Clinical trials: Spinal Cord Injuries (SCI)
ALS (Amyotrophic Lateral Sclerosis), TBI Traumatic Brain Injury
Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro
The goal of this study is refine the usability of a BCI capable communication platform. The study will take place in the United States area and will enroll up to 10 participants with late stage ALS, traumatic brain injury (TBI)…
- Conditions
- ALS (Amyotrophic Lateral Sclerosis), TBI Traumatic Brain Injury, SCI - Spinal Cord Injury, Stroke
- Trial name
- NCT07209943
- Testing
- Cognixion + Apple Vision Pro
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cognixion
Spinal Cord Injuries, Peripheral Nerve Injuries
Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI)
The purpose of this research is to examine the effects that functional electrical stimulation (FES) therapy has on the way the arms, brain and spinal cord work.
- Trial name
- NCT06672458
- Testing
- MyndMove Short Term Therapy, Conventional Short Term Therapy, MyndMove Long Term Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Spinal Cord Injuries, Cognitive Decline
SCED Myokines and Cognition in SCI
Rationale: Individuals with spinal cord injury (SCI) suffer from accelerated cognitive aging. In able-bodied individuals, a vast amount of studies have shown that exercise interventions can improve cognitive function.
- Trial name
- NCT05822297
- Testing
- Neuromuscular electrical stimulation
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Adelante, Centre of Expertise in Rehabilitation and Audiology
Stroke, Spinal Cord Injuries (SCI)
ZEPU-AI1 Gait Robot Training Study (ZEPUAI1RCT)
Walking problems caused by stroke, spinal cord injury, or orthopedic surgery are common and can seriously limit a person's independence.
- Conditions
- Stroke, Spinal Cord Injuries (SCI), Gait Disorders, Neurologic
- Trial name
- NCT07735676
- Testing
- ZEPU-AI1 Gait Training and Evaluation System, Standard-of-Care Rehabilitation (Individualized Rehabilitation and Exercise)
- Where
- Bangladesh
- Volunteers
- 51 people
- Sponsor
- Bangladesh Medical University
Spinal Cord Injuries
Locomotor Training With Exoskeleton EKSO-GT in Patients With Incomplete Motor Spinal Cord Injury in a Hospital Setting
The aim of this observational, non-controlled, non-profit study is to describe the responses to rehabilitative training with the robotic exoskeleton EKSO-GT in patients with incomplete motor Spinal Cord Injury (AIS C or D).
- Trial name
- NCT02600013
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
Spinal Cord Injuries, Cardiovascular Diseases
Role of Endothelial Function in SCI CVD Risk
Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear.
- Conditions
- Spinal Cord Injuries, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- NCT06443151
- Testing
- Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid), venous occlusion plethysmography, Acetylcholine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Craig Hospital
Spinal Cord Injury, Acute, Spinal Cord Injury (SCI), Initial Encounter
Duraplasty for Acute Traumatic Spinal Cord Injury
The goal of this clinical trial is to learn if a procedure called "expansile duraplasty" can improve recovery in adults who have experienced an acute traumatic spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury, Acute, Spinal Cord Injury (SCI), Initial Encounter, Spinal Cord Injury Cervical
- Trial name
- DATSCI (NCT07280351)
- Testing
- Expansile duraplasty
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, San Francisco
Spinal Cord Injuries (SCI), Spinal Cord Injury
Clinical Testing of Invasive Spinal Cord Stimulation and Evaluation of Its Physiological Effects Using the Electroencephalography
The aim of the study is to identify the specific characteristics of brain network dysfunctions and assess the recovery of their functionality through the recording of resting-state electroencephalography (EEG) during…
- Trial name
- NCT06725836
- Testing
- Implantation of electrodes into the epidural space for spinal cord stimulation, Selection of the optimal spinal cord stimulation program for spastic syndrome suppression, Selection of the optimal spinal cord stimulation program for volitional motor control
- Where
- 3 sites in Russia
- Volunteers
- 35 people
- Sponsor
- Artur Biktimirov
Spinal Cord Injury
Enhancement of Pressure Healing With Pulsatile Lavage
The purpose of this study is to investigate the use of pulsatile lavage to enhance the healing of pressure ulcers in individuals with spinal cord injury (SCI).
- Trial name
- NCT00047619
- Testing
- Pulsatile Lavage
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury, SCI
ARC-IM Therapy To Support and Promote Recovery of Ambulatory Functions in People With Subacute and Chronic Spinal Cord Injury
The EIGER study aims to evaluate the safety and preliminary efficacy of ARC-IM Therapy (Epidural Electrical Stimulation) to support and promote recovery of ambulatory functions, such as walking, in people with subacute and…
- Conditions
- Spinal Cord Injury, SCI, SCI - Spinal Cord Injury, Subacute Spinal Cord Injury
- Trial name
- EIGER (NCT07234903)
- Testing
- ARC-IM Therapy
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Spinal Cord Injury
C-Brace II Spinal Cord Injury
A randomized, repeated measures comparative design study to compare use of a micro-processor controlled knee-ankle-foot orthosis vs.
- Trial name
- NCT03930056
- Testing
- C-Brace II, Traditional Care KAFO intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries, Neurogenic Bladder
Motor & Autonomic Concomitant Health Improvements With Neuromodulation & Exercise Training: An SCI RCT
Spinal cord injury (SCI) disrupts many aspects of life, including the loss of volitional movement and involuntary control of bodily functions; both crucial functional recovery priorities for this population.
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder, Neurogenic Bowel
- Trial name
- MACHINE (NCT04726059)
- Testing
- Transcutaneous Spinal Cord Stimulation, Activity-Based Therapy
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of British Columbia
Spinal Cord Injury(SCI)
Multilevel Multimodal Neurophysiological Integration for Investigating the Network Modulatory Mechanisms of Epidural Spinal Cord Stimulation
This study will examine how the brain, spinal cord, and muscles communicate in people with spinal cord injury. Researchers will use noninvasive brain and muscle recordings together with spinal electrical recordings to better…
- Trial name
- NCT07732972
- Testing
- participants will be divided into two disease cohorts: the spinal cord injury (SCI) group and the non-spinal cord injury (non-SCI) group.
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Spinal Cord Injuries (SCI)
The Predictive Value of Lower Extremity Hypertonia on Neurogenic Detrusor Overactivity After Spinal Cord Injury
The goal of this observational study is to evaluate whether increased lower extremity muscle tone can serve as an independent predictor of neurogenic detrusor overactivity (NDO) in adult patients (aged 18-80 years) with upper…
- Trial name
- NCT07695662
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital
Spinal Cord Injury (SCI)
Interdisciplinary Value-based Cognitive Behavioral Treatment for People With Traumatic Spinal Cord Injury
The goal of this clinical trial is to address the critical need for effective interventions by developing and testing an interdisciplinary values-based cognitive behavioral therapy (V-CBT) program for individuals with spinal cord…
- Trial name
- VALIANT (NCT06599632)
- Testing
- Values-based Cognitive Behavioral Therapy (V-CBT)
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- University of Southern Denmark
Female Sexual Dysfunction, Multiple Sclerosis
Effects of Spinal Cord Injury on Female Sexual Response
The long term aims of this project are to 1) Understand the effect of varying degrees and levels of SCI and dysfunction(SCI/D)on females sexual response: 2) Identify the specific neuronal pathways involved in female sexual…
- Conditions
- Female Sexual Dysfunction, Multiple Sclerosis, Spinal Cord Injury
- Trial name
- NCT00142714
- Testing
- Sympathetic manipulation on sexual arousal in women
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Spinal Cord Injuries
Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI
The purpose of this study is to test the efficacy of mild breathing bouts of low oxygen (intermittent hypoxia) combined with transcutaneous electrical spinal cord stimulation on restoring hand function in persons with chronic…
- Trial name
- NCT04854057
- Testing
- AIH - Intermittent Hypoxia - hypoxia air mixture, TESS - Transcutaneous Electrical Spinal Cord Stimulation + Functional Task Practice
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injuries, Postprandial Hypotension
Low-GI Diet Vs High-GI Diet in Individuals with SCI
The purpose of this pilot research project is to examine the impact of a low-glycemic index (GI) diet on postprandial hypotension and glucose control in individuals with chronic spinal cord injury.
- Conditions
- Spinal Cord Injuries, Postprandial Hypotension, Glucose Metabolism Disorders
- Trial name
- NCT05334342
- Testing
- Low-GI Diet, High-GI Diet
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Ohio State University
Spinal Cord Injuries
Neuro-navigated TMS for Chronic SCI Patients
Can neuro-navigated Transcranial Magnetic Stimulation be used as an additional outcome measure to EM-SCI assessments in a Spinal cord injury trial? Compare EM-SCI assessment with nTMS in ten chronic thoracic SCI patients Compare…
- Trial name
- NCT06075056
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College Hospital NHS Trust