Clinical trials: Speech Disorders, active
Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis)
Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS)
Eighteen million people worldwide are affected by speech disorders. Locked-in syndrome (LIS) represents the most extreme form of communication disability resulting from motor impairment.
- Trial name
- SpeechBCI (NCT07698496)
- Testing
- Chronic speech BCI
- Where
- 4 sites in France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Grenoble
Aphasia
Neural Bases of Vocal Sensorimotor Impairment in Aphasia
Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control.
- Trial name
- NCT04742894
- Testing
- Visual Feedback Training
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Stuttering
Development and Pilot Testing of Virtually Simulated Intervention for Patients Having Stuttering
This study aims to develop and pilot test a culturally appropriate virtual reality (VR)-based speech restructuring intervention for individuals with stuttering in Pakistan.
- Trial name
- NCT07833969
- Testing
- Virtually Simulated Intervention
- Where
- Pakistan
- Volunteers
- 10 people
- Sponsor
- Riphah International University
Stroke, Aphasia
Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits
The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment.
- Conditions
- Stroke, Aphasia, Reading Disorder
- Trial name
- NCT06213272
- Testing
- Phono-Motor Therapy, Aerobic Exercise Training (AET), Stretching
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Kessler Foundation
Stroke, Ischemic Stroke
Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen
Cognitive problems are common after a stroke and must be identified early so that rehabilitation can be initiated to improve outcome.
- Conditions
- Stroke, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral, Cognitive Dysfunction
- Trial name
- OCS-PRECISE (NCT07897916)
- Where
- 2 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- University of Copenhagen
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Conductive Hearing Loss
Wideband Tympanometry as a Non-behavioral Test of the Speech-weighted Middle Ear Transfer Function.
There is a need for a non-behavioral clinical test that provides an assessment of how speech is conducted through the middle ear for the optimization of middle ear implants.
- Trial name
- NCT07557771
- Testing
- Wideband Tympanometry
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ankyloglossia, Impairment of Speech
Effectivity of P1821, a Novel Tongue Strengthening and Endurance Enhancing Speech Flow Exercise
The P1821 initiative constitutes an innovative intervention specifically engineered to enhance tongue muscular strength and endurance.
- Conditions
- Ankyloglossia, Impairment of Speech, Slurred Speech
- Trial name
- NCT07719582
- Testing
- P1821
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dream Video LLC
Expressive Aphasia, Aphasia Following Cerebral Infarction
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia (BG-Aphasia-01)
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with aphasia to generate text on a computer screen and audible…
- Conditions
- Expressive Aphasia, Aphasia Following Cerebral Infarction, Aphasia Following Nontraumatic Intracerebral Hemorrhage, Aphasia Non Fluent
- Trial name
- BG2-Aphasia-01 (NCT07791459)
- Testing
- BrainGate Neural Interface System
- Volunteers
- 5 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Myasthenia Gravis Generalised
Detecting Fatigue From Voice in Generalised Myasthenia Gravis
The goal of this observational study is to learn if computer analysis of voice recordings can detect a type of exhaustion called "central fatigue" in adults with generalised myasthenia gravis.
- Trial name
- NCT07033559
- Volunteers
- 240 people
- Sponsor
- Thymia Limited
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Remote Digital Assessments for Cognitive Disorders
Memory and thinking problems in older adults, including mild cognitive impairment (MCI) and Alzheimer's disease (AD), can be difficult to assess promptly because evaluation often depends on in-person specialist visits.
- Trial name
- MonitorCog-AI (NCT07883746)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Subjective Cognitive Decline (SCD), Subjective Cognitive Complaints (SCCs)
The Signature of Alzheimer's Disease in Subjective Cognitive Decline
This study focuses on improving early detection of Alzheimer's disease (AD) in patients with subjective cognitive decline (SCD), a preclinical stage of cognitive impairment, in the context of emerging disease-modifying therapies…
- Conditions
- Subjective Cognitive Decline (SCD), Subjective Cognitive Complaints (SCCs), Subjective Cognitive Impairment, Subjective Cognitive Concerns
- Trial name
- SIGN-AL (NCT07402161)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Policlinico S. Donato
Childhood Apraxia of Speech
Motor-based Intervention for Childhood Apraxia of Speech: DTTC-Connect
Childhood apraxia of speech (CAS) is a complex motor speech disorder that significantly limits a child's ability to communicate in daily activities, with difficulties often persisting into adolescence and adulthood.
- Trial name
- NCT07526246
- Testing
- Dynamic Temporal and Tactile Cueing - Connect (DTTC-Connect)
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- New York University
Psychotic Disorder
Speech-based Assessment of Relapse Risk in People With Psychosis
This observational, multinational study assesses the feasibility of speech and self-report data collection across six languages for Artificial Intelligence (AI)-driven relapse risk estimation in psychosis.
- Trial name
- TRUSTING-WP4 (NCT07397975)
- Testing
- Weekly online speech assessments via a smartphone app collect speech and self-report data. Recordings are securely transferred and analyzed by an AI-based backend to calculate relapse risk scores.
- Where
- 7 sites in Czechia, Ireland and 4 more
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Philipp Homan
Logopenic Progressive Aphasia, Primary Progressive Aphasia
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
AD afflicts over 5.5. million Americans and is one of the most expensive diseases worldwide. In AD the variant in which language functions are most affected are referred to as 'logopenic variant Primary Progressive Aphasia'…
- Trial name
- NCT03887481
- Testing
- High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Aphasia, Acquired, Chronic Stroke
VR and Scrip Training of PWA, Randomized Controlled Trial
The goal of this RCT is to investigate if computerized script training may promote functional communication and nonverbal cognitive functions of Cantonese-speaking PWA, and whether VR may further magnify the treatment outcomes.
- Trial name
- VRSTPWA (NCT06722092)
- Testing
- VR-based script training, Conventional script training
- Volunteers
- 105 people
- Sponsor
- The Hong Kong Polytechnic University
Selective Mutism, Anxiety Disorder of Childhood
VR Homework Exercises for Selective Mutism Treatment
Selective mustism (SM) is an anxiety disorder that manifests in childhood. Children with Children with SM do not speak in certain social situations where this is expected of them.
- Trial name
- NCT06882629
- Testing
- 'Speaking at school, a matter of doing' combined with VR homework exercises
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Luuk Stapersma
Aphasia, Stroke
Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia
The postulate of this study is that rehabilitation combining linguistic and metacognitive training will result in a significant improvement in language performance correlated with changes in functional cerebral connectivity…
- Trial name
- METALEX (NCT06930131)
- Testing
- Semantic rehabilitation
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Stuttering, Childhood, Stuttering
Network Connectivity and Temporal Processing in Adolescents Who Stutter
The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter.
- Trial name
- NCT05286151
- Testing
- Rhythm discrimination
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Aphasia
Based on the Spatio-temporal Coding Characteristics of Frontotemporal Network, This Paper Explores the Mechanism of Five-tone Speech Training in Reshaping Language Fluency Function.
To explore the mechanism of five-tone speech training in reshaping language fluency function and the clinical efficacy of aphasia language function, daily communication ability and communication efficiency based on the temporal…
- Trial name
- NCT07329751
- Testing
- Traditional Chinese Medicine Five-Tone Therapy, Melodic Intonation Training, Standard speech therapy; Routine medical treatment; Health education
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fujian University of Traditional Chinese Medicine