Clinical trials: Spinal Cord Injuries (SCI)
Spinal Cord Injuries
Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI
The purpose of this study is to test the efficacy of mild breathing bouts of low oxygen (intermittent hypoxia) combined with transcutaneous electrical spinal cord stimulation on restoring hand function in persons with chronic…
- Trial name
- NCT04854057
- Testing
- AIH - Intermittent Hypoxia - hypoxia air mixture, TESS - Transcutaneous Electrical Spinal Cord Stimulation + Functional Task Practice
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury, Paraplegia
Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI
The primary objective of this study is to achieve successful walking skills using exoskeletal walking devices over the course of 36 sessions in 3 months at specific velocities and distances in people with chronic SCI who are…
- Conditions
- Spinal Cord Injury, Paraplegia, Tetraplegia
- Trial name
- EAWSCI (NCT02314221)
- Testing
- Exoskeletal-assisted walking (ReWalk, Ekso)
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
SCI-VIP: Predictive Outcome Model Over Time for Employment (PrOMOTE)
This study will be an extension of the Spinal Cord Injury Vocational Integration Program (SCI-VIP). The study involves research about how to help Veterans with spinal cord injury (SCI) gain employment.
- Trial name
- PrOMOTE (NCT01141647)
- Testing
- Vocational Rehabilitation
- Where
- 7 sites in United States
- Volunteers
- 1,047 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage
The annual incidence of colorectal cancer in the US during 2005 was approximately 150,000 cases and this neoplasm claimed 56,000 lives (American Cancer Society).
- Trial name
- NCT00745095
- Testing
- Neostigmine
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Acute Spinal Cord Injury
AC105 in Patients With Acute Traumatic Spinal Cord Injury
The principal aim of this study was to establish the feasibility of rapid administration, safety, and tolerability of AC105 in patients with acute spinal cord injury.
- Trial name
- AC105 (NCT01750684)
- Testing
- AC105
- Volunteers
- 15 people
- Sponsor
- Acorda Therapeutics
Spinal Cord Injuries, Inpatient
Exoskeletal-Assisted Walking in SCI Acute Inpatient Rehabilitation
The purpose of this research study is to test the effect of early exoskeletal-assisted walking (EAW) training (combined into regular acute inpatient rehabilitation (AIR)) on improving functional recovery and reducing pain and…
- Trial name
- NCT04221373
- Testing
- Ekso™ powered exoskeleton, Standard of care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Cord Injury
FES Rowing for Skeletal Health After SCI
Following a complete spinal cord injury (SCI), individuals experience progressive bone loss, especially in the legs, with up to 70% of persons with SCI sustaining a fracture at some point during their lifetime.
- Trial name
- FES-R (NCT02008149)
- Testing
- Rowing exercise
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Extending Veteran Participation in the Validation of the SCI-QOL/CAT
The field of spinal cord injury rehabilitation medicine lacks a reliable, patient reported, health-related quality of life measurement tool.
- Trial name
- NCT01238549
- Where
- 2 sites in United States
- Volunteers
- 284 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Enhancement of Pressure Healing With Pulsatile Lavage
The purpose of this study is to investigate the use of pulsatile lavage to enhance the healing of pressure ulcers in individuals with spinal cord injury (SCI).
- Trial name
- NCT00047619
- Testing
- Pulsatile Lavage
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury, Respiratory Muscle Weakness
Albuterol to Improve Respiratory Strength in SCI
Spinal cord injury (SCI), especially involving the cervical and upper thoracic segments, can significantly compromise respiratory muscle function.
- Trial name
- NCT02508311
- Testing
- Oral Albuterol Extended Release
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Biomechanics of Wheelchair Transfers
This is a laboratory-based study to evaluate the risk of shoulder injury associated with transfers between wheelchair and vehicle in persons with spinal cord injury.
- Trial name
- NCT00645567
- Testing
- Unassisted Manual Transfer, Standard Transfer Board, Glide n' Go
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
ProACTIVE SCI Physical Activity Intervention
This study will employ a randomized, wait-list controlled trial. A total of 30 participants (15 experimental, 15 wait-list control) between 18-65 years of age who have chronic SCI ≥ 1 year prior will be recruited.
- Trial name
- NCT03111030
- Testing
- ProacTive SCI
- Where
- 2 sites in Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Spinal Cord Injuries, Neuropathic Pain
Evaluation of Initiation Time on the Efficacy of Gabapentin in Treating Neuropathic Pain in SCI
Neuropathic pain is a common complaint in those with spinal cord injury (SCI) that has a significant negative effect on quality of life. Efficacy of various treatments, however, remains controversial.
- Trial name
- NCT04256603
- Testing
- Gabapentin, No gabapentin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- MetroHealth Medical Center
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS
Rehabilitation interventions such as physical training and neural stimulation after spinal cord injury (SCI) have been shown to increase neural plasticity.
- Trial name
- NCT03851302
- Testing
- Active Remote Ischemic Conditioning, Isometric hand exercise
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Bronx VA Medical Center
Orthostatic Hypotension, Spinal Cord Injury
A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
With upright postures, there is an immediate redistribution of blood to the dependent circulation; venous return and central venous filling pressure are reduced, resulting in diminution of cardiac output and blood pressure.
- Trial name
- NCT00426842
- Testing
- Midodrine Hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Paraplegia, Quadriplegia
Robotically Assisted Treadmill Training in Spinal Cord Injury (SCI)
This proposal investigates the hypothesis that progressive aerobic exercise with Lokomat is feasible in people with motor incomplete spinal cord injury, and three months of training will improve cardiovascular fitness and gait…
- Conditions
- Paraplegia, Quadriplegia, Spinal Cord Injury, Tetraplegia
- Trial name
- NCT00385918
- Testing
- Lokomat Training, Home stretching then Lokomat training
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury, Tetraplegia
Rehabilitation of the Upper Extremity With Enhanced Proprioceptive Feedback Following Incomplete Spinal Cord Injury
The purpose of this study is to determine if tetraplegic individuals with incomplete spinal cord injury (SCI) who remain unable to move their arms normally 1 year after their SCIs are able to sense and move the affected arm(s)…
- Conditions
- Spinal Cord Injury, Tetraplegia, Paresis, Plegia
- Trial name
- NCT00833105
- Testing
- AMES treatment
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Oregon Health and Science University
Spinal Cord Injuries
Effect of Vibration Therapy on Bone in Persons With Sub-acute Spinal Cord Injury
The purpose of this research study is to determine the effect of mechanical vibrations on bones of persons with spinal cord injury.
- Trial name
- NCT00886145
- Testing
- Vibration: Right Leg and No Vibration: Left Leg.
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- William A. Bauman, M.D.
Spinal Cord Injury
Developing a Home Telehealth Program to Manage Pressure Ulcers in SCI/D
The Veteran's Health Administration (VHA) is a national leader in using distance technology to monitor patients' self-care via an in-home messaging device with disease management protocols (DMPs).
- Trial name
- NCT00624806
- Testing
- Daily telephone calls, Weekly telephone calls
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injuries
Improving Ventilatory Capacity in Those With Chronic High Level SCI
The purpose of this study is to find out if taking the drug Buspar will increase breathing capacity in individuals with spinal cord injuries.
- Trial name
- NCT05041322
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Spaulding Rehabilitation Hospital