Clinical trials: Solitary Lung Nodule
Pulmonary Nodule, Solitary, Whole-genome Methylation Sequencing
Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
Lung cancer is the first cancer in China in terms of morbidity and mortality. The problem of early diagnosis/treatment has always been concerned.
- Trial name
- NCT05415670
- Testing
- Whole-genome Methylation Sequencing(GM-seq)
- Where
- 2 sites in China
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Geneplus-Beijing Co. Ltd.
Solitary Pulmonary Nodule, Coin Lesion, Pulmonary
The Watch the Spot Trial
This study will compare two clinically accepted protocols for surveillance imaging in individuals who are found to have a small pulmonary nodule on chest computed tomography (CT) scans.
- Conditions
- Solitary Pulmonary Nodule, Coin Lesion, Pulmonary, Lung Neoplasms, Carcinoma, Non-small-cell Lung
- Trial name
- WTS (NCT02623712)
- Testing
- More Frequent Surveillance Strategy, Less Frequent Surveillance Strategy
- Where
- United States
- Volunteers
- 34,686 people
- Sponsor
- Kaiser Permanente
Solitary Pulmonary Nodules, Lung Cancer
Plasma Metabolomics as a Tool to Distinguish PET-positive Malignant From PET-positive Benign Nodules
Positron emission tomography-computed tomography (PET-CT) is an important technique in lung cancer staging, where almost no lung lesion goes undetected.
- Trial name
- NCT07087080
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 350 people
- Sponsor
- Hasselt University
AI (Artificial Intelligence), Pulmonary Nodule, Solitary
DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution
This study is a multi-centre prospective observational cohort study recruiting patients with 5-30mm solid and part-solid pulmonary nodules that have been detected on CT chest scans performed as part of routine practice.
- Conditions
- AI (Artificial Intelligence), Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer
- Trial name
- DOLCE (NCT05389774)
- Where
- 10 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Pulmonary Nodules, Solitary, Pulmonary Nodules, Multiple
Early Adjuvant Diagnosis of Pulmonary Nodules Based on CTC.
The goal of this observational clinical trial is to evaluate the value of circulating tumor cell detection in the early diagnosis of malignant pulmonary nodule.
- Trial name
- NCT06187935
- Where
- China
- Volunteers
- 172 people
- Sponsor
- China-Japan Friendship Hospital
Solitary Lung Nodule, Multiple Pulmonary Nodules
A Prospective, Non-interventional Cohort Study of Subsolid Pulmonary Nodules
Some studies have shown that the model for judging and predicting the growth of sub-solid pulmonary nodules through big data and deep learning can detect nodule growth earlier.
- Trial name
- NCT06458673
- Where
- China
- Volunteers
- 1,184 people
- Sponsor
- Guangdong Provincial People's Hospital
Pulmonary Nodule, Solitary, Lung Cancer
Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier
The goal of this observational study is to learn how a physician uses the results of the Percepta® Nasal Swab test to manage people with a newly identified pulmonary nodule.
- Trial name
- NIGHTINGALE (NCT06426628)
- Where
- 23 sites in United States, Puerto Rico
- Volunteers
- 2,400 people
- Sponsor
- Veracyte, Inc.
Pulmonary Nodule, Solitary
Added Value of a Small Camera (Iriscope) in the Endoscopic Diagnosis of Peripheral Lung Nodules and Masses
Since the beginning of lung screening program in the different countries around the world by chest CT scan, numerous lung nodules and masses of unknown etiology are diagnosed.
- Trial name
- NCT05445635
- Testing
- Iriscope
- Where
- Belgium
- Volunteers
- 91 people
- Sponsor
- Erasme University Hospital
Pulmonary Nodule, Solitary, Pulmonary Cancer
Cios Mobile 3D Spin for Robotic Bronchoscopy
Evaluate the clinical utility and early performance of the Cios 3D Mobile Spin in conjunction with the Ion Endoluminal System, to visualize and facilitate the sampling of pulmonary nodules between 1-3 cm via the airway.
- Conditions
- Pulmonary Nodule, Solitary, Pulmonary Cancer, Lung Cancer, Lung Cancer, Nonsmall Cell
- Trial name
- NCT04740047
- Testing
- Ion Endoluminal System
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
LungLB in Subjects Presenting With Indeterminate Pulmonary Nodules
Correlate performance of LungLB Test with outcome of a scheduled biopsy.
- Trial name
- NCT05171491
- Where
- 12 sites in United States
- Volunteers
- 425 people
- Sponsor
- LungLife AI
Nodule Solitary Pulmonary, NSCLC
A Registry to Evaluate the Performance of the BDX-XL2 Test
The purpose of the ORACLE Registry is to demonstrate clinical utility of the BDX-XL2 test; specifically, the potential to reduce unnecessary invasive procedures, such as biopsies and surgeries, on benign lung nodules while not…
- Trial name
- ORACLE (NCT03766958)
- Where
- 15 sites in United States
- Volunteers
- 842 people
- Sponsor
- Biodesix, Inc.
Lung Lesion(s) Requiring Evaluation, Pulmonary Metastasis
Percutaneous Localization: Open-label Registry of Thoracic Surgery
The objectives of this study are to evaluate intraoperative percutaneous lung lesion marking assisted by electromagnetic guided percutaneous navigation and related tools.
- Conditions
- Lung Lesion(s) Requiring Evaluation, Pulmonary Metastasis, Pulmonary Nodule, Solitary, Peripheral Lung Lesions
- Trial name
- PLOTS (NCT04066699)
- Testing
- Percutaneous localization of suspicious lung lesion(s) using electromagnetic navigation and tools.
- Where
- 5 sites in United States
- Volunteers
- 70 people
- Sponsor
- Veran Medical Technologies
Pulmonary Nodules, Solitary
Virtual Bronchoscopic Navigation to Increase Diagnostic Yield in Patients With Pulmonary Nodules
Background Transthoracic computed tomography (CT)-guided procedures are the current gold Standard for obtaining diagnostic biopsies of solitary pulmonary nodules (SPN) in the peripheral lung.
- Trial name
- NAVIGATOR (NCT05383105)
- Testing
- Virtual bronchoscopic navigation
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- University Medical Center Groningen
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
iNod™ Ultrasound-Guided Needle Biopsy System Study
The purpose of this study is to collect information on the iNod™ System's safety and ability to see the iNod™ biopsy needle in real-time in endobronchial lesions, peripheral lung nodules, or lung masses.
- Conditions
- Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Biopsy, Fine-Needle
- Trial name
- NCT05804435
- Testing
- iNod™ System
- Sponsor
- Boston Scientific Corporation
Lung Cancer, Pulmonary Nodule, Solitary
Application of Carbon Dioxide for Identifying the Intersegmental Plane in Thoracoscopic Segmentectomy
With the increasing acceptance of routine computed tomography (CT) screenings, early-stage lung cancer detection is becoming more frequent.
- Conditions
- Lung Cancer, Pulmonary Nodule, Solitary, Segmentectomy, Pulmonary Nodule, Multiple
- Trial name
- NCT05350137
- Testing
- 100% oxygen, Carbon dioxide
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Tongji Hospital
Lung Cancer, Solitary Pulmonary Nodule
Liquid Biopsy With PET/CT Versus PET/CT Alone in Diagnosis of Small Lung Nodules
The purpose of this study is to determine if a liquid biopsy, a method of detecting cancer from a blood draw, combined with a PET/CT scan, a type of radiological scan, is better at determining whether a lung nodule is cancerous…
- Conditions
- Lung Cancer, Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
- Trial name
- NCT05066776
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Palo Alto Veterans Institute for Research
Pulmonary Nodule, Solitary
Is Bronchoscopy Necessary in the Preoperative Workup of GGO Lung Cancer?(ECTOP-1005)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1005). It aims to evaluate the role of flexible bronchoscopy in the pre-operative workup of ground glass opacity featured lung cancer.
- Trial name
- NCT03591445
- Testing
- Flexible Bronchoscopy
- Where
- China
- Volunteers
- 615 people
- Sponsor
- Fudan University
Lung Cancer, Pulmonary Nodule, Solitary
Safety and Long-term Effects of COVID-19 Vaccines in Patients With Pulmonary Tumor
The objective of this study is to assess the inoculation-related symptoms and long-term effects of COVID-19 vaccines in patients with lung cancer or pulmonary nodules in a real-world setting.
- Conditions
- Lung Cancer, Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, COVID-19 Pneumonia
- Trial name
- CoVac-Lung (NCT04894682)
- Testing
- Vaccine inoculation against SARS-CoV-2
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
Dynamic Evolution of Pulmonary Nodules and Influence Factors of Its Clinical Decision-making
The researchers are aimed to investigate the dynamic evolution of indeterminate pulmonary nodules by a long-term follow-up of patients with different characteristics.
- Trial name
- DEPICT (NCT04857333)
- Testing
- CT scan, Antibiotics, Surgical Resection
- Where
- China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- GuiBin Qiao
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
Nitrous Oxide for Identifying the Intersegmental Plane in Segmentectomy: A Randomized Controlled Trial
Lung cancer is currently one of the most common malignant tumors in the world. In recent years, with the popularity of high-resolution CT, more and more early-stage lung cancers have been found.
- Conditions
- Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer
- Trial name
- NCT04302350
- Testing
- nitrous oxide
- Where
- 2 sites in China
- Volunteers
- 81 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University