Clinical trials: Sound Perception
Tinnitus
Comparison of Single Versus Repeat Doses of AM-101 in the Treatment of Acute Inner Ear Tinnitus
The purpose of the study is to evaluate the therapeutic benefit and safety of intratympanic AM-101 injections in comparison to placebo in the treatment of persistent acute inner ear tinnitus.
- Trial name
- TACTT1 (NCT01270282)
- Testing
- AM-101 0.81 mg/mL
- Where
- 16 sites in United States, Belgium and 2 more
- Volunteers
- 82 people
- Sponsor
- Auris Medical, Inc.
Hearing Loss, Sensorineural, Hearing Loss, Conductive
Wide Frequency Band Test of Hearing in Veterans
The accurate assessment of auditory status is critical for planning treatment for Veterans with hearing loss to include medical and audiological management.
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis
- Trial name
- CWTBAFV (NCT02019888)
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Age-related Macular Degeneration, Dementia
Words on the Brain: Can Reading Rehabilitation for Age-Related Vision Impairment Improve Cognitive Functioning?
Age-related vision impairment and dementia both become more prevalent with increasing age. Research into the mechanisms of these conditions has proposed that some of their causes (e.g., macular degeneration/glaucoma and…
- Conditions
- Age-related Macular Degeneration, Dementia, Low Vision, Low Vision Aids
- Trial name
- WOTB (NCT04276610)
- Testing
- Low Vision Reading Rehabilitation
- Where
- 2 sites in Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Hearing Loss, Sensorineural, Cochlear Synaptopathy
Evaluation of the CochSyn Test Prototype to Measure Cochlear Synaptopathy
This study investigates a newly developed test, The CochSyn test that can quantify cochlear synaptopathy (CS) (a new type of sensorineural hearing loss (SNHL)) earlier than the current golden standard pure-tone audiogram.This…
- Conditions
- Hearing Loss, Sensorineural, Cochlear Synaptopathy, Cochlear Hearing Loss
- Trial name
- EarDiTech (NCT06114680)
- Testing
- CochSyn test prototype, Universal Smart Box (USB)
- Where
- Belgium
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- University Ghent
Cochlear Implant, Cochlear Hearing Loss
Degree of Benefit From Low-Frequency Acoustic Amplification Using the Advanced Bionics Acoustic Earhook
The primary objective of this study is to obtain a greater understanding of the range in benefit from acoustic amplification combined with electric stimulation in cochlear implant recipients with low-frequency hearing who do not…
- Trial name
- NCT04041596
- Testing
- Advanced Bionics' Acoustic Earhook
- Where
- United States
- Sponsor
- NYU Langone Health
Hearing Loss
Evaluation of the Clinical Benefit of a Transmitter for Contralateral Routing of Signals (CROS)
This study will evaluate the clinical benefit of a transmitter for contralateral routing of signals. The benefit will be evaluated in noisy environments regarding speech intelligibility when the CROS system is adjusted to…
- Trial name
- NCT05106413
- Testing
- BiCROS fitting, Monaural fitting, Unaided condition
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Sonova AG
Tinnitus, Subjective
MRI Study of Noninvasive Transcranial Electrical Stimulation in Tinnitus
The purpose of this research is to understand how a neuromodulation technique, transcranial electrical stimulation (tES), affects brain function in adults with chronic tinnitus measured with functional magnetic resonance imaging…
- Trial name
- NCT03544359
- Testing
- Transcranial electrical stimulation (tES)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Tinnitus
Neramexane for Tinnitus
Tinnitus is commonly referred to as "ringing of the ears" - the perception of sounds in the absence of an external source of acoustic signals.
- Trial name
- NCT00405886
- Testing
- Neramexane
- Where
- 2 sites in Austria, Germany
- Volunteers
- 431 people
- Sponsor
- Merz Pharmaceuticals GmbH
Deafness
Influence of the Sensory Profile of Deaf Children With Autism Spectrum Disorders on the Outcome of Cochlear Implantation
An unpublished study conducted at Toulouse University Hospital revealed that 30% of implanted children with Autism Spectrum Disorders abandon their implant, while 70% of them keep it.
- Trial name
- PSIC-TSA (NCT04663022)
- Testing
- Dunn's sensory profile questionnaire
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Toulouse
Hearing Loss, Sensorineural, Cochlear Hearing Loss
Evaluation of the CochSyn Device in Clinical Practice
This study investigates a new type of auditory evoked brain potentials for the quantification and classification of peripheral hearing damage (The CochSyn Test).
- Conditions
- Hearing Loss, Sensorineural, Cochlear Hearing Loss, Cochlear Synaptopathy, DFNA9
- Trial name
- Earditech 2 (NCT07091071)
- Testing
- CochSyn device
- Where
- 3 sites in Belgium
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Ghent
Sensorineural Hearing Loss
Phase I/IIa Study Evaluating Safety and Efficacy of an Intratympanic Dose of PIPE-505 in Subjects With Hearing Loss
This is a randomized, double-blind study of PIPE-505, or placebo, in subjects with hearing loss associated with speech-in-noise impairment.
- Trial name
- NCT04462198
- Testing
- PIPE-505
- Where
- 8 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Vestibular Disorder, Sudden Hearing Loss
Prognosis of Vestibular Dysfunction in Patients With Idiopathic Sudden Sensorineural Hearing Loss
Idiopathic sudden sensorineural hearing loss (ISSNHL) refers to idiopathic sensorineural hearing loss of at least 30 dB over at least three test frequencies occurring over a 72-hour period.
- Trial name
- NCT03951584
- Testing
- ISSNHL with vertigo
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Hearing Loss
Clinical Performance, Safety and Patient Reported Outcomes of an Active Osseointegrated Steady-State Implant System
The aim of this clinical investigation is to collect data on objective and subjective hearing performance, quality of life and safety in adult subjects with conductive hearing loss, mixed hearing loss or single-sided…
- Trial name
- NCT04041700
- Testing
- Osia 2 system
- Where
- 3 sites in Australia, Hong Kong
- Volunteers
- 29 people
- Sponsor
- Cochlear
Chronic Suppurative Otitis Media, Hearing Impairment
Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi
This community-based cross-sectional survey will estimate the frequency and risk factors of Chronic Suppurative Otitis Media and Hearing Impairment in Children ages 4-6 years in the Chikwawa District.
- Trial name
- NCT02779907
- Testing
- No Intervention
- Where
- Malawi
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Severe Sudden Sensorineural Hearing Loss
Efficacy of SENS 401 in Subjects With Severe or Profound Sudden Sensorineural Hearing Loss
Primary objective of the study is to assess the efficacy of SENS-401 on hearing loss in comparison to placebo at the end of the 4-week treatment period
- Trial name
- AUDIBLE-S (NCT03603314)
- Testing
- SENS-401
- Where
- 26 sites in Bulgaria, Canada and 8 more
- Volunteers
- 115 people
- Sponsor
- Sensorion
Hearing Loss
Development and Assessment of a Spanish-Language Hearing Loss Toolkit for Self-Management
The objective of this application is to develop and evaluate Spanish-language hearing education materials for adults. Our hypothesis is that participants will demonstrate better understanding of their hearing loss and associated…
- Trial name
- NCT04534387
- Testing
- Spanish-Language Hearing Loss Toolkit for Self-Management, American Speech-Language-Hearing Association (ASHA) Audiology Series Spanish Language Handouts
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Hearing Loss, Sensorineural, Hearing Loss, Bilateral
Societal Merit of Intervention on Hearing Loss Evaluation
The primary objective of this study is to determine the (long term) effect of intervention with a CI in adult participants with progressive postlingual moderate/severe-to-profound sensorineural hearing loss on societal related…
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Bilateral, Hearing Loss, Adult-Onset, Hearing Loss, Bilateral Sensorineural, Progressive
- Trial name
- SMILE (NCT05525221)
- Where
- 5 sites in Netherlands
- Volunteers
- 156 people
- Sponsor
- Radboud University Medical Center
Tinnitus
Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts
The goal of the study is to reduce tinnitus (ringing in the ear) loudness and improve the quality of life for those that are affected by tinnitus.
- Trial name
- NCT03621735
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Hearing Loss, Presbycusis
Predicting Success With Hearing Aids
The primary complaint of individuals with hearing loss is difficulty understanding speech in the presence of background noise. Although hearing aids help individuals understand speech in background noise better, there is a high…
- Trial name
- NCT00371449
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Hearing Loss, Binaural, Cochlear Implantation
Mi2000 TICI Follow-up
This Post-Market Clinical Follow-up (PMCF) investigation aims to further collect evidence on safety and performance of the Mi2000 TICI.
- Trial name
- M2FU (NCT07902414)
- Testing
- Cochlear Implantation
- Where
- 6 sites in Austria, Belgium and 2 more
- Volunteers
- 36 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
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