Clinical trials: Spatial Navigation, active
Traumatic Brain Injury
Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic Brain Injury
Impairments in spatial memory and spatial navigation are commonly reported amongst patients presenting post-traumatic brain injury (TBI).
- Trial name
- NCT07271524
- Testing
- Transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 25 people
- Sponsor
- Friedhelm Hummel
Spine Fusion, Spine Injury
Spine Surgery Video Observation Study. The Creation of a Benchmark Video (RGB-Depth) Dataset to Investigate the Feasibility of Developing a Markerless Tracking System for Spine Surgery.
The primary study objective is to build a video dataset, consisting of both colour and depth information, of spine surgery that includes both 'open' and 'minimally invasive' (MIS) surgeries.
- Conditions
- Spine Fusion, Spine Injury, Spine Degeneration, Navigation, Spatial
- Trial name
- SPIVOS (NCT06580379)
- Testing
- Spine surgery
- Volunteers
- 25 people
- Sponsor
- Imperial College London
Cerebral Palsy (CP)
Cortical Correlates of Spatial Navigation Skills in an Immersive Virtual Reality Environment
The goal of this study is to investigate the neural mechanisms that undergoes spatial navigation skills in children/adolescents aged between 8 and 17 years.
- Trial name
- NCT06710301
- Testing
- Preliminary assessment, Navigation task with EEG recording
- Where
- 2 sites in Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Lung Nodules, Biopsy
Efficacy and Safety of Robotic-assisted Bronchoscopy Combined With the ICNVA Strategy in Biopsy of Peripheral Pulmonary Nodules
To assess the efficacy and safety of robotic-assisted bronchoscopy system (bronchial navigation and positioning device) combined with ICNVA strategy for peripheral pulmonary nodule biopsy through a prospective, single-center…
- Conditions
- Lung Nodules, Biopsy, Navigation, Spatial
- Trial name
- NCT07136961
- Testing
- Robot-Assisted Bronchoscopy (RAB)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Mild Cognitive Impairment (MCI)
Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment
The goal of this one-arm clinical trial is to determine whether participants with mild cognitive impairment (MCI) can successfully navigate a virtual reality (VR) maze.
- Trial name
- SNav (NCT07225400)
- Testing
- Spatial Navigation training
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Brain Neoplasms, Cerebral Aneurysm
Clinical Trial for the Validation of AR Based Neuronavigation System
The goal of this clinical trial is to test augmented reality (AR) based neuronavigation system in surgeries for patients of brain neoplasm or cerebral vascular disease.
- Conditions
- Brain Neoplasms, Cerebral Aneurysm, Cerebral Arteriovenous Malformation, Navigation, Spatial
- Trial name
- NCT05776706
- Testing
- AR-based navigation
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Spatial Navigation
Modulating Goal-directed Navigation Using Noninvasive Brain Stimulation
Our specific aim is to examine the effects of TMS on spatial processing during goal-directed navigation. In these experiments the investigators will utilize a scalp-recorded brain oscillation called right posterior theta that is…
- Trial name
- NCT05801861
- Testing
- Active 10-Hz TMS to the parietal cortex, Active single pulse TMS to the parietal cortex
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Vestibular Dysfunction, Bilateral Vestibular Loss
Spatial Orientation, Navigation, and Neuropsychologic Function in Patients With Vestibular Implant
The vestibular system, located in the inner ear, provides information to the brain information about how head acceleration and orientation relative to gravity.
- Conditions
- Vestibular Dysfunction, Bilateral Vestibular Loss, Vestibular Implant
- Trial name
- NCT07627087
- Testing
- vestibular implant stimulation
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Mild Cognitive Impairment, Alzheimer Disease
Spatial Navigation for the Early Detection of Alzheimer's Disease.
Alzheimer's Disease (AD) is the most common form of dementia and may contribute to 60-70 % of all cases. An early, accurate diagnosis of AD will become increasingly important with disease-modifying therapies.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Healthy Aging
- Trial name
- ALLO-task (NCT06385951)
- Testing
- Procedure for patients, Procedure for healthy controls
- Where
- Belgium
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Aging, Anxiety
Neurobiological Mechanisms of Aging and Stress on Prospective Navigation
Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress…
- Conditions
- Aging, Anxiety, Memory Impairment
- Trial name
- NCT03896529
- Testing
- Anticipatory psychological stress
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers
To establish the diagnostic and prognostic models that could help the preclinical identification of subjects at higher risk of clinical progression to mild cognitive impairment and dementia based on combined features of baseline…
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT06561906
- Testing
- Multimodal magnetic resonance imaging scanning, behavioral, genetic and plasma biomarker testing
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Blindness, Visual Impairment
The Impact of the Years of Blindness on Sleep and Dreaming Processes and the Relationships With Spatial Abilities
This study aims to assess the impact of blindness on sleep and dreaming processes and the relationship with spatial perceptual performance, examining the link with clinical and psychological indices, neurobiological features, and…
- Trial name
- NCT06631807
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istituto Italiano di Tecnologia
Memory, Delayed
Neural Correlates of Real World Spatial Navigation in Humans
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world…
- Trial name
- NCT04874220
- Testing
- Deep Brain Stimulation, Memory and spatial navigation tasks, Physiological Signals
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Duke University
Cerebral Palsy, Healthy Volunteers
Assessment of Navigation Abilities in Children With Cerebral Palsy and Their Peers
Spatial navigation skills are very important in everyday activities and quality of life but spatial navigation abilities are not part of the standard process of assessment and rehabilitation of patients.
- Trial name
- NCT06320106
- Testing
- Virtual Reality baseline assessment
- Where
- Italy
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Brain Injuries, Traumatic, Brain Injury Traumatic Severe
Online Memory Intervention for Individuals with Traumatic Brain Injury
This study will examine the behavioural and neurophysiological efficacy and feasibility of an online spatial navigation intervention for improving memory and brain health in individuals who have sustained moderate-severe…
- Conditions
- Brain Injuries, Traumatic, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate, Brain Injury, Chronic
- Trial name
- NCT04331392
- Testing
- Spatial Navigation Intervention, Educational Videos
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Toronto Rehabilitation Institute
Epilepsy, Autobiographical Memory
Capturing Autobiographical Memory Formation in Real World Spaces Using Multimodal Recordings
The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted…
- Trial name
- CAPTURE (NCT06883981)
- Testing
- Free and Cued Recall Memory. Temporal Sequence and Spatial Memory
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Utah