Clinical trials: Spinal Cord Injury(SCI)
Acute Spinal Cord Injury
AC105 in Patients With Acute Traumatic Spinal Cord Injury
The principal aim of this study was to establish the feasibility of rapid administration, safety, and tolerability of AC105 in patients with acute spinal cord injury.
- Trial name
- AC105 (NCT01750684)
- Testing
- AC105
- Volunteers
- 15 people
- Sponsor
- Acorda Therapeutics
Spinal Cord Injury
Indego Exoskeleton After SCI
The purpose of this study is to assess the use of Indego as a gait training tool for subjects with complete or incomplete paraplegia as a result of spinal cord injury (SCI) who have preserved lower extremity function.
- Trial name
- NCT02793635
- Testing
- Indego Powered Exoskeleton
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Parker Hannifin Corporation
Spinal Cord Injury
Cardiovascular Health/Outcomes: Improvements Created by Exercise and Education in SCI (CHOICES)
This study aims to determine whether body weight-supported treadmill training (BWSTT) has beneficial effects, over and above arm-cycle ergometry training (ACET) on indicators of cardiovascular disease (CVD) risk in individuals…
- Trial name
- CHOICES (NCT01718977)
- Testing
- Body Weight Supported Treadmill Training, Arm Cycle Ergometry Training
- Where
- 3 sites in Canada
- Volunteers
- 46 people
- Sponsor
- University of British Columbia
Osteoporosis, Bone Loss
Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)
Individuals with spinal cord injury sustain significant loss of bone mass in their lower extremities (20-40% or more). This study evaluates the ability of PTH and weight-bearing, two interventions that build bone, to increase…
- Conditions
- Osteoporosis, Bone Loss, Spinal Cord Injury
- Trial name
- NCT00826228
- Testing
- teriparatide, weight-bearing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Thomas J. Schnitzer
Spinal Cord Injuries (SCI), Osteoporosis
Osteoporosis Awareness in Chronic Spinal Cord Injury
Osteoporosis is a common and serious complication of spinal cord injury (SCI), substantially increasing the risk of fragility fractures.
- Conditions
- Spinal Cord Injuries (SCI), Osteoporosis, Health Knowledge, Attitudes
- Trial name
- NCT07725081
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Afyonkarahisar Health Sciences University
Spinal Cord Injuries, Exercise Program
Exercise Program for Individuals With SCI in Community
Patients with spinal cord injury (SCI) who have reduced mobility have difficulty exercising on their own without proper guidance in the community.
- Conditions
- Spinal Cord Injuries, Exercise Program, Rehabilitation
- Trial name
- NCT06524453
- Testing
- Wheelchair accessible exercise program
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Spinal Cord Injury
Gastrointestinal and Urinary Tract Microbiome After SCI
Changes in the GI microbiota and/or metabolomics have been linked to evolving transformations in immune system function and infection rates in experimental SCI in animal models.
- Trial name
- NCT02903472
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 43 people
- Sponsor
- University of British Columbia
Spinal Cord Injury
Blood Flow Restriction Exercise for Those With SCI
Spinal cord injuries (SCI) are among the most debilitating conditions an individual can sustain with the estimates of SCI incidence in the United States at 12,000 new cases per year.
- Trial name
- NCT04889092
- Testing
- Blood Flow Restriction exercise, Traditional resistance exercise
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Paraplegia, Spinal
Activity-Dependent Transspinal Stimulation in SCI
Robotic gait training is often used with the aim to improve walking ability in individuals with Spinal Cord Injury. However, robotic gait training alone may not be sufficient.
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, Spastic
- Trial name
- NCT03669302
- Testing
- Robotic gait training, Robotic gait training and low-frequency transspinal stimulation, Robotic gait training and high-frequency transspinal stimulation
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- City University of New York
Spinal Cord Injury, Stroke
Medical Device for Magnetic Therapy for Spinal Cord Injuries (SCI)
A medical device for magnetic therapy for spinal cord injuries (SCI) will be disclosed. The apparatus comprises a combination of several magnets enclosed in a supportive cover.
- Trial name
- SCIMAG (NCT02333695)
- Testing
- Spinal Magnetic Stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- American Society Of Thermalism And Climatology Inc
Aortic Aneurysm, Thoracoabdominal
Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging
Aortic aneurysms represent the most common and dangerous aortic diseases. Although conventional aortic repair techniques cure the disease, there is a high risk of paraplegia particularly in extensive thoracoabdominal aneurysms…
- Trial name
- PAPAartis (NCT03434314)
- Testing
- Minimally-Invasive Segmental Artery Coil-Embolization
- Where
- 29 sites in Austria, France and 7 more
- Volunteers
- 500 people
- Sponsor
- University of Leipzig
Spinal Cord Injuries
Safety of Cultured Allogeneic Adult Umbilical-cord or Placental Derived Mesenchymal Stem Cell Intrathecal Injection for SCI
This trial will study the safety and efficacy of intrathecal injection of cultured allogeneic adult umbilical-cord or placental derived mesenchymal stem cells for the treatment of spinal cord injury
- Trial name
- NCT05018793
- Testing
- Cultured Allogeneic Adult Umbilical-cord or Placental Derived Mesenchymal Stem Cell Intrathecal injection
- Where
- 2 sites in United States, Greece
- Volunteers
- 15 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Spinal Cord Injuries, Inflammation
Neuromodulation as an Anti-inflammatory Treatment in SCI
The goal of this single-blinded randomized, controlled trial is to assess the impact of 1-hour of active transcutaneous auricular vagus nerve stimulation (taVNS) vs sham taVNS on serum biomarkers of the inflammatory reflex and…
- Trial name
- NCT05730049
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Spinal Cord Injuries, Paraplegia and Tetraplegia
Self-balancing Personal Exoskeleton for SCI (WIP)
This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).
- Trial name
- NCT07536386
- Testing
- Hands-free exoskeleton
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Wandercraft
Spinal Cord Injury
Effects of Salsalate on Prandial-Induced Vascular Inflammation After Spinal Cord Injury (SCI)
The overall study objectives are to examine whether: 1. Persons with spinal cord injury (SCI) having elevated body mass are at greater cardiovascular disease (CVD) risk for fasting and postprandial lipidemia, glycemia, and…
- Trial name
- NCT01201759
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
Spinal Cord Injuries (SCI)
VR-Integrated C-Mill® Combined With Conventional Therapy in Motor-Incomplete SCI
This study investigates the effects of C-Mill® treadmill training, which integrates virtual reality and gamified tasks, combined with conventional physiotherapy, on walking ability, mobility, functional independence, and…
- Trial name
- NCT07141784
- Testing
- C-Mill® Treadmill Training Combined with Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- Ankara City Hospital Bilkent
Spinal Cord Injuries, Neurogenic Detrusor Overactivity
TTNS in SCI Patients With Neurogenic Detrusor Overactivity
This is a prospective, single-arm, pilot study to assess effectiveness and tolerability of transcutaneous tibial nerve stimulation (TTNS) in managing neurogenic detrusor overactivity in spinal cord injury patients.
- Trial name
- NCT07785258
- Testing
- TTNS
- Where
- Singapore
- Volunteers
- 12 people
- Sponsor
- National University Hospital, Singapore
Spinal Cord Injuries
Lokomat® vs RoboGait® Under Different Guidance Force Settings in Motor-Incomplete SCI
This study compares two robotic-assisted gait training systems, Lokomat® and RoboGait®, used under different guidance force (GF) settings, in people with motor-incomplete spinal cord injury (iSCI).
- Trial name
- NCT07137780
- Testing
- Lokomat® V6 (GF < 90%), Lokomat® V6 (GF ≥ 90%), RoboGait®
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- Ankara City Hospital Bilkent
Spinal Cord Injuries
Effects of CB1 Antagonist/Reverse Agonist Rimonabant on Walking Abilities in Incomplete Spinal Cord Injury
This is a placebo controlled study comparing Rimonabant 5 mg per day for 90 days with placebo for the same period. Objective is to improve walking abilities of spinal cord injury individuals (incomplete lesions) and demonstrate…
- Trial name
- RIMOFATSCI-2 (NCT05622994)
- Testing
- Rimonabant
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Nacional de Parapléjicos de Toledo
Deep Brain Stimulation, Neuro: Spinal Cord Injury
Deep Brain Stimulation of the Lateral Hypothalamus to Augment Motor Function of Patients With Spinal Cord Injury
The purpose of this study is to evaluate safety of Deep Brain Stimulation (DBS) of the lateral hypothalamus (LH) and whether the use of DBS can increase motor performance in patients with chronic spinal cord injury (SCI).
- Trial name
- HoT-DBS (NCT04965727)
- Testing
- Device implantation
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Jocelyne Bloch