Clinical trials: Spinal Anesthesia for Cesarean Section
Pain, Obesity
Effect of Body Mass Index on the Dose of Intrathecal Hyperbaric Bupivacaine for Elective Cesarean Section
Combined spinal - epidural (CSE) anesthesia is a well established technique used for elective Cesarean section. As its name suggests, it combines two anesthesia techniques - spinal and epidural.
- Trial name
- NCT00403663
- Testing
- bupivacaine 0.75% with fentanyl and morphine
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Caesarean Section, Spinal Anesthesia
Evaluating the Effectiveness of Ondansetron Versus Dexamethasone Versus Placebo for the Control of Intraoperative Nausea and Vomiting in Patients Undergoing Lower-segment Caesarean Section Under Spinal Anesthesia
The goal of this randomized controlled trial is to evaluate the effectiveness of Ondansetron, Dexamethasone, and Placebo for intraoperative nausea and vomiting in patients undergoing caesarian section under spinal anesthesia.
- Trial name
- ODP (NCT05583214)
- Testing
- Ondansetron 8mg, Dexamethasone 8mg, Normal saline
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Muhammad Mubariz
Ketamine Adverse Reaction, Effects of; Anesthesia, Spinal and Epidural, in Pregnancy
Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?
Pain control after cesarean delivery is associated with improved breastfeeding and infant rooming-in times. In addition, inadequate analgesia leads to elevated plasma catecholamine concentrations, which negatively affect every…
- Conditions
- Ketamine Adverse Reaction, Effects of; Anesthesia, Spinal and Epidural, in Pregnancy, Complication of Labor and/or Delivery
- Trial name
- NCT00486902
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Northwestern University
Shivering, Hypothermia
Effect of Preoperative Intranasal Dexmedetomidine on Incidence of Intraoperative Shivering in Patients Undergoing Cesarean Section Under Spinal Anesthesia
Shivering is a common and distressing complication occurring in 40% to 60% of women undergoing cesarean section under spinal anesthesia.
- Conditions
- Shivering, Hypothermia, Cesarean Section, Spinal Anaesthesia
- Trial name
- NCT07855536
- Testing
- Dexmedetomidine, Meperidine, Normal Saline 0.9%
- Volunteers
- 99 people
- Sponsor
- Assiut University
Ultrasound
Ultrasound Versus Palpation for Spinal Anesthesia Success
Aim is to investigate the difference in number of attempts to place neuraxial block comparing handheld ultrasound versus use of palpation alone for women with impalpable bony landmarks undergoing spinal anesthesia for elective…
- Trial name
- Accuro (NCT03679663)
- Testing
- Ultrasound
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pain, Postoperative
Comparing Analgesic Effects of Wound Infiltration Using Bupivacaine, Tramadol, and Tramadol Plus Bupivacaine
The goal of this study's clinical trial is to compare in post-operative analgesic effectiveness of wound infiltration using bupivacaine, tramadol, and tramadol plus bupivacaine in patients undergoing elective cesarean section…
- Trial name
- NCT06076707
- Testing
- bupivacain-tramadol
- Where
- Ethiopia
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Wollo University
Pregnancy
Predicting Hypotension Related to Spinal Anesthesia for Caesarean Section With Ultrasonography
Spinal anesthesia is the main technique for caesarean section. This anesthesia is followed by a hypotension in 40% to 90% despite preventing tools. Hypotension is responsible of foetale and maternal suffering.
- Trial name
- NCT02471924
- Testing
- Trans thoraciq cardiac ultrasonography
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Spinal Anesthesia Induced Hypotension
COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial
The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension.
- Trial name
- NCT06836986
- Testing
- Norepinephrine Bolus, Phenylephrine bolus
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- Dow University of Health Sciences
Cesarean Section Complications, Hypotension
Can Right Toe Perfusion Index or Pleth Variability Index Predict Spinal Anesthesia Induced Hypotension?
Spinal anesthesia for caesarean section is associated with a decrease in systemic vascular resistance and cardiac output and may cause hypotension in a significant portion of the parturients.
- Conditions
- Cesarean Section Complications, Hypotension, Spinal Anesthesia, Perfusion Index
- Trial name
- NCT03956186
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Cesarean Section Complications, Hemodynamic Instability
Norepinephrine in Caesarian Section
Postspinal hypotension is a frequent maternal complication in caesarian delivery under neuraxial anesthesia which is most commonly treated with the administration of phenylephrine infusion.
- Conditions
- Cesarean Section Complications, Hemodynamic Instability, Foetal Stress
- Trial name
- NCT05264870
- Testing
- Norepinephrine
- Where
- Belgium
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Hypotension
Diastolic Performance and Norepinephrine in Spinal-Induced Hypotension for Cesarean Delivery
Background and rationale: The best agent to prevent spinal-induced hypotension is still uncertain but norepinephrine showed fewer effects on heart rate and cardiac output.
- Trial name
- NORA-CS (NCT04560634)
- Testing
- Norepinephrine, ClearSight®, Edwards Lifescience, Irvine, CA
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Shivering
Role of Intravenous Dexmedetomidine in Reducing Shivering After Shivering Cesarean Section Due to Spinal Anesthesia
"After spinal anesthesia, some patients may experience shivering, which can be uncomfortable and even lead to complications. Dexmedetomidine is a medication that can help prevent or reduce this shivering.
- Trial name
- NCT06711913
- Testing
- Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Liaquat National Hospital & Medical College
Cesarean Delivery
Prevention of Intraoperative Nausea and Vomiting During Cesarean Section
The study investigates the incidence of intraoperative nausea and vomiting under spinal anesthesia using a phenylephrine infusion with and without prophylactic antiemetics.
- Trial name
- NCT01216410
- Testing
- Metoclopramide, Phenylephrine infusion, Combination Group
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- Duke University
Cesarean Section, Transversus Abdominis Plane (TAP) Block
The Effect of TAP Block on Maternal-Infant Bonding
Cesarean delivery is a common surgical procedure that is typically performed under spinal anesthesia. Postoperative pain management has a significant impact on both the mother's physical recovery and the quality of…
- Trial name
- NCT06858891
- Testing
- Transversus abdominis plane (TAP) block
- Volunteers
- 132 people
- Sponsor
- Adiyaman University Research Hospital
Hypotension, Anesthesia; Adverse Effect, Spinal and Epidural
ONDANSETRON AND EFFECTIVE DOSE IN 50% OF SUBJECTS OF PROPHYLACTIC NOREPINEPHRINE INFUSIONS FOR PREVENTING SPINAL ANESTHESIA-INDUCED HYPOTENSION DURING CESAREAN DELIVERY
Spinal anesthesia is the preferred technique for elective cesarean section as per ASA guidelines. Hypotension is the main complication of this technique and is secondary to both sympatholysis and its associated decrease in…
- Conditions
- Hypotension, Anesthesia; Adverse Effect, Spinal and Epidural, Cesarean Section
- Trial name
- NCT04703088
- Testing
- Ondansetron 4 MG, 0.9% Saline
- Volunteers
- 60 people
- Sponsor
- Laval University
Cesarean Section Complications, Spinal Anesthesia
Vasopressor Infusion in Cesarean Delivery
Comparison will be conducted between continuous variable infusions of both drugs (Phenylephrine and Norepinephrine) with starting doses of 0.75 mcg/Kg/min and 0.1 mcg/Kg/min respectively for prophylaxis against Post-spinal…
- Trial name
- NCT03248791
- Testing
- Phenylephrine, Norepinephrine, Bupivacaine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Post-Dural Puncture Headache
Effectiveness of Nebulized Dexmedetomidine for Treatment of Obstetric Post-Dural Puncture Headache
Postdural puncture headache (PDPH) is a common complication, following neuraxial techniques. The obstetric population is particularly prone to PDPH. Therefore, treatment of PDPH is a key issue in obstetric anesthesia.
- Trial name
- NCT04327726
- Testing
- Dexmedetomidine Nebulization, 0.9% Saline Nebulization
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Zagazig University
Spinal Anesthesia
Hyperbaric Prilocaine 2% vs Hyperbaric Bupivacaine 0.5% in Caesarean Section
Comparison between effects of hyperbaric bupivacaine 0.5% vs Hyperbaric prilocaine 2% in spinal anesthesia of women undergoing elective caesarean section such as onset time of sensory and motor block, duration of sensory and…
- Trial name
- NCT06680167
- Testing
- Spinal anesthesia (heavy bupivacaine 0.5%), spinal anesthesia (hyperbaric Prilocaine 2%)
- Where
- Egypt
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Sohag University
Hypotension During Surgery, Hypotension Drug-Induced
Hypotension Prediction Index vs Norepinephrine Infusion for Prevention of Spinal Hypotension for Cesarean Delivery
The goal of this randomized controlled trial is to compare for non inferiority for fetal wellbeing Hypotension Prediction Index - Guided Therapy and Continuous Norepinephrine Infusion in in the Prevention of Spinal…
- Trial name
- NCT05970770
- Testing
- Hypotension Prediction Index, Norepinephrine
- Volunteers
- 150 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Planned Cesarean Section
Acute Preoperative Stress and Hypotension After Spinal Anesthesia. SAS for "Salivary Amylase and Stress "
Spinal anesthesia is the technique of choice for planned cesarean section. It is associated with a high frequency of maternal hypotension.
- Trial name
- SAS (NCT01862055)
- Where
- France
- Volunteers
- 79 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris