Clinical trials: South Asian
Dyslipidemia
Colesevelam, Lipids And Sugars, South Asian Canadian Trial
To evaluate the effect of colesevelam on LDL levels and A1c in high-risk , dysglycemic South Asians (with diabetes, and/or with CAD and concomitant metabolic syndrome) whose LDL remains above target despite optimal statin use.
- Trial name
- CLASS-ACT (NCT02504736)
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Canadian Collaborative Research Network
IgA Nephropathy, Renal Insufficiency, Chronic
Which of the Commonly Available and Approved Drugs in Addition to Standard of Care Can Significantly Improve the Slope of Estimated Glomerular Filtration Rate at Two Years When Compared to Standard of Care Alone in South-Asian Kidney Biopsy-proven Adult (≥18 Years) Primary IgA Nephropathy?
Global Burden of Diseases ranks chronic kidney disease (CKD) as the 12th leading cause of death, with an estimated 20% increase from 2010 to 2019.
- Conditions
- IgA Nephropathy, Renal Insufficiency, Chronic, IgA Vasculitis, IGA Glomerulonephritis
- Trial name
- IA-GRACE-IgANT (NCT06676384)
- Testing
- Oral prednisolone and SoC, Gut-directed budesonide and SoC, Mycophenolate mofetil (MMF) and SoC
- Where
- 12 sites in India
- Volunteers
- 585 people
- Sponsor
- Christian Medical College, Vellore, India
COVID-19, Microbial Colonization
Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease
Determining whether in the mouth there are differences between the participant groups in the nature and activity of mucosal innate immunity, in immune responses to SARS-COV2 antigens, or in the oral microbiome
- Conditions
- COVID-19, Microbial Colonization, Oral Disease, Periodontal Diseases
- Trial name
- MIMSA (NCT05212766)
- Testing
- COVID infection, COVID vaccination, Oral examination
- Where
- United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- King's College London
Type 2 Diabetes Mellitus
Novel Model for South Asian Treatment in Diabetes (NaMaSTe-Diabetes) Trial in Primary Care
South Asians (SA) living in Canada and globally have high rates of type 2 diabetes (diabetes). Despite the burden of diabetes in this population, diabetes management remains poor.
- Trial name
- Namaste (NCT02136654)
- Testing
- Culturally tailored diabetes program
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of British Columbia
Attitude to Health
Health and Cancer Issues in the South Asian Community
The goal of this research study is to learn about the health practices, health knowledge, and attitudes of South Asian Americans who live in Houston or the surrounding area.
- Trial name
- NCT00479830
- Testing
- Focus Groups, Questionnaire, Interview
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Hypertension, Diabetes
Hypertension Related Damage to the Microcirculation in South Asian: Emergence, Predictive Power and Reversibility
Damage to very small blood vessels is a consequence, but can also precede high blood pressure. Such damage, measured by disturbances in the vessels in the retina (back of the eye) is a strong predictor of heart disease and…
- Conditions
- Hypertension, Diabetes, Cardiovascular Disease, Retinopathy
- Trial name
- NCT00331370
- Testing
- GP training and Health Education
- Where
- Pakistan
- Volunteers
- 2,880 people
- Sponsor
- Aga Khan University
Cardiovascular Diseases, Diabetes
South Asian HeArt Risk Assessment Project - Pilot
People who originate from the Indian subcontinent known as South Asians are the fastest growing group of non-white Canadians. They suffer an excess prevalence of abdominal obesity, type 2 diabetes and heart disease.
- Conditions
- Cardiovascular Diseases, Diabetes, Abdominal Obesity
- Trial name
- SAHARA-Pilot (NCT01577719)
- Testing
- Multimedia Lifestyle Improvement, Usual Care
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- McMaster University
Behavior, Health, Pre Diabetes
Developing a Lifestyle Intervention for South Asians
This study aims to test the hypothesis that a culturally tailored lifestyle intervention can improve health behaviors among South Asians with prediabetes and diabetes
- Conditions
- Behavior, Health, Pre Diabetes, Diabetes
- Trial name
- NCT03861546
- Testing
- Healthy lifestyle Shared Medical Appointment (SMA) program
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Emory University
Obesity
Mirabegron and Brown Adipose Tissue
Obesity and type 2 diabetes (T2D) are emerging problems worldwide. In particular South Asian individuals (representing 20% of the world population) have an increased risk of obesity and related disorders.
- Trial name
- Mirab (NCT03012113)
- Testing
- Mirabegron, Short term mild cooling
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Asthma
Can Education for South Asians With Asthma and Their Clinicians Reduce Unscheduled Care? A Randomised Trial
People from ethnic minority groups suffer worse ill-health from asthma than those from majority groups. No studies have reduced emergency care for people from minority groups.
- Trial name
- OEDIPUS (NCT00214669)
- Testing
- PACE (Professional Asthma Care Education), Lay Led Expert Patient Programme, Asthma self management education by a specialist nurse
- Where
- United Kingdom
- Volunteers
- 375 people
- Sponsor
- Barts & The London NHS Trust
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Influence of Prior Walking on Postprandial Metabolism and Endothelial Function.
The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in healthy South Asian and White European women.
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT03712501
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Cardiovascular Diseases, Atherosclerotic Cardiovascular Disease
Generalizability of REDUCE-IT Results to People of South Asian Descent With Atherosclerotic Cardiovascular Disease in Canada (REDUCE-IT Canada SA)
The REDUCE-IT Canada SA Study is a cross-sectional study aiming to determine the proportion of study participants who meet the Health Canada-approved indication for icosapent ethyl (IPE;Vascepa®).
- Conditions
- Cardiovascular Diseases, Atherosclerotic Cardiovascular Disease, Myocardial Infarction, Coronary Heart Disease
- Trial name
- NCT05271591
- Where
- 5 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Cardiovascular Risk Factor, Insulin Resistance
Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology
This platform will enable investigation the cardiovascular risk reduction and the increase in participant engagement in their heart-healthy goals, through the use of virtual care/telemedicine with a digital platform that connects…
- Conditions
- Cardiovascular Risk Factor, Insulin Resistance, PreDiabetes, Diabetes
- Trial name
- HealthPals (NCT03167996)
- Testing
- Use of HealthPals (Telemedicine supported by digital health platform)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Hyperlipidemia
Translating a Heart Disease Lifestyle Intervention Into the Community
Translating a Heart Disease Lifestyle Intervention in the Community study will evaluate the feasibility and initial effectiveness of a community-based, culturally-targeted, lifestyle intervention to improve the cardiovascular…
- Conditions
- Obesity, Hyperlipidemia, Hypertension, Pre-diabetes
- Trial name
- NCT01647438
- Testing
- Lifestyle Intervention, Print Health Education
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cardiovascular Diseases
Elucidating the High Cardiovascular Disease Risk in South Asians
The goals of this cross-sectional study are to compare immune cell composition and release of incretin hormones following a meal in healthy Dutch South Asians and Dutch Europids.
- Trial name
- CAMI (NCT05829018)
- Testing
- Mixed meal test
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Cardiovascular Risk Factor
Impact of Plant Sterol Supplement on LDL-C Lowering in Low-to-Moderate Risk South Asian Patients
The purpose of this study is to measure the incremental effectiveness of a twice daily plant sterol supplement in a population of South Asian patients who have low-to-moderate cardiovascular disease (CVD) risk.
- Trial name
- NCT04030247
- Testing
- Plant Sterol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Coronary Artery Disease, Heart Diseases
South Asians and Coronary Plaque Registry
Individuals who self-report as SAs will be recruited to participate in this registry as well as non-SA controls for comparison. All individuals who consent to participate will 1) complete a survey assessing demographics, medical…
- Trial name
- NCT05367297
- Testing
- Coronary CT Angiogram
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes Mellitus, Type 2
Comparative Metabolomics in Diabetes Patients From Sri Lanka and Switzerland
This study is a case-control study, where the assumed different subtypes of type 2 diabetes in people of Tamil ethnicity and Swiss origin living in Bern, Switzerland will be examined by measuring the metabolite profiles and the…
- Trial name
- NCT05787457
- Testing
- Clinical examination, Blood testing, MRI
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Healthy Volunteers
Sunlight Exposure and Vitamin D Status of Children of South Asian Ethnicity Living in the UK
The purpose of this study is to examine the amount of sunlight exposure and vitamin D status of adolescent schoolchildren of South Asian ethnicity in each season throughout the year.
- Trial name
- NCT01623414
- Where
- United Kingdom
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Manchester
PCOS, Infertility
Glucose Metabolism and Live Birth Outcomes in PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine and reproductive disorder in which insulin resistance (IR) is proposed as a key pathophysiological feature of the disease's symptoms and consequences.
- Conditions
- PCOS, Infertility, Diabetes, PreDiabetes
- Trial name
- NCT04364087
- Testing
- Oral glucose tolerance test
- Where
- Vietnam
- Volunteers
- 1,208 people
- Sponsor
- Mỹ Đức Hospital