Clinical trials: Spinal Cord Injuries
Spinal Cord Injuries, Brown Sequard
Effects of Breathing and Walking Treatments on Recovery Post-Spinal Cord Injury
Change to Reflect What Was Done and reason Changes Were Made. The purpose of this study is to determine (1) if a specific breathing treatment (intermittent hypoxia) can promote changes in breathing function and (2) if pairing…
- Conditions
- Spinal Cord Injuries, Brown Sequard, Central Cord Syndrome
- Trial name
- NCT01272011
- Testing
- Intermittent Hypoxia, Locomotor Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Spasticity, Cerebrovascular Accident
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity
Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of upper limb spasticity in adults followed by an open-label extension…
- Conditions
- Spasticity, Cerebrovascular Accident, Multiple Sclerosis, Traumatic Brain Injury
- Trial name
- NCT04815967
- Testing
- Phase 2; Low Dose MYOBLOC (10,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 3; MYOBLOC
- Where
- 9 sites in United States, Hungary and 1 more
- Volunteers
- 32 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC
Hypotension, Orthostatic, Hypotension
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury
The goal of this study is to determine the efficacy of the drug Droxidopa (Northera) in increasing blood pressure in subject with hypotension, low blood pressure, which is classified as blood pressure less than 110/70 in males…
- Conditions
- Hypotension, Orthostatic, Hypotension, Spinal Cord Injuries
- Trial name
- NCT03602014
- Testing
- Northera
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries, Inpatient
Exoskeletal-Assisted Walking in SCI Acute Inpatient Rehabilitation
The purpose of this research study is to test the effect of early exoskeletal-assisted walking (EAW) training (combined into regular acute inpatient rehabilitation (AIR)) on improving functional recovery and reducing pain and…
- Trial name
- NCT04221373
- Testing
- Ekso™ powered exoskeleton, Standard of care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Cord Injury
Bowel Care and Cardiovascular Function After Spinal Cord Injury
The main goal of this project is to determine the effects of lidocaine lubricant on cardiovascular function during routine bowel care in individuals with spinal cord injury.
- Trial name
- NCT01567605
- Testing
- Lidocaine lubricant
- Where
- 2 sites in Canada
- Volunteers
- 13 people
- Sponsor
- Simon Fraser University
Stroke, Peripheral Neuropathy
Arm Motor Control on Bi and Uni ADLs
This study is being performed to assess how certain chronic disabilities - stroke, upper extremity (UE) amputation, spinal cord injuries (SCI), cerebral palsy (CP) - differ from healthy subjects in their ability to perform ADLs.
- Conditions
- Stroke, Peripheral Neuropathy, Spinal Cord Injuries, Cerebral Palsy
- Trial name
- BiAs (NCT02778529)
- Testing
- Bilateral assessment robots (BiAS)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Spinal Cord Injuries
Intermittent Catheterization in Spinal Cord Injured Men
The aim of this investigation is to study how the position of different catheters affect drainage of the bladder.
- Trial name
- NCT02230540
- Testing
- SelfCath (comparator), Product A SelfCath and urine bag, Conveen Security+, Product B SelfCath and urine bag, Conveen Contour
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Coloplast A/S
Spinal Cord Injuries
Effect of Botulinum Toxin A on Detrusor Overactivity and Renal Function in Chronic Spinal Cord Injured Patients
To investigate the clinical effect of detrusor botulinum toxin A (BoNT-A) injection on neurogenic detrusor overactivity (NDO) and renal function and to compare the difference of expressions of sensory receptors and nerve growth…
- Trial name
- NCT01682603
- Testing
- Botulinum toxin A
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Acute Spinal Cord Injury
Spinal Cord Injury Neuroprotection With Glyburide
The purpose of this study is to determine the safety of using oral Glyburide in patients with acute traumatic cervical spinal cord injuries (SCI).
- Trial name
- SCING (NCT02524379)
- Testing
- Glyburide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Ohio State University
Spinal Cord Injury, Sleep Apnea, Obstructive
Sleep-Disordered Breathing in Chronic SCI
The purpose of this study is to examine impact of Sleep Disordered Breathing (SDB) treatment in persons with chronic Spinal Cord Injury (SCI).
- Trial name
- NCT02176928
- Testing
- AutoPAP
- Where
- 4 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injuries
A Novel Cooling Vest to Protect Persons With SCI From Hyperthermia
Persons with higher levels of spinal cord injury (above the 6th thoracic vertebrae: Hi-SCI) are unable to maintain their core body temperature (Tcore) within the normal range (97.5-99.7 °F) when exposed to warm environments.
- Trial name
- NCT05441449
- Testing
- Cooling Vest
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Slow Breathing
Slow Yogic-Derived Breathing and Respiration and Cardiovascular Variability in Spinal Cord Injury Patients
This research will aid in understanding of slow-breathing and its effect on heart rate and blood pressure in people with a spinal cord injury (SCI).
- Trial name
- SCOGA (NCT05480618)
- Testing
- Slow Breathing
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injuries
Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with…
- Trial name
- NCT02323698
- Testing
- Caffeine, AIH
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injuries
Improving Gait Performance in Individuals With Spinal Cord Injuries: an Intervention Using Robotic Exoskeletons
The purpose of this study is to investigate whether robotic exoskeleton training can improve walking performance after SCI as compared to conventional physical therapy.
- Trial name
- NCT03011099
- Testing
- Robotic exoskeleton training, Conventional physical therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injuries, Spinal Cord Diseases
Vaporized Cannabis and Spinal Cord Injury Pain
This study will demonstrate that vaporized marijuana results in antinociception when compared to placebo in subjects with spinal cord injury.
- Trial name
- NCT01555983
- Testing
- Vaporization of Cannabis
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Barth Wilsey
Female Sexual Dysfunction, Spinal Cord Injuries
Effect of Peripheral Neuromodulation on Vaginal Blood Flow
The researchers want to see if nerve stimulation interventions cause a change in vaginal blood flow. This intervention was performed in women who have neurogenic (spinal cord injury) or non-neurogenic sexual dysfunction and…
- Trial name
- NCT04384172
- Testing
- Transcutaneous electrical nerve stimulation - Tibial Nerve, Transcutaneous electrical nerve stimulation - Genital Nerve
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Spinal Cord Injuries
Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI
The purpose of this study is to test the efficacy of mild breathing bouts of low oxygen (intermittent hypoxia) combined with transcutaneous electrical spinal cord stimulation on restoring hand function in persons with chronic…
- Trial name
- NCT04854057
- Testing
- AIH - Intermittent Hypoxia - hypoxia air mixture, TESS - Transcutaneous Electrical Spinal Cord Stimulation + Functional Task Practice
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Spaulding Rehabilitation Hospital
Pressure Ulcers, Spinal Cord Injuries
Self-Management to Prevent Ulcers in Veterans With SCI (Spinal Cord Injury)
Pressure ulcers (PrUs) are the most frequent significant medical complication after spinal cord injury (SCI). PrU prevalence, morbidity, mortality, and recurrence rates are high, and most persons with SCI will have at least one…
- Trial name
- NCT00763282
- Testing
- Self Management (SM), Motivational Interviewing (MI), Education (ED)
- Where
- 5 sites in United States
- Volunteers
- 144 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury (Quadraplegia)
Reanimation in Tetraplegia
The purpose of this clinical study is to allow the investigation of the Neural Bridging System for participants with tetraplegia to assess if the investigational device can reanimate a paralyzed limb under voluntary control by…
- Trial name
- NCT01997125
- Testing
- Neural Bridge System
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Marcia Bockbrader
Spinal Cord Injury
Respiratory Resistance Training on Sleep Quality in Persons With Spinal Cord Injury
The purpose of this study is to determine if the use of a respiratory resistance trainer will increase respiratory muscle strength, improve sleep quality and improve quality of life in individuals with spinal cord injury.
- Trial name
- NCT00629850
- Testing
- Powerlung Performer
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Texas State University, San Marcos