Clinical trials: Sperm DNA Fragmentation
Antioxidants, Infertility, Male
Oxidative Stress In Semen And Male Infertility
The proposed research aims to study the effects of antioxidant therapy, commonly used in male infertility treatment, on semen analysis.
- Conditions
- Antioxidants, Infertility, Male, Semen Quality
- Trial name
- NCT03464656
- Testing
- Fairhaven Pro for men, Semen analysis, Sperm DNA fragmentation
- Where
- Qatar
- Volunteers
- 100 people
- Sponsor
- Hamad Medical Corporation
Infertility, Spermatozoa
Ejaculatory Abstinence in IUI Cycles
Intrauterine insemination (IUI) combined with ovarian stimulation, has been an extensively used procedure for the treatment of patients with unexplained infertility.
- Conditions
- Infertility, Spermatozoa, Reproductive Disorder
- Trial name
- NCT04361292
- Testing
- INTRAUTERINE INSEMINATION
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Infertility
Split Cohort Trial Comparing IVF Outcomes After the Use of Testicular vs. Ejaculated Sperm for ICSI
The primary objective of this study is to determine if there is a difference in in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) outcomes when using testicular sperm versus ejaculated sperm in couples…
- Trial name
- NCT03483298
- Testing
- ICSI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility (IVF Patients), Oocyte Competence
The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture
This study aims to assess the effect of age of the male partner and the reproductive ability of sperm prepared via sperm selection devices (Zymot) compared to routine embryologist selected sperm after density gradient…
- Conditions
- Infertility (IVF Patients), Oocyte Competence, Sperm DNA Fragmentation, Paternal Age
- Trial name
- EPIC (NCT06629766)
- Testing
- Microfluidic sperm separation device, Density grade centrifugation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Male Infertility
Impact of Antioxidant Treatment on DNA Fragmentation Index
Increased sperm DNA Fragmentation Index implies decreased male fertility in vivo and in vitro. There is need for developing new strategies for improvement of male fertility.
- Trial name
- Androferti (NCT03466229)
- Testing
- Androferti
- Volunteers
- 79 people
- Sponsor
- Region Skane
Sperm DNA Fragmentation, Embryo Quality
Sperm Selection by Microfluidic Separation Improves Embryo Quality
This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility.
- Conditions
- Sperm DNA Fragmentation, Embryo Quality, Fertility Disorders, Infertility
- Trial name
- SPERM (NCT03085433)
- Testing
- Microfluidic Sperm Sorting, in vitro fertilization
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility,Male, Vitamin D Deficiency
Vitamin D and Human Sperm DNA Fragmentation
The purpose of this study will be to investigate if there is a correlation between Vitamin D levels and Sperm DNA Fragmentation. This is a prospective, cohort study.
- Trial name
- NCT03829943
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Sanford Health
Infertility, Male
Reproductive Outcomes of Different Sperm Selection Techniques for ICSI Patients With Abnormal Sperm DNA Fragmentation.
Comparing the reproductive outcomes of different sperm selection techniques; Density gradient centrifugation (DGC), Testicular sperm (Testi), Physiological ICSI (PICSI), and Magnetic activated cell sorting (MACS) in abnormal…
- Trial name
- NCT04482517
- Testing
- Density Gradient Centrifugation, Physiological ICSI, Magnetic activated cell sorting
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Ganin Fertility Center
Male Infertility
Effect of Antioxidant Probiotic Administration on Seminal Quality and Reproductive Outcomes.
The quality of semen plays a fundamental role in correct fertilization and development of normal embryos that result in a live birth. Unfortunately, semen quality has declined during the last decades, and reduced more and more.
- Trial name
- NCT04585984
- Testing
- Experimental - Probiotic
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Fundación IVI
Male Infertility, Oligoasthenospermia
Investigation of the Effects of Stem Cell Supportive Treatment on Semen Parameters and Assisted Reproductive Techniques (ICSI) in Infertile Male Patients With Oligoasthenospermia(Decrease Sperm Number and Quality)
This study evaluated whether Stemregen® dietary supplementation could improve sperm quality and assisted reproductive treatment outcomes in men with severe oligoasthenozoospermia who had previously experienced at least one failed…
- Trial name
- STEMRN (NCT07800052)
- Testing
- Stemregen
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kocaeli University
Sperm DNA Fragmentation, Sperm DNA Impact on ART Outcomes
Clinical Thresholds of Double-strand Breaks in Sperm's DNA in ART
The goal of this prospective observational study is to learn about the impact of double-strand sperm DNA fragmentation (dsSDF) on assisted reproductive technology (ART) outcomes and to derive clinically relevant threshold values…
- Trial name
- DSBs (NCT07621991)
- Testing
- LensHooke X12 Device
- Where
- 2 sites in India
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
RECURRENT PREGNANCY LOSS
Sperm DNA Fragmentation in Recurrent Pregnancy Loss
In human, 2% of couples experimented Recurrent pregnancy loss (RPL). Currently, while etiological investigations were performed, 40 to 50 % of RPL were unexplained.
- Trial name
- PARTHOM (NCT02572154)
- Testing
- Blood and sperm samples
- Where
- 3 sites in France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Semen Quality
Sperm Quality in Consecutive Sperm Samples After 4-7 Days and 2 Hours of Sexual Abstinence
The main purpose of the study is to assess to which degree a series of sperm parameters known to be associated with fertilization and implantation potential in artificial reproductive technology (ART) differ in consecutive sperm…
- Trial name
- NCT02667080
- Testing
- 2-7 days of Sexual abstinence, 2 hours of sexual abstinence
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Male Infertility
Valuation of Variable Dose of Docosahexanoic Acid for the Improvement of the Parameters of Male Fertility
Sperm parameters will be examined before DHA (DHA=Docosahexanoic Acid) consumption, after one months and after 2 months taken Docosahexanoic Acid or placebo.
- Trial name
- DHA (NCT02889341)
- Testing
- DHA
- Volunteers
- 60 people
- Sponsor
- Vida Recoletas Sevilla
Male Infertility
Relationship Between Sperm Head Vacuoles and Sperm DNA Alterations in Infertile Men
In men presenting sperm alterations, the selection of genetically undamaged spermatozoa need to be improved in order to increase the success of assisted reproduction treatments.
- Trial name
- VATES (NCT02006446)
- Testing
- Sperm Samples
- Where
- 2 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Cryopreservation, Human Spermatozoa Parameters
Hypotaurine Supplementation Benefits in Cryopreservation
Although it is widely used, slow freezing can induce strong functional and nuclear spermatic alterations reducing the chances of pregnancy.
- Conditions
- Cryopreservation, Human Spermatozoa Parameters, Hypotaurine Supplementation, Spermatozoa DNA Alterations
- Trial name
- HYPOTAURINE (NCT04011813)
- Testing
- Hypotaurine : antioxidant and osmoregulator
- Volunteers
- 33 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sperm DNA Fragmentation, Male Fertility
Impact of Telomere Biology and Sperm DNA Fragmentation on Embryonic Development
The proposed project we intend to assess the implication of the telomeric pathway in male infertility. To get this, several analyzes will be carried out: 1. Determination of the TL by means of two methods: Q-FISH and PCR. 2.
- Conditions
- Sperm DNA Fragmentation, Male Fertility, Telomeres, Sperm
- Trial name
- NCT05508217
- Where
- Spain
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Male Infertility
Strategies for Reducing Sperm DNA Fragmentation in ICSI Semen Samples: a Prospective Randomized Controlled Trial
Comparing second ejaculate and physiological ICSI (PICSI) as strategies for improvement of abnormal sperm DNA fragmentation in patients undergoing ICSI.
- Trial name
- NCT04496232
- Testing
- PICSI, Second ejaculate
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ganin Fertility Center
Blastocyst, Implantation Rate
Sperm DNA Fragmentation Effects on Blastocyst Morphology Grading, Pregnancy Rate and Implantation Rate
Retrospective cohort study for 189 couples assigned to normal and abnormal Sperm DNA fragmentation (SDF) groups.To determine the effect of SDF on blastocyst's trophectoderm (TE), Inner cell mass (ICM) morphology grading, and…
- Trial name
- NCT04144621
- Testing
- ICSI
- Where
- Egypt
- Volunteers
- 189 people
- Sponsor
- Ganin Fertility Center
Male Infertility, Sperm DNA Fragmentation
Microfluidics Versus Density Gradient Centrifugation for Sperm Preparation in IVF
This randomized controlled trial aimed to compare the effectiveness of microfluidic sperm sorting and density gradient centrifugation (DGC) in reducing sperm DNA fragmentation index (DFI) and improving clinical outcomes in IVF.
- Conditions
- Male Infertility, Sperm DNA Fragmentation, In Vitro Fertilization (IVF)
- Trial name
- MCvsDGC (NCT07004309)
- Testing
- Microfluidic sperm sorting, Density Gradient Centrifugation
- Where
- Vietnam
- Volunteers
- 119 people
- Sponsor
- Hanoi Medical University