Clinical trials: Spastic Dysphonia
Laryngeal Dystonia, Spasmodic Dysphonia
Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor
The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
- Trial name
- NCT05150106
- Testing
- Clinical assessments of laryngeal function
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Laryngeal Dystonia
tDCS for Laryngeal Dystonia
This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).
- Trial name
- NCT06830174
- Testing
- Starstim system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Dysphonia, Spastic, Dysphonia
Reversal of Botulinum Neurotoxin Injection Related Dysphonia With Pyridostigmine
The purpose of this study is to evaluate the effects of pyridostigmine (Mestinon) on patient vocal outcomes after undergoing laryngeal botulinum neurotoxin (BoNT) injections, which is a standard treatment for spasmodic dysphonia.
- Conditions
- Dysphonia, Spastic, Dysphonia, Laryngeal Dystonia
- Trial name
- NCT05110417
- Testing
- Pyridostigmine Bromide 60 Milligrams (mg)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Eastern Virginia Medical School
Spasmodic Dysphonia
Dysphonia Pain Perception Following Botulinum Toxin Injections
Spasmodic dysphonia (SD) is a chronic voice disorder which can cause a significant decrease in voice related quality of life with no cure.
- Trial name
- NCT06767215
- Testing
- Ice Compress, No ice compress
- Where
- Canada
- Volunteers
- 116 people
- Sponsor
- University of British Columbia
Voice Disorders
Dextromethorphan to Treat Patients With Voice Spasms
This study will examine how dextromethorphan, a drug that alters reflexes of the larynx (voice box), might change voice symptoms in people with voice disorders due to uncontrolled laryngeal muscle spasms.
- Trial name
- NCT00055549
- Testing
- Dextromethorphan, Lorazepam
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spasmodic Dysphonia, Laryngeal Dystonia
rTMS in Spasmodic Dysphonia
Focal dystonia is a neurological movement disorder characterized by excessive involuntary muscle contractions of any body part. Spasmodic dysphonia (SD) is a type of focal dystonia characterized by excessive contraction of…
- Trial name
- NCT02957942
- Testing
- 1Hz repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Adductor Spasmodic Dysphonia
The Effect of Vocal Rest Versus Vocalization Following Xeomin® Injections in Spasmodic Dysphonia
This study will compare the effects of vocal rest versus continuous vocalization for one hour immediately following botulinum toxin injections for adductor spasmodic dysphonia.
- Trial name
- NCT03129087
- Testing
- Vocal rest versus vocalization
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Laryngeal Dystonia, Spasmodic Dysphonia
Transcranial Magnetic Stimulation in Laryngeal Dystonia
This randomized clinical trial with a crossover design aims to investigate the effects of neuromodulation through repetitive transcranial magnetic stimulation (rTMS) applied to patients diagnosed with laryngeal dystonia.
- Trial name
- NCT07683767
- Testing
- Active rTMS, Speech-Language Therapy
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Adductor Spasmodic Dysphonia
Effects of Vocal Exercises for Spasmodic Dysphonia
The purpose of this study is to assess the effect of voice exercise and voice rest on subject's perception of vocal handicap and communicative participation following Botox injections for adductor spasmodic dysphonia.
- Trial name
- NCT03349086
- Testing
- Voice Exercise
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison