Clinical trials: Sound Sensitivity
Asthma, Pulmonary Function
VCSIP Follow-up Study
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function and decrease wheeze at 5 years of age in their offspring.
- Conditions
- Asthma, Pulmonary Function, Wheezing, In Utero Nicotine
- Trial name
- VCSIPRenewal (NCT03203603)
- Testing
- No active intervention
- Where
- 2 sites in United States
- Volunteers
- 242 people
- Sponsor
- Oregon Health and Science University
Asthma, Wheezing
Vitamin C Supplementation to Pregnant Smokers: Follow-up of 2 Randomized Trials Plus Changes in DNA Methylation
In a randomized clinical trial (RCT) published in JAMA, the investigators have provided evidence that vitamin C supplementation (500 mg daily during pregnancy) ameliorates the effects of maternal smoking during pregnancy on…
- Conditions
- Asthma, Wheezing, In Utero Nicotine, Pulmonary Function
- Trial name
- VCSIP-ECHO (NCT03206710)
- Testing
- No current intervention
- Where
- 2 sites in United States
- Volunteers
- 395 people
- Sponsor
- Oregon Health and Science University
Asthma
Exploring a Cessation Intervention for Smokers
An estimated 6.6 million parents who smoke visit pediatric emergency departments (PED) annually. Up to 50% of these parental smokers are from low-income, racially/ethnically diverse households in which a variety of…
- Trial name
- NCT01728038
- Testing
- Cessation Counseling
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Respiratory Syncytial Virus (RSV) Infection, Acute Lower Respiratory Tract Infections
Assessing the Burden of Respiratory Syncytial Virus (RSV)
This study examines the impact of Respiratory Syncytial Virus (RSV) on people of all ages, from infants to the elderly. It uses hospital records collected between January 2018 and December 2024 to understand: How often does RSV…
- Conditions
- Respiratory Syncytial Virus (RSV) Infection, Acute Lower Respiratory Tract Infections, Bronchiolitis, Pneumonia
- Trial name
- NCT07015255
- Where
- United Arab Emirates
- Volunteers
- 1,500 people
- Sponsor
- Abu Dhabi Health Services Company
Asthma (Diagnosis), Community-Acquired Pneumonia (CAP)
Multimodal Assisted Diagnosis for Pediatric Respiratory Diseases Using Questionnaires, Cough Sounds, and Breath Sounds
This study aims to establish a standardized, synchronized data collection system for pediatric symptom questionnaires, cough sounds, and breath sounds, and to construct a multimodal database of pediatric respiratory diseases…
- Trial name
- NCT07613242
- Testing
- Multimodal respiratory data collection
- Where
- China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Shanghai Children's Medical Center
Asthma
A Study of the Treatment-Sparing Effects of AEROVANT™ AER 001 Inhalation Powder in Asthma Patients, AEROTRIAL
A multi-center, Phase IIb, double-blind, randomized, placebo controlled, parallel-group, repeated-dose study in male and female patients with moderate to severe asthma in which patients will be stabilized on AEROVANT then doses…
- Trial name
- NCT00801853
- Testing
- Aerovant
- Where
- 71 sites in United States, Hungary and 2 more
- Volunteers
- 424 people
- Sponsor
- Aerovance, Inc.
Wheezing
Longitudinal Preschool Wheeze Biomarker Study
Preschool children (aged 1-5 years) account for 75% of all UK childhood wheezing hospitalisations. This has not changed over 20 years, meaning current treatments are not working and a new approach is needed.
- Trial name
- NCT06237660
- Testing
- Bronchoscopy, with bronchoalveolar lavage and endobronchial biopsy, Skin prick test, Finger prick blood test
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Imperial College London
Asthma, Asthma in Children
Prospective Multicentre Study on Symptoms in First-onset Bronchial Asthma in Children and Adolescents
Bronchial asthma may present with symptoms other than the commonly reported complaints (cough, chest tightness, shortness of breath and wheezing).
- Conditions
- Asthma, Asthma in Children, Dyspnea, Cough
- Trial name
- NCT06201494
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Charles University, Czech Republic
Asthma
Inflammatory and Immune Profiles During a Severe Exacerbation in Preschool Asthmatic Children (<5 Years)
Asthma/wheeze begins in the first years of life and is the most common chronic disease in preschool children (< 5 years). Different phenotypes have been suggested: Episodic-Viral Wheeze (EVW), absence of symptoms between…
- Trial name
- VIRASTHMA2 (NCT03960359)
- Testing
- Clinical, microbiological and inflammatory phenotype
- Volunteers
- 150 people
- Sponsor
- University Hospital, Lille
Asthma, Obesity
Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics (Glitz Asthma)
Asthmatics who are significantly overweight tend to have more severe symptoms, more flare ups, and are more likely to have poorly-controlled asthma when compared to other asthmatics.
- Trial name
- GLITZ (NCT00787644)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Vermont
Asthma, Status Asthmaticus
Steroids in Children Hospitalized With Asthma
Asthma is the most common chronic disease of children. A short (3-5 day) course of a short-acting steroid such as Prednisone or Prednisolone has long been the standard of care for asthma exacerbation.
- Conditions
- Asthma, Status Asthmaticus, Wheezes
- Trial name
- NCT02780479
- Testing
- Dexamethasone, Prednisone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Asthma
Preschool Wheeze: Inflammation/Infection Guided Management
This is a single-centre, randomised-controlled trial, comparing management of preschool wheeze. It specifically aims to compare management of preschool wheeze using current clinical guidelines to management determined by…
- Trial name
- PrIGMa (NCT02517099)
- Testing
- Beclometasone, Co-amoxiclav, Azithromycin
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Asthma, Wheeze
The Development of Novel Clinical Tests to Diagnose and Monitor Asthma in Preschool Children
The study will ascertain the ability of preschool lung function tests to distinguish healthy children from those with wheeze, and to differentiate phenotypes of wheezy children (high and low risk for asthma as defined by API) in…
- Conditions
- Asthma, Wheeze, Obstructive Sleep Apnea, Food Allergy
- Trial name
- WheezyER (NCT02743663)
- Testing
- Bronchodilator response, Allergy Skin Test, Multiple-Breath Washout
- Where
- Canada
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Respiratory Syncytial Virus
A Prospective, Epidemiological Study to Assess the Disease Burden of Respiratory Syncytial Virus Associated, Suspected Lower Respiratory Tract Infections in Newborns, From 0 to 2 Years of Age and Risk of Development of Wheeze and Asthma From 0 to 6 Years of Age
The purpose of this study is to assess the incidence and associated healthcare utilization of RSV-associated, suspected LRTI in a general population of infants from birth up to 2 years of age, and also to assess the accuracy of a…
- Trial name
- NCT01995175
- Testing
- Nasal swab sampling, Blood sampling, Diary cards
- Where
- 23 sites in United States, Argentina and 6 more
- Volunteers
- 2,409 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma
A Study to Evaluate the Dosing of AMG 827 for Subjects With Inadequately Controlled Asthma
The purpose of this study is to determine if AMG 827 is effective compared to placebo as measured by change in Asthma Control Questionnaire (ACQ) composite scores.
- Trial name
- NCT01199289
- Testing
- AMG 827
- Where
- 49 sites in United States, Austria and 8 more
- Volunteers
- 315 people
- Sponsor
- Amgen
Wheezing, Asthma
Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
This is a parallel, Phase 3, 2-arm study to evaluate the efficacy and long-term safety of dupilumab treatment in children 2 to <6 years of age with uncontrolled asthma and/or recurrent severe asthmatic wheeze.
- Trial name
- NCT06191315
- Testing
- Dupilumab
- Where
- 74 sites in United States, Argentina and 14 more
- Volunteers
- 90 people
- Sponsor
- Sanofi
Asthmatic Crisis, Wheezing
Optimizing Vitamin D Status in Children With Wheeze / Asthma (OPTIVIT)
Vitamin D deficiency is highly prevalent in the UK. Research shows that vitamin D enhances the immune system and may help protect against chest infections that can cause wheezing illness or worsen asthma symptoms.
- Trial name
- OPTIVIT (NCT02880930)
- Testing
- Fultium-D3 drops (Internis)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen Mary University of London
Misophonia
Treatment for Youth (Ages 8 to 16 Years Old) With Misophonia (U-HEAR)
If someone is really sensitive to certain noises and sounds, they might have misophonia. U-HEAR is a study created to find out what helps kids and teens with misophonia. There are two treatments being tested in this study.
- Trial name
- U-HEAR (NCT04365543)
- Testing
- Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents (UP-C/A) for youth with misophonia, Psychoeducation and Relaxation Therapy (PRT)
- Where
- 2 sites in United States
- Volunteers
- 124 people
- Sponsor
- University of South Florida
Asthma, Lung Diseases
Childhood Asthma Research and Education (CARE) Network Trial - Acute Intervention Management Strategies (AIMS)
This study will determine the effectiveness of initiating a high-dose inhaled corticosteroid (ICS) or a leukotriene receptor antagonist (LTRA) in addition to an inhaled beta2-agonist (albuterol) at the onset of respiratory tract…
- Trial name
- AIMS (NCT00319488)
- Testing
- Inhaled Corticosteroid (Budesonide), Leukotriene Receptor Antagonist (Montelukast Sodium), Inhaled Albuterol
- Where
- 6 sites in United States
- Volunteers
- 238 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Auscultation, Breathing Sound
Enhancing Respiratory Auscultation Skills Among Medical Students: Digital Stethoscopes in Medical Education
Objectives: This study aims to assess the effectiveness of a novel digital stethoscope curriculum integrated into respiratory auscultation training for medical students.
- Conditions
- Auscultation, Breathing Sound, Asthma, Pneumonia
- Trial name
- NCT06359158
- Testing
- Digital stethoscope use
- Where
- Taiwan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University