Clinical trials: Sound Perception
Sensorineural Hearing Loss, Cochlear Hearing Loss
Listening Effort in Cochlear Implant Users
Listening with a cochlear implant remains difficult and most listeners will report high levels of listening effort.The present study is a "pilot" aiming to evaluate listening effort for cochlear implant users.
- Trial name
- NCT03212924
- Testing
- Pupillometry, Evaluation of speech comprehension in quiet, Evaluation of speech comprehension in noise
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Oticon Medical
Hearing Loss, Hearing Loss, Conductive
Cross-sectional Evaluation of the Subjective Performance and Satisfaction With Ponto Sound Processors
The study is a non-interventional, observational, cross-sectional, study on users of Ponto sound processors. The purpose of this study is to evaluate subjectively assessed hearing performance and satisfaction with Oticon…
- Conditions
- Hearing Loss, Hearing Loss, Conductive, Hearing Loss, Unilateral
- Trial name
- BC112 (NCT05356221)
- Testing
- Ponto Sound processor
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Oticon Medical
Usher Syndrome, Type 1B
Study of Subretinally Injected AAVB-081 in Patients With Usher Syndrome Type IB (USH1B) Retinitis Pigmentosa
The purpose of the 081-101 study is to evaluate the safety and tolerability of a single subretinal injection of AAVB-081 in USH1B patients with retinitis pigmentosa due to a mutation in the MYO7A gene.
- Trial name
- NCT06591793
- Testing
- AAVB-081
- Where
- 3 sites in Italy, United Kingdom
- Volunteers
- 15 people
- Sponsor
- AAVantgarde Bio Srl
Hearing Loss, Bilateral or Unilateral
Performance of a Hearing Aid Platform Including Different Styles of Hearing Aids
The reason for this study is to evaluate a new hearing aid product generation replacing the one on the market. The goal is to evaluate the audiological performance, usability as well as features and functions.
- Trial name
- NCT02298452
- Testing
- Hearing aid.
- Where
- Switzerland
- Volunteers
- 253 people
- Sponsor
- Phonak AG, Switzerland
Deafness; Sensoneural Single Sided, Conductive Hearing Loss
Clinical Performance of a New Implant System for Bone Conduction Hearing
To study the initial experience with implanting and fitting the new Bone conduction system in patients with conductive, mixed or Single sided Sensorineural deafness.
- Conditions
- Deafness; Sensoneural Single Sided, Conductive Hearing Loss, Mixed Hearing Loss
- Trial name
- NCT03086135
- Testing
- Osia System
- Where
- 5 sites in United States, Australia and 3 more
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Cochlear
Tinnitus
Clinical Benefit of Hearing Aid Tinnitus Feature on Tinnitus-Related Annoyance in Tinnitus Patients in Belgium
Tinnitus, the perception of sound without an external source, affects around 15% of the global adult population (Jarach et al., 2022).
- Trial name
- NCT07711249
- Testing
- Sonova manufactured hearing aids with built-in Tinnitus feature
- Volunteers
- 170 people
- Sponsor
- Sonova AG
Hearing Loss, Ear Diseases
Benefits of the HiResolution Bionic Ear System in Adults With Asymmetric Hearing Loss
The purpose of this feasibility study is to evaluate the benefit of unilateral implantation in adults who have severe to profound sensorineural hearing loss in one ear, and up to moderate sensorineural hearing loss in the other…
- Conditions
- Hearing Loss, Ear Diseases, Hearing Disorders, Otorhinolaryngologic Diseases
- Trial name
- NCT02811549
- Testing
- HiResolution Bionic Cochlear Implant
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Advanced Bionics
Cockayne Syndrome
Observational Study to Assess Natural History in Cockayne Syndrome Patients
This is an Observational Study of children under the age of 11 diagnosed with Cockayne Syndrome to assess the natural progression of Cockayne Syndrome disease, with special attention to hearing and physical changes in length or…
- Trial name
- NCT00985413
- Where
- 4 sites in United States, France and 1 more
- Volunteers
- 40 people
- Sponsor
- DNage B.V.
Sensorineural Hearing Loss
FX-322 in Sensorineural Hearing Loss
This is a phase 1/2 study of FX-322 at two dose levels compared to placebo in male and female adults otherwise healthy with stable sensorineural hearing loss.
- Trial name
- NCT03616223
- Testing
- FX-322
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Frequency Therapeutics
Hearing Loss
Quality Control of CE-Certified Phonak Hearing Aids - 2020_26
Phonak Hearing Devices pass through different development and study phases. At an early stage, feasibility studies are conducted to investigate new algorithms, features and functions in an isolated manner.
- Trial name
- NCT04496791
- Testing
- RIC (Receiver in Canal) hearing aid/ hearing instrument (HI)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Sonova AG
Hearing Loss
Implantation With the Nucleus CI532 Cochlear Implant in Adults
The aim of this study is to investigate the clinical benefit for patients implanted with the Nucleus® CI532 cochlear implant. The Nucleus® CI532 has a pre-curved, perimodiolar array, the EA32, which is introduced into the cochlea…
- Trial name
- NCT02677220
- Testing
- CI532 cochlear implant
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Cochlear
Hearing Loss
An Investigation to Validate Speech Perception Assessment for Adult Cochlear Recipients Using a Mobile Research App
The study is a feasibility, prospective, repeated-measures, multi-country, multi-centre, study of the Mobile Research App to measure and validate speech perception endpoints in adult cochlear implant recipients.
- Trial name
- VALDE-MU (NCT06098482)
- Testing
- Mobile Research App (MRA), SOC/validated delivery of the speech perception test material
- Where
- 4 sites in United States, Australia and 1 more
- Volunteers
- 46 people
- Sponsor
- Cochlear
Hearing Loss
Evaluation of the Clinical Benefit of a Transmitter for Contralateral Routing of Signals (CROS)
This study will evaluate the clinical benefit of a transmitter for contralateral routing of signals. The benefit will be evaluated in noisy environments regarding speech intelligibility when the CROS system is adjusted to…
- Trial name
- NCT05106413
- Testing
- BiCROS fitting, Monaural fitting, Unaided condition
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Sonova AG
Misophonia
Study of Auditory Perception After Progressive Exposure to Aversive Sounds in People With Misophonia
The primary objective of the project is to characterise and measure the auditory perception of subjects with misophonia compared with the auditory perception of control subjects.
- Trial name
- PROMISE (NCT06921187)
- Testing
- Psychoacoustic test, semi-structured interviews, Exposure to unpleasant sounds
- Where
- 2 sites in France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Age-Related Hearing Loss
Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss
This study aims to demonstrate that the investigational drug AUT00063 is effective and safe in the treatment of age-related hearing loss.
- Trial name
- CLARITY-1 (NCT02345031)
- Testing
- AUT00063
- Where
- 13 sites in United States
- Volunteers
- 78 people
- Sponsor
- Autifony Therapeutics Limited
Subjective Tinnitus
Efficacy, Safety and Tolerability of Neramexane in Comparison to Placebo in Patients With Subjective Tinnitus
The purpose of this study is to investigate the safety and efficacy of neramexane mesylate in the treatment of subjective tinnitus in comparison to placebo.
- Trial name
- NCT00772980
- Testing
- Neramexane mesylate
- Where
- 56 sites in Belgium, Czechia and 4 more
- Volunteers
- 400 people
- Sponsor
- Merz Pharmaceuticals GmbH
Hearing Loss, Unilateral, Cochlear Implants
Impact of Anatomy-Based Cochlear Implant Programming on Early Performance
The purpose of this study is to evaluate the impact of different audio processor frequency settings on performance outcomes in new cochlear implant users using electric-only stimulation in the implanted ear with normal hearing to…
- Conditions
- Hearing Loss, Unilateral, Cochlear Implants, Hearing Loss, Sensorineural, Single-Sided Deafness (SSD)
- Trial name
- NCT06734039
- Testing
- Programming of cochlear implant audio processor frequency settings
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Med-El Corporation
Hearing Loss
Comparing the Performance of a Categorical Loudness Scaling Based Fitting With a Behavioural Fitting in Adults With a Nucleus Cochlear Implant 3 Months Post-activation
This study aims to collect data in newly implanted cochlear implant-recipients to inform future development of fitting methods to optimally and efficiently program a cochlear implant.
- Trial name
- CALOS4 (NCT05709223)
- Testing
- Categorical loudness scaling based fitting using the research fitting system., Behavioural fitting using Custom Sound Suite (CSS 6.3) Software
- Where
- 4 sites in United States, Australia and 1 more
- Volunteers
- 17 people
- Sponsor
- Cochlear
Autism Spectrum Disorder (ASD)
Brain Stimulation and Sensory Integration in Children With ASD
The goal of this clinical trial is to find out if brain stimulation can help improve sensory integration in children ages 6 to 12 with autism spectrum disorder (ASD).
- Trial name
- NCT07182331
- Testing
- Continuous Theta Burst Stimulation to Bilateral DLPFC
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Neurolab Plus
Hearing Loss
Comparison of Hearing Aid Fitting Outcomes Between Self-fit and Professional Fit for MDHearing Smart Hearing Aids
Hearing aids are commonly used to help people with hearing loss hear better in daily listening environments. MDHearing Smart hearing aids are designed to use the MDHearing app to adjust hearing aids to each individual's hearing…
- Trial name
- NCT05165121
- Testing
- MDHearing smart hearing aid
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- MDHearingAid