Clinical trials: Spinal Cord Injury(SCI)
Spinal Cord Injuries (SCI)
A Comprehensive Assessment of Altered Embodiment in Individuals With Spinal Cord Injury
Spinal cord injury (SCI) occurs when trauma or other factors damage the spinal cord, disrupting the flow of sensory information from the body to the brain.
- Trial name
- SCI_Embodiment (NCT06688916)
- Testing
- Behavioral assessment, Functional Magnetic Resonance Imaging (fMRI)
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spinal Cord Injury
Coronary Computed Tomography (CT) to Measure Coronary Calcification in Spinal Cord Injury (SCI)
Although conventional risk factors for coronary heart disease (CHD) have been identified and routinely used to determine risk for CHD in the general population, a systematic approach to determine population-specific risk for CHD…
- Trial name
- NCT01065896
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injuries
Training Therapists in Motivational Interviewing
The purpose of this study is to test the efficacy of a Motivational Interviewing intervention on therapy participation as performed by physical and occupational therapists in an inpatient setting with patients with spinal cord…
- Trial name
- NCT03322202
- Testing
- Motivational Interviewing
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury (=3 Years), Sublesional Bone Loss Secondary to SCI
Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI
Treatment for sublesional bone loss (osteoporosis) in persons with chronic, motor-complete spinal cord injury (SCI) has been limited and unsuccessful to date.
- Trial name
- Chronic Romo (NCT04232657)
- Testing
- Romosozumab, Denosumab
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries (SCI), Blood Pressure
AI-Guided Predictions of Blood Pressure Dysregulation Using Perfusion Index as a Novel Biomarker in Persons With Spinal Cord Injury
The goal of this clinical trial is to determine if perfusion index (PI) can reliably predict changes in systolic blood pressure (SBP) in persons with spinal cord injury (SCI) during a cool temperature challenge.
- Conditions
- Spinal Cord Injuries (SCI), Blood Pressure, Thermoregulation, Perfusion Index
- Trial name
- NCT07699094
- Testing
- Controlled Cool Thermal Challenge (18°C)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injury (SCI), Gait
Implant for Walking After Incomplete SCI
This is a device study that will evaluate the effect of an implanted stimulator on improving walking in people with incomplete spinal cord injury.
- Trial name
- NCT06965127
- Testing
- NNP-LE
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Louis Stokes VA Medical Center
Spinal Cord Injury
SCI-FACT: The Effectiveness of Focused ACT for SCI Patients
Research has found that patients with a Spinal Cord Injury (SCI) suffer with longstanding mental health difficulties, likely due to the impact of the lifelong physical and health problems that come with their injury.
- Trial name
- NCT07167290
- Testing
- Focused Acceptance and Commitment Therapy
- Volunteers
- 8 people
- Sponsor
- University of Lincoln
Spinal Cord Injury (SCI)
FLO2 for Recovery After SCI
Acute intermittent hypoxia (AIH) involves short (~1-2min) bouts of breathing low oxygen air to stimulate spinal neuroplasticity.
- Trial name
- NCT03833674
- Testing
- Daily AIH Block, Respiratory Strength Training Block, AIH + Strength Training Block
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Florida
Spinal Cord Injury, Spinal Cord Involvement
Clinical Trial of a Serious Game for Individuals With SCI/D
This study will evaluate the efficacy of a newly developed serious game, SCI HARD, to enhance self-management skills, self-reported health behaviors, and quality of life among adolescents and young adults with spinal cord injury…
- Conditions
- Spinal Cord Injury, Spinal Cord Involvement, Spina Bifida, Transverse Myelitis
- Trial name
- NCT02341950
- Testing
- SCI Hard
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Michigan
Injuries, Spinal Cord
The WISE Trial - Walking Improvement for SCI With Exoskeleton
A randomized, controlled trial comparing exoskeleton gait training with standard gait training or no gait training in community-dwelling participants with chronic incomplete spinal cord injury
- Trial name
- WISE (NCT02943915)
- Testing
- Ekso GT Rehabilitation Therapy, Body Weight Supported (BWS) Treadmill Training
- Where
- 10 sites in United States
- Volunteers
- 45 people
- Sponsor
- Ekso Bionics
Spinal Cord Injury Cervical, Respiratory Failure
Epidural Spinal Cord Stimulation for Respiratory Recovery in Cervical SCI
This multicenter, single-arm exploratory IIT evaluates epidural spinal cord electrical stimulation (ESCES) in 20 adults with C1-C5 SCI and respiratory failure.
- Trial name
- NCT07722130
- Testing
- Epidural spinal cord stimulation
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Zhongda Hospital
Urinary Retention, Neurogenic Bladder
Connected Catheter (C2P) Study for Bladder Management
The objective of this study is to evaluate the safety and essential performance of the C2P System in males with neurogenic lower urinary tract dysfunction (NLUTD), both in an acute clinical setting and an extended period of home…
- Trial name
- NCT03626324
- Testing
- C2P
- Where
- 8 sites in United States
- Volunteers
- 27 people
- Sponsor
- Spinal Singularity
Spinal Cord Injuries
Orthostatic, Respiratory, Balance-Intervention
The purpose of this study is to help understand how training breathing muscles will impact balance, blood pressure, and quality of life of participants with spinal cord injury.
- Trial name
- ORB-I (NCT04210063)
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
SCI - Spinal Cord Injury, SCI
NeuroRise: Intrathecal CE-1 Treatment for Traumatic SCI
The purpose of this study is to assess the safety and tolerability of intrathecal administration of CE-1 at a weight-based dose (cells/kg BW), capped at a maximum total dose of 1×10⁸ cells in 10 mL, with administered volume…
- Conditions
- SCI - Spinal Cord Injury, SCI, Spinal Cord Injury
- Trial name
- NeuroRise (NCT07739043)
- Testing
- Human allogeneic, culture expanded, UC-MSC
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Cell Therapy LLC
Spinal Cord Injury
Neurofeedback for Treatment of Central Neuropathic Pain (CNP) in Sub-acute Spinal Cord Injury (SCI)
Spinal Cord Injury (SCI) affects a person's ability to move and feel sensation in the body. SCI is also an indirect cause of a persistent pain, called Central Neuropathic Pain (CNP).
- Trial name
- NCT02178917
- Testing
- Neurofeedback therapy, No neurofeedback therapy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Spinal Cord Injuries, Gait Disorders, Neurologic
Effectiveness of a Powered Exoskeleton Combined With FES for Patients With Chronic SCI: a RCT
While there are a number of prospective studies evaluating powered exoskeletons in SCI patients, to date, not a single well-designed, randomized clinical trial has been published.
- Trial name
- Ekso-FES (NCT05187650)
- Testing
- Ekso (EksoNR, Ekso Bionics), FES (RehaMove2, Hasomed)
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Mario Widmer
SCI - Spinal Cord Injury
Double Dose 4-AP on Functional Recovery After Spinal Cord Injury
The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP).
- Trial name
- NCT06853015
- Testing
- Dalfampridine, STDP stimulation, Exercise training
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Cethrin in Acute Cervical Spinal Cord Injury
This is a multicenter, randomized, double-blind, placebo-controlled Phase IIb/III study designed to evaluate the efficacy and safety of Cethrin as a treatment for acute cervical spinal cord injury.
- Trial name
- NCT02053883
- Testing
- Cethrin (BA-210)
- Sponsor
- BioAxone BioSciences, Inc.
SCI - Spinal Cord Injury
Food Intake and Thermogenesis in High Spinal Cord Injury
The purpose of this research is to determine the effects of food on cardiovascular and metabolic health in men with and without spinal cord injury (SCI).
- Trial name
- NCT07103993
- Testing
- Low meal condition, Moderate meal condition, High meal condition
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injuries, Neurological Injury
Physiological Changes Induced Through MEP Conditioning in People With SCI
The study team is currently recruiting volunteers who are interested in participating in a brain-spinal cord-muscle response training study that aims to better understand the changes that take place in the nervous system as a…
- Conditions
- Spinal Cord Injuries, Neurological Injury, Paralysis, Spasticity, Muscle
- Trial name
- NCT04286191
- Testing
- Operant Conditioning, Control Group
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina