Clinical trials: Speech
Aging, Mild Cognitive Impairment
Internet-based Conversational Engagement Clinical Trial
The study aims to randomize 320 (160 Caucasian, 160 African American) socially isolated adults 75+ years old (50:50 split between those with normal cognition and mild cognitive impairment (MCI)) recruited from the community to…
- Trial name
- I-CONECT (NCT02871921)
- Testing
- Conversational Engagement
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Laryngomalacia, Gastro Esophageal Reflux
Initiation of Acid Suppression Therapy Prospective Outcomes for Laryngomalacia
Laryngomalacia (LM) is the most common cause of stridor in infants. Symptoms of gastroesophageal reflux (GER) are often seen in the setting of LM; therefore, acid suppression therapy (AST) has been empirically used in the…
- Trial name
- NCT04614974
- Testing
- Famotidine, Speech Language Therapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Reema Padia
Aphasia
Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia
Transcranial Magnetic Stimulation (TMS) has been demonstrated to improve language function in subjects with chronic aphasia in a number of small studies, many of which did not include a control group.
- Trial name
- NCT03651700
- Testing
- Active TMS, CILT
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- H. Branch Coslett
Aphasia, Stroke
Dosage and Predictors of Naming Treatment Response in Aphasia
This study examines aphasia treatment response among Veterans and non-Veterans living with aphasia. It seeks to identify cognitive and neural factors which are predictive of positive response to treatment targeting naming…
- Trial name
- NCT02005016
- Testing
- Naming therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- VA Office of Research and Development
Unrecognized Condition
Preoxygenation With Optiflow™ - the Effect of Speech on Lung Oxygenation.
If a patient speaks during the process of preoxygenation with high-flow nasal oxygen via the Optiflow™ system, is the efficacy reduced as measured by end-tidal lung oxygen content?
- Trial name
- NCT03766646
- Testing
- Optiflow
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Stroke
Stimulating Language in Subacute StrokE
The investigators will study the effects of transcranial direct current (tDCS) stimulation during language therapy for naming in individuals with aphasia in the acute and subacute post stroke period.
- Trial name
- SLISSE (NCT02674490)
- Testing
- A-tDCS (1 mA), SALT
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University
Nonfluent Aphasia, Stroke
Augmenting Language Therapy for Aphasia: Levodopa
The purpose of this study is to evaluate the effectiveness of the medication levodopa, in combination with speech-language treatment, on the language outcome of study subjects with nonfluent aphasia (i.e.
- Trial name
- NCT01429077
- Testing
- levodopa/carbidopa
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Hearing Loss
Clinical Applications for Time-Compressed Speech Tests
The purpose of this study is to determine the effects of age-related cognitive changes on hearing aid benefit based on hearing aid compression time constants.
- Trial name
- NCT00371839
- Testing
- Audiological Evaluation
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Parkinson's Disease
An RCT of a Telemedicine Intervention for Hypokinetic Dysarthria in PD
Nearly 90% of people with Parkinson's disease have speech and voice disorders that negatively impact their ability to communicate effectively in daily life.
- Trial name
- NCT04617496
- Testing
- Combined speech and exercise intervention, Health education
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- VA Office of Research and Development
Aphasia
TMS in Aphasia Recovery
Stroke often causes substantial problems in speaking or understanding speech. Treatments for these problems are currently very limited.
- Trial name
- NCT04777214
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pennsylvania
Sensorineural Hearing Loss
Phase I/IIa Study Evaluating Safety and Efficacy of an Intratympanic Dose of PIPE-505 in Subjects With Hearing Loss
This is a randomized, double-blind study of PIPE-505, or placebo, in subjects with hearing loss associated with speech-in-noise impairment.
- Trial name
- NCT04462198
- Testing
- PIPE-505
- Where
- 8 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Stuttering, Stuttering, Childhood
Speech Processing in Stuttering
This research is being done to better understand stuttering, specifically how people who stutter may process and/or produce speech.
- Conditions
- Stuttering, Stuttering, Childhood, Stuttering, Adult
- Trial name
- NCT04929184
- Testing
- Speech and non-speech tasks
- Where
- 2 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Mild Cognitive Impairment, Primary Progressive Aphasia
Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease
The primary objective of this research is to evaluate the effects of non-invasive brain stimulation and computerized cognitive training on executive functioning in individuals with Primary Progressive Aphasia (PPA), mild…
- Conditions
- Mild Cognitive Impairment, Primary Progressive Aphasia, Dementia
- Trial name
- NCT05978804
- Testing
- Computerized Cognitive Training, Active tDCS (tDCS) on DLPFC
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Stuttering, Adult
Bihemispheric Transcranial Direct Current Stimulation* on Speech Fluency
It will be determined whether bihemispheric stimulation (anodal to the left IFG and cathodal to the right IFG) is used with fluency-facilitating conditions for 5 consecutive days in individuals with stuttering and whether there…
- Trial name
- TDCS (NCT06278233)
- Testing
- Transcranial direct current stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Biruni University
Aphasia, Cerebrovascular Accident
Treating Intention In Aphasia: Neuroplastic Substrates
The purpose of this study is to determine if an "intentional act" improves treatment response for patients with nonfluent aphasia. The treatment involves naming pictures and saying members of categories.
- Trial name
- NCT00567242
- Testing
- Word-finding with intention component, Word-finding with no intention component
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Depression
The ISLAND Study: InSuLa Assessed Needs for Depression
While there are many effective options for treating a major depressive episode, there are no clinical markers that predict the likelihood of remission with an initial trial of either an antidepressant medication or psychotherapy.
- Trial name
- ISLAND (NCT02137369)
- Testing
- Selective serotonin re-uptake inhibitor, Cognitive Behavioral Therapy, Combination treatment (SSRI + CBT)
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Emory University
Stroke
Speech Therapy for Aphasia: Comparing Two Treatments
This is a behavioral speech therapy trial for individuals who have suffered a stroke on the left side of the brain and have difficulty speaking.
- Trial name
- PMvSFA (NCT02153710)
- Testing
- Semantic Feature Analysis therapy, Phonomotor Therapy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
Down Syndrome
Down Syndrome Speech Intelligibility Diagnostic Treatment Study
The 'Down syndrome speech intelligibility diagnostic treatment study' is a pilot clinical intervention study assessing the efficacy of an integrative speech treatment approach for individuals with Down syndrome (DS).
- Trial name
- NCT04059354
- Testing
- Speech therapy addressing phonology and motor learning
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Wisconsin, Madison
Hearing Loss, Sensorineural, Dysarthria
Application of Ideal Binary Masking to Disordered Speech
Dysarthria and hearing loss are communication disorders that can substantially reduce intelligibility of speech and the addition of background noise adds a further challenge.
- Trial name
- NCT05244603
- Testing
- Ideal binary mask
- Where
- United States
- Volunteers
- 435 people, healthy volunteers welcome
- Sponsor
- Utah State University
Language Development
STEM (Science, Technology, Engineering & Math) Familia Talk
After development of the Talk Stem Familia (TSF) smart-speaker application prototype, the study will evaluate the prototype's efficacy in a within-subjects pre-post design study.
- Trial name
- NCT03766906
- Testing
- Talk STEM Familia app
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.