Clinical trials: Spasm
Benign Essential Blepharospasm, Hemifacial Spasm
Effects of DaxibotulinumtoxinA for Blepharospasm and Hemifacial Spasm
The goal of this clinical trial is to test the effects of DaxibotulinumtoxinA-Lanm (Daxxify) in patients with benign essential blepharospasms (BEB) and hemifacial spasms (HFS). The main questions to answer: 1.
- Trial name
- NCT06195241
- Testing
- DaxibotulinumtoxinA
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Montefiore Medical Center
Hyperactivity in Children With Down Syndrome, Impulsivity in Children With Down Syndrome
Guanfacine for Hyperactivity in Children With Down Syndrome (HYPEbeGONE_DS)
The primary purpose of this study is to determine efficacy of guanfacine immediate release (GIR) for the treatment of hyperactivity/impulsivity and inattention in children 6-12 years of age with Down syndrome (DS) after 8 weeks…
- Trial name
- HYP01 (NCT06042257)
- Testing
- Guanfacine Hydrochloride Immediate Release
- Where
- 14 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Rachel G. Greenberg, MD, MB, MHS
Attention Deficit Hyperactivity Disorder, Behavior Hyperactive
Attention Deficit Hyperactivity Disorder
The ADA cohort aims for the systematic and standardized collection of sociodemographic, clinical and neuropsychological data, during 2 visits (inclusion and 12 months), from patients suffering from the co-occurrence of ADHD…
- Conditions
- Attention Deficit Hyperactivity Disorder, Behavior Hyperactive, Behavior Disorders
- Trial name
- ADA (NCT06232226)
- Testing
- Patients suffering from the co-occurrence of ADHD and addiction(s)
- Where
- 3 sites in France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Infantile Spasm
Treatment of Refractory Infantile Spasms With Fenfluramine
This is a phase II clinical trial in which children with refractory infantile spasms (also called epileptic spasms or West syndrome) will be treated with fenfluramine, to evaluate efficacy, safety, and tolerability.
- Trial name
- NCT04289467
- Testing
- Fenfluramine
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Orange County
Duodenal Spasm, ERCP
Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP
This study aims to evaluate the efficacy of intravenous lidocaine infusion on duodenal peristalsis during Endoscopic Retrograde Cholangiopancreatography (ERCP).
- Conditions
- Duodenal Spasm, ERCP, Sedation
- Trial name
- LIDO ERCP (NCT07333859)
- Testing
- Lidocaine Hydrochloride 2%, 0.9 % Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Interstitial Cystitis, Levator Spasm
A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain
The goal of this clinical trial is to compare two different treatment patterns in patients with chronic bladder pain. The main questions the investigators are seeking to answer is if bladder pain improves before and after…
- Conditions
- Interstitial Cystitis, Levator Spasm, Bladder Pain Syndrome
- Trial name
- NCT05658874
- Testing
- Multimodal Bundle Drugs, Operative Cystoscopy, Behavioral health consultation/therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Jocelyn Fitzgerald
Anorexia Nervosa
Body Composition in Adolescents With Anorexia Nervosa
Body Mass Index (BMI) is currently the most widely recommended parameter for identifying underweight subjects. Among eating disorder diseases, anorexia nervosa (AN) is the one with the highest mortality rate and with relapses…
- Trial name
- COCOMETANNER (NCT06800742)
- Testing
- Collection of anthropometric and biochemical parameters
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Auxologico Italiano
TMD/Orofacial Pain, Muscle Spasm
Dry Needling for Temporomandibular Disorder
This randomized controlled trial investigates the clinical effectiveness of dry needling in individuals with myofascial temporomandibular disorder (TMD).
- Trial name
- DN-TMD (NCT07123883)
- Testing
- Dry Needling
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Atlas University
Internal Mammary Artery Syndrome, Vasodilation
Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow
Forty-six consecutive patients undergoing elective primary coronary artery bypass grafting were enrolled. After the left IMA was harvested, free flow was measured under controlled hemodynamic conditions before any intervention…
- Trial name
- NCT06301880
- Testing
- The topical application of a vasodilator on the LIMA graft
- Where
- Syria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Damascus University
Epilepsy, West Syndrome
Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents
Rare epilepsies as a whole account for 20-30% of epilepsies, but knowledge about prognostic factors is currently limited. This means that it is difficult to provide adequate information to families at diagnosis and during…
- Conditions
- Epilepsy, West Syndrome, Dravet Syndrome
- Trial name
- EPIRARE (NCT05126914)
- Where
- 11 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Study to Assess Bronchospasm Potentially Induced by Next-Generation Propellant vs HFA Propellant in an MDI in Participants With Well/Partially Controlled Asthma
A study to assess bronchospasm potentially induced by HFO MDI as compared with HFA MDI in participants with well controlled or partially controlled asthma
- Trial name
- NCT05850494
- Testing
- HFA MDI, HFO MDI
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- AstraZeneca
Attention Deficit Hyperactivity Disorder Symptoms
Implementation Strategies for Caregiver and Teacher Use of Behavioral Interventions: Aim 2
The purpose of this study is to pilot test for feasibility and initial promise an implementation strategy resource package that aims to support caregivers in using behavioral interventions for children with hyperactive…
- Trial name
- NCT07321327
- Testing
- Positive Behavior Management Toolkit for Caregivers, Positive Behavioral Management Toolkit for Teachers
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD)
Exploring Eye Vergence Markers ADHD) and ASD
The investigators study aims to evaluate the utility of eye vergence, an eye-tracking measure, as an indicator of visuo-spatial attention in children aged 4-17 years and adults, using computer-based eye-tracking tasks.
- Trial name
- NCT06885060
- Testing
- BGaze ADHD Diagnostic Test, Oddball/Alerting Computer Task, Facical Emotion Computer Task
- Where
- 3 sites in Spain, United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Elizabeth Kilbey
Achalasia, Esophageal Spasm, Diffuse
Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders
This is prospective data recording study. All patients will receive standard medical care and no experimental interventions will be performed.
- Conditions
- Achalasia, Esophageal Spasm, Diffuse, Gastroparesis, Swallowing Disorder
- Trial name
- POEM (NCT05905016)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- AdventHealth
Bronchitis Obstructive, Bronchiolitis; Obstruction
Comparing the Efficacy of Two Valved Holding Chambers in Acute Wheezing
The incidence of physician confirmed asthma is approximately 4-7% in children. An additional 5% of children suffer from infection-related bronchiolitis and obstructive bronchitis.
- Conditions
- Bronchitis Obstructive, Bronchiolitis; Obstruction, Bronchospasm; Bronchitis
- Trial name
- CHAMBER (NCT03900494)
- Testing
- VHC 1, VHC 2
- Where
- 4 sites in Finland
- Volunteers
- 80 people
- Sponsor
- Tampere University
Attention Deficit Hyperactivity Disorder Symptoms
Caregiver Implementation Strategies Field Pre-Test
The purpose of this study is to field pre-test an implementation strategy resource package that aims to support caregivers in using behavioral interventions for children with hyperactive, inattentive, or impulsive behaviors.
- Trial name
- NCT06770036
- Testing
- Implementation Resource Package for Caregivers
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia
Coronary Artery Disease, Radial Artery Spasm
Association Between Radial Artery Access Point and Radial Artery Spasm
This prospective clinical study aims to investigate whether the puncture site distance from the radial styloid process affects the incidence of radial artery spasm (RAS) during coronary angiography.
- Trial name
- NCT07060820
- Testing
- Radial Artery Puncture at 0-20 mm, Radial Artery Puncture at >21 mm
- Where
- Turkey (Türkiye)
- Volunteers
- 380 people
- Sponsor
- Mersin Medicalpark Hastanesi
Acute Low-back Pain, Muscle Spasm; Back Pain
Efficacy and Safety of Etoricoxib/Tizanidine Versus Etoricoxib for Acute Low Back Pain Associated to Muscle Spasm
This is a Phase III, longitudinal, multicenter, randomized, double-blind clinical trial. The aim of the study is to evaluate the efficacy and safety of a fixed-dose combination of etoricoxib and tizanidine compared to etoricoxib…
- Trial name
- NCT06863662
- Testing
- Etoricoxib + Tizanidine fixed dose, Etoricoxib fixed dose
- Where
- Mexico
- Volunteers
- 136 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Infantile Colic, Infantile Spasm
The Effect of Spa and Massage on Babies on Colic Symptoms
Although various complementary health approaches have been examined to alleviate colic symptoms, there seems to be a limited number of studies on SPA and massage applications.
- Trial name
- NCT05538936
- Testing
- Baby SPA, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Hyperextension Spasms, Involuntary Movements
NETTI Wheelchair: Does Dynamic Mode or Static Mode Affect the Sitting Position in Patients With Involuntary Movements ?
This study compares two modes of the NETTI wheelchair (dynamic or sitting) for patients with hyperkinetic syndromes, to discover which mode is the most comfortable and best suited to these patients.
- Trial name
- DYNAMIC SYSTEM (NCT06351189)
- Testing
- Observation
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes