Clinical trials: Spinal Block
Hip Arthroplasty, Knee Arthroplasty
Effect of Combined Use of Naloxone and Tramacet on Postop Analgesia in Elderly Patients Having Joint Replacement Surgery
Patients over 70 years of age, scheduled for joint replacement surgery will be randomized to tramacet/ naloxone plus morphine PCA or to morphine PCA to assess quality of analgesia in the postoperative period.
- Conditions
- Hip Arthroplasty, Knee Arthroplasty, Spinal Anesthesia
- Trial name
- NCT00679614
- Testing
- tramacet, naloxone, tramacet, Acetaminophen
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lumbar Disc Herniation
QLB vs ESPB for Lumbar Spinal Surgery
Ultrasound-guided quadratus lumborum block (QLB) is a fascial plane block where local anesthetic is injected adjacent to the quadratus lumborum muscle to anesthetize the thoracolumbar nerves.
- Trial name
- NCT06477198
- Testing
- QLB, ESPB, Postoperative analgesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Sedation During Lower Extremity Surgery Under Spinal Anesthesia
Remimazolam Concentration and Sedation Depth During Lower Extremity Surgery Under Spinal Anesthesia
This study will examine how the amount of remimazolam predicted to reach its site of action relates to the depth of sedation during lower extremity surgery under spinal anesthesia.
- Trial name
- NCT07863063
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Spinal Anesthesia, Vascular Surgery
Hyperbaric Novabupi® in Spinal Anesthesia in Lower Limbs Vascular Surgery
This is a multicenter, randomized, double-blind, active-controlled study to evaluate the non-inferiority of hyperbaric Novabupi® versus hyperbaric Neocaine® in spinal anesthesia in lower limbs vascular surgery.
- Trial name
- NCT03883763
- Testing
- bupivacaine S75:R25 plus 8% glucose, bupivacaine S50:R50 plus 8% glucose
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Cristália Produtos Químicos Farmacêuticos Ltda.
Spinal Hypotension, Doppler
Doppler Indices to Predict Spinal Hypotension During Cesarean Section
Spinal anesthesia is safe and advisable anesthetic during cesarean section, despite that spinal induced hypotension is a common associated problem.
- Trial name
- NCT06825806
- Testing
- Femoral artery Doppler
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Post Operative Pain
Value of IPACK Block (Interspace Between the Popliteal Artery and Capsule of Knee) With Spinal Anesthesia Versus Fentanyl Based Spinal Anesthesia for Knee Arthroscopic Meniscectomy
Postoperative analgesia is provided by local anesthesia combined with intrathecal narcotics. In addition, for the first 24 hours, this combination has a parenteral opioid sparing effect.
- Trial name
- NCT05833776
- Testing
- spinal anesthesia using hyperbaric bupivacaine 0.5% (3ml) with fentanyl (25ug)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Tourniquet Pain
Ketamine Reduces Tourniquet Pain In Patients Undergoing Lower Limb Surgery Under Spinal Anaesthesia
A prospective, double blind, randomised controlled trial to evaluate the effect of ketamine in reducing tourniquet pain for patients undergoing lower limb surgery under spinal anaesthesia.
- Trial name
- NCT03357055
- Testing
- Ketamine, Normal saline
- Volunteers
- 60 people
- Sponsor
- Dr Foo Li Lian
Hypotension
Norepinephrine To Prevent Hypotension After Spinal Anesthesia For Cesarean Delivery: A Dose Finding Study
Spinal anesthesia is the most common anesthetic technique for elective Cesarean delivery (CD), but the most frequent unwanted side effect is hypotension, which can cause nausea and vomiting, as well as effects on the fetus.
- Trial name
- NCT02654847
- Testing
- Norepinephrine, Normal Saline
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Surgery Ambulatory
Spinal or Intravenous Dexmedetomidine in Ambulatory Surgery
The primary objective of this double blind randomized study is to determine the effect of dexmedetomidine on onset and duration of the sensory and motor block and on the influence on bladder function after spinal anesthesia with…
- Trial name
- NCT02282319
- Testing
- spinal dexmedetomidine 0.5 mcg, spinal chloroprocaine 40 mg, IV dexmedetomidine 0.5 mcg/kg
- Where
- 2 sites in Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Pregnancy
Predicting Hypotension Related to Spinal Anesthesia for Caesarean Section With Ultrasonography
Spinal anesthesia is the main technique for caesarean section. This anesthesia is followed by a hypotension in 40% to 90% despite preventing tools. Hypotension is responsible of foetale and maternal suffering.
- Trial name
- NCT02471924
- Testing
- Trans thoraciq cardiac ultrasonography
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Femoral Fracture
Dose Finding Study for Continuous Spinal Anaesthesia
Fixation of fractured neck of femur is a common Orthopedic surgery. Anaesthesia can be challenging in some cases like in haemodynamical unstable patients.
- Trial name
- NCT01680120
- Testing
- Continuous spinal anaesthesia
- Where
- Ireland
- Volunteers
- 15 people
- Sponsor
- Cork University Hospital
Inguinal Hernia
Inflammatory Response: General vs Spinal Anesthesia
Objective: This study aimed to compare the effects of general and spinal anesthesia on the inflammatory response by measuring intercellular adhesion molecule-1 (ICAM-1), P-selectin (SELP), and thrombomodulin (TM) levels in…
- Trial name
- NCT07567534
- Testing
- inflammatory response during inguinal hernia repair.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sezen Kumaş Solak
Labor Pain, Analgesia
Sacral Spread of Sensory Block After Dural Puncture Epidural Technique Compared With Epidural for Labour Analgesia
Neuraxial labor analgesia is a very widely used technique for labor pain relief with a high efficacy and safety. EA (Epidural analgesia) can guarantee a proper control of pain in 95-100% of cases in the first stage of labor, but…
- Trial name
- NCT05217134
- Testing
- DPEA
- Where
- 2 sites in Italy
- Volunteers
- 108 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pain, Postoperative
Intrathecal Paracetamol Before Spinal Anaesthesia With Chloroprocaine HCl 1% for Short Knee Procedures
This is a phase II, single centre, randomised, parallel-group, double-blind, three doses, placebo-controlled, exploratory efficacy and safety study.
- Trial name
- NCT03428230
- Testing
- 30 mg Paracetamol 3% (1 mL), 60 mg Paracetamol 3% (2 mL), 90 mg Paracetamol 3% (3 mL)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Sintetica SA
Spinal Anesthesia, Postoperative Complications
D-FAB-POUR Trial: Dexmedetomidine vs Fentanyl as Adjuvants to Bupivacaine on Postoperative Urinary Retention
This study aims to compare two medications, dexmedetomidine and fentanyl, when used alongside a commonly used spinal anesthetic called bupivacaine in patients undergoing lower limb surgery.
- Conditions
- Spinal Anesthesia, Postoperative Complications, Dexmedetomidine, Fentanyl
- Trial name
- D-FAB-POUR (NCT07117565)
- Testing
- Intervention 1: Intrathecal Dexmedetomidine with Bupivacaine, Intervention 2: Intrathecal Fentanyl with Bupivacaine
- Where
- Nepal
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Spinal Anesthesia Evaluation, Cesarean Delivery
Dose-to-block Level Relation in Single Shot Spinal Anesthesia for Cesarean Section.
The study is designed to support or deny relation between the dose of hyperbaric bupivacaine given intrathecally and extent of spinal block level.
- Trial name
- SpinDoBlock (NCT06729567)
- Testing
- Spinal block level analysis, data collection
- Where
- Poland
- Volunteers
- 362 people
- Sponsor
- Centre of Postgraduate Medical Education
Delirium, Pain, Back
Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion
This initial study is a feasibility study for implementing thoracolumbar interfascial plane, or TLIP, blocks in older adults undergoing spinal fusion. TLIP blocks are done by using anesthesia.
- Conditions
- Delirium, Pain, Back, Spinal Fusion, Thoracolumbar Interfascial Plane Block
- Trial name
- NCT05461092
- Testing
- Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine, Blood Test, 3D CAM Delirium Severity Scoring
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Iowa
Femoral Neck Fractures, Regional Anesthesia
Comparison of Regional Anaesthesia Methods for Femoral Neck Fracture Surgery
Femoral fracture surgery is frequently performed especially in geriatric population. Compared to general anaesthesia, regional anaesthesia is preferred to general anaesthesia in the geriatric patient population due to lower…
- Trial name
- NCT06224439
- Testing
- hypobaric spinal anaesthesia, lumbar plexus block, hyperbaric spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Post Spinal Hypotension
Perfusion Index vs Positional Hemodynamic Changes to Predict Hypotension After Spinal Anaesthesia in Caesarean Section
Comparative Study between the Perfusion Index and Positional Haemodynamic Changes for Prediction of Hypotension after Spinal Anaesthesia in Caesarean Section
- Trial name
- NCT05587153
- Testing
- perfusion index in all parturient recruited for the study
- Where
- 2 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Hypotension
Can Passive Leg Raise Prevent Spinal Anesthesia-induced Hypotension During Cesarean Section?
All over the world, spinal anesthesia is widely used in cesarean sections due to its superiority over general anesthesia. Due to reasons such as increased sensitivity to local anesthetics and increased intra-abdominal pressure in…
- Trial name
- NCT04673253
- Testing
- Passive leg Raise, control
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Antalya Training and Research Hospital