Clinical trials: Spinal Cord Injuries
Spinal Cord Injury
Enhancing Quality of Life Through Exercise: A Tele-Rehabilitation Approach
Pilot randomized controlled trial evaluating a Self-Determination Theory (SDT) video-based tele-rehabilitation physical activity intervention aimed to enhance basic psychological needs, motivation, physical activity (PA), and…
- Trial name
- NCT02833935
- Testing
- Physical Activity Intervention
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- The Craig H. Neilsen Foundation
Bone Blood Flow Regulation
Exploration of Blood Flow Regulation to Bone in Humans
Without blood flow, bone cannot maintain its integrity. Bone blood flow responds to various local and systemic factors, however, bone perfusion in humans remains relatively unstudied.
- Trial name
- NCT04083794
- Testing
- Laboratory based assessments
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Detrusor Hyperreflexia
A Study Evaluating Oxybutynin in Patients With Neurogenic Overactive Bladder Associated With a Neurological Condition
This study will evaluate the efficacy and safety of an anticholinergic drug treatment administered by transdermal patch to treat overactive bladder in adults who have spinal cord injury.
- Trial name
- NCT00224029
- Testing
- Oxybutynin transdermal system
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- Watson Pharmaceuticals
Spinal Cord Injuries, Deglutition Disorders
Respiratory Capacity and Swallowing Function in Spinal Disorders: A Pilot Study
This study is part of a larger grant, for which the overall goal is to collect measurements of liquid flow through the oropharynx (i.e., mouth and throat) during swallowing.The focus of this study is to evaluate the flow of…
- Trial name
- NCT04114604
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Trigeminal Nerve Injuries, Post-herpetic Neuralgia
Transcranial Magnetic Stimulation for Facial Pain
Complex oro-facial pain is a poorly diagnosed and poorly treated cause of significant suffering and disability. This study will explore the ability of fMRI to identify patients with complex oro-facial pain who respond to…
- Conditions
- Trigeminal Nerve Injuries, Post-herpetic Neuralgia, Facial Pain, Nervus Intermedius Neuralgia
- Trial name
- NCT02633306
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota
Spinal Cord Injury
Biomechanics of Wheelchair Transfers
This is a laboratory-based study to evaluate the risk of shoulder injury associated with transfers between wheelchair and vehicle in persons with spinal cord injury.
- Trial name
- NCT00645567
- Testing
- Unassisted Manual Transfer, Standard Transfer Board, Glide n' Go
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Skilled Motor Training and tDCS to Improve Leg Function After Spinal Cord Injury
The study investigates the effect of using transcranial direct current stimulation (tDCS) and skilled stepping training versus skilled stepping training with sham-tDCS in improving ankle and leg motor control in persons with…
- Trial name
- SLT (NCT01962675)
- Testing
- Transcranial direct current stimulation + step training
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Miami
Spinal Cord Injury, Spinal Cord Injury Cervical
Neuromodulation After Spinal Cord Injury to Improve Limb Function
The University at Buffalo (UB) Department of Rehabilitation Sciences is looking for adult volunteers with and without spinal cord injuries for a study on hand movement.
- Trial name
- NCT06815601
- Testing
- rTMS, Motor training
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Cervical Spinal Cord Injury
Diaphragm Pacing in Individuals With Spinal Cord Injuries
This project will evaluate the effects of intramuscular diaphragm stimulation (pacing) and test the hypothesis that diaphragm pacing enhances neuromuscular diaphragm activation and respiratory function in adults with cervical…
- Trial name
- NCT04179799
- Testing
- Diaphragm Pacing
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Spinal Cord Injuries, Neuropathic Pain
Capsaicin 8% Patch for Spinal Cord Injury Neuropathic Pain
A prospective case control study to determine the effectiveness and longevity of 8% capsaicin patch(es) in treating neuropathic pain in persons with spinal cord injury.
- Trial name
- Capsaicin (NCT02441660)
- Testing
- Capsaicin 8% Patch, Low Dose Capsaicin 0.025% Well Patch
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Spinal Cord Injury
Use of an Oral Beta-2 Agonist in Persons With Spinal Cord Injury
The primary purpose of this study is to determine the effect of administration of the oral beta-2 adrenergic agonist, albuterol, on respiratory muscle strength in individuals with cervical (neck) and high thoracic (upper back)…
- Trial name
- NCT00755079
- Testing
- extended release beta-2 adrenergic agonist
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injuries, Slow Breathing
Slow Yogic-Derived Breathing and Respiration and Cardiovascular Variability in Spinal Cord Injury Patients
This research will aid in understanding of slow-breathing and its effect on heart rate and blood pressure in people with a spinal cord injury (SCI).
- Trial name
- SCOGA (NCT05480618)
- Testing
- Slow Breathing
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury
Lokomat Versus Strength Training in Chronic Incomplete Spinal Cord Injury
The purpose of this pilot study is to investigate whether gait specific robotic supported bodyweight supported treadmill training and lower extremity strength training have similar beneficial effects on walking function and other…
- Trial name
- NCT01087918
- Testing
- RAGT, Strength Training
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Acute Spinal Cord Injury
AC105 in Patients With Acute Traumatic Spinal Cord Injury
The principal aim of this study was to establish the feasibility of rapid administration, safety, and tolerability of AC105 in patients with acute spinal cord injury.
- Trial name
- AC105 (NCT01750684)
- Testing
- AC105
- Volunteers
- 15 people
- Sponsor
- Acorda Therapeutics
Osteoporosis, Bone Loss
Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)
Individuals with spinal cord injury sustain significant loss of bone mass in their lower extremities (20-40% or more). This study evaluates the ability of PTH and weight-bearing, two interventions that build bone, to increase…
- Conditions
- Osteoporosis, Bone Loss, Spinal Cord Injury
- Trial name
- NCT00826228
- Testing
- teriparatide, weight-bearing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Thomas J. Schnitzer
Spinal Cord Injuries
Musculoskeletal Plasticity After Spinal Cord Injury
Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population.
- Trial name
- NCT02622295
- Testing
- Single-session electrically induced exercise, Electrically-induced exercise training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Richard K Shields
Spinal Cord Compression Due to Metastasis to Spine
High-precision Radiotherapy of Motor Deficits Due to Metastatic Spinal Cord Compression
The major goal of this clinical study is to investigate to which extent high-precision radiotherapy (RT) with modern techniques can prevent progression or recurrence of motor deficits (weakness) of the legs following RT.
- Trial name
- PRE-MODE (NCT03070431)
- Testing
- High-precision RT 5x5 Gy in 1 week
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University Hospital Schleswig-Holstein
Spinal Cord Diseases, Spinal Cord Injuries
An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain
The purpose of this study is to assess the safety of the long-term use of pregabalin at doses up to 600 mg/day in patients with central neuropathic pain (post spinal cord injury pain, post stroke pain, and multiple sclerosis…
- Conditions
- Spinal Cord Diseases, Spinal Cord Injuries, Neuralgia, Pain
- Trial name
- NCT01202227
- Testing
- pregabalin
- Where
- 26 sites in Japan
- Volunteers
- 104 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Spinal Cord Injury, Urinary Tract Infection
Colonizing Neurogenic Bladders With Benign Flora
The purpose of the research is to determine whether we can get harmless bacteria to live in the bladders of persons with spinal cord injury who practice intermittent bladder catheterization.
- Trial name
- NCT00371631
- Testing
- Insertion of urinary catheters coated with E. coli 83972
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury at C4-C6 Level
High Definition Neuromuscular Stimulation in Tetraplegia
The purpose of this study is to demonstrate high definition non-invasive neuromuscular stimulation of an upper extremity in tetraplegic participants.
- Trial name
- NCT04075812
- Testing
- Neuromuscular Stimulator
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Ohio State University