Clinical trials: Soft-tissue Sarcomas
Colorectal Cancer, Sarcoma
Lipid Mediators & Cancer: Montelukast, SPM, and Almonds
The purpose of this study is to create a prospective investigation to examine the effects of montelukast, almonds/almond oil, and specialized pro-resolving mediators (SPMs) on lipid profiles and tumor-associated macrophages…
- Conditions
- Colorectal Cancer, Sarcoma, Brain Tumors, Endometrial Cancer
- Trial name
- NCT06887673
- Testing
- No Interventions, Sports Pro Resolve 4 g, Double Wood SPM 4 g
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- University of South Florida
Glioma, Cholangiocarcinoma
Metformin And Chloroquine in IDH1/2-mutated Solid Tumors
This phase Ib, open-label, single-center, non-randomized clinical trial will evaluate the toxicity and efficacy of metformin and chloroquine in isocitrate dehydrogenase 1/2-mutated (IDH1/2MT) patients with a glioma, intrahepatic…
- Conditions
- Glioma, Cholangiocarcinoma, Chondrosarcoma
- Trial name
- MACIST (NCT02496741)
- Testing
- Metformin and chloroquine combination
- Where
- 3 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Bone Sarcoma, Soft Tissue Sarcoma
In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma
Sarcoma which has spread to the lungs is most often treated with surgery. Even with surgery, most patients will not be cured and will die from their disease, probably because of small cancer cells that are present in the lungs at…
- Conditions
- Bone Sarcoma, Soft Tissue Sarcoma, Pulmonary Metastases
- Trial name
- NCT02811523
- Testing
- Doxorubicin
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Acute Myeloid Leukemia, Myeloid Sarcoma
VAM in Secondary AML, AML With Extramedullary Involvement, and Myeloid Sarcoma
The mitoxantrone liposomal enhances the tissue permeability of mitoxantrone by incorporating liposomal groups compared to the conventional mitoxantrone formulation, while also reducing the concentration of free mitoxantrone…
- Trial name
- NCT07028086
- Testing
- VAM_GROUP
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Ruijin Hospital
Angiosarcoma
Prospective Observational Study of Localized Angiosarcoma of Any Site: ProStars
This study will be a multi-institutional, prospective, observational study of patients with localized primary AS of any site within ISG and RTR centers.
- Trial name
- ProStars (NCT06375941)
- Testing
- Observational
- Where
- 19 sites in Italy
- Volunteers
- 250 people
- Sponsor
- Italian Sarcoma Group
HLA-A*0201 Positive Cells Present, Locally Advanced Malignant Neoplasm
Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer
This phase I clinical trial evaluates the safety and feasibility of administering NY-ESO-1 TCR (T cell receptor)engineered peripheral blood mononuclear cells (PBMC) and peripheral blood stem cells (PBSC) after a myeloablative…
- Conditions
- HLA-A*0201 Positive Cells Present, Locally Advanced Malignant Neoplasm, NY-ESO-1 Positive, Unresectable Malignant Neoplasm
- Trial name
- NYESO SCT (NCT03240861)
- Testing
- 18F-FHBG, Aldesleukin, Busulfan
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Relapsed or Refractory Pediatric Malignant Solid Tumors (Including Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma, Osteosarcoma)
Liposomal Irinotecan, Vincristine, Temozolomide, and Anlotinib for R/R Pediatric Solid Tumors
This is a prospective, single-center, single-arm interventional trial conducted at Tianjin Medical University Cancer Institute and Hospital.
- Trial name
- NCT07444918
- Testing
- Liposomal Irinotecan, Vincristine, Temozolomide, and Optional Anlotinib
- Volunteers
- 33 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Soft Tissue Sarcoma
Ferumoxytol-Enhanced MRI in Adult/Pedi Sarcomas
This research study is a pilot study to evaluate a new contrast agent, ferumoxytol, for the purpose of imaging lymph node metastases in patients with soft tissue sarcoma. This contrast agent is an investigational drug.
- Trial name
- NCT01663090
- Testing
- Ferumoxytol
- Where
- 4 sites in United States
- Sponsor
- Dana-Farber Cancer Institute
Soft Tissue Sarcoma
Study of Oral Ridaforolimus in Combination With Standard Chemotherapy for Soft Tissue Sarcoma
Ridaforolimus has been tested in almost 2 dozen studies; however, it has not previously been tested in combination with the standard of care chemotherapy for sarcoma as this study will.
- Trial name
- NCT01296659
- Testing
- ridaforolimus
- Where
- United States
- Sponsor
- The University of Texas Health Science Center at San Antonio
Sarcoma, Gastro-intestinal Stromal Tumors (GIST)
Prospective Multicentric Randomized Study of Glivec® in Advanced GIST Expressing C-kit: Interruption After 5 Years vs Maintenance
Gastrointestinal stromal tumors (GISTs) are associated with a dismal prognosis in localized and advanced phase with a major resistance to conventional chemotherapy agents.
- Trial name
- NCT00367861
- Testing
- interruption of Glivec®
- Where
- 8 sites in France
- Volunteers
- 564 people
- Sponsor
- Centre Leon Berard
Glioma, Sarcoma
A Phase I Study of SU101 in Pediatric Patients With Refractory Malignancy
A dose escalation scale consisting of 5 dosage levels is being used to determine the maximum tolerated dose (MTD) of SU101. A minimum of 3 and a maximum of 6 patients will be enrolled at each dose level.
- Trial name
- NCT00001573
- Testing
- SU101
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Oligoprogressive
Locally ablatiVe therApy in oLigO-pRogressive sOlid tUmorS (VALOROUS)
This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective.
- Conditions
- Breast Cancer, Oligoprogressive, Head and Neck Cancer, Sarcoma
- Trial name
- VALOROUS (NCT06103669)
- Testing
- Ablative local therapy
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of California, Davis
Soft Tissue Sarcoma
Gemcitabine and Docetaxel With Radiation in Adults With Soft Tissue Sarcoma of the Extremities
The purpose of this Phase 1 research study is to obtain data or information on the safety and effectiveness of the combination of gemcitabine, docetaxel with radiation.
- Trial name
- NCT04037527
- Testing
- Gemcitabine, Docetaxel, Radiation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Wake Forest University Health Sciences
Sarcoma
Rosiglitazone in Treating Patients With Liposarcoma
RATIONALE: Rosiglitazone may help liposarcoma cells develop into normal fat cells. PURPOSE: Phase II trial to study the effectiveness of rosiglitazone in treating patients who have liposarcoma.
- Trial name
- NCT00004180
- Testing
- rosiglitazone maleate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Dana-Farber Cancer Institute
Melanoma, Gastrointestinal Neoplasms
Pilot Study to Determine Pro-Inflammatory Cytokine Kinetics During Immune Checkpoint Inhibitor Therapy
This research aims to identify clinical strategies to manage adverse events during immune checkpoint inhibitor therapy by (1) determining the impact of checkpoint inhibitors on metabolism through major CYP enzymes and (2)…
- Conditions
- Melanoma, Gastrointestinal Neoplasms, Genitourinary Cancer, Thoracic Cancer
- Trial name
- ICI-PICK (NCT05707286)
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Indiana University
Neurofibromatosis Type 1, Sarcoma
Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, ifosfamide, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00304083
- Testing
- filgrastim, doxorubicin hydrochloride, etoposide
- Where
- 17 sites in United States
- Volunteers
- 48 people
- Sponsor
- Sarcoma Alliance for Research through Collaboration
Kidney Cancer, Leukemia
Traumeel® S in Preventing and Treating Mucositis in Young Patients Undergoing Stem Cell Transplantation
RATIONALE: Traumeel® S (a mouth rinse) may be effective in preventing or decreasing the severity of oral mucositis caused by chemotherapy in young patients who are undergoing stem cell transplantation.
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Neuroblastoma
- Trial name
- NCT00080873
- Testing
- Traumeel S
- Where
- 44 sites in United States, Australia and 2 more
- Volunteers
- 195 people
- Sponsor
- Children's Oncology Group
HIV Infections, Giant Lymph Node Hyperplasia
Rituximab in the Treatment of HIV Associated Multicentric Castleman Disease Dependent on Chemotherapy
This trial is aimed to study the efficacy of 4 weekly cycles of rituximab in HIV-infected patients with multicentric Castleman disease (giant lymph node hyperplasia) dependent on chemotherapy.
- Trial name
- NCT00127569
- Testing
- Rituximab
- Volunteers
- 25 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Soft Tissue Sarcoma (STS), Bone Cancer Tumor
Development of a Radiomics Model With MR to Predict the Occurence of a Infiltration of Muscoskeletal Tumor
The goal of this observational study is to evaluate the feasibility and clinical utility of radiomics to diagnose peri-lesion tumour infiltration of tumours in participants with a suspect of Bone Cancer Tumor or Soft Tissue…
- Trial name
- NCT06774729
- Where
- Italy
- Volunteers
- 122 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Endometrial Cancer, Kidney Cancer
Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether giving chemotherapy after surgery is more effective than surgery alone in…
- Conditions
- Endometrial Cancer, Kidney Cancer, Ovarian Cancer, Pheochromocytoma
- Trial name
- NCT00002641
- Testing
- filgrastim, doxorubicin hydrochloride, ifosfamide
- Where
- 45 sites in Austria, Belgium and 11 more
- Volunteers
- 350 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
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