Clinical trials: Solitary Mass
Healthy Volunteers
A Single-dose Study to Investigate the Effect of Injection Site on KAI-9531 Relative Bioavailability in a Range of Body Mass Indices
The main objective of the study is to assess the relative bioavailability of KAI-9531 subcutaneous (SC) injection in the upper arm and thigh compared to the abdomen.
- Trial name
- NCT07044401
- Testing
- KAI-9531
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Kailera
Healthy
Mass Balance Study of KBP-5074 in Healthy Male Subjects
This is a Phase 1, open-label, nonrandomized, single-dose mass balance and metabolite identification study in healthy male subjects.
- Trial name
- NCT04634812
- Testing
- KBP-5074
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- KBP Biosciences
Mass Balance Study
Study on [14C]HMPL-453（FGFR Inhibitor） in Healthy Chinese Adult Male Subjects
To evaluate the absorption, metabolism and excretion in healthy Chinese male subjects after a single oral dose of [14C]HMPL-453
- Trial name
- NCT07644442
- Testing
- HMPL-453
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hutchmed
Kidney Neoplasms
The Effect of Pre-treatment Biopsy for Non-neoplastic Renal Disease vs no Biopsy on Estimated Glomerular Filtration Rate in Patients With Small Renal Mass: a Single-center, Single-blinded, Randomized, Parallel Group Clinical Trial
The purpose of this study is to determine if biopsy for non-neoplastic renal disease for patients with a small renal mass results in greater postoperative renal function than the current standard of care (no additional biopsy).
- Trial name
- NCT02841020
- Testing
- Additional biopsy
- Sponsor
- University of Virginia
HIV Infected Individuals, Osteopenia
Zoledronic Acid for the Prevention of TDF-sparing ART-induced Bone Mass Density Loss in Treatment-naive HIV Positive Individuals
The goal of this clinical trial is to learn if zolendric acid can prevent the anticipated deterioration of bone mass after antiviral treatment initiation for people that were recently diagnosed with HIV.
- Trial name
- NCT06762730
- Testing
- Zoledronic Acid 5 mg/Bag 100 ml Inj
- Where
- 3 sites in Israel
- Volunteers
- 110 people
- Sponsor
- Hadassah Medical Organization
Healthy Volunteers
A Study of the Absorption, Metabolism and Excretion of [14C]XZP-3621 in Human
This non-randomized, single group, open-label study will investigate the mass balance, routes of elimination, pharmacokinetics, metabolism, safety and tolerability of a single oral dose of [14C]XZP-3621 in healthy volunteers.
- Trial name
- NCT05836805
- Testing
- [14C]XZP-3621
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Xuanzhu Biopharmaceutical Co., Ltd.
Solitary Mass, Lung Diseases
Comparison for Pethidine Requirement in Patients Received Spinal Morphine 0.2 and 0.3 mg for Post Lobectomy Analgesia
The purpose of the study is to evaluate the amount of total pethidine requirement during the 48 hour postoperative period after receiving spinal morphine 0.2 and 0.3 mg.
- Trial name
- pain (NCT01236495)
- Testing
- spinal morphine 0.3 mg, spinal morphine 0.2 mg
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Solid Tumors
An Open Label Multi-center Extension Study to Evaluate Long-term Safety/ Tolerability of Dovitinib in Patients With Solid Tumors Who Continue to Receive Treatment With Dovitinib (TKI258) in Novartis-sponsored Single Agent Dovitinib Studies Which Fulfilled the Requirements for the Primary Objective
The study allowed continued safety follow-up of patients who were on single agent dovitinib or dovitinib in combination with fulvestrant treatment in a Novartis-sponsored study which had met its primary endpoint and were…
- Trial name
- NCT02116803
- Testing
- dovitinib, fulvestrant
- Where
- 9 sites in United States, Austria and 5 more
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Healthy Volunteers
The Effects of Sex, Body Mass Index, Day-to-Day Subject Variability for the ProLung Test and Variability of a Single Device When Volume-Averaged Thoracic Bioconductance is Measured With the ProLung Test
Assess the repeatability of the ProLung Test
- Trial name
- NCT03993028
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fresh Medical Laboratories
Osteopenia, Osteoporosis
Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis
The primary objective was to describe the safety and tolerability of up to 10 years or 7 years denosumab administration as measured by adverse event monitoring, immunogenicity and safety laboratory parameters in participants who…
- Trial name
- NCT00523341
- Testing
- Denosumab
- Volunteers
- 4,550 people
- Sponsor
- Amgen
Type 2 Diabetes Mellitus, Weight Loss
Mass Balance Study of [14C]HRS9531 in Healthy Male Subjects
This study was a single-center, single-dose, open-label study in healthy male subjects to investigate the absorption, metabolism and excretion of HRS9531 after a single subcutaneous injection of [14C]HRS9531.
- Trial name
- NCT06855147
- Testing
- [14C]HRS9531
- Where
- China
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
HIV-associated Lipodystrophy Syndrome
An Study to Investigate the Recovery, Excretion, and Pharmacokinetics of 14C-GSK1265744 Administered as a Single Oral Dose and a Study to Describe the Pharmacokinetics of a Supratherapeutic Dose of GSK1265744 in Healthy Adult Subjects
This will be a two-part study in healthy adults. Part A is a phase 1, non-randomized, open label, single-dose, single-centre mass balance study utilizing a radiolabeled dose to investigate the recovery, excretion, and…
- Trial name
- NCT01848340
- Testing
- GSK1265744B (sodium salt) containing 14C-GSK1265744B, 150 mg GSK1265744B
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
The Aim of This Study is to Determine the Influence of BMI and Lymph Node Status on OS in CRC Patients in the Long Term
BMI and Lymph Node Count in Colorectal Cancer
Background and aim: Colorectal Cancer (CRC) is one of the most frequent cancer entities in the western world. It is known that obesity is one of the major risk factors for CRC.
- Trial name
- NCT06334926
- Testing
- no intervention, retrospective data analysis
- Where
- Austria
- Volunteers
- 1,192 people
- Sponsor
- Klinikum Floridsdorf
Healthy Volunteers
A Study to Assess the Metabolism, Excretion, and Mass Balance of Radio-Labeled Plazomicin
This is a single-center, open label, non-randomized metabolism, excretion, and mass balance study of a single IV infusion of [14C]-plazomicin in healthy, adult male subjects.
- Trial name
- NCT03177278
- Testing
- [14C]-plazomicin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Achaogen, Inc.
Healthy Male Volunteers
Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]GRT6019
The main purpose of this study is to determine the mass balance recovery and the metabolite profile of a single dose of carbon-14 ([14C]) GRT6019
- Trial name
- NCT07479745
- Testing
- [14C]GRT6019
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Solid Tumors
Study to Evaluate Effect of a Single Dose of Sotatercept (ACE-011) on Red Blood Cell Mass and Plasma Volume in Participants With Solid Tumors
What hematopoietic precursor compartments as well as hemoglobin subtypes are affected by dosing with sotatercept (ACE-011)? Based upon a similar prior study with Procrit, Celgene has determined that all of these goals could be…
- Trial name
- NCT01190644
- Testing
- Sotatercept
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Merck Sharp & Dohme LLC
NASH With Fibrosis
Single Dose ADME Study of [14C]-Rencofilstat in Healthy Male Subjects
This is a single-center, single-period, single-dose, open-label, non-randomized study to assess the mass balance recovery, metabolite profile and metabolite identification of 14C- labelled rencofilstat ([14C] CRV431).
- Trial name
- NCT05737433
- Testing
- [14C]-rencofilstat 225mg
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hepion Pharmaceuticals, Inc.
Adenopathy, Uterine Fibroids
A Clinical Study on the Feasibility and Safety of Abdominal Endoscopic Single-port Surgery System to Assist Gynecological Day Surgery
In this study, a prospective study is used to select patients who will undergo intra-abdominal endoscopic single-port surgery system for benign gynecological diseases from February 2025 to December 2026 in the Second Affiliated…
- Conditions
- Adenopathy, Uterine Fibroids, Ovarian Cysts, Adnexal Mass
- Trial name
- NCT06828419
- Testing
- Domestic single-port laparoscopic surgery system
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Healthy Volunteers
Mass Balance Study of NV-5138 in Healthy Male Subjects
The objective of this study is to assess the mass balance and routes of excretion of total radioactivity after a single oral dose of 1600 mg [14C]-NV-5138.
- Trial name
- NCT05384977
- Testing
- [14C]-NV-5138
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Supernus Pharmaceuticals, Inc.
Healthy Volunteers
A Study to Detect Radioactivity of [14C]-OPC-167832 in Urine and Feces in Healthy Men
The purpose of this study is to determine the relative amounts of radioactivity excreted in urine and feces following a single oral dose of [14C]-OPC-167832 in healthy male participants.
- Trial name
- NCT07314320
- Testing
- [14C]-OPC-167832
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.