Clinical trials: Specificity
Prostate Cancer
68Ga-PSMA PET/CT in Prostate Cancer
This is a single-center, multi-arm, open-label, phase III trial in up to 500 patients with biopsy-proven prostate cancer. Participants will receive regular standard of clinical care.
- Trial name
- NCT04684628
- Testing
- 68Ga-PSMA PET/CT
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Saskatchewan
Atrial Fibrillation
Sensitivity and Specificity of a Mobile Lead-one ECG Like Device for the Detection of Atrial Fibrillation (AF)
Atrial Fibrillation(AF) is one of the most common abnormal heart rhythms and approximately 3% of the general population have AF.
- Trial name
- NCT03524625
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
COVID-19
Diagnostic Value of Patient - Reported and Clinically Verified Olfactory Disorders (COVID-19)
Participants are healthcare workers and adult outpatients referred in a COVID-19 screening center. Patients-reported symptoms are collected, then participants underwent a simple olfactory test (CODA for Clinical Olfactory…
- Trial name
- COVID-OLFA (NCT04407494)
- Testing
- Reporting of anosmia, ageusia and other clinical symptoms
- Where
- France
- Volunteers
- 809 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
High Sensitivity and Specificity (With 95% Confidence Interval) of RealDetect™ COVID-19 RT-PCR Kit
Performance Evaluation of RealDetect™ COVID-19 RT-PCR Kit for the Detection of SARS-CoV-2 Virus
The novel Severe acute respiratory syndrome coronavirus 2 (SARS-C0V 2) originated in Wuhan, China in December 2019. As of April 15 2020, the virus has spread across 213 countries/territories with 1,914,916 cases and 123,010…
- Trial name
- NCT04403672
- Testing
- performance evaluation study of RealDetect RT-PCR Kit for COVID-19 detection
- Where
- Bangladesh
- Volunteers
- 120 people
- Sponsor
- Bangladesh Medical Research Council (BMRC)
Alzheimer Disease, Mild Cognitive Impairment
Validation of the Montreal Cognitive Assessment in Patients With Mild and Major Neurocognitive Disorder
The primary aim of our study is to investigate the specificity, the sensitivity, and the overall diagnostic accuracy of the MoCA for mild and major NCD in a German-speaking population.
- Trial name
- MoCA-Valid (NCT03581643)
- Where
- Switzerland
- Volunteers
- 430 people
- Sponsor
- Andreas Monsch
Generalized Chronic Periodontitis
Activated MMP-8 as Diagnostic Test for Periodontitis
Background: Untreated periodontal disease may influence general health. However, how may a physician who is not trained in periodontal probing detect untreated periodontitis? Activated matrix metalloproteinase-8 (aMMP-8) in…
- Trial name
- MMP-8 (NCT02280122)
- Testing
- no intervention provided
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Goethe University
Lymphoma
Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Relapsed and Refractory Lymphoma
Patients with relapsed or refractory lymphoma often develop resistance to chemotherapy. Chimeric antigen receptor-modified T cell (CART) therapy showed promising effect in B-cell malignancies these years.
- Trial name
- NCT03468153
- Testing
- Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Ruijin Hospital
NMO Spectrum Disorder, NMDA-R Encephalitis
Sensitivity and Specificity of TSA-CBA for Autoantibodies Against Neural Antigen Determination
Determination of autoantibodies against fragments derived from neurons, glia, and myelin sheath is instrumental in aiding diagnosis, differential diagnosis, as well as determining disease status of neuromyelitis optica spectrum…
- Conditions
- NMO Spectrum Disorder, NMDA-R Encephalitis, Diagnostic Self Evaluation, Immune System Diseases
- Trial name
- STAND (NCT05414890)
- Testing
- CBA-TSA
- Where
- China
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
HPV Infection, HPV Positive Oropharyngeal Squamous Cell Carcinoma
The SPOT-HPV Study
The purpose of this research is to evaluate a new test for oral HPV DNA in saliva ('oral rinse test').
- Trial name
- NCT05524025
- Testing
- Salivary TTMV-HPV DNA Test, Blood TTMV-HPV DNA Test
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Septic Shock, Fluid Reponsiveness
This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume Overload
Reliability of the LVOT-VTI versus lung ultrasonography for early detection of fluid intolerance during fluid resuscitation of septic patients.
- Trial name
- lvotvti (NCT07797751)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dyspepsia, GERD
Sensitivity and Specificity of the Modified Helicobacter Test INFAI
Study to confirm the sensitivity of the C^13-UBT using the new test meal for H. Pylori in patients with dyspepsia and GERD taking PPI Secondary objectives : to compare the sensitivity and specificity of the C^13-UBT using the new…
- Trial name
- NCT04294823
- Testing
- Helicobacter Pylori Diagnostic, Vital signs measurments, endoscopy
- Where
- France
- Sponsor
- International Pharmaceutical Consultancy
Breast Cancer
Screening for Breast Cancer With Digital Breast Tomosynthesis
Randomized trial comparing the performance of tomosynthesis and 2D Digital Mammography vs 2D Digital Mammography only in respect to incidence of advanced cancers (interval and following round) and interval cancers.
- Trial name
- NCT02698202
- Testing
- Digital Breast Tomosynthesis
- Where
- Italy
- Volunteers
- 26,877 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Spinal Cord Injuries
Task-specificity for Locomotor Recovery Following SCI
The primary goal of the proposed study is to identify the contributions of the amount of task-specific practice on locomotor (i.e., walking) recovery in patients with chronic (> 1 yr) motor incomplete spinal cord injury (iSCI).
- Trial name
- NCT03144388
- Testing
- Variable Stepping Training, Variable Non-specific Training
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Indiana University
Leukemia, Lymphoma
Pilot Study on the Infusion of ARI-0001 Cells in Patients With CD19+ Leukemia or Lymphoma Refractory to Therapy
To assess the infusion of ARI-0001 cells (Adult differentiated autologous T-cells from peripheral blood, expanded and transduced with a lentivirus to express a chimeric antigen receptor with anti-CD19 specificity [A3B1]…
- Trial name
- CART19-BE-01 (NCT03144583)
- Testing
- Adult differentiated autologous T-cells
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Sara V. Latorre
Horton Disease
Chewing Gum Test for the Diagnosis of Giant Cell Arteritis (Horton's Disease) - ChewingHort
It is hypothesized that chewing-gums may be a useful test to unmask jaws intermittent claudication in order to enhance the diagnosis of Giant Cell Arteritis (GCA).
- Trial name
- ChewingHort (NCT04010097)
- Testing
- chewing gum
- Where
- 6 sites in France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology
Accuracy of the Red Reflex Test in the Pediatric Population
This study is designed to investigate the sensitivity and specificity of the Red Reflex Test (RRT), with and without dilation, for early detection of ocular abnormalities in children and newborns.
- Conditions
- Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology, Optic Nerve Diseases, Retinal Disease
- Trial name
- NCT04125043
- Testing
- Direct ophthalmoscope
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
BCC - Basal Cell Carcinoma, BCC
The Diagnostic Accuracy of Advanced Imaging in Identifying Suspected Skin Cancer (Basal Cell Carcinoma) Around the Eyes
The purpose is to investigate the diagnostic value (sensitivity and specificity) of dermal-Optical Coherence Tomography (D-OCT, VivoSight Dx), in patients with clinically suspected BCC lesions inside the periocular region and…
- Conditions
- BCC - Basal Cell Carcinoma, BCC, Skin Diseases, Eyelid Tumor
- Trial name
- dOCT-pBCC (NCT06279143)
- Where
- Denmark
- Volunteers
- 210 people
- Sponsor
- Vejle Hospital
Obesity and Overweight
Exploring the Role of Baduanjin on Lumbar and Hip Mobility Index in Obese People Based on Infrared Thermography and Meridian Point Specificity
This study aimed to explore whether Baduanjin, a traditional fitness practice, can improve waist and hip mobility in obese individuals.
- Trial name
- NCT07035639
- Testing
- The Baduanjin intervention was designed following traditional Chinese health preservation principles and conducted under the guidance of certified instructors. The training sessions were led by nation
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Chengdu Sport University
Feeding Behavior, Inhibition (Psychology)
Specificity of Flavor-Nutrient Learning: An fMRI Experiment
This is an etiology study designed to examine the how people's brains and behaviors respond to regularly consuming a beverage. Participants are assessed at 2 behavioral assessments (Wave 1 and Wave 2), 2 scans (at the BRIC), and…
- Trial name
- NCT02624206
- Testing
- Juice A, Juice B
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hypertension
Accuracy of AOBP in a Chinese Population
Background: Traditional office blood pressure (BP) measurement is often inaccurate and is inferior to out-of-office measurements, such as ambulatory blood pressure monitoring (ABPM), in predicting cardiovascular outcomes.
- Trial name
- NCT03454178
- Testing
- WatchBP Office (BP measurement machine)
- Where
- Hong Kong
- Volunteers
- 149 people
- Sponsor
- Chinese University of Hong Kong