Clinical trials: Sound Perception
Tinnitus
Vagus Nerve Stimulation (VNS) Paired With Tones for Tinnitus
Assess the safety and efficacy of VNS paired with tones for tinnitus using a randomized, controlled, parallel study design.
- Trial name
- NCT01962558
- Testing
- VNS Treatment, VNS Control
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- MicroTransponder Inc.
Single Sided Deafness
Implantation of the Cochlear® Nucleus® System in Adults With Single-Sided Deafness
The objective of this feasibility study is to obtain preliminary safety and efficacy data associated with cochlear implantation in individuals with severe to profound sensorineural hearing loss contralateral to an ear with…
- Trial name
- NCT01670006
- Testing
- Cochlear Nucleus Cochlear Implant System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cochlear
Hearing Loss
Bilateral Cochlear Implantation in Children With the MED-EL Cochlear Implant
The purpose of this study is to evaluate and document longitudinal efficacy in young children implanted bilaterally with MED-EL COMBI 40+ / PULSARCI100/SONATATI100 cochlear implant systems.
- Trial name
- NCT00784043
- Testing
- Cochlear Implant
- Where
- 9 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- Med-El Corporation
Hearing Loss
Hearing Changes After Surgery
The purpose of this study is to measure the potential effects of surgical drilling noise and/or vibration exposure on the hearing in the ear contralateral to the surgical site during skull-based surgeries
- Trial name
- NCT04322747
- Testing
- Distortion product otoacoustic emissions (DPOAE)
- Where
- United States
- Sponsor
- Gateway Biotechnology, Inc.
Hearing Loss
Innovations in Clinical Care of CE Approved Nucleus Cochlear Implant Recipients
This study is to evaluate new approaches to device fitting and diagnostics for cochlear implant users. The evaluation can be performed in the laboratory in an acute session or in real world environments with take-home device use…
- Trial name
- NCT05270876
- Testing
- Cochlear Implant and sound processor device fitting paradigm or diagnostic/measurement technique
- Where
- 5 sites in Australia, Belgium
- Volunteers
- 20 people
- Sponsor
- Cochlear
Hearing Loss, Binaural, Hearing Loss, Monaural
Evaluation of Different Phone Solutions in CI and Hearing Aid Users and Bimodal Recipients
Communication on telephone is challenging for people with hearing loss. For hearing aid users, for instance, the inventions for improving speech intelligibility on the phone range from an integrated tele coil and individual…
- Trial name
- PhoneCIHA (NCT03036410)
- Testing
- standard telephone setting, DECT, EasyCall
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- Advanced Bionics AG
Treatment of Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
A Clinical Trial of EHT102 Injection in Pediatric Patients With Biallelic hOTOF Mutations
This study is a multicenter, single-arm, open-label Phase I/II clinical trial, which is designed to evaluate the safety, tolerability and efficacy of EHT102 injection in treating congenital hearing loss secondary to biallelic…
- Trial name
- NCT07288580
- Testing
- EHT102 Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Euhearing Therapeutics Co., Ltd
Hearing Loss
Clinical Evaluation of the Nucleus 5 Cochlear Implant (CI) System
To evaluate the performance of the Nucleus 5 Cochlear Implant System.
- Trial name
- NCT01072409
- Testing
- Nucleus 5 Cochlear implant, Cochlear implantation
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Cochlear
Hearing Loss
A Clinical Investigation of the Benefit: BTE Hearing Aids Versus ITE Hearing Aids
The current study will evaluate a new in-the-ear (ITE) hearing aid hardware. The goal is to evaluate the audiological performance, usability, feature function, and to identify unexpected or unwanted behaviour from the devices.
- Trial name
- NCT04168229
- Testing
- Mermaid 9 ITE, Mermaid 9 BTE
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- Bernafon AG
Hearing Loss, Bilateral Sensorineural
A Pivotal Study to Evaluate the Efficacy and Safety of a Totally Implantable Cochlear Implant (TICI) System in Adults
This clinical study examines the performance of an investigational totally implantable cochlear implant (TICI) system. The system includes an implantable microphone under the skin to detect speech and sound from the environment…
- Trial name
- ENTERPRISE (NCT07139327)
- Testing
- Cochlear Implant
- Where
- 8 sites in Australia, France
- Volunteers
- 36 people
- Sponsor
- Cochlear
Hearing Loss, Conductive, Hearing Loss, Mixed
Clinical Investigation Study of Safety and Performance of the Sentio System.
Prospective, open label, single-arm, multi-centre investigation, designed to follow clinical practice for Sentio bone conduction devices in 50 subjects, during 10 clinical visits, and 24 months follow-up.
- Conditions
- Hearing Loss, Conductive, Hearing Loss, Mixed, Hearing Loss, Unilateral
- Trial name
- NCT05166265
- Testing
- Active transcutaneous bone conduction hearing system
- Where
- 6 sites in Germany, Netherlands and 1 more
- Volunteers
- 51 people
- Sponsor
- Oticon Medical
Mixed Hearing Loss, Single-Sided Deafness
Osia 2 Pediatric Expansion Study
The CochlearTM Osia®2 System was cleared by the Food and Drug Administration November 15, 2019 (K191921) for individuals aged 12 years and older who present with conductive or mixed hearing loss (up to 55 dB HL) or…
- Conditions
- Mixed Hearing Loss, Single-Sided Deafness, Conductive Hearing Loss
- Trial name
- NCT05000931
- Testing
- Osia 2 System
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- Cochlear
Hearing Loss
Multi-Centre Study on the Performance of the Ponto BHX Implant System (in Adult Patients)
This multi-centre study funded by Oticon Medical AB will be conducted at seven hospitals across Europe (UK, Spain, Denmark). Patients with a hearing loss and that are already planned for treatment with a percutaneous (through the…
- Trial name
- NCT04310202
- Testing
- Abbreviated Profile of Hearing Aid Benefit (APHAB), Glasgow Benefit Inventory (GBI), Additional follow-up visits after surgery
- Where
- 6 sites in Denmark, Spain and 1 more
- Volunteers
- 50 people
- Sponsor
- Oticon Medical
Hearing Impairment
Clinical Evaluation of the Nuance Audio Hearing Aid in Adults With Mild to Moderate Hearing Difficulties
The research will produce clinical effectiveness performance metrics using standardised procedures of the Nuance Audio hearing device.
- Trial name
- NCT07100522
- Testing
- Hearing aid in spectacle frame form factor, hearing aid
- Where
- Australia
- Volunteers
- 21 people
- Sponsor
- Luxottica Group S.p.A.
Mixed Hearing Loss, Conductive Hearing Loss
Comparative Study of Non-surgical Hearing Devices Based on Bone Conduction
This study will investigate the performance of four non-surgical bone conduction devices.
- Trial name
- NCT07580287
- Testing
- Bone conduction devices
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oticon Medical
Sudden Sensorineural Hearing Loss
Phase I Clinical Study of HY01 in Patients
Phase I clinical study on the safety, tolerance, efficacy and pharmacokinetics of repeated intratympanic HY01 in patients with sudden sensorineural hearing loss.
- Trial name
- NCT04961099
- Testing
- HY01
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Heyu (Suzhou) Pharmaceutical Technology Co., Ltd
Sensorineural Hearing Loss, Low-Frequency Residual Hearing
Perimodiolar Implant Performance in Adults With Low-Frequency Residual Hearing
The purpose of the feasibility study is to investigate hearing performance (audiometry and speech perception) using the CI632 in a group of adults (n=15) with low-frequency residual hearing who meet inclusion criteria.
- Trial name
- NCT04741009
- Testing
- CI632 Slim Modiolar Electrode
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Cochlear
Conductive Hearing Loss, Mixed Hearing Loss
Osia CPT Code Study
To evaluate the clinical efficacy of the Osia 2 system in patients with conductive or mixed conductive hearing loss in a US cohort.
- Trial name
- NCT04320407
- Testing
- Osia 2 System
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Cochlear
Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants, Adolescents and Adults With Hearing Loss Due to Otoferlin Mutations
Regeneron is conducting a study of an investigational new drug called DB-OTO. DB-OTO is a gene therapy that is being developed to treat pediatric and adult participants who have severe-to profound and profound hearing loss due to…
- Trial name
- CHORD (NCT05788536)
- Testing
- DB-OTO
- Where
- 17 sites in United States, Germany and 3 more
- Volunteers
- 36 people
- Sponsor
- Regeneron Pharmaceuticals
Hearing Loss
fNIRS, Listening Effort, and Motivation
The purpose of the current study is to measure oxygenation in the PFC using fNIRS in a sample of older adults with hearing loss.
- Trial name
- NCT05893992
- Testing
- Hearing aids with noise management features for listening in noise, Hearing aid for listening in quiet environments
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Sonova AG