Clinical trials: Soft-tissue Sarcomas
Locally Advanced or Metastatic Solid Tumors
Study to Assess Safety, Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Participants With Locally Advanced or Metastatic Solid Tumors
The primary objective of this study was to determine the safety and tolerability of pamiparib, the maximum tolerated dose (MTD) or maximum administered dose (MAD) for pamiparib combined with TMZ, to select the recommended Phase 2…
- Trial name
- NCT03150810
- Testing
- Pamiparib, Temozolomide
- Where
- 22 sites in United States, Australia and 2 more
- Volunteers
- 139 people
- Sponsor
- BeiGene
Solid Tumor
A Study in Advanced Solid Tumors
The primary purpose of this study is to help answer the following research question(s): To see how the body absorbs, processes, and gets rid of cetuximab when the drug is taken in combination with carboplatin [pharmacokinetic…
- Trial name
- NCT01063075
- Testing
- Cetuximab, Carboplatin, 5 - FU
- Where
- 8 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Eli Lilly and Company
Soft Tissue Sarcoma, Undifferentiated Pleomorphic Sarcoma
Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcoma
This is an open label, two-stratum, phase 2 clinical trial evaluating the efficacy of 9-ING-41 in combination with gemcitabine/docetaxel in patients ≥10 years of age with advanced sarcoma.
- Conditions
- Soft Tissue Sarcoma, Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma, Leiomyosarcoma
- Trial name
- NCT05116800
- Testing
- Gemcitabine, 9-ING-41, Docetaxel
- Where
- 2 sites in United States
- Sponsor
- Brown University
Tumor Hyperinsulinism (Tumor HI)
A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
The objectives of this study are to evaluate the glycemic efficacy, safety, and tolerability of ersodetug as add-on to standard of care (SOC) therapy for treatment of hypoglycemia in patients with Tumor Hyperinsulinism (Tumor HI).
- Trial name
- Tumor HI (NCT06881992)
- Testing
- Ersodetug
- Where
- 13 sites in United States, France and 3 more
- Volunteers
- 16 people
- Sponsor
- Rezolute
BCC - Basal Cell Carcinoma, SCC - Squamous Cell Carcinoma
L19IL2/L19TNF in Skin Cancer Patients
Phase II, open label, multicentric, proof-of-principle basket trial in patients with malignant tumors of the skin amenable to intratumoral injection, and in a curative or neoadjuvant or palliative intention.
- Conditions
- BCC - Basal Cell Carcinoma, SCC - Squamous Cell Carcinoma, Merkel Cell Carcinoma, Keratoacanthoma of Skin
- Trial name
- IntriNSiC (NCT05329792)
- Testing
- L19IL2/L19TNF
- Where
- 14 sites in France, Italy and 1 more
- Volunteers
- 70 people
- Sponsor
- Philogen S.p.A.
Oral Cancer, Osteosarcoma
Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed Tomograhy
The primary endpoint is the assessment of the clinical value of a novel high-resolution mobile PET-CT scanner for intraoperative margin assessment in oral squamous cell carcinoma, soft tissue sarcoma and osteosarcoma surgery.
- Conditions
- Oral Cancer, Osteosarcoma, Soft Tissue Sarcoma, Oral Squamous Cell Carcinoma (OSCC)
- Trial name
- qMAP (NCT06726512)
- Testing
- XEOS AURA 10
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Neuroblastoma, Rhabdomyosarcoma
Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO)
Methodology: Prospective, multicentric, open, non-randomised, non-therapeutic, interventional study
- Conditions
- Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, Osteosarcoma
- Trial name
- MICCHADO (NCT03496402)
- Testing
- Sampling on blood, bone marrow and cerebrospinal fluid
- Where
- 30 sites in France
- Volunteers
- 600 people
- Sponsor
- Institut Curie
Advanced Soft Tissue Sarcoma
Pegylated Liposomal Doxorubicin (PLD) Versus Active Surveillance for Advanced Soft Tissue Sarcoma Patients Who Had Controlled Disease After Standard Anthracycline-based Treatment (MELODY)
Maintenance Pegylated Liposomal Doxorubicin (PLD) Versus Active Surveillance for Advanced Soft Tissue Sarcoma Patients Who Had Controlled Disease After Standard Anthracycline-based Treatment (MELODY)
- Trial name
- MELODY (NCT06981637)
- Testing
- Pegylated liposomal doxorubicin
- Where
- 7 sites in Taiwan
- Volunteers
- 81 people
- Sponsor
- National Health Research Institutes, Taiwan
Epithelioid Sarcoma
An Observational Study on Epithelioid Sarcoma
Prospective Italian study aimed to provide a description of the population affected by Epithelioid Sarcoma (ES)
- Trial name
- EPISObs (NCT03099681)
- Testing
- Treatment for Epitheloid Sarcoma
- Where
- 11 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Italian Sarcoma Group
Lung Cancer
Cytogenetic and Molecular Genetic Studies in Bone Sarcomas
To establish a serial ascertainement of specimens from patients with bone sarcomas to be used in ongoing cytogenetic and molecular genetic analyses.
- Trial name
- NCT00579930
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Kaposi Sarcoma, Human Immunodeficiency Virus
Impact of Valganciclovir on Severe IRIS-Kaposi Sarcoma Mortality: an Open-label, Parallel, Randomized Controlled-trial.
Kaposi sarcoma (KS) has an unpredictable course, patients with disseminated KS starting combined Antiretroviral Therapy can develop Immune Reconstitution Syndrome (IRIS), with a severe clinical presentation and high mortality…
- Conditions
- Kaposi Sarcoma, Human Immunodeficiency Virus, Immune Reconstitution Syndrome
- Trial name
- NCT03296553
- Testing
- Valganciclovir, Antiretroviral Combinations
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- National Institute of Cancerología
Castration-Resistant Prostate Carcinoma, Metastatic Colorectal Carcinoma
Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial
This trial compares cryoablation combined with stereotactic body radiation therapy to stereotactic body radiation therapy alone to see how well they work in treating patients with pain from cancer that has spread to the bones…
- Conditions
- Castration-Resistant Prostate Carcinoma, Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm
- Trial name
- NCT04693377
- Testing
- Cryosurgery, Quality-of-Life Assessment, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Myeloproliferative Disorders, Kidney Cancer
Light-Emitting Diode Therapy in Preventing Mucositis in Children Receiving Chemotherapy With or Without Radiation Therapy Before Bone Marrow Transplantation
RATIONALE: Light-emitting diode (LED) therapy may be able to prevent mucositis of the mouth. PURPOSE: Randomized phase II trial to determine the effectiveness of LED therapy in preventing mucositis of the mouth in children who…
- Conditions
- Chronic Myeloproliferative Disorders, Kidney Cancer, Leukemia, Lymphoma
- Trial name
- NCT00036712
- Testing
- management of therapy complications, pain therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical College of Wisconsin
Breastcancer, Phyllodes Breast Tumor
Establishing Technique for PECS2 Catheter Insertion
The investigators are trying to establish an easy technique for insertion of a catheter for continuous infusion while performing pectoral type 2 (serratus) block, as a post operative pain controlling measure for cases undergoing…
- Trial name
- ETCI (NCT03030677)
- Testing
- Pectoralis II block & catheter without Lidocaine dissection, Pectoralis II block & catheter with Lidocaine dissection, catheter insertion
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kasr El Aini Hospital
Sarcoma, Soft Tissue, Retroperitoneal Sarcoma
Colorectal Resections in Patients With Retroperitoneal Sarcoma
COLOSARC-Q is a multicenter study with the objective of providing an up-to-date assessment of colorectal resections and reconstruction techniques in the context of multivisceral resections for retroperitoneal sarcomas, as well as…
- Trial name
- COLOSARC-Q (NCT06943612)
- Where
- 16 sites in Germany, Switzerland
- Volunteers
- 120 people
- Sponsor
- Heidelberg University
Sarcoma, Kaposi, HIV Infections
A Study of Targretin Capsules in Patients With AIDS-Related Kaposi's Sarcoma
The purpose of this study is to see if it is safe and effective to give Targretin capsules to patients with AIDS-related Kaposi's sarcoma (KS).
- Trial name
- NCT00002212
- Testing
- Bexarotene
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Ligand Pharmaceuticals
Soft Tissue Sarcoma Adult, Angiosarcoma
Propranolol and Pembrolizumab in Advanced Soft Tissue Sarcoma Patients
The goal of this phase 2 clinical trial is to test efficacy and tolerability of combining propranolol and pembrolizumab in patients with advanced angiosarcoma or undifferentiated pleomorphic sarcoma.
- Conditions
- Soft Tissue Sarcoma Adult, Angiosarcoma, Undifferentiated Pleomorphic Sarcoma
- Trial name
- PROPANE (NCT05961761)
- Testing
- Propranolol, Pembrolizumab
- Where
- 4 sites in Denmark, Norway and 1 more
- Volunteers
- 80 people
- Sponsor
- Niels Junker
Sarcoma
Study of RAD001 in Soft Tissue Extremity and/or Retroperitoneal Sarcomas
The goal of this clinical research study is to learn if the study drug RAD001 can stop or slow the growth of resectable soft tissue sarcoma.
- Trial name
- NCT01048723
- Testing
- RAD001
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Soft Tissue Sarcoma, Uterine Sarcoma
Continuing vs Intermittent Trabectedin in Patients With Advanced Soft Tissue Sarcoma
This randomization discontinuation trial will allow for concomitant evaluation of the following: Side effects and benefits of immediate continuation of Trabectedin after the sixth cycle Side effects and benefits of a drug holiday
- Trial name
- T-DIS (NCT01303094)
- Testing
- Trabectedin, Drug: holiday
- Where
- 16 sites in France
- Volunteers
- 53 people
- Sponsor
- Centre Oscar Lambret
Cancer
Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as thrombopoietin and G-CSF may increase the number of immune cells found in…
- Trial name
- NCT00003597
- Testing
- recombinant human thrombopoietin, carboplatin, etoposide
- Where
- 24 sites in United States, Australia
- Volunteers
- 16 people
- Sponsor
- Children's Oncology Group
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.