Clinical trials: Speech and Language Disorder
Stroke, Aphasia
Studying Language With Brain Stimulation in Aphasia
The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.
- Trial name
- NCT05660304
- Testing
- Cortico-cortical paired associative stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Aphasia, Stroke
HD-tDCS for Phonological Impairment in Aphasia
This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.
- Trial name
- NCT06010030
- Testing
- Targeted Transcranial Direct Current Stimulation, Speech Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Medical College of Wisconsin
Alzheimer Disease, Mild Cognitive Impairment
Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders
The primary objective of the study is to evaluate the feasibility of eliciting continuous narrative speech in different neurodegenerative and psychiatric indications, using remote, self-administered speech tasks, as measured by…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia With Lewy Bodies, Dementia, Vascular
- Trial name
- RHAPSODY (NCT04939818)
- Where
- 2 sites in United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Stuttering
Genetic Linkage Studies of Stuttering
Stuttering is an abnormality in speech that affects the rhythm of speech. People who stutter know what they wish to say, but at the time are unable to say it because of involuntary repetition, unnecessary lengthening…
- Trial name
- NCT00001604
- Where
- 3 sites in United States, Japan and 1 more
- Volunteers
- 3,044 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Stroke, Aphasia
Language Processing and TMS
This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.
- Conditions
- Stroke, Aphasia, Language
- Trial name
- NCT05425615
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Aphasia
Pairing Word Retrieval and Physical Endurance Tasks to Treat Anomia in People With Aphasia
Many individuals have difficulty with word retrieval, also called anomia, following cerebrovascular accident (CVA). These difficulties impede effective communication in everyday conversations and can negatively impact the…
- Trial name
- NCT03326687
- Testing
- Treatment ABAB, Treatment BABA
- Where
- United States
- Sponsor
- University of Nebraska Lincoln
GERD
Pre- and Post-Therapy Evaluation of Air-Associated Symptoms in Patients With Gastro-esophageal Reflux Disease (GERD): Assessing the Role of Speech and Language Therapy
Patients with gastroesophageal reflux disease (GERD) may present with concomitant gas-related symptom (GRS) such as supragastric or gastric belching, and aerophagia.
- Trial name
- LAS (NCT07634614)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Prof Urs Zingg
Stuttering
Assessment of Stuttering Severity in Adults and Adolescences in Conversational and Narrative Contexts
The aim of this study is to assess stuttering severity in both narration and conversation in adults and adolescences in order to determine which situation is more stressful so that more reliable and accurate measures for…
- Trial name
- NCT04082104
- Testing
- Stuttering Severity Instument version 3
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Alzheimer Disease
ADvanced ALzheimer Disease and Effects of Protologic and LAnguage Rehabilitation Tools in Nursing Home (ADALPA)
Background: During Alzheimer's disease when cognitive disorders become too severe, language and communication are no longer present and/or mobilizable, and as a consequence there is a frequent discontinuation of Care and morever…
- Trial name
- ADALPA (NCT06993285)
- Testing
- Protologic and LAnguage adaptation rehabilitation
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Central Hospital, Nancy, France
Stroke, Aphasia
Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits
The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment.
- Conditions
- Stroke, Aphasia, Reading Disorder
- Trial name
- NCT06213272
- Testing
- Phono-Motor Therapy, Aerobic Exercise Training (AET), Stretching
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Kessler Foundation
Stuttering
Genetic Factors Related to Stuttering
Stuttering is an abnormality in speech that affects the rhythm of speech. People who stutter know what they wish to say, but at the time are unable to say it because of involuntary repetition, unnecessary lengthening…
- Trial name
- NCT00001602
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Primary Progressive Aphasia, Frontotemporal Dementia
Long-term Effect of TMS in Primary Progressive Aphasia
There are very few treatments for neurodegenerative disorders, and the efficacy of these treatments is generally modest. Recent studies have shown a short-term positive effect of non-invasive neuromodulation techniques such as…
- Conditions
- Primary Progressive Aphasia, Frontotemporal Dementia, Alzheimer Disease
- Trial name
- RECONNECT (NCT05842473)
- Testing
- Transcranial Magnetic Stimulation (active), Language therapy
- Where
- Spain
- Volunteers
- 63 people
- Sponsor
- Hospital San Carlos, Madrid
Speech Sound Disorder
BiOfeedback, Online for Sibilant Treatment
The goal of this clinical trial is to evaluate the efficacy of sibilant biofeedback treatment delivered via telepractice in six children ages 8:0-17;11 who present with distortions of /s/.
- Trial name
- BOOST (NCT07041723)
- Testing
- Visual-acoustic biofeedback for Sibilants
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Montclair State University
Aphasia, Stroke
Telerehabilitation for Aphasia (TERRA)
Speech-language therapy is generally found to be helpful in the rehabilitation of aphasia. However, not all patients with aphasia have access to adequate treatment to maximize their recovery.
- Conditions
- Aphasia, Stroke, Stroke Rehabilitation
- Trial name
- TERRA (NCT04682223)
- Testing
- Semantically-focused therapy tasks, Phonologically-focused therapy tasks
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of South Carolina
Healthy, Speech Disorders
Development of Normative Ultrasound Databases of Tongue Surface Configuration
Our past ultrasound research has indicated a need for baseline normative tongue data against which to compare our disordered speech populations.
- Trial name
- NCT00001218
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Aphasia
Determining Learning Ability in People With Aphasia
Aphasia is an impairment in the expression or comprehension of language that results from stroke, traumatic brain injury or progressive neurological disease.
- Trial name
- NCT05119023
- Testing
- SRT Observational Learning, AGL Observational Learning, AGL Rule-based Learning
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- MGH Institute of Health Professions
Aphasia, Global, Stroke
tDCS and Speech Therapy to Improve Aphasia
To study the effect of combined tDCS plus speech therapy compared to sham-tDCS plus speech therapy in subacute stroke patients suffering from moderate or severe aphasia.
- Conditions
- Aphasia, Global, Stroke, Transcranial Direct Current Stimulation, Speech Therapy
- Trial name
- MP-LOGA (NCT02395874)
- Testing
- tDCS + speech therapy
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Medical Park AG
Parkinson Disease, Dysarthria
Dysarthria Management for Minor Groups
This study develops and conduct a small-scale clinical trial study in which the linguistic and cultural diversity of the participants is considered.
- Trial name
- NCT06593860
- Testing
- Remote speech rehabilitation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Florida State University
Dysarthria, Huntington Disease
Characterization of the Profile of Dysarthria in Huntington's Disease, Using the Clinical Evaluation Battery of Dysarthria
Huntington's disease is a hereditary disease of rare autosomal dominant transmission, both neurodegenerative and neuro-psychiatric.
- Trial name
- Huntington (NCT03142217)
- Testing
- Study of dysarthria in patients with Huntington's disease
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Aphasia, Acquired, Speech Therapy
Anomia Therapy and Executive Function Training in Chronic Post-stroke Aphasia: Pilot Study of Multidimensional Effects
The goal of this clinical trial is to measure the effects of a speech therapy protocol combining anomia therapy and executive function training on naming and discourse in people with chronic aphasia, and to study the related…
- Trial name
- ATAC2PILOT (NCT06712225)
- Testing
- Anomia therapy: semantic feature analysis and phonological components analysis;, Executive function training: computerized equipment
- Volunteers
- 8 people
- Sponsor
- University Hospital, Montpellier