Clinical trials: Sperm DNA Fragmentation
Male Infertility
Tobacco and Sperm Genome: Effects of Smoking Cessation
Tobacco is a male infertility risk factor. Many studies comparing smokers to non-smokers have shown effects on spermatogenesis and the quality of the male gamete.
- Trial name
- TABAGERM (NCT03552081)
- Testing
- Fragmented DNA evaluation in blood and semen samples
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Chronic Myeloid Leukemia, Gastrointestinal Stromal Tumors
Impact of the Inhibitors of Tyrosine Kinase on the Male Fertility
Evaluate the possible deleterious effects of tyrosine kinase inhibitors on sperm concentration, after 6 months of therapy, which corresponds to 2 cycles of spermatogenesis and on the sperm nuclear integrity.
- Trial name
- GLIFERTI (NCT01114087)
- Testing
- Imatinib treatment
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Insemination, Artificial
Impact of Aluminum on Sperm DNA Quality
Between 1950 and 2013, aluminum production was multiplied by thirty in the world. Today, men's exposure to aluminum, including food products, cosmetics, air and water contamination, and a number of drugs (vaccine, gastric…
- Trial name
- NCT03549533
- Testing
- samples of sperm
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sperm DNA Fragmentation
Effect of Different Sperm Processing Methods in ICSI Outcome.
A total 180 semen samples from couples diagnosed with unexplained infertility were SDF index tested , then total 120 semen samples of patients' husbands with abnormal SDF index were randomly divided and then processed by swim up…
- Trial name
- NCT03668106
- Testing
- sperm processing method
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Benha University
Male Infertility, Sperm DNA Fragmentation
Nordic Sperm DNA Study
Introduction The goal of this prospective observational study with an embedded randomized controlled trial (RCT) is to investigate the prevalence and clinical significance of sperm DNA fragmentation (damage to the genetic…
- Conditions
- Male Infertility, Sperm DNA Fragmentation, Lifestyle Intervention
- Trial name
- NCT07779954
- Testing
- Lifestyle change
- Volunteers
- 800 people
- Sponsor
- Regionshospitalet Viborg, Skive
Oligospermia, DNA Damage
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF
In patients with oligospermia in the ejaculate or previous ICSI failures if it concurs with high DNA fragmentation, it has been hypothesized that the use of sperm obtained from the testicle would improve the clinical results…
- Conditions
- Oligospermia, DNA Damage, IVF, ICSI
- Trial name
- NCT04795440
- Testing
- Testicular biopsy
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Fundación IVI
DNA Damage
sperDNA Fragmentation a a Predictor for Outcome After Varicocelectomy,m
Varicocele is often associated with infertility and reduction in sperm quality, and it is one of the most common causes of reversible male infertility.
- Trial name
- NCT07144891
- Testing
- Sperm DNA fragmentation
- Volunteers
- 1 people
- Sponsor
- Assiut University
Infertility, Male
The Role of Micro Nutrient Supplement in Improvement of the Sperm DNA Fragmentation
Male from infertile couples are tested for semen analysis and sperm DNA fragmentation. Any case with high DNA fragmentation index (DFI) will be randomized indicated for multi-micro nutrient supplement (PROfortil™) in 3 months and…
- Trial name
- NCT04509583
- Testing
- PROFortil, Vitamin E
- Where
- Vietnam
- Volunteers
- 71 people
- Sponsor
- Hue University of Medicine and Pharmacy
Teratozoospermia, Sperm DNA Fragmentation
PGT-A Evaluates Advanced Sperm Selection in Embryos From High Teratozoospermia Males
In this study of 264 couples, sperm selection techniques in males with high teratozoospermia index and sperm DNA fragmentation significantly increased fertilization, blastocyst development rates, and maintained comparable embryo…
- Conditions
- Teratozoospermia, Sperm DNA Fragmentation, Infertility
- Trial name
- NCT06231589
- Testing
- Sperm Selection
- Where
- Egypt
- Volunteers
- 264 people
- Sponsor
- Ganin Fertility Center
Male Infertility, Cancer
Epigenetic and Genetic Effects in Cancer Patients: Analysis Pre and After Treatment
The prognosis in cancer patients has improved over the years. Survivor rates have increased significantly, and paternity has become an important concern in more than 50% of young male survivors.
- Conditions
- Male Infertility, Cancer, Epigenetic Disorder
- Trial name
- NCT04200118
- Testing
- Observational
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- IVI Barcelona
Infertility, Male
To Study the Effect of Magnetic Activated Sperm Sorting on the Outcome of in Vitro Fertilization-embryo Transplantation
Recent studies have evaluated the use of magnetic-activated sperm sorting (MASS) to reduce apoptotic spermatozoa and improve the outcome of infertile male with assisted reproductive technology (ART).
- Trial name
- MASS (NCT03968367)
- Testing
- Magnetic activated sperm sorting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Li-jun Ding
Infertility, Male
Sperm Separation Efficiency to Maximize Pregnancy Rates: MACS vs. FERTILE Chip
The goal of this observational study is to compare clinical outcomes of two techniques for sperm cell sorting, microfluidic sorting and magnetic activated cell sorting (MACS) technique, in males with high DNA fragmentation within…
- Trial name
- FERTIMACS (NCT04061486)
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Vida Recoletas Sevilla
Sperm DNA Fragmentation, Infertility, Male
Impact of Escitalopram on Sperm DNA Fragmentation
Double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or suicidal ideation.
- Trial name
- NCT03527043
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Unexplained Infertility, Male Infertility
Royal Jelly Supplementation in Unexplained Male Infertility
This randomized, double-blind, placebo-controlled clinical trial investigates the effects of oral Royal Jelly supplementation on sperm DNA fragmentation and pregnancy rates in couples with unexplained infertility.
- Conditions
- Unexplained Infertility, Male Infertility, Sperm DNA Fragmentation
- Trial name
- NCT07337265
- Testing
- Lyophilized Royal Jelly
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Medipol University
Sperm DNA Fragmentation, Infertility
Advanced Sperm Selection Techniques and Their Contribution to Blastocyst Euploidy Rates
Comparing different advanced sperm selection techniques like Physiological ICSI (PICSI) and magnetic activated cell sorting (MACS) in terms of the PGT-A outcomes of each arm blastocysts
- Trial name
- NCT05494216
- Testing
- PICSI, MACS
- Where
- Egypt
- Volunteers
- 515 people
- Sponsor
- Ganin Fertility Center
Sperm DNA Fragmentation
Sperm Selection by Either PICSI or MACS in Cases With Abnormal Sperm DNA Fragmentation Index for ICSI
On the day of ICSI, choosing the best sperm by either PICSI or magnetic activated cell sorting (MACS) in cases with abnormal DNA is not fully investigated.
- Trial name
- NCT03398317
- Testing
- PICSI, MACS
- Where
- Egypt
- Volunteers
- 396 people
- Sponsor
- Ganin Fertility Center
Infertility, Male
The Paternal Clock: Uncovering the Consequences of Advanced Paternal Age on Sperm DNA Fragmentation
Sperm DNA fragmentation (SDF) serves as a marker for chromatin and DNA damage in sperm. Assessing sperm DNA integrity is crucial in male fertility evaluation since high levels of SDF are associated with a greater number of…
- Trial name
- Paternal Clock (NCT05894356)
- Testing
- Study chart review
- Where
- Canada
- Volunteers
- 4,250 people
- Sponsor
- Clinique Ovo
Observe Effect of Antioxidant on Sperm DNA Fragmention
Effect of Natural Antioxidant Supplement on Sperm DNA Fragmentation
Observational study to see the effect of use of natural Antioxidant supplement on sperm DNA fragmentation. Subjects will take the natural antioxidant for 3 months prior to repeat testing.
- Trial name
- NCT03646825
- Testing
- Natural Antioxidant supplement
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Colorado Center for Reproductive Medicine
DNA Damage, DNA Strand Breaks
Comparison of Two Different Sperm Processing Methods and Their Effects on Sperm DNA Fragmentation and Embryo Development
The goal of this clinical trial is to learn if the LensHooke CA0 device lowers DNA fragmentation in sperm samples compared to a gradient/swim-up technique. The main questions it aims to answer are: 1.
- Conditions
- DNA Damage, DNA Strand Breaks, Sperm DNA Fragmentation
- Trial name
- NCT06990841
- Testing
- sperm separation device
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Richard Kordus, PhD, HCLD (ABB)
Sperm Preservation, Irradiated Semen
Impact of Ionizing Treatment on the Nuclear Structure of Human Spermatozoa.
Differentiated thyroid cancer is the third cause of cancer in young men of childbearing age. Its treatment by irradiation with Radioactive Iodine 131 therapy (RAT) could alter spermatogenesis and result in azoospermia and…
- Trial name
- NCT04715828
- Testing
- Cryopreserved semen, Acute and low irradiation, Long and low irradiation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand