Clinical trials: Solid Organ Transplantation
Cytomegalovirus Infection
Quantiferon - Cytomegalovirus (CMV) and the Prediction of CMV Infection In High Risk Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut, and the liver.
- Trial name
- NCT00817908
- Where
- Canada
- Volunteers
- 131 people
- Sponsor
- University of Alberta
Solid Organ Transplant
iPeer2Peer Pediatric Thoracic Transplantation
With the on-going presence of a chronic illness, daily immunosuppressive medications, and the need for continuous medical supervision, pediatric transplant recipients face considerable psychosocial stresses.
- Trial name
- NCT04253548
- Testing
- iPeer2Peer Support Mentorship Program
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- The Hospital for Sick Children
Cytomegalovirus Infections, Solid Organ Transplantation Recipient
CMV Refractory and Resistant Infection in Solid Organ Transplant Recipients in Argentina
This study will describe the frequency and characteristics of refractory and resistant cytomegalovirus (CMV) infection in adults who received a solid organ transplant in Argentina between 2017 and 2024.
- Conditions
- Cytomegalovirus Infections, Solid Organ Transplantation Recipient, Solid Organ Transplantation
- Trial name
- NCT07787767
- Where
- Argentina
- Volunteers
- 200 people
- Sponsor
- Hospital Italiano de Buenos Aires
Pediatric Solid Organ Transplant Patients
Standard Dose Versus High-Dose Inactivated Flu Vaccine in Pediatric Solid Organ Transplant Patients
This is a phase I trial in which the both the safety and immunogenicity of the standard dose flu vaccine will be compared with high dose flu vaccine in children that have undergone solid organ transplantation (SOT).
- Trial name
- NCT01525004
- Testing
- High-Dose trivalent inactivated influenza vaccine, Standard dose trivalent inactivated influenza vaccine
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Vanderbilt University
Acute Kidney Injury
Cell Cycle Arrest Proteins for Early Diagnosis of Acute Kidney Injury After Solid Organ Transplant
Renal failure is a common complication of lung transplant (LUTX) and orthotopic liver transplantation (OLTX). Early diagnosis of acute kidney injury (AKI) in this cohort is of utmost importance, since AKI after solid organ…
- Trial name
- LUTX/OLTX_AKI (NCT05907434)
- Testing
- Nephrocheck (AKI score)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Policlinico Hospital
Influenza Vaccine
Intradermal Versus Intramuscular Trivalent Influenza Vaccine in Adult Solid Organ Transplant Recipients
Influenza virus is an important cause of morbidity in the transplant population and can lead to viral and bacterial pneumonia and contribute to the development of rejection.
- Trial name
- NCT01180699
- Testing
- Influenza vaccine: Vaxigrip or Fluviral and Intanza
- Where
- Canada
- Volunteers
- 229 people
- Sponsor
- University of Alberta
Cancer, Hematopoietic System--Cancer
Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients
This study is being done because the investigators would like to learn more about how well the COVID-19 vaccine works in participants with cancer or those who have received a transplant or cellular therapy.
- Conditions
- Cancer, Hematopoietic System--Cancer, Transplant-Related Cancer, Solid Tumor Malignancy
- Trial name
- NCT05164016
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- St. Jude Children's Research Hospital
Influenza, Solid Organ Transplant
Early Flu Shots in SOT
Although time from transplant has been a factor in vaccine response, there is limited data on immunizations that occur in the first post-transplant year, and there are no data that suggest influenza vaccination early…
- Trial name
- NCT03327987
- Testing
- standard of care influenza vaccine
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Cytomegalovirus Infections, Infection in Solid Organ Transplant Recipients
Letermovir for Secondary Prophylaxis in Solid Organ Transplant Recipients
This is a research study to test the tolerability and clinical effectiveness of the study drug, Letermovir (LET), when used as secondary prophylaxis following treatment of Cytomegalovirus (CMV) infection and disease in a solid…
- Conditions
- Cytomegalovirus Infections, Infection in Solid Organ Transplant Recipients, Neutropenia, Antiviral Toxicity
- Trial name
- NCT05626530
- Testing
- Letermovir
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Tufts Medical Center
Chronic Kidney Disease, Stage 4, Chronic Kidney Disease, Stage 5
BZLF1 Peptide Vaccine (OSU-2131) With QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants
This phase 1B trial tests the safety, side effects and best dose of rh-Hsc70- BZLF1 peptide complex (OSU-2131) with Stimulon (Trademark) QS-21 and evaluates how well it works in preventing Epstein-Barr virus (EBV) infection and…
- Conditions
- Chronic Kidney Disease, Stage 4, Chronic Kidney Disease, Stage 5, EBV-Related Lymphoproliferative Disorder, EBV-Related Malignant Neoplasm
- Trial name
- NCT06741072
- Testing
- Biospecimen Collection, Dulbecco''s Phosphate-Buffered Saline, Peptide Vaccine
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Invasive Fungal Infection, Hematological Malignancy
Prospective Clinical Evaluation of Beta-D-Glucan Assay in Blood and BAL
In patients with invasive fungal infection (IFI) rapid diagnosis is essential for early initiation of appropriate antifungal therapy and thereby survival. Conventional culture is still the Gold-Standard for diagnosis of IFI.
- Conditions
- Invasive Fungal Infection, Hematological Malignancy, Receipt of Solid Organ Transplant
- Trial name
- NCT01576653
- Testing
- Fungitell Assay in BAL
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Robert Krause, MD
CMV Specific Immune Response, Kidney Transplant
Risk Factors Associated With the Absence of CMV-specific Cellular Immune Response in the Early Post-transplant Period in Low-risk CMV-seropositive Kidney Transplant Recipients
The goal of this observational study is to identify risk factors associated with the absence of CMV-specific cellular immune response in low-risk CMV-seropositive kidney transplant recipients in the early post-transplant period.
- Conditions
- CMV Specific Immune Response, Kidney Transplant, Kidney Transplant Recipient, CMV Reactivation
- Trial name
- PREDICOR (NCT07621835)
- Where
- Spain
- Volunteers
- 236 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Cytomegalovirus Infections, Heart Transplantation
Quantiferon CMV to Identify Treatment Need for Asymptomatic CMV Infection After Solid Organ Transplant (QUANTIFOT)
Context Cytomegalovirus (CMV) infection is a frequent and potentially severe event in solid organ transplant (SOT) recipients. Most of available treatment display adverse effects that limit their use.
- Conditions
- Cytomegalovirus Infections, Heart Transplantation, Kidney Transplantation, Lung Transplantation
- Trial name
- QUANTIFOT (NCT06341543)
- Testing
- Quantiferon CMV (assay that determine the presence of CMV-specific T lymphocytes)., Communication of the result of the QF-CMV to the clinician in charge
- Where
- France
- Volunteers
- 288 people
- Sponsor
- University Hospital, Grenoble
Surgical Operation With Transplant of Whole Organ
CRISTEL Study: Monitoring of Pregnancies in Women After Solid Organ Transplantation
The objective of this research is to obtain standardized and independent data on the number of pregnancies occurring in France and their follow-up up to 1 year postpartum (or post-pregnancy termination).
- Trial name
- CRISTEL (NCT07592806)
- Testing
- Blood sample
- Volunteers
- 2,000 people
- Sponsor
- Hopital Foch
Invasive Fungal Infection, Solid Organ Transplantation
Liposomal Amphotericin B for Invasive Fungal Disease in Solid Organ Transplant Recipients
This real-world observational study aims to evaluate the effectiveness, safety, and therapeutic drug monitoring (TDM) of liposomal amphotericin B (L-AmB) in solid organ transplant recipients with invasive fungal disease (IFD).
- Conditions
- Invasive Fungal Infection, Solid Organ Transplantation, Opportunistic Infections
- Trial name
- LAMB-SOT (NCT07656493)
- Testing
- Liposomal Amphotericin B, Alternative Systemic Antifungal Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sichuan Provincial People's Hospital
Solid Organ Transplant, Fusariosis
Fusariosis in Solid-Organ Transplant Recipients
This exempt chart review study will try to determine the clinical presentation, prognostic factors, response to different treatment modalities and mortality among patients diagnosed with fusariosis after solid-organ…
- Trial name
- NCT00518778
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Cytomegalovirus Infections, Solid Organ Transplant
A Dose-Escalation Study Evaluating Safety and Tolerability of Viral-Specific T Cells Against CMV in Adult Solid Organ Transplant Recipients
This study measures the tolerability of viral-specific T cells against Cytomegalovirus (CMV) in adult solid organ transplant (SOT) recipients. Participants are expected to be on study for 52 +/- 3 weeks.
- Trial name
- NCT03950414
- Testing
- CMV specific T-cells
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Wisconsin, Madison
COVID-19
Covid Vaccination in Liver Transplantation
The goal of this retrospective study is to evaluate the proportion of seroconversion after 2 doses mRNA anti-SARS-CoV2 vaccination in a cohort of high risk liver transplanted patients.
- Trial name
- VACCHEPA (NCT05079165)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Cytomegalovirus (CMV) Infection
CytoGam for CMV Infection or Disease in Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a significant opportunistic pathogen and a major cause of morbidity and mortality in solid organ transplant recipients.
- Trial name
- NCT07009548
- Testing
- Cytogam
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fernanda P Silveira, MD, MS
COVID-19, Vaccine Adverse Reaction
COVID19 Vaccine in SOT Adult Recipients
Background: ISHLT and AASLD guidelines recommend SARS-CoV2 vaccination in all individuals undergoing lung and liver transplantation, but there are currently scarce data on the safety and efficacy of these vaccines in this…
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Response Impaired, Vaccine Reaction
- Trial name
- COVID19_VaxSOT (NCT05116748)
- Testing
- COVID19 mRNA vaccine
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico