Clinical trials: Solid Organ Transplant Complications
Kidney Transplantation
Urinary Tract Infections in Kidney Transplant Recipients
The purpose of this study is to better estimate the prevalence of urinary tract infections (UTI) in kidney transplant (KIT) recipients, and especially multidrug resistant (MDR) bacteria.
- Trial name
- URIKIT (NCT03211026)
- Testing
- No intervention
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Poitiers University Hospital
Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD)
A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases
The purpose of this study is to assess the efficacy and safety of tabelecleucel in participants with EBV-associated diseases.
- Conditions
- Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD), EBV+ Lymphoproliferative Disease With Acquired (Non-congenital) Immunodeficiency (EBV+ AID LPD), EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)
- Trial name
- NCT04554914
- Testing
- Tabelecleucel
- Where
- 40 sites in United States, Austria and 5 more
- Volunteers
- 190 people
- Sponsor
- Pierre Fabre Medicament
Solid Organ Transplant Recipient, Skin Cancer
The Organ Transplant Recipient HPV and Skin Cancer Study
Solid organ transplant recipients (OTRs) receive lifelong immunosuppressive therapy, which puts them at increased risk of cutaneous and mucosal cancers.
- Conditions
- Solid Organ Transplant Recipient, Skin Cancer, Skin Dysplasia, HPV Infection
- Trial name
- NCT05284877
- Testing
- No intervention
- Where
- 3 sites in Denmark
- Volunteers
- 1,500 people
- Sponsor
- Merete Haedersdal
Complication of Transplanted Organ, Nos
Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance
This open-label, proof-of-principle two center cohort study will evaluate the ability of autologous hematopoietic stem cell transplantation to induce tolerance in recipients of deceased or live donor liver transplants (ASCOTT).
- Trial name
- ASCOTT (NCT02549586)
- Testing
- Autologous Hematopoietic Stem Cell Transplant
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- Gary A Levy, O. Ont. MD. FRCP AGAF
Transplantation Infection, Kidney Transplant; Complications
Intestinal Microbiome Dynamics in Solid Organ and Stem Cell Transplant Recipients
This is a pilot study designed to investigate the alterations in the gut microbiome that occur during the course of kidney transplantation, liver transplantation, allogeneic hematopoietic stem cells and mesenchymal stem cells…
- Conditions
- Transplantation Infection, Kidney Transplant; Complications, Stem Cell Transplant Complications, Liver Transplant; Complications
- Trial name
- NCT04281797
- Testing
- Intestinal microbiome new generation sequencing
- Where
- Belarus
- Volunteers
- 90 people
- Sponsor
- Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology
HHV8, HHV8 Infection
HHV8 and Solid Organ Transplantation
Solid organ transplant candidates will undergo serological screening for HHV8 at time of listing and transplantation. In the event of a recipient/donor mismatch R-/D+ or in the presence of a seropositive recipient (R+), blood…
- Conditions
- HHV8, HHV8 Infection, HHV8-Related Malignant Neoplasm, Kaposi Sarcoma
- Trial name
- NCT05081141
- Testing
- Diagnostic test for HHV8 exposure
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
HIV Infections, Kidney Disease
Kidney and Liver Transplantation in People With HIV
With improved anti-HIV drug therapy, HIV infected patients are now living longer. These patients are at risk for liver and kidney failure and may need organ transplants.
- Conditions
- HIV Infections, Kidney Disease, Liver Disease
- Trial name
- NCT00074386
- Where
- 21 sites in United States
- Volunteers
- 275 people
- Sponsor
- University of California, San Francisco
RENAL INSUFFICIENCY, CHRONIC, LIVER FAILURE, ACUTE
Safety and Efficacy of ProQuad® in Children 6-24 Month Being Evaluated for Solid Organ Transplant
A prospective, multisite study to evaluate the Impact of Measles, Mumps, Rubella and Varicella ProQuad® vaccination in pediatric patients 6-24 months of age who are being considered and/or evaluated for any solid organ transplant…
- Conditions
- RENAL INSUFFICIENCY, CHRONIC, LIVER FAILURE, ACUTE, HEART DISEASE
- Trial name
- ProQuad® (NCT02687763)
- Testing
- ProQuad
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Chronic Kidney Disease, Autoimmune Diseases
Capillary Sampling in Clinical Populations Undergoing Monitoring
Many people with long-term health conditions require regular blood tests to monitor their disease or medications. These blood tests are usually performed by taking blood from a vein during a hospital or clinic appointment.
- Conditions
- Chronic Kidney Disease, Autoimmune Diseases, Solid Organ Transplant Recipients
- Trial name
- CAPSICUM (NCT07802665)
- Testing
- Blood sampling with capillary sampling device(s)
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Acute Kidney Injury, Chronic Kidney Diseases
Molecular Prediction of Development, Progression or Complications of Kidney, Immune or Transplantation-related Diseases
Managing patients with renal failure requires an understanding of the molecular mechanisms that lead to its occurrence (i.e. upstream of the disease), its worsening and its persistence (i.e.
- Conditions
- Acute Kidney Injury, Chronic Kidney Diseases, Solid-organ Transplantation, Cancer
- Trial name
- NEPHROGENE2 (NCT05318196)
- Testing
- Biological samples collection
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Toulouse
Solid Organ Transplant Complications, Solid Organ Transplant Recipients
Phase I Trial on the Safety of Delayed Infusion of a Naïve T Cell-Depleted Hematopoietic Graft With Memory T Cells in Solid Organ Transplant Recipients
The goal of this clinical trial is to evaluate the safety and feasibility of inducing hematopoietic mixed chimerism to promote immune tolerance and potentially reduce the need for lifelong immunosuppression in pediatric and adult…
- Conditions
- Solid Organ Transplant Complications, Solid Organ Transplant Recipients, Solid Organ Transplant Rejection
- Trial name
- DUALGRAFT (NCT06997471)
- Testing
- Investigational cellular therapy consisting on a HSCT using a graft enriched in CD34+, depleted of naïve T-lymphocytes and supplemented with memory lymphocytes
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Francisco Hernández Oliveros
Malignancy, Transplant Complication
Epidemiology of Complications After Solid Organ Transplantation - EpCOT Study
Cancer remains a major cause of morbidity and mortality post solid organ transplantation. While mortality from the other leading causes of death post-transplantation (e.g.
- Conditions
- Malignancy, Transplant Complication, Cancer, Kidney Failure
- Trial name
- EpCOT (NCT02991105)
- Where
- 2 sites in United Kingdom
- Volunteers
- 85,410 people
- Sponsor
- University of Birmingham
Solid Organ Transplantation, Pregnancy
Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth.
- Conditions
- Solid Organ Transplantation, Pregnancy, Long-term Follow-up, Kidney Transplant
- Trial name
- NCT07291258
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Acute Kidney Injury
Cell Cycle Arrest Proteins for Early Diagnosis of Acute Kidney Injury After Solid Organ Transplant
Renal failure is a common complication of lung transplant (LUTX) and orthotopic liver transplantation (OLTX). Early diagnosis of acute kidney injury (AKI) in this cohort is of utmost importance, since AKI after solid organ…
- Trial name
- LUTX/OLTX_AKI (NCT05907434)
- Testing
- Nephrocheck (AKI score)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Policlinico Hospital
Immunocompromised Host, Organ Transplantation
Cancer Risk in Organ Transplant Recipients and End-Stage Renal Disease
Background: Solid organ transplantation provides life-saving treatment for end-stage organ disease but is associated with an increased cancer risk because of the need for long-term immunosuppression End-stage renal disease…
- Conditions
- Immunocompromised Host, Organ Transplantation, Cancer
- Trial name
- NCT00904579
- Where
- 9 sites in United States
- Volunteers
- 19,929,901 people
- Sponsor
- National Cancer Institute (NCI)
End-stage Renal Failure
The ONE Study UK Treg Trial
A study to assess cell therapy as a treatment to prevent kidney transplant rejection. The trial will involve purification of naturally occurring regulatory T cells (nTregs) from living-donor renal transplant recipients.
- Trial name
- ONETreg1 (NCT02129881)
- Testing
- Autologous regulatory T Cell Product
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cytomegalovirus Infections, Varicella Zoster Virus Infection
Herpesvirus Immunology in Solid Organ Transplant Recipients - Liver Transplant Study
Liver transplantation is the only curative treatment of end-stage liver disease, and every year, around 60 patients undergo liver transplantation in Denmark.
- Conditions
- Cytomegalovirus Infections, Varicella Zoster Virus Infection, Liver Transplant; Complications
- Trial name
- HISTORY (NCT05532540)
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Susanne Dam Nielsen, MD, DMSc
Kidney Transplant; Complications
Solid Organ Transplant SHINGRIX
This study will assess the immune responses to the recombinant, AS01-adjuvanted varicella zoster virus subunit (HZ/su) vaccine or SHINGRIX in immunosuppressed patients, particularly those who have received a renal transplant, and…
- Trial name
- NCT03993717
- Testing
- SHINGRIX
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Emory University
Viral Infections
Virus Surveillance in Pediatric Solid Organ Transplant Recipients
Viral infections are an important complication of transplantation. Immunosuppressive therapy interferes with T cell immunity resulting in a high incidence of viral infection.
- Trial name
- NCT00886158
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Seattle Children's Hospital
Cervical Cancer
Protecting Young Special Risk Females From Cervical Cancer Through Human Papilloma Virus (HPV) Vaccination
A research project is currently being undertaken looking at Human Papilloma Virus (HPV) vaccination in special risk groups. It aims to see if young women with a chronic illness respond well to the HPV vaccine or whether they may…
- Trial name
- HPV (NCT00964210)
- Testing
- Licensed quadrivalent HPV vaccine, Gardasil
- Where
- Australia
- Volunteers
- 240 people
- Sponsor
- Murdoch Childrens Research Institute