
- Where
- 33 sites in France
- Volunteers
- 2,171 people
- Sponsor
- Hospices Civils de Lyon
Sarcoma
Evaluating the Use of Educational Videos in Newly Diagnosed Patients in a Medical Oncology Sarcoma Clinic
This study aims to evaluate how sarcoma-specific educational videos improve patients' knowledge of their disease and treatment options before their first clinic appointment.
- Trial name
- NCT06805773
- Testing
- Educational videos, Standard of Care
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Rhabdomyosarcoma
TAA-Specific CTLS for Solid Tumors (TACTASOM)
This is a clinical trial for patients with a solid tumor which has come back, or may come back, or has not gone away after treatment, including the standard treatment we know for these diseases.
- Trial name
- NCT02239861
- Testing
- TAA-Specific CTLs
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Baylor College of Medicine
Spindle Cell Sarcoma of Bone, Osteosarcoma
European Study in Bone Sarcoma Patients Over 40 Years
The study is a first step of a process to establish the standard chemotherapy treatment with the aim to improve outcome for patients with these rare tumours. For this reason the study will be non-controlled clinical trial.
- Trial name
- EUROBOSS (NCT02986503)
- Testing
- Doxorubicin+cisplatin+ifosfamide, Doxorubicin+cisplatin+ifosfamide+methotrexate
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 100 people
- Sponsor
- Italian Sarcoma Group
Gastric Cancer, Bladder Cancer
Safety, Tolerability and Pharmacokinetics of Oral CPL304110, in Adult Subjects With Advanced Solid Malignancies
The purpose of the study is to determine to evaluate safety and tolerability of CPL304110 when administered once daily to adults with advanced solid malignancies.
- Conditions
- Gastric Cancer, Bladder Cancer, Squamous Non-small Cell Lung Cancer, Cholangiocarcinoma
- Trial name
- NCT04149691
- Testing
- CPL304110
- Where
- 7 sites in Poland
- Volunteers
- 37 people
- Sponsor
- Celon Pharma SA
Sarcoma
Advanced MR Imaging in Sarcoma Patients
We intend to investigate the clinical application of two emerging imaging modalities for which the technical capability is currently in place at Mayo Clinic.
- Trial name
- NCT02705391
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Mayo Clinic
Bladder Cancer, Breast Cancer
A Study Comparing Oral Picoplatin With Intravenous Picoplatin in Subjects With Solid Tumors
Picoplatin is a new platinum-based chemotherapy drug that has been studied in a variety of cancers. Phase 1 and 2 studies have demonstrated that picoplatin may be effective in patients whose cancer returns or does not improve…
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Gastrointestinal Neoplasm
- Trial name
- NCT00465725
- Testing
- Picoplatin
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Poniard Pharmaceuticals
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