Clinical trials: Spinal Cord Injury(SCI)
Acute Spinal Cord Injury (SCI)
Expanded Access to Elezanumab
This is an expanded access program (EAP) for eligible participants. This program is designed to provide access to Elezanumab prior to approval by the local regulatory agency. Availability will depend on territory eligibility.
- Trial name
- NCT04278235
- Testing
- Elezanumab
- Sponsor
- AbbVie
Incomplete Spinal Cord Injury (SCI)
Transcutaneous Spinal Cord Stimulation (tSCS) During Assisted Cycling Training for Incomplete Spinal Cord Injury.
The goal of this clinical trial is to learn if transcutaneous spinal cord stimulation works to improve lower limb motor function in adults with incomplete spinal cord injury.
- Trial name
- tSCS_SJD_PMI_1 (NCT07445685)
- Testing
- Transcutaneous spinal cord stimulation on the dorsal region between T11 and T12
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundació Sant Joan de Déu
Spinal Cord Injuries, Pain, Neuropathic
Using NI-ES to Treat Spinal Cord Injury (SCI)
NI-ES therapy is a treatment that is being studied to potentially treat pain associated with SCI and may help movement below the injury site.
- Trial name
- NCT04097015
- Testing
- Alpha-Stim M
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- SCI Research Advancement
Spinal Cord Injuries (SCI), Paraplegia and Tetraplegia
Self-balancing Personal Exoskeleton for SCI
This study aims to demonstrate the safety and effectiveness of the Eve personal exoskeleton in individuals with spinal cord injury (SCI).
- Trial name
- NCT06777576
- Testing
- Hands-free exoskeleton
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wandercraft
Tetraplegia/Tetraparesis, Quadriplegia
VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration
The VOICE Study is an early feasibility study to evaluate the initial clinical safety and efficacy of the N1 and R1 Systems device design concept in providing an ability to communicate.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Cervical Spinal Cord Injury, Amyotrophic Lateral Sclerosis
- Trial name
- NCT07224256
- Testing
- N1 Implant, R1 Robot
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Neuralink Corp
Spinal Cord Injury
Study Effects of Intermittent Hypoxia on Restoring Hand Function Following SCI
The goal of the study is to examine the effects of repeated breathing episodes of mild intermittent hypoxia (reduced oxygen) training on hand strength and grasping ability following cervical spinal injury, and to determine…
- Trial name
- NCT01272336
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Emory University
Spinal Cord Injuries (SCI)
RTsMS and Body Weight-support Treadmill Training After Incomplete Spinal Cord Injury
The aim of this study is to assess the feasibility of combining rTsMS with BWSTT for gait and sensorimotor recovery in individuals with incomplete spinal cord injury.
- Trial name
- NCT06886308
- Testing
- Repetitive trans-spinal magnetic stimulation
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- Universidade Federal de Pernambuco
Acute Spinal Cord Injury (SCI), Spinal Cord Diseases
NG004 in Incomplete Spinal Cord Injury Patients
This is a randomized, double-blind, placebo controlled, multicenter trial of NG004 in patients with acute traumatic incomplete cervical SCI.
- Conditions
- Acute Spinal Cord Injury (SCI), Spinal Cord Diseases, Spinal Cord Injuries, Trauma Nervous System
- Trial name
- SPROUT-2 (NCT07840196)
- Testing
- NG004
- Where
- 10 sites in Germany, Switzerland
- Volunteers
- 120 people
- Sponsor
- NovaGo Therapeutics AG
Spinal Cord Injury Cervical, Tetraplegia/Tetraparesis
Implantable Wireless Brain-Computer Interface Systems in Patients With Tetraplegia
Objectives of Study: This trial aims to evaluate the safety and efficacy of an implantable wireless brain-computer interface system in patients with tetraplegia resulting from spinal cord injury.
- Conditions
- Spinal Cord Injury Cervical, Tetraplegia/Tetraparesis, Spinal Cord Injuries (SCI)
- Trial name
- LEAP (NCT07784088)
- Testing
- IWBCIS
- Where
- China
- Volunteers
- 34 people
- Sponsor
- BCIFlex Medical Technology Co., Ltd.
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Plus Finasteride Treatment After Spinal Cord Injury
The purpose of this study is to determine whether testosterone plus finasteride treatment will improve musculoskeletal health, neuromuscular function, body composition, and metabolic health in hypogonadal men who have experienced…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injuries
- Trial name
- NCT02248701
- Testing
- Testosterone Enanthate, Finasteride
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury
This study was initially designed to test the efficacy of Venlafaxine HCl in reducing incidence of the onset of major depression after a new spinal cord injury (SCI).
- Trial name
- NCT00735670
- Testing
- Venlafaxine HCl
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
Spinal Cord Injuries
Scale Up of Project Workout on Wheels Internet Intervention (WOWii)
This study is designed is to test the feasibility, fidelity, and effectiveness of scaling up an evidence- and theory-based virtually delivered physical activity intervention (WOWii) for individuals living with chronic SCI for…
- Trial name
- WOWii (NCT05353842)
- Testing
- WOWii Program
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Craig Hospital
Depression, Spinal Cord Injuries
Treatment of Depression Post-SCI
Depression is more common after a spinal cord injury (SCI) than in the general population. Unfortunately, it is unknown how depression is typically treated in individuals with SCI or if commonly used treatment methods are…
- Trial name
- NCT04263285
- Testing
- rTMS
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Medical University of South Carolina
Spinal Cord Injury, Paraplegia, Spinal
tSCS Combined With Rehabilitation Training in Treating Paraplegic Patients After SCI
This clinical trial aims to evaluate the safety and efficacy of transcutaneous spinal cord stimulation (tSCS) combined with rehabilitation training for treating paraplegia after spinal cord injury (SCI).
- Trial name
- tSCScwRT (NCT07907952)
- Testing
- Transcutaneous Spinal Cord Stimulation Combined with Rehabilitation Training
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Spinal Cord Injuries, Obesity
The SEEA (SCI Energy Expenditure and Activity) Study
People with SCI are at higher risk of obesity and chronic diseases, such as hypertension, high cholesterol, diabetes and cardiovascular disease, than the general population.
- Conditions
- Spinal Cord Injuries, Obesity, Metabolic Syndrome, Cardiovascular Diseases
- Trial name
- SEEA (NCT04748835)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Baylor Research Institute
Spinal Cord Injury
Improving Hand and Arm Function After Spinal Cord Injury (SCI)
The long-term goal of this project is to develop rehabilitation strategies that facilitate optimal restoration of skilled hand use in individuals with spinal cord injury (SCI).
- Trial name
- NCT01143597
- Testing
- Arm and hand training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Miami
Pressure Injuries, Spinal Cord Injuries (SCI)
Electrical Stimulation for Clinical and Psychosocial Outcomes in Chronic Pressure Injuries
Pressure injuries are chronic wounds that frequently occur in immobilized patients and are associated with delayed healing, reduced quality of life, and significant psychological burden.
- Conditions
- Pressure Injuries, Spinal Cord Injuries (SCI), Traumatic Brain Injury
- Trial name
- NCT07493889
- Testing
- High-Voltage Monophasic Pulsed Current Electrical Stimulation, Standard Wound Care
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Spinal Cord Injury
High Frequency SARS for Neurogenic Bladder and Bowel Emptying
The purpose of this study is to determine if bladder emptying can be achieved using stimulation of the sacral roots at certain frequencies. Neurogenic bladder dysfunction occurs after spinal cord injury (SCI).
- Trial name
- SARS600 (NCT05214378)
- Testing
- Finetech-Brindley Sacral Anterior Roots Stimulation System
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Spinal Cord Injury (SCI), Initial Encounter
Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury II (PROMPT-SCI II) Trial
Spinal cord injuries (SCI) are among the most catastrophic survivable events experienced by human beings. Affected individuals remain with lifelong neurological impairment involving motor, sensory, bladder and bowel functions…
- Trial name
- PROMPT-SCI II (NCT07472985)
- Testing
- activity-based therapy
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Acute Spinal Cord Injury, Spinal Cord Injuries
Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial
The study involves the 'first-in-human' evaluation of a novel optical sensor which uses near-infrared spectroscopy (NIRS) technology to assess oxygenation and hemodynamics of the injured spinal cord.
- Trial name
- NCT04811235
- Testing
- Near Infra-Red Spectroscopy (NIRS) Sensor
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia