Clinical trials: Solitary Mass
Mass Balance Study
Study on Mass Balance of [14C]HMPL-306（Isocitrate Dehydrogenase Inhibitor） in Healthy Chinese Adult Male Subjects
To evaluate the absorption, metabolism and excretion in healthy Chinese male subjects after a single oral dose of [14C]HMPL-306
- Trial name
- NCT06671873
- Testing
- 100 µCi [14C] HMPL-306
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hutchmed
Healthy Volunteers
Pharmacokinetic and Mass Balance Study of Orally Administered [14C]-AZD4205 in Healthy Adult Male Volunteers
This is a phase I, open label, healthy volunteers, ADME study with single oral administration of [14C]-AZD4205.
- Trial name
- NCT04225208
- Testing
- [14C]-AZD4205, single 50 mg oral dose administrated on day 1
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Dizal Pharmaceuticals
Healthy Participant Study
RE104 Radiolabeled Mass Balance (hAME) Study
The purpose of this study is to characterize the absorption, metabolism and routes of excretion of RE104 and its metabolites in healthy volunteers.
- Trial name
- NCT07146191
- Testing
- 2-[14C]-RE104 for Injection
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Reunion Neuroscience Inc
Obesity, Obesity (Body Mass Index >30 kg/m2)
ENLIGHT Trial: ESG With Fundal Mucosal Ablation
The ENLIGHT Trial is a single-center, randomized controlled trial evaluating whether adding fundal mucosal ablation (FMA) to endoscopic sleeve gastroplasty (ESG) improves weight loss and metabolic outcomes in adults with obesity.
- Trial name
- NCT07792226
- Testing
- Endoscopic Sleeve Gastroplasty (ESG), Fundal Mucosal Ablation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- West Virginia University
Healthy Subjects
A Study to Evaluate ACT-132577 in Healthy Male Subjects
The primary purpose of this study is to investigate the rate and routes (urine and feces) of elimination of ACT-132577, and the mass balance in urine and feces
- Trial name
- NCT03100591
- Testing
- 14C-radiolabeled ACT-132577
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Healthy
Study in Healthy Male Subjects Designed to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C] LC15-0444
This was an open-label, non-randomised, single-dose study in 6 healthy male subjects. Subjects attended a screening visit within 28 days before drug administration.
- Trial name
- NCT01603238
- Testing
- [14C]-LC15-0444
- Where
- South Korea
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Lymphoma, Non-Hodgkin
A Mass Balance Study of DZD8586 in Healthy Male Participants (TAI-SHAN15)
This phase I study is designed to evaluate absorption, metabolism and excretion (AME) profiles of [14C]-DZD8586, to determine the routes, rates of elimination, and mass balance of DZD8586 in healthy adult male participants.
- Trial name
- NCT07454863
- Testing
- DZD8586
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Dizal Pharmaceuticals
Type 2 Diabetes Mellitus
Effect of Conjugated Linoleic Acid Alone and in Conjunction With Vitamin E in Patients With Type 2 Diabetes Mellitus
Conjugated linoleic acids (CLAs) comprise a family of linoleic acid (18:2n-6; LA) isomers that are formed by biohydrogenation and oxidation processes in nature.
- Trial name
- NCT01099163
- Testing
- Tonalin SG1000T FFA
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Cardiovascular Disease, Overweight
Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Body Mass Index ≥ 27
The purpose of the study is to determine whether administration of 150 mg clopidogrel is effective in reducing the one-year incidence of thromboischemic events in patients with high on-clopidogrel platelet reactivity compared to…
- Trial name
- PLATO-dose (NCT01509365)
- Testing
- clopidogrel
- Where
- Tunisia
- Volunteers
- 116 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Non-Small Cell Lung Cancer, Metastatic Melanoma
A Study to Investigate 14C-bemcentinib in Healthy Male Subjects
The aims of this Study were to determine: How much of the Study Drug (bemcentinib) ends up in urine and faeces How much of the Study Drug and its breakdown products get into the bloodstream The breakdown products (metabolites) of…
- Conditions
- Non-Small Cell Lung Cancer, Metastatic Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndromes
- Trial name
- 8479217 (NCT06469138)
- Testing
- Bemcentinib
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- BerGenBio ASA
Healthy Participants
Metabolism, Excretion, and Mass Balance Study of Quemliclustat in Healthy Adult Participants (ARC-24)
The purpose of the study is to investigate the routes of elimination and overall mass balance of 100 mg quemliclustat containing 75 μCi [14C] following a single IV infusion of [14C]-quemliclustat in healthy adult male…
- Trial name
- NCT07364214
- Testing
- Quemliclustat
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Arcus Biosciences, Inc.
Healthy
Single Dose Mass Balance Study With C14 - Labeled AAI101 in Healthy Male Volunteers
This is an open-label, single dose, pharmacokinetic (PK) study conducted at 1 study center in the United States (USA). This study will evaluate the absorption, distribution, metabolism, and elimination (ADME), mass balance…
- Trial name
- NCT03775668
- Testing
- 1 µCi of 14C-AAI101 + 500 mg AAI101
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Allecra
Healthy
A Study to Assess the Absorption, Metabolism and Excretion of [14C]-ANG-3777
The purpose of this study is to assess the mass balance recovery and metabolic profiling and identification of 14C-ANG-3777 administered as a single IV dose.
- Trial name
- NCT04931524
- Testing
- carbon-14-[14C]-ANG-3777
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Angion Biomedica Corp
Malaria, Plasmodium Infections
Effectiveness of Mass Drug Administration for Reducing Seasonal Malaria Transmission in Zanzibar
The overall aim of this study is to determine the effectiveness of two rounds of mass drug administration (MDA) with dihydroartemisinin-piperaquine (DHAp) + single low dose (SLD) primaquine for reducing seasonal malaria…
- Trial name
- MaDrAZ (NCT02721186)
- Testing
- MDA with DHAp and SLD Primaquine
- Where
- Tanzania
- Volunteers
- 22,500 people, healthy volunteers welcome
- Sponsor
- Ulrika Morris
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
A Single Dose Of GSK189075 Taken By Mouth Containing Small Amounts Of Radioactivity Studied In Healthy Male Volunteers
This study will look at the relative amounts of GSK189075 that are found in samples of blood, urine, and feces of healthy male volunteers.
- Trial name
- NCT00501683
- Testing
- Radiolabelled GSK189075
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
A Single Dose Metabolism and Mass Balance Study of 14C-ABR-215050 in Healthy Subjects
This is a single site, open label, single dose, non-randomized study in healthy male and female subjects. The subjects will be evaluated for plasma, urine and feces levels of 14C-ABR-215050 during 21 days.
- Trial name
- NCT01048203
- Testing
- ABR-215050
- Where
- Sweden
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Active Biotech AB
Osteoporotic Fracture
Phase I Clinical Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of LYN101
This is a Phase 1, two-part, first-in-human, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single dose of LYN101 in healthy subjects (part A)…
- Trial name
- NCT07178327
- Testing
- LYN101
- Where
- 2 sites in China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Shanghai TTM-Bio Technology Co., Ltd
Healthy
A Study of Tirzepatide at Different Injection Sites in Participants With Different Body Sizes
The purpose of this study is to compare the amount of tirzepatide that gets into the blood stream and how long it takes the body to get rid of it, when injected under the skin of the upper arm and thigh compared to the abdomen.
- Trial name
- NCT04050670
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Neoplasms
Roniciclib Mass Balance Study
The purpose of this trial is to investigate the fate of the roniciclib (study drug) in the body in a so called mass-balance study.
- Trial name
- NCT02390154
- Testing
- roniciclib (BAY 1000394)
- Where
- Hungary
- Volunteers
- 7 people
- Sponsor
- Bayer
Healthy Subjects
A Single Ascending Dose Study of ACT-541468 in Healthy Male Subjects
The main objectives of this first-into-man study were to investigate the safety, tolerability and the pharmacokinetic profile of single oral doses of ACT-541468 in healthy male adults.
- Trial name
- NCT02919319
- Testing
- ACT-541468 (Formulation A), ACT-541468 (Formulation B), 14C-labeled ACT-541468
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.